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Individuals with co-occurring autism and psychosis are poorly supported by current psychiatric systems yet commonly present to both autism and psychosis services. Diagnostic overshadowing, fragmented pathways and unadapted interventions drive poorer outcomes. Psychosis services must embed neurodevelopmentally informed assessment, formulation, staff training and routine treatment adaptations to deliver equitable, effective care for this underserved population.
Transition-aged youth (TAY) are vulnerable to experiencing mental health disorders, yet research is scarce on treatment outcomes for TAY receiving cognitive behavioural therapy (CBT), particularly for anxiety and related disorders. The present study aims to investigate whether there are differences in treatment outcomes for TAY relative to adults following completion of mixed-age disorder-specific CBT groups for social anxiety disorder (SAD), generalized anxiety disorder (GAD), and obsessive-compulsive disorder (OCD). A sample of 844 participants, including 232 TAY (aged 17–25) and 612 adults were compared on symptom specific measures (i.e. SPIN, GAD-7, Y-BOCS), group cohesion, attendance, drop-out rates, and general symptoms of low mood, stress, and anxiety (i.e. DASS-21) pre- and post-disorder specific CBT group treatment using linear mixed effects models. Although there were significant reductions in disorder-specific clinical symptoms and general symptoms of depression, stress, and anxiety in both TAY and adults from pre- to post-treatment, there were no significant differences between age groups in terms of treatment response, suggesting TAY responded as effectively as adults in mixed age treatment groups. There were no significant differences in terms of drop-out or group cohesion across age groups. TAY individuals had marginally lower attendance compared with adults, although this finding was not significant. These findings suggest that treatment as usual is effective in yielding significant improvement in anxiety and related symptoms across age groups. While these findings are encouraging for TAY who seek treatment, further research evaluating whether age-specific group CBT could enhance treatment outcomes for TAY is critical.
Key learning aims
(1) To increase clinician awareness of treatment considerations for transition-aged youth with anxiety and related disorders.
(2) To learn about potential differences in treatment outcomes (i.e. symptom severity, attendance, and completion rates) of transition-aged youth receiving mixed-aged, disorder specific group cognitive behavioural therapy for anxiety and related disorders.
Between 2023 and 2025, four outbreaks of zoonotic Cryptosporidium parvum infection involving 39 laboratory-confirmed cases occurred at a single animal-contact visitor attraction in South West England. A retrospective outbreak investigation, incorporating elements of a descriptive case series, was undertaken to identify factors associated with repeated transmission and to draw insights for infection prevention and control. The study integrated epidemiological, veterinary, environmental, and molecular data, including exposure questionnaires, animal faecal testing, environmental sampling, observational assessments, and genotyping of human and animal isolates. Zoonotic gp60 subtype IIaA15G2R1 predominated across outbreaks. In the fourth outbreak, identical gp60 subtypes and shared multiple-locus variable-number tandem-repeat analysis alleles in lamb and human samples supported zoonotic transmission. Environmental sampling identified faecal indicator organisms and Shiga toxin-producing E.coli on high-touch surfaces. An observational assessment identified frequent opportunities for faecal–oral exposure during close contact with young ruminants. Despite compliance with industry standards, persistent environmental contamination, in-pen contact, and child behavioural factors were identified as plausible contributors to transmission. These findings highlight the challenges of preventing zoonotic infection in this setting and support refinement of existing guidance.
Caregivers of children with CHD frequently experience psychological distress related to the chronic and unpredictable demands of their child’s diagnosis. Peer support can mitigate distress and promote resilience, but few studies have explored factors affecting its implementation or the experiences of those who provide or facilitate peer support. This study aimed to identify barriers, facilitators, and recommendations for optimising peer support from the unique perspectives of leaders of patient/family organisations within the CHD community.
Methods:
Using online crowdsourcing methods, qualitative data on the implementation of peer support was collected from 16 leaders representing five patient/family organisations. Crowdsourced data were coded and analysed using thematic analysis, with themes categorised as barriers, facilitators, and recommendations.
Results:
Four overarching themes were constructed: 1) Training and Expertise, highlighting the value of lived experience alongside the need for structured training in mental health and bereavement; 2) Peer Mentor Wellbeing, including burnout, secondary traumatic stress, and the importance of clear role boundaries and expectations; 3) Partnerships and Collaboration, emphasising relationships with clinical care centres; and (4) Support for all Families and Family Members, including fathers, siblings, and bereaved families.
