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1 results

  • Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease

  • Rebecca Kerestes, Pramit M. Phal, Chris Steward, Bradford A. Moffat, Simon Salinas, Kay L. Cox, Kathryn A. Ellis, Elizabeth V. Cyarto, David Ames, Ralph N. Martins, Colin L. Masters, Christopher C. Rowe, Matthew J. Sharman, Olivier Salvado, Cassandra Szoeke, Michelle Lai, Nicola T. Lautenschlager, Patricia M. Desmond
  • Journal:
    BJPsych Open / Volume 1 / Issue 2 / October 2015
    Published online by Cambridge University Press:
    02 January 2018, pp. 139-148
    • Article
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  • Background

    Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns.

    Aims

    To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE 4) allele.

    Method

    Participants were 22 SMC carrying the APOE ɛ4 allele (ɛ4+; mean age 72.18 years) and 58 SMC non-carriers (ɛ4–; mean age 72.79 years). Connectivity of four dorsal and ventral seeds was examined. Relationships between PCC connectivity and physical activity measures were explored.

    Results

    ɛ4+ individuals showed increased connectivity between the dorsal PCC and dorsolateral prefrontal cortex, and the ventral PCC and supplementary motor area (SMA). Greater levels of physical activity correlated with the magnitude of ventral PCC–SMA connectivity.

    Conclusions

    The results provide the first evidence that ɛ4+ individuals at increased risk of cognitive decline show distinct alterations in dorsal and ventral PCC functional connectivity.