High-quality intergenerational relationships positively influence cognitive functioning in older parents. However, there is insufficient information on how they shape the trajectories of mothers’ and fathers’ cognitive functioning decline in multi-child families, owing to the complexity of intergenerational relationships, such as multi-dimensional and ambivalent natures and differences varying across children. Drawing on three waves of data (2014, 2016 and 2018) from a nationally representative survey – the China Longitudinal Ageing Social Survey (N = 9,404) – we used the k-means clustering method to discern patterns of intergenerational relationships in multi-child Chinese families, as well as the growth curve models, to examine the associations between parent–child relationship types and the trajectories of older parents’ cognitive functioning. Five types of intergenerational relationship were identified: alienated, stressfully interacting, independent, beneficially interacting and tight-knit. We then investigated the associations between trajectories of cognitive functioning and the most distant type, the closest type, and the heterogeneity of parent–child relationships across multiple children. The most distant parent–child relationship was significantly related to cognitive functioning trajectories with the alienated (tight-knit) type associated with the lowest (highest) levels of cognitive functioning and the fastest (slowest) cognitive decline. However, the closest parent–child relationship was not significantly related to cognitive functioning trajectories. Moreover, greater variation in relationships with multiple children was correlated with lower levels of cognitive functioning and faster cognitive functioning decline. These associations were stronger among mothers than fathers. This study provides new insights into the potentially protective role of intergenerational relationships in older parents’ cognitive functioning and their gendered differences.

Substantial changes resulting from the interaction of environmental and dietary factors contribute to an increased risk of obesity, while their specific associations with obesity remain unclear. Identify inflammation-related dietary patterns (DPs) and explore their associations with obesity among urbanized Tibetan adults under significant environmental and dietary changes.Totally, 1826 subjects from the suburbs of Golmud City were enrolled in an open cohort study, of which 514 were followed up. Height, weight, and waist circumference were used to define overweight and obesity. DPs were derived using reduced rank regression with 41 food groups as predictors and hs-CRP and prognostic nutritional index as inflammatory response variables. Altitude was classified as high or ultra-high. Two DPs were extracted. DP-1 was characterized by having high consumptions of sugar-sweetened beverages, savory snacks, and poultry, and a low intake of tsamba. DP-2 had high intakes of poultry, pork, animal offal, and fruits, and a low intake of butter tea. Participants in the highest tertiles (T3) of DPs had increased risks of overweight and obesity (DP-1: OR=1.37, 95% CI: 1.07, 1.77; DP-2: OR=1.48, 95% CI: 1.18, 1.85) than those in the lowest tertiles (T1). Participants in T3 of DP-2 had an increased risk of central obesity (OR=2.25, 95% CI: 1.49, 3.39) than those in T1. The positive association of DP-1 with overweight and obesity was only significant at high altitudes, while no similar effect was observed for DP-2. Inflammation-related DPs were associated with increased risks of overweight and/or obesity.

Significant differences in life-history traits between the southern population (S) and northern (N) population of the cabbage beetle Colaphellus bowringi make it an excellent model for studying inheritance in this insect. In the present study, we observed the life-history traits of pure strains, F1, reciprocal backcross and reciprocal F2 progeny under a photoperiod of L:D 15:9 h at 22 °C. The S population had shorter larval development time, longer pupal time, higher body weight, growth rate and weight loss compared with the N population. In the F1 testing, the larval development time and body weight in hybrid populations were intermediate between the parents, and the paternal parents played a greater role in determining the larval development time, while the maternal parents exhibited a greater role in determining the body weight. The pupal time of hybrid populations was significantly shorter than that of the parents. In the reciprocal backcross testing, both father and grandfather affected the larval development time, while both mother and grandmother affected the body weight. Consistently, in the reciprocal F2 cross testing, the grandfather was more influential in determining the larval development time, and grandmother was more important in determining the body weight. In all tested populations, females had greater body weight, higher growth rate and weight loss than males. Hybridization pattern did not affect sex dimorphism and sex ratio. Overall, these findings suggest that different pathways (maternal or paternal effects) were involved in the inheritance of various life-history traits in C. bowringi.