Discussion:
The results provide insight into the implementation of peer support, with recommendations for next steps including hospital-community partnerships to improve access and intentional programme design to protect peer mentor wellbeing. Further understanding of caregiver and peer mentor needs is critical for elucidating ways to develop and implement optimal models of peer support.
Point-of-care technology (POCT) has expanded rapidly, particularly since the COVID-19 pandemic. However, less is known about which POCT applications and features patients and caregivers prioritize for lung disease management.
Methods:
We refined a patient-facing survey based on feedback from an online focus group recruited through community and advocacy volunteer networks. The survey was then administered via ResearchMatch to uncompensated U.S. volunteers, who indicated interest in lung disease research (April 1 to May 14, 2025; 6,333 invitations). POCT perceptions were measured via a 10-point Likert scale.
Results:
We received 214 responses (3.4% response rate). Respondents were predominantly patients (79%), female (71%), and older than 60 years (59%). Mean ratings suggested strong perceived benefits across nine POCT benefits and low concern across most drawbacks. The greatest concern was insurance coverage for POCT-associated costs (mean score: 6.7/10). Obstructive lung conditions were most frequently prioritized for future POCT applications.
Conclusion:
Among a national sample of ResearchMatch volunteers affected by lung disease, interest in POCT was high, and insurance coverage remained the most salient concern. By describing preferences and concerns of patients, this study informs future design, regulatory approval, and clinical integration. These findings provide evidence for POCT developers, clinicians, and policymakers focused on improving patient-centered care.
Currently, there is no food frequency questionnaire (FFQ) that has been validated in Australia to assess both nutrient intake and food safety practices in pregnant women(1). Validation of FFQ for use in pregnant women is important given the specific nutritional requirements and increased food safety risks during pregnancy, particularly listeriosis, as compared with the general population. Additionally, many pregnancies in Australia are unplanned, and preconception nutrition is strongly linked to positive pregnancy outcomes. Therefore, the Pregnancy-Australian Eating Survey (Preg-AES) FFQ was developed to assess dietary intake and food safety practices among women of childbearing age in Australia. This study aimed to: (i) evaluate the preliminary outcomes of reproducibility and relative validity of nutrient intakes derived from the Preg-AES FFQ against 24-hour dietary recalls (24HRs) and weighed food records (WFRs) among women of childbearing age in Australia, (ii) evaluate the preliminary outcomes of reproducibility of food safety practices of the Preg-AES FFQ, and (iii) assess the feasibility and acceptability of the validation methodology. The Preg-AES FFQ was adapted from the validated AES FFQ(2), consists of 127 questions, with an additional ten questions related to dietary intakes of foods potentially harbouring Listeria monocytogenes and 27 questions on safe food handling practices. The FFQ was administered twice, three months apart to assess reproducibility, and compared with mean intakes from three-day WFR and three-day 24HR, respectively, to assess relative validity. All nutrients were adjusted using the nutrient density method. Reproducibility of nutrient intakes and food safety practices were measured using intra-class correlation coefficient (ICC) and weighted kappa. Relative validity was assessed using Pearson correlations and Bland-Altman plots. Feasibility was described from recruitment and follow-up data. Acceptability was analysed using frequency data, via closed- and open-ended responses at three months. At baseline, 51 participants were included (mean age 27.3 ± 6.8; 66.7% Australian-born; 33.3% university-educated). Reproducibility testing included n = 35; relative validity testing included n = 29 (WFR) and n = 36 (24HR). Preliminary reproducibility results indicated ICCs ranged from 0.133 (thiamine) to 0.725 (protein). Preliminary relative validity coefficients confirmed that the Preg-AES FFQ had moderate validity against WFR and relatively lower validity against 24HR. Preliminary acceptability findings showed 91–97% of participants were satisfied with the administration of all dietary assessment methods and in-person sessions. This pilot study may inform a larger validation study in a representative Australian sample, to enhance the accuracy of the Preg-AES FFQ as a dietary assessment tool in clinical and research settings in Australia to optimise perinatal health outcomes.
