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The concept of communicative competence has been rendered as context-abstracted code-bound knowledge for language teaching and assessment. This Element offers a different perspective on 'communication' and 'competence'. Section 1 offers the rationale for this re-orientation. Section 2 examines the conceptual and pedagogic affordances and delimitations of the prevailing approach to communicative competence; Section 3 describes a conceptual re-framing of language use as ecological languaging in terms of embodied, situation-sensitive action through which people coordinate with others, artefacts, and environments; Section 4 explores assessment approaches built on Bayesian principles for tracking learner development and progress by taking account of prior accomplishment, expert opinion, and emerging performance to create probabilistic trajectories; Section 5 focusses on professional developments related to conceptual refinement, curriculum design, teaching materials, and teacher education. Section 6 considers some key future challenges. This Element is also available as Open Access on Cambridge Core.
Two functional genetic polymorphisms, ADH1B rs1229984 and ALDH2 rs671, play key roles in ethanol metabolism and are especially prevalent in East Asian populations. The rs1229984 variant accelerates the conversion of ethanol to acetaldehyde, whereas rs671 reduces enzymatic activity for converting acetaldehyde into acetic acid. These variants affect alcohol use disorder risk and have been implicated in various systemic conditions.
Aims
To investigate the broader associations of ADH1B rs1229984 and ALDH2 rs671 with habitual alcohol use in large, unselected populations.
Method
We analysed data from 146 374 Taiwanese adults (aged 20–90 years) enrolled in the Taiwan Biobank.
Results
Both variants showed clear associations with habitual alcohol use. The ADH1B rs1229984 CC genotype was associated with a higher prevalence of drinking, indicating a substantial contribution to alcohol-related behaviour. The ALDH2 rs671 A allele was linked to markedly reduced drinking, reflecting known intolerance among carriers rather than implying a uniformly larger effect than ADH1B. Beyond alcohol use, rs671 showed a protective association with gout, whereas rs1229984 was not significantly associated with chronic diseases after correction.
Conclusions
In this large population sample, both ADH1B rs1229984 and ALDH2 rs671 demonstrate meaningful, genotype-dependent effects on habitual alcohol use. Their combined effects underscore the importance of evaluating gene–gene interactions rather than attributing disproportionate influence to a single locus.
The stability of two bubbles rising initially in line through a viscous liquid is revisited using a global linear stability analysis formulated within an arbitrary Lagrangian–Eulerian framework, complemented by fully resolved embedded boundary method simulations. Whereas previous studies attributed the promoted in-line stability of oblate bubbles to a deformation-enhanced wake entrainment, the present analysis demonstrates that the dominant stabilizing mechanism arises instead from an inclination-induced rotational feedback generated as the trailing bubble (TB) experiences the asymmetric shear of the leading bubble’s wake. This inclination–shear coupling, rather than deformation itself, governs the recovery of stability with increasing aspect ratio. Furthermore, the results reveal that the unstable drafting–kissing–tumbling mode originates from short-range, two-way coupling between the bubbles, whereas the asymmetric side-escape mode corresponds to a long-range, one-way interaction dominated by the TB response. In addition, a previously unreported oscillatory global mode emerges from the unsteady recirculation linking the two bubbles, acting as a hydrodynamic spring whose effective stiffness and damping govern the oscillation frequency and growth rate. Together, these findings identify inclination-induced lift as the primary mechanism controlling the stability of rising bubble pairs and provide a unified framework for interpreting their stationary and oscillatory transitions across a broad range of inertial and deformable regimes.
Current flying-car designs lack scalability for diverse missions. This paper presents a modular design platform for developing reconfigurable flying-cars, embedding modularity across structural, electrical, and flight control domains. A full-scale sightseeing prototype demonstrates the platform’s feasibility and flexibility. The work contributes to design methodology by illustrating how modular architectures improve cross-mission adaptability, scalability, and lifecycle efficiency in complex mechatronic systems. (project introduction video available at https://www.aidilab.ai/flying-car)
Direct numerical simulations are performed on compressible turbulent boundary layers with micro-blowing controls applied to the walls at a free stream Mach number of 2.0 to investigate the influences of wall-blowing mass flux and spatial arrangements on drag reduction. Using law-of-the-wall for uniform blowing control, an estimation of skin friction is proposed based on Reynolds number and wall-blowing mass flux. At a given Reynolds number, the drag reduction rate increases almost logarithmically with wall-blowing mass flux within the control region. Downstream of the interaction zone, the drag reduction rate increases linearly. The disparities of the drag reduction rate in the integral sense among cases with different spatial arrangements are attributed to the asymmetric pressure gradient associated with flow compression, and expansion at the commencement and termination of the micro-blowing region.
