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5 results

  • Evolution of Sleep Complaints in Myotonic Dystrophy Type 1: A 9-Year Longitudinal Study

  • Luc Laberge, Alexandre Maltais, Julie Auclair, Jean Mathieu, Cynthia Gagnon
  • Journal:
    Canadian Journal of Neurological Sciences / Volume 51 / Issue 1 / January 2024
    Published online by Cambridge University Press:
    17 March 2023, pp. 137-139
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  • The objective was to characterize the progression of sleep complaints in 115 dystrophy type 1 (DM1) patients who filled out a sleep questionnaire twice at a 9-year interval. Daytime napping (22.1% vs. 34.5%, p < 0.05), early awakenings (11.4% vs 21.1%, p < 0.05), nonrestorative sleep (39.5% vs 51.8%, p < 0.05), stimulant use (7.0% vs 19.3%, p < 0.01), breathing cessation (10.7% vs 23.2%, p < 0.01), and nighttime urination (42.5% vs 54.9%, p < 0.05) increased between Time 1 and Time 2. Sleep-related complaints are prominent and augment rapidly in DM1 patients. Physicians need to better identify and treat them to help alleviate the burden they impose on patients and their caregivers.

  • Responsiveness of Daytime Sleepiness and Fatigue Scales in Myotonic Dystrophy Type 1

  • Luc Laberge, Benjamin Gallais, Julie Auclair, Yves Dauvilliers, Isabelle Côté, Jean Mathieu, Cynthia Gagnon
  • Journal:
    Canadian Journal of Neurological Sciences / Volume 49 / Issue 2 / March 2022
    Published online by Cambridge University Press:
    20 April 2021, pp. 287-290
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  • Daytime sleepiness and fatigue are prominent symptoms of myotonic dystrophy type 1 (DM1) that can be amenable to treatment in the context of randomized controlled trials. No study has yet documented whether self-reported measures of daytime sleepiness and fatigue can detect change over time and the meaning of this change. The aim was to explore indicators of responsiveness to change and interpretability for the Daytime Sleepiness Scale and the Fatigue Severity Scale in 115 DM1 prospectively followed patients. Results suggest that these two self-reported questionnaires are sufficiently sensitive to detect changes beyond expected measurement error over time in this population.

  • Prevalence of Lifestyle Risk Factors in Myotonic Dystrophy Type 1

  • Cynthia Gagnon, Maud-Christine Chouinard, Luc Laberge, Diane Brisson, Daniel Gaudet, Mélissa Lavoie, Nadine Leclerc, Jean Mathieu
  • Journal:
    Canadian Journal of Neurological Sciences / Volume 40 / Issue 1 / January 2013
    Published online by Cambridge University Press:
    23 September 2014, pp. 42-47
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  • Background:

    The prevalence of unhealthy lifestyle habits such as smoking has seldom been described in neuromuscular disorders, including myotonic dystrophy type 1 (DM1). However, it is essential to document the unhealthy lifestyle habits as they can exacerbate existing impairments and disabilities. The objectives are: 1) To determine the prevalence of risk factors among individuals with DM1; 2) To compare the prevalence among classic and mild phenotypes.

    Method:

    A survey was done on a sample of two-hundred (200) patients with DM1 as part of a larger study. Lifestyle risk factors included being overweight or obese, tobacco smoking, illicit drug use, excessive alcohol consumption and physical inactivity. A registered nurse administered the validated public health survey. Categorization of risk factors were based on national standards and compared with provincial and regional prevalences.

    Results:

    50% of DM1 patients were overweight or obese, 23.6% were regular smokers, and 76% were physically inactive. Except for overweight and obesity, significant differences were observed between patients with classic and mild phenotypes for all the other lifestyle risk factors: those with the classic phenotype being more often regular smokers, consuming more often illicit drugs and being less physically active.

    Conclusions:

    The results of this study will provide guidance for the development of better adapted and focussed health promotion interventions in the future.

  • Chapter 28 - Myotonic dystrophy and sleepiness

  • from Section 3 - Medical, Psychiatric and Neurological Causes Of Sleepiness
  • Edited by Michael J. Thorpy, Michel Billiard
  • Book:
    Sleepiness
    Published online:
    04 February 2011
    Print publication:
    27 January 2011, pp 316-328

  • Summary

    This chapter reviews the manner in which sleep deprivation and circadian misalignment lead to impaired performance among healthcare providers. Several sleep and circadian factors affect the performance of physicians-in-training as well as other healthcare providers. In addition to acute sleep restriction, residents suffer chronic sleep restriction. Extended-duration work shifts also increase the likelihood of fatigue-related, self-reported medical errors. As learning is central to medical residency, any factor impairing resident learning is of concern. The only randomized evidence regarding elimination of 30-h shifts, and substitution with 16-h shifts, suggests that errors could in fact decrease by more than double this amount with widespread implementation of a 16-h shift limit. Lab- and field-based studies show us that extended resident shifts impair cognition and likely impair learning. Such impairment translates into error, poor patient care, and resident harm.