As avionics systems become increasingly complex, traditional fault prediction methods are no longer sufficient to meet modern demands. This paper introduces four advanced fault prediction methods for avionics components, utilising a multi-step prediction strategy combined with a stacking regressor. By selecting various standard regression models as base regressors, these base regressors are first trained on the original data, and their predictions are subsequently used as input features for training a meta-regressor. Additionally, the Tree-structured Parzen Estimator (TPE) algorithm is employed for hyperparameter optimisation. The experimental results demonstrate that the proposed stacking regression methods exhibit superior accuracy in fault prediction compared to traditional single-model approaches.

In this article, we study the following Schrödinger equation

\begin{align*}\begin{cases}-\Delta u -\frac{\mu}{|x|^2} u+\lambda u =f(u), &\text{in}~ \mathbb{R}^N\backslash\{0\},\\\int_{\mathbb{R}^{N}}|u|^{2}\mathrm{d} x=a, & u\in H^1(\mathbb{R}^{N}),\end{cases}\end{align*}

where $N\geq 3$, a > 0, and $\mu \lt \frac{(N-2)^2}{4}$. Here $\frac{1}{|x|^2} $ represents the Hardy potential (or ‘inverse-square potential’), λ is a Lagrange multiplier, and the nonlinearity function f satisfies the general Sobolev critical growth condition. Our main goal is to demonstrate the existence of normalized ground state solutions for this equation when $0 \lt \mu \lt \frac{(N-2)^2}{4}$. We also analyse the behaviour of solutions as $\mu\to0^+$ and derive the existence of normalized ground state solutions for the limiting case where µ = 0. Finally, we investigate the existence of normalized solutions when µ < 0 and analyse the asymptotic behaviour of solutions as $\mu\to 0^-$.

In hypersonic flight the shock wave and turbulent boundary layer interaction (STBLI) sharply increases wall heat transfer that intensifies the aerodynamic heating problems. In this work the STBLI is modelled by compression ramp flow with a Mach number of 5, a Reynolds number based on momentum thickness of 4652 and a wall to recovery temperature ratio of 0.5. The aerodynamic heat generation and transport mechanisms are investigated in the interaction based on theoretical analysis and direct numerical simulation (DNS) that agrees with previous studies. A prediction correlation of wall heat flux in STBLI is deduced theoretically and validated by some representative data including the present DNS, which improves the prediction accuracy and can be applied to a wider $Ma$ range compared with the canonical Q-P theory. The correlation indicates that the sharp increase of wall heat transfer in the STBLI can be explained by the boundary layer compression and the convection transport enhancement. Based on the DNS results, the aerodynamic heat generation and transport mechanisms are revealed in the separation, recirculation and reattachment zones in the STBLI. From this perspective, the peak heat flux can be further explained by the enhancement of near-wall turbulent energy dissipation, compression aerodynamic heat generation and the near-wall turbulent transport. The generation and transport of compression aerodynamic heat reveal the underlying mechanism of the strong correlation between the peak heat flux ratios and the pressure ratios in STBLIs.

Purple nutsedge (Cyperus rotundus L.) is one of the world’s resilient upland weeds, primarily spreading through its tubers. Its emergence in rice (Oryza sativa L.) fields has been increasing, likely due to changing paddy-farming practices. This study aimed to investigate how C. rotundus, an upland weed, can withstand soil flooding and become a problematic weed in rice fields. The first comparative analysis focused on the survival and recovery characteristics of growing and mature tubers of C. rotundus exposed to soil-flooding conditions. Notably, mature tubers exhibited significant survival and recovery abilities in these environments. Based on this observation, further investigation was carried out to explore the morphological structure, nonstructural carbohydrates, and respiratory mechanisms of mature tubers in response to prolonged soil flooding. Over time, the mature tubers did not form aerenchyma but instead gradually accumulated lignified sclerenchymal fibers, with lignin content also increasing. After 90 d, the lignified sclerenchymal fibers and lignin contents were 4.0 and 1.1 times higher than those in the no soil-flooding treatment. Concurrently, soluble sugar content decreased while starch content increased, providing energy storage, and alcohol dehydrogenase activity rose to support anaerobic respiration via alcohol fermentation. These results indicated that mature tubers survived in soil-flooding conditions by adopting a low-oxygen quiescence strategy, which involves morphological adaptations through the development of lignified sclerenchymal fibers, increased starch reserves for energy storage, and enhanced anaerobic respiration. This mechanism likely underpins the flooding tolerance of mature C. rotundus tubers, allowing them to endure unfavorable conditions and subsequently germinate and grow once flooding subsides. This study provides a preliminary explanation of the mechanism by which mature tubers of C. rotundus from the upland areas confer flooding tolerance, shedding light on the reasons behind this weed’s increasing presence in rice fields.

