The epidemiology of rapid-cycling bipolar disorder in the community is
To investigate the epidemiological characteristics of rapid-cycling and
non-rapid-cycling bipolar disorder in a large cross-national community
The Composite International Diagnostic Interview (CIDI version 3.0) was
used to examine the prevalence, severity, comorbidity, impairment,
suicidality, sociodemographics, childhood adversity and treatment of
rapid-cycling and non-rapid-cycling bipolar disorder in ten countries
(n = 54 257).
The 12-month prevalence of rapid-cycling bipolar disorder was 0.3%.
Roughly a third and two-fifths of participants with lifetime and 12-month
bipolar disorder respectively met criteria for rapid cycling. Compared
with the non-rapid-cycling, rapid-cycling bipolar disorder was associated
with younger age at onset, higher persistence, more severe depressive
symptoms, greater impairment from depressive symptoms, more out-of-role
days from mania/hypomania, more anxiety disorders and an increased
likelihood of using health services. Associations regarding childhood,
family and other sociodemographic correlates were less clear cut.
The community epidemiological profile of rapid-cycling bipolar disorder
confirms most but not all current clinically based knowledge about the