To classify the clinical characteristics of ocular toxocariasis in Japan, the prevalence of antibodies to Toxocara antigens was examined in patients with uveitis of unknown aetiology. From 1982 to 1993, serum specimens of 383 cases and intraocular fluid samples of 22 cases were serologically screened for Toxocara infection with five immunodiagnostic tests. Fifty-five sera and 11 intravitreous fluid samples were estimated to have significantly high antibody levels against larval excretory–secretory (ES) antigens of T. canis. Eight cases were positive in both serum and vitreous fluid, and three were positive only in the vitreous fluid. Among the 58 antibody positive samples, 20 cases were omitted due to a lack of detailed description of ocular findings. The remaining 38 cases are described in this study. Of these 38 cases, 34 (89%) were older than 20 years of age. Ocular lesions were located in the posterior fundus in 11 cases, in the peripheral fundus in 18 cases, and in both areas in seven cases. Of the eight cases in which papillary oedema or redness was observed, chorioretinal lesions were also present in seven of them. Tractional retinal detachment was present in five cases. These observations suggest that ocular toxocariasis in Japan has a different clinical profile compared with those in the other countries, and indicate a need for revised classification of ocular toxocariasis.

We have reported a blood flow increase in the prefrontal cortex during the performance of the computer version TMT. Although TMT-A was first performed and followed by TMT-B in the previous study, the order was reversed in the present study,i.e., TMT-B was first performed and then followed by TMT-A, and differences in the change of blood flow were compared between the two modes of TMT.

Nine healthy student volunteers (20.7 ± 1.6 yr) performed two different sets of TMT-B. After a resting period of 30 sec, they performed four different sets of TMT-A. Changes of oxyHb and deoxyHb were monitored by 22-channel NIRS from 30 sec before the start of TMT-B through 30 sec after the end of TMT-A. The mean changes of blood flow over a period of 10 sec just before the start of TMT-B and TMT-A, and over a period of 100 sec after the start of TMT-B and TMT-A were determined.

The increase of oxyHb was prominent in the right lateral prefrontal cortex.

The results suggest that the blood flow increases in the prefrontal cortex during the start of either TMT-A or TMT-B. The location of blood flow increase did not change whether TMT-B was performed first or after TMT-A. Therefore, the blood flow increase observed only in the right prefrontal cortex in the previous study could not be due to familiarization of the test. In contrast, TMT-A apparently exhibits a familiarization effect, since blood flow increase was not observed when TMT-A was performed after TMT-B.

We measured concentration changes of oxyHb and deoxyHb in the prefrontal cortex during the performance of the computer version Trail Making Test(TMT) by multichannel NIRS using near infrared light pairs which are more sensitive for detecting changes of oxyHb and deoxyHb.

Sixteen healthy student volunteers performed four different TMT-A sets, and following 30 a sec resting period, two different TMT-B sets. Changes of oxyHb and deoxyHb were monitored by 22 channel NIRS from 30 sec before the start of TMT-A through 30 sec after the end of TMT-B. The mean changes in subjects over a period of 10 sec just before the start of TMT-A and TMT-B, and a period of 50 to 60 sec after the start of TMT-A and TMT-B were determined. OxyHb increased while deoxyHb decreased in the bilateral prefrontal cortices during the performance of TMT. The increase of oxyHb was prominent in the right lateral prefrontal cortex, especially during TMT-A.

On the other hand, deoxyHb significantly decreased in the bilateral prefrontal cortices especially during TMT-A.

The results suggest that blood flow increases in the prefrontal cortex during the performance of the computer version TMT.

In the by now well known talks he gave at Princeton, Saul Kripke claimed that “[t]heoretical identities … are generally identities involving two rigid designators and therefore are examples of the necessary a posteriori.” (Published as “Naming and Necessity,” in G. Harmon and D. Davidson, eds., Semantics of Natural Language (Dordrecht, 1972) 253-355; (hereafter referred to as “NN”; this quote p. 331.) A rigid designator is an expression that designates the same object in all possible worlds when it is used. So Kripke is claiming that ‘Water is H20’ and ‘Heat is the motion of molecules’ are generally identities involving expressions like ‘water’ and ‘the motion of molecules’ which designate the same objects in all possible worlds. If the identity statement is true, both sides designate the same object rigidly, i.e., in all possible worlds, and therefore the statement is necessarily true. On the other hand, whether it is true is determined ultimately by appeal to experience. It follows that if true, the identity is necessary a posteriori.