This study aimed to understand the potassium voltage-gated channel KQT-like subfamily, member 1 gene polymorphism in a rural elderly population in a county in Guangxi and to explore the possible relationship between its gene polymorphism and blood sugar. The 6 SNP loci of blood DNA samples from 4355 individuals were typed using the imLDRTM Multiple SNP Typing Kit from Shanghai Tianhao Biotechnology Co. The data combining epidemiological information (baseline questionnaire and physical examination results) and genotyping results were statistically analyzed using GMDR0.9 software and SPSS22.0 software. A total of 4355 elderly people aged 60 years and above were surveyed in this survey, and the total abnormal rate of glucose metabolism was 16·11 % (699/4355). Among them, male:female ratio was 1:1·48; the age group of 60–69 years old accounted for the highest proportion, with 2337 people, accounting for 53·66 % (2337/4355). The results of multivariate analysis showed that usually not doing farm work (OR 1·26; 95 % CI 1·06, 1·50), TAG ≥ 1·70 mmol/l (OR 1·19; 95 % CI 1·11, 1·27), hyperuricaemia (OR 1·034; 95 % CI 1·01, 1·66) and BMI ≥ 24 kg/m2 (OR 1·06; 95 % CI 1·03, 1·09) may be risk factors for abnormal glucose metabolism. Among all participants, rs151290 locus AA genotype, A allele carriers (AA+AC) were 0.70 times more likely (0.54 to 0.91) and 0.82 times more likely (0.70 to 0.97) to develop abnormal glucose metabolism than CC genotype carriers, respectively. Carriers of the T allele at the rs2237892 locus (CT+TT) were 0.85 times more likely to have abnormal glucose metabolism than carriers of the CC genotype (0.72 to 0.99); rs2237897 locus CT gene. The possibility of abnormal glucose metabolism in the carriers of CC genotype, TT genotype and T allele (CT + TT) is 0·79 times (0·67–0·94), 0·74 times (0·55–0·99) and 0·78 times (0·66, 0·92). The results of multifactor dimensionality reduction showed that the optimal interaction model was a three-factor model consisting of farm work, TAG and rs2237897. The best model dendrogram found that the interaction between TAG and rs2237897 had the strongest effect on fasting blood glucose in the elderly in rural areas, and they were mutually antagonistic. Environment–gene interaction is an important factor affecting abnormal glucose metabolism in the elderly of a county in Hechi City, Guangxi.

Previous research has suggested a potential link between folic acid (FA) supplementary therapy and gastric ulcers (GU). To investigate this relationship further, we conducted a Mendelian randomisation (MR) analysis using data from the UK Biobank. Our analysis primarily employed inverse-variance weighted (IVW) methods, including both fixed-effect and random-effect models. To ensure the robustness of our findings, additional methods such as the simple median, the weighted median and the penalised weighted median were also applied. The MR analysis aimed to explore the causal effect of FA supplementary therapy on GU. Seven SNP at genetic loci associated with FA supplementary therapy were identified. Both the random-effect and fixed-effect IVW models indicated that genetically predicted FA supplementary therapy significantly reduced the risk of GU (OR, 0·870; 95 % CI 0·826, 0·917, P < 0·001). This result was consistent across other methods, with similar outcomes observed using the simple median (OR, 0·835; 95 % CI 0·773, 0·901, P < 0·001), the weighted median (OR, 0·854; 95 % CI 0·794, 0·919, P < 0·001) and the penalised weighted median (OR, 0·849; 95 % CI 0·789, 0·914, P < 0·001). Leave-one-out sensitivity analysis confirmed that no individual SNP significantly drove the association between FA supplementary therapy and GU. This MR study provides genetic evidence that FA supplementary therapy may decrease the risk of GU.