Nutrition during pregnancy and postpartum is critical in maternal and infant health, with poor dietary intake during this period contributing to adverse outcomes and long-term health risks(1). Dietary intake is influenced by behavioural, physiological, and social factors(2), and understanding the patterns, and their determinants, can inform targeted nutrition interventions. This study aimed to assess changes in diet quality and food and nutrient intakes from pregnancy to one year postpartum in Australian women and compare to national nutrition recommendations. Associations between diet quality, sociodemographic and health characteristics were also investigated. This study was an analysis of data from the ORIGINS pregnancy cohort (2017–2022). Women were included if they had complete dietary data at both timepoints, were aged ≥ 19 years, and were not pregnant one year postpartum. Dietary intake was assessed via the Australian Eating Survey food frequency questionnaire and diet quality was assessed using the Australian Recommended Food Score (ARFS). Sociodemographic data were self-reported; clinical health data were extracted from hospital medical records. Paired sample t-tests analysed changes in diet quality and intake. Linear regression estimated associations between maternal characteristics and diet quality, with adjustment for covariates. Food group and nutrient intakes were compared to recommendations in the Australian Guide to Healthy Eating and Nutrient Reference Values. Among 337 women (33.1 (4.5) years, 49.9% Australian-born, 51.3% university educated), mean (95% CI) diet quality was suboptimal during pregnancy and one year postpartum (ARFS 34.0 (33.0, 35.0) vs. 34.8 (33.8, 35.8) points out of 73, p = 0.038). One year postpartum, participants reported consuming more vegetables, meat, protein, and retinol equivalents, but less fruit, dairy, carbohydrate, saturated fat, iodine, and folate (p < 0.05). Across both timepoints, alignment with recommendations was poor for all food groups, macronutrients and key micronutrients. None of the women met the daily intake targets for all five food groups during pregnancy, and only one woman met the targets one year postpartum. Lower diet quality during and after pregnancy was linked to not having had a university education, and a higher pre-pregnancy BMI. Postpartum, younger age and lower income was also associated with poorer diet quality and having a BMI in the overweight category before pregnancy (p < 0.05). Findings underscore persistent nutritional inadequacies and social disparities among pregnant and postpartum women in Australia and provide evidence to support updates to national dietary guidelines and the development of targeted nutrition interventions, particularly for women experiencing socioeconomic disadvantage.
A translation of two rival accounts of an expedition that deteriorated into friction and feuding, offering an unusually intimate view of chivalry and conquest at the close of the Middle Ages.
Le Canarien tells the gripping story of a French expedition that conquered three of the Canary Islands between 1402 and 1405. It is the only surviving written account of this pivotal moment in the history of the archipelago. The European invaders successfully employed strategies that would become the template for the colonization of the New World. The islanders were overwhelmed by the devastating military superiority of the invaders who killed countless people and sold many others into slavery, before beginning the process of colonization.
Le Canarien was written by two chaplains who took part in the expedition and celebrated it as a grand chivalric and crusading enterprise to convert the indigenous peoples of Lanzarote, Fuerteventura and El Hierro to Christianity. Their mission was led by two French noblemen, Jean IV de Béthencourt and Gadifer de La Salle, who fell out disastrously with one another during its course. As a result, there are two rival versions of the story: one bitterly accuses Béthencourt of treachery, whilst the other expresses surprise and incomprehension at Gadifer's allegations. This book presents translations of each of these versions of Le Canarien that reveal the dark truths hidden behind the façade of chivalry and open a fascinating window into late medieval views on crusading, conversion and conquest.
This is our third scholarly translation of a fifteenth-century French chivalric narrative. Our original intent was to focus our attention upon chivalric biographies, an important genre of historical writing that flourished during the Late Middle Ages, and so we began with The Deeds of Arms of Jean II Le Meingre, dit Boucicaut (Woodbridge, 2016). Then we were given the exciting opportunity to work on an advanced copy of Professor Michelle Szkilnik's scholarly edition of Jean de Bueil's great military memoir, Le Jouvencel, suivi du commentaire de Guillaume Tringant (Paris, 2018), which we translated as Jean de Bueil's Le Jouvencel (Woodbridge, 2020). That brought us into the wider field of military and chivalric memoirs, and led us to Le Canarien, an account of an extraordinary French expedition to conquer and convert the Canary Islands at the beginning of the fifteenth century.