We present ALMA detection of the [O iii] 88 μm line and 850 μm dust continuum emission in a Y-dropout Lyman break galaxy, MACS0416_Y1. The [O iii] detection confirms the object with a spectroscopic redshift to be z = 8.3118±0.0003. The 850 μm continuum intensity (0.14 mJy) implies a large dust mass on the order of 4×106M⊙. The ultraviolet-to-far infrared spectral energy distribution modeling, where the [O iii] emissivity model is incorporated, suggests the presence of a young (τage ≍ 4 Myr), star-forming (SFR ≍ 60M⊙yr−1), and moderately metal-polluted (Z ≍ 0.2Z⊙) stellar component with a stellar mass of 3 × 108M⊙. An analytic dust mass evolution model with a single episode of star formation does not reproduce the metallicity and dust mass in ≍ 4 Myr, suggesting an underlying evolved stellar component as the origin of the dust mass.

The present study focused on parents’ social cue use in relation to young children's attention. Participants were ten parent–child dyads; all children were 36 to 60 months old and were either typically developing (TD) or were diagnosed with autism spectrum disorder (ASD). Children wore a head-mounted camera that recorded the proximate child view while their parent played with them. The study compared the following between the TD and ASD groups: (a) frequency of parent's gesture use; (b) parents’ monitoring of their child's face; and (c) how children looked at parents’ gestures. Results from Bayesian estimation indicated that, compared to the TD group, parents of children with ASD produced more gestures, more closely monitored their children's faces, and provided more scaffolding for their children's visual experiences. Our findings suggest the importance of further investigating parents’ visual and gestural scaffolding as a potential developmental mechanism for children's early learning, including for children with ASD.

Pneumococcal serotype replacement is an important issue after the introduction of pneumococcal conjugate vaccine (PCV) in children. After the introduction of 13-valent PCV, the incidence of invasive pneumococcal diseases (IPD) caused by Streptococcus pneumoniae serotype 12F (Sp12F) have increased in some countries; however, an outbreak of Sp12F has not reported in the post-13-valent PCV era. We experienced a local outbreak of Sp12F during March through May 2016 in Tsuruoka city, Japan after the introduction of 13-valent PCV in 2013. The IPD patients were two children and seven adults, three of whom died with a rapid disease progress. Although the clear transmission route was not determined, eight of the nine patients (89%) had close contact with children, which suggests that transmitted colonisation of Sp12F among children and adults might be the source of transmission. Continuous monitoring of IPDs, along with the determination of pneumococcal serotypes, is warranted in the post–13-valent PCV era. New IPD control strategies may be needed if this fatal outbreak continues to occur.

Studies of the subsurface microbiology of the Äspö Hard Rock Laboratory, Sweden have revealed the presence of many different bacteria in the deep groundwaters which appear to maintain reducing conditions. Experiments were conducted to study the rock-water and microbial interactions. These used crushed Äspö diorite, Äspö groundwater and iron- and sulphate-reducing bacteria in flowing systems under anaerobic conditions. In column experiments, there was evidence of loss and mobilization of fine-grained crushed material (<5 μm) which had originally adhered to grain surfaces in the starting material. The mobilized fines were trapped between grains. The degree of mineralogical alteration was greater in the experiments when bacteria were present. In both column and continuously stirred reactor experiments, there is evidence for the formation of a secondary clay. These experiments have shown that microbial activity can influence rock-water interactions even in nutrient-poor conditions.

Evidence suggests that cultural experiences and learning multiple languages have measurable effects on children's development of executive function (EF). However, the precise impact of how bilingualism and culture contribute to observed effects remains inconclusive. The present study aims to investigate how these factors shape the development of early EF constructs longitudinally, between monolingual and bilingual children at ages 3, 3½ and 4 years, with a set of EF tasks that are uniquely relevant to the effects of bilingualism and cultural practices. We hypothesize that the effects of bilingualism and cultural backgrounds (i.e., Eastern) are based on different, though related, cognitive control processes associated with different EF constructs. Results revealed a significant bilingualism effect on cognitive control processes measuring selective attention, switching, and inhibition; while an effect of culture was most pronounced on behavioral regulation/response inhibition. Contributions of bilingualism and cultural experiences on individual EF constructs across development are discussed.