The Indo-Pacific Warm Pool (IPWP) significantly influences the global hydrological cycle through its impact on atmospheric-oceanic circulation. However, gaining a comprehensive understanding of the hydrologic climate dynamics within the IPWP and its broader effects on the global climate have been hindered by spatial and temporal limitations in paleoclimate records on orbital timescales. In this study, we reconstructed precipitation records (approximated from δ18Osw-ivc) over the past 450 kyr, based on planktonic foraminiferal Mg/Ca and δ18O data obtained from International Ocean Discovery Program Site U1486 in the western tropical Pacific. The δ18Osw-ivc record revealed a generally consistent pattern with precession variations over the past 450 kyr, closely corresponding to changes in boreal summer insolation at the equator. The δ18Osw-ivc record displayed an anti-phased relationship with Chinese speleothem δ18O records on the precession band, with lower precipitation in the western tropical Pacific and higher precipitation in the East Asia summer monsoon region during periods of high Northern Hemisphere summer insolation. This anti-phased correlation primarily resulted from the north-south migration of the Intertropical Convergence Zone (ITCZ), influenced by the interhemispheric insolation contrast. By considering additional δ18Osw-ivc records from various locations within the IPWP region, we identified synchronous precipitation changes within the IPWP on the precession band. The synchronization of precipitation on both margins of the ITCZ’s seasonal range and differences between central and marginal regions of the ITCZ within the IPWP revealed the expansion and contraction of the ITCZ on precession band.

This study examines how voters’ perceptions of ideological incongruence with political parties affect their satisfaction with democracy. Using panel data from the British Election Study, we first demonstrate that greater misperception of party positions correlates with higher perceived ideological distance from one's preferred party. We then show that this increased perceived incongruence is associated with lower satisfaction with democracy when controlling for objective measures of incongruence. These findings are consistent across several alternative measures and specifications, and similar results are found in cross-sectional data from Europe. The results suggest that subjective perceptions of representation, potentially distorted by misperceptions, play a role in shaping citizens’ attitudes toward the political system. While the limitations of the study warrant caution in interpretation, the study contributes to the literature by highlighting the importance of perceived ideological congruence for understanding the link between representation and satisfaction with democracy.

Despite stroke being one of the major and increasing burdens to global health, therapeutic interventions in intracerebral haemorrhage (ICH) continue to be a challenge. Existing treatment methods, such as surgery and conservative treatment have shown limited efficacy in improving the prognosis of ICH. However, more and more studies show that exploring the specific process of immune response after ICH and taking corresponding immunotherapy may have a definite significance to improve the prognosis of cerebral haemorrhage. Therefore, immune interventions are currently under consideration as therapeutic interventions in the ICH. In this review, we aim to clarify unique immunological features of stroke, and consider the evidence for immune interventions. In acute ICH, activation of glial cells and cell death products trigger an inflammatory cascade that damages vessels and the parenchyma within minutes to hours of the haemorrhage. Immune interventions that ameliorate brain inflammation, vascular permeability and tissue oedema should be administered promptly to reduce acute immune destruction and avoid subsequent immunosuppression. A deeper understanding of the immune mechanisms involved in ICH is likely to lead to successful immune interventions.

This study investigated the impact of diallyl disulfide (DADS) on oxidative stress induced by hydrogen peroxide (H2O2) in ovine rumen epithelial cells (RECs). Initially, the effects of DADS were evaluated on cellular reactive oxygen species (ROS) levels, antioxidant capacity in RECs were estimated. Then, RNA-seq analysis was conducted in DADS-treated and untreated cells to analyze the differential gene expression, as well as Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Finally, the effects of DADS on Kelch-like ECH associated protein 1/the nuclear factor erythroid 2-related factor 2 (Keap1/Nrf2) signaling pathway in RECs were evaluated. Results showed that DADS remarkably enhanced superoxide dismutase (SOD) activity and total antioxidant capacity (T-AOC) (P < 0.05) while reducing ROS and malonaldehyde production (P < 0.05) in H2O2-treated RECs. Transcriptomic analysis revealed that DADS might influence glutathione synthesis through cysteine and methionine metabolism, thereby affecting the transcription of genes involved in immunity and oxidative stress. The DADS treatment resulted in increased nuclear translocation of Nrf2 and upregulation of mRNA and protein levels of quinone oxidoreductase 1, heme oxygenase 1, and Nrf2. The Nrf2-specific inhibitor nullified the protective effects of DADS on malonaldehyde formation induced by H2O2 and decreased T-AOC and SOD activities. In conclusion, DADS demonstrated the ability to alleviate oxidative stress in RECs by promoting antioxidative capacity through the Keap1/Nrf2 signaling pathway.