There are a number of good scholarly editions of Le Canarien which we review in the introduction below. This translation is based upon the edition published in 2008 by the Institut de Recherche et d’Histoire des Textes as Le livre nommé Le Canarien. Textes français de la conquête des Canaries au XVe siècle. This was produced by an admirably expert team, Eduardo Aznar, Dolores Corbella, Berta Pico, Maryse Privat, and Antonio Tejera, and also includes a nicely informative critical apparatus.
Our work has been much facilitated by help from specialists and experts. For advice on the forests and flora of the Canaries, we are very grateful to Ben Davis, arboriculturalist, woodland and forestry expert, and possessor of an extensive specialist library.
[73] Because it is true that many knights, hearing accounts of the great adventures, the acts of valour and the fine feats of arms undertaken in former times by those who embarked on expeditions and on the conquest of unbelievers, hoping thereby to change their hearts and convert them to the Christian faith, took heart and courage and resolved to follow their example and thus to flee vice and follow virtue, so as in their last moments to win eternal life, Jean de Béthencourt, a knight born in the kingdom of France, undertook this mission for the glory of God, and for the advancement and propagation of our holy faith in southern parts, in particular on certain islands called the Canary Islands, abode of unbelievers of many faiths and many different languages – one of the best of which and the most important and the most populated and the best endowed with provisions and other resources is Gran Canaria. That explains why this book is entitled Le Canarien, in which, if it please God, one will find recorded, as time goes on, many very strange things.
And we, Brother Pierre Boutier, monk of Saint-Jouin de Marnes, and Jean Le Verrier, priest, both of us chaplains and servants of Béthencourt named above, have undertaken to record in writing all that happened to him in the early days of his conquest and all his manner of governance – which we are able to certify from the moment he left the kingdom of France until 19 April 1406 when the said Béthencourt landed on the islands – after which the duty to record in writing fell into other hands that will accurately record their deeds until the moment when their conquest will be complete.
[72] Because it is true that many knights, hearing accounts of the great adventures, the acts of valour and the fine feats of arms undertaken in former times by those who embarked on expeditions and on the conquest of unbelievers, hoping thereby to change their hearts and convert them to the Christian faith, took heart and courage and resolve to follow their example and thus to flee vice and follow virtue, so as in their last moments to win eternal life, Gadifer de La Salle and Jean de Béthencourt, both knights born in the kingdom of France, undertook this mission for the glory of God, and for the advancement and propagation of our holy faith in southern parts, in particular in certain islands called the Canary Islands – the finest and largest of which is Gran Canaria – abode of unbelievers of many faiths and many different languages, hoping to convert the inhabitants and propagate our faith among them. And that explains why this book is entitled Le Canarien.
And we, Brother Pierre Boutier, monk of Saint-Jouin de Marnes, and my lord Jean Le Verrier, priests, chaplains and servitors of the knights named above, have undertaken to record in writing all that happened to them in the early days of their conquest and all their dispositions – which we are able to certify from the moment they left the kingdom of France until 19 April 1404 when the said Béthencourt landed back on the islands [74] – after which the duty to record in writing fell into other hands that will accurately record their deeds until the moment when their conquest will be complete.
Le Canarien is an account of a French expedition to the Canary Islands between 1402 and 1405. Echoing chivalric and crusading narratives, it celebrated the heroism, endurance and success of Jean IV de Béthencourt (1362–1425) and Gadifer de La Salle (c.1350–c.1423) in conquering the islands of Lanzarote, Fuerteventura and El Hierro and forcing the indigenous peoples to convert to Christianity. Le Canarien is invaluable as the main source of evidence for the first phase in a century of European colonisation that destroyed the societies and cultures of the indigenous peoples of the Canary Islands. It also offers a window into contemporary debates about chivalry and knighthood, praising the Christian service of the French knights and examining the rivalry and feud that erupted between the two leaders. Le Canarien survives in two different versions, manuscript G (London, British Library MS Egerton 2709) and manuscript B (Rouen, Bibliothèque Municipale MS suppl. 1399) that recount the story from their rival perspectives.
The Canary Islands
The Canary Islands are an archipelago in the Atlantic Ocean, located off the north-west coast of Africa. Many of the islands were inhabited during the Middle Ages by the descendants of the Berber societies of northern Africa, though there were important cultural differences between the indigenous peoples of the different islands who were largely isolated from one another.