A new species of Roscoea is described and illustrated. Roscoea megalantha Tosh.Yoshida & R.Yangzom occurs in the Eastern Zone of Bhutan and neighbouring Arunachal Pradesh in India. A distribution map and an IUCN conservation assessment are given. A key to the three species of Roscoea found in Bhutan is provided.

Between May 1983 and July 1984 glaciological parties of the 24th and 25th Japanese Antarctic Research Expeditions (JARE–24 and 25) carried out ice-core drilling using a thermal drill, down to 700.5 m depth at Mizuho Station (70°41'53"S, 44°19'54"E), as a part of the Glaciological Research Program in east Dronning Maud Land, Antarctica.

The thermal drill, 3.9 m long and capable of taking a core 1.5 m long and 130 mm in diameter, is an improved version of a drill used by JARE–15 in 1975. The most important improvement was the monitoring system during drilling, for which a micro-computer was fitted in the drill. By using this system, such accidents as heater burn-out, tank overflow and failure of water suction would immediately be brought to our attention. The drilling speed was about 1.6 m/h, when the optimum output was 3.6 kW. The core recovery rate was above 99%.

The core quality was good down to a depth of 80 m. Between 80 and 120 m, cracks were found at intervals of 0.15–0.5 m, and horizontal cracks were found continuously at intervals of 0.01 m or less.

Immediately after the core was pulled, the stratigraphy was observed and bulk density was measured. A dust band, presumably volcanic particles, was seen at only 500.2 m depth during stratigraphic observation. The following analyses were carried out at Mizuho Station within a month of recovery:

• (1) Density determination by the hydrostatic method.

• (2) Measurement of total gas content.

• (3) Thin-section analyses, including observation of cracking around air bubbles and the crystalline texture, and ice-fabric studies.

The 700.5 m core has been brought to Japan, and the following analyses are now under way:

• (1) Oxygen-isotope ratio.

• (2) Concentration of microparticles.

• (3) Electric conductivity.

• (4) Chemistry of soluble impurities.

Airborne radio echo-sounding was carried out in order to measure the thickness of the ice sheet in the Shirase Glacier drainage basin and map the bedrock topography. It was found that the elevation of bedrock was approximately at sea-level from Shirase Glacier to 100 km up-stream of the glacier and thereafter it was 500–100 m higher. Investigation of the echo intensity reflected from the bedrock indicates that at ice thicknesses less than 1000 m absorption was about 5.2 dB/100 m, but at greater ice thicknesses echo intensity did not depend upon the ice thickness but became approximately constant. Where ice thicknesses were greater than 1000 m in the main flow area of the Shirase Glacier drainage basin, the reflection strengths of about 9 dB were greater than outside the basin. Since the increase in echo intensity was considered to be due to the existence of water, the strong echo observed in the main part of the basin supported an hypothesis that the base of the basin was wet and the ice sheet was sliding on the bedrock.

The thickness of supraglacial debris on the Khumbu Glacier, Nepal Himalaya, has been mapped by a combination of direct measurements and morphological and lithological studies. All three processes, englacial, supraglacial, and subglacial, must be considered in establishing the distribution of debris. Taking advantage of the lithological characteristics of the debris and their bedrock source, the denudation rate of the schistose bedrock was estimated to be about 0.02 mm a−1. A rough estimate of the production rate of supraglacial debris indicated that most of the present debris has formed since the last advance of the glacier, which took place a few hundred years B.P.

The impulse radar was found to be useful in surveying the internal structures of wet snow patches in mountain regions. Radar profiles revealed that the thickness of the perennial ice was 30 m, possibly the thickest in Japan. An unconformity widely extended nearly parallel to the surface at the depth of 2 to 9 m and divided the ice into two parts.

In this paper we present the results of spectroscopic observations for 34 emission-line stars (ELSs) in the Orion belt region, which were detected in an extensive survery. Spectral classification and the intensities of Hα and Hβ emission have revealed that the observed ELSs are probably T-Tauri type stars.