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18 results

  • 6.4 - Inflammation and Immune Responses

  • from 6 - Modulators
  • Edited by Mary-Ellen Lynall, University of Cambridge, Peter B. Jones, University of Cambridge, Stephen M. Stahl, University of California, San Diego
  • Book:
    Cambridge Textbook of Neuroscience for Psychiatrists
    Published online:
    08 November 2023
    Print publication:
    16 November 2023, pp 316-325

  • Summary

    Multiple psychiatric disorders have been associated with abnormalities in the immune system and evidence from human and animal studies suggests that the immune system is likely to be implicated in the pathogenesis of these disorders, at least in a subset of patients. However, our understanding of how the immune system contributes to symptoms in humans is in its infancy. Moreover, translating this new understanding to improved clinical care will require biomarkers of immune dysfunction that allow us to identify which patients might benefit from alternative immunomodulatory treatment approaches. Following a brief primer on the immune system and its relationship to the brain, this chapter summarises the immune abnormalities associated with psychiatric disorders in case–control studies, outlines the evidence for a causal contribution of immunopathology to psychiatric conditions and considers possible sources of the observed inflammation.

  • Introduction

  • Edited by Mary-Ellen Lynall, University of Cambridge, Peter B. Jones, University of Cambridge, Stephen M. Stahl, University of California, San Diego
  • Book:
    Cambridge Textbook of Neuroscience for Psychiatrists
    Published online:
    08 November 2023
    Print publication:
    16 November 2023, pp 1-3

  • Summary

    In the past 100 years, there has been a revolution in our understanding of the brain. So far, this has done little to disrupt mainstream psychiatric practice. That is set to change. New neuroscience-based treatments are emerging, while evidence from neuroscience and genetics are calling into question traditional diagnostic boundaries. Psychiatrists of the future will need to integrate their understanding of brain imaging, molecular diagnostics, psychological factors and social context to provide neuroscience-informed care plans.

Cambridge Textbook of Neuroscience for Psychiatrists
  • Edited by Mary-Ellen Lynall, Peter B. Jones, Stephen M. Stahl
  • Published online:
    08 November 2023
    Print publication:
    16 November 2023
  • Cambridge Textbook of Neuroscience for Psychiatrists is a 'one stop shop' for what any psychiatrist needs to know about the brain. Understanding the brain and mind requires a vast array of techniques and conceptual approaches. The Editors have assembled a team of basic neuroscientists, geneticists, psychologists, psychiatrists, neurologists, neurosurgeons and endocrinologists who bring you the cutting edge of translational neuroscience that addresses the material most relevant to current or future psychiatric practice. The book showcases what is known, highlights aspects that are less well understood and defines key outstanding questions. A revolution in our understanding of the brain has, so far, done little to disrupt mainstream psychiatric practice. That is set to change. The chapters align with the UK MRCPsych neuroscience syllabus and link to the USA National Neuroscience Curriculum Initiative (NNCI). Highly illustrated and accessible, this book will appeal to psychiatrists, neuroscientists, psychologists, other healthcare students and professionals.