This study was conducted to explore the effects of organic trace elements on milk composition, serum trace element concentrations, antioxidant and immune function, and metabolites in dairy cows. Thirty Holstein cows with similar body condition scores (3.5 ± 0.25 points) and parity were randomly divided into a control group (C), a 50% organic group (O_50), and a 100% organic group (O_100), with 10 cows in each group. The C group was fed a basal diet supplemented with 3% inorganic trace element premix, the O_50 group received 1.5% inorganic and 1.5% organic trace element premix, and the O_100 group received 3% organic trace element premix. Organic trace elements were supplemented from 21 days postpartum for 90 days. The results showed that milk protein concentration showed a linear response to organic trace element supplementation, with the highest value in the O_50 group (P < 0.05). Lactose concentration showed an increased quadratic effect (P < 0.01), whereas total solids (TS) and solid-not-fat (SNF) concentrations decreased linearly and quadratically. Serum selenium (Se) concentration increased linearly with increasing organic trace element supplementation (P < 0.05). Malondialdehyde (MDA) concentration decreased linearly (P < 0.05), whereas serum immunoglobulin A (IgA), superoxide dismutase activity, and immunoglobulin G (IgG) concentration increased significantly (P < 0.05). Liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis identified 70 and 76 differential metabolites in the O_50 and O_100 groups, respectively, compared with the C group. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis indicated that these metabolites were mainly involved in inflammatory mediator regulation, lysine degradation, sphingolipid metabolism, cytochrome P450-mediated drug metabolism, and ABC transporters. In conclusion, dietary supplementation with organic trace elements improved milk composition, antioxidant capacity, immune function, and serum metabolic profiles in dairy cows.
In this paper, we investigate the influences of wall temperature on compressible turbulent boundary layers at free-stream Mach number 6.0 and moderate Reynolds numbers. The findings demonstrate that turbulent statistics, including the logarithmic scaling of Reynolds stresses in the overlap region, the presence of very-large-scale motions in the outer layer, and their superposition on near-wall turbulence, exhibit qualitative invariance across varying wall temperatures. However, the reduced scale separation between near-wall small-scale motions and outer-layer large-scale motions leads to a contraction in the vertical extent of Reynolds stresses adhering to the logarithmic law. Very-large-scale motions are attenuated in viscous units but intensified in global scalings due to the lower free-stream Reynolds number, following approximately the power law. Their superposition effects on near-wall turbulence, when weighted by density, show only weak dependence on wall temperature. Conversely, the modulation of near-wall velocity and temperature fluctuations by very-large-scale motions diminishes with decreasing wall temperature. Through detailed analysis of spanwise spectra in the outer region, a distinct inertial subrange obeying the classical $-5/3$ scaling law is identified, alongside a universal scaling over the dissipative range. These observations suggest that the mechanisms governing energy cascade processes and the associated small-scale turbulent fluctuations remain independent of wall temperature variations.
Since 2007, the Taiwan Health Technology Assessment (HTA) system has developed from a review process for new drug reimbursement into a core element of National Health Insurance (NHI) decision-making. This study examines Taiwan’s development of a sustainable, learning-oriented HTA ecosystem.
Methods
This article synthesizes more than 15 years of HTA development in Taiwan, highlighting recent advancements, including parallel reviews, temporary reimbursement pathways, managed entry agreements (MEAs), real-world evidence (RWE) guidelines, precision medicine frameworks, and structured health technology reassessment. Drawing on national policy sources, administrative datasets, and published evaluations, four interrelated domains were analyzed: institutional development and governance; access pathways for high cost and high clinical impact; infrastructure for evidence generation; and mechanisms to strengthen patient and patient organization involvement (PPI).
Results
In 2024, 196 rapid HTA assessments were completed, reflecting increased system capacity and methodological sophistication. This evolution builds on earlier HTA-driven policy experiences, including immune checkpoint inhibitors supported by HTA, MEA design, and national RWD collection. These developments formed the groundwork for managing uncertainty, assessing high-cost therapies, and supporting life cycle evidence. Parallel review improved timely access to novel medicines without compromising assessment rigor. The Taiwan Cancer Drugs Fund provided a structured model for temporary reimbursement and RWD collection. Formal PPI processes expanded the integration of patient voices.
Conclusions
Taiwan’s HTA system is transitioning into a learning health system that supports adaptive coverage, continuous reassessment, and sustainable access to new medical technologies. Developments offer guidance to health systems seeking to balance access, evidence development, and financial sustainability.
Oil-based drilling fluids (OBDFs) are widely used in high-temperature ultra-deep wells, high-inclination wells, horizontal wells and various complex wellbores due to their excellent lubricity, high temperature stability, salt tolerance and contamination resistance. However, the intrusion of drill cuttings during drilling destabilizes water-in-oil (W/O) emulsion drilling fluids. Therefore, bentonite – a common component of drill cuttings – was selected to study the factors influencing its dispersion stability in W/O emulsions. The macroscopic stability of the system was evaluated via static observation, and the dispersion state was characterized using optical microscopy. Additionally, the viscosity, the contact angle of bentonite after adsorption of various surfactants, the interfacial tension and the charge of the bentonite particles were measured. The results indicate that various surfactants affect dispersion stability through distinct mechanisms. The system stabilized by a non-ionic surfactant exhibited low interfacial tension and the greatest stability. Furthermore, dispersion stability increased with surfactant concentration. Finally, binary surfactant systems were formulated with Span80. Calcium stearate demonstrated a significant synergistic effect with Span80, improving the stability of the bentonite dispersed in the emulsion, with an optimal ratio of 1:1. The mechanism of the stable dispersion of bentonite in oil was analysed, providing theoretical guidance for improving the stability of W/O emulsion drilling fluids during drilling operations.
In environments impacted by extreme disasters, the prevalence of human-made disasters and high-risk situations has been increasing. It has become an important issue to enhance situational awareness and strengthen response capabilities for medical professionals, building upon their existing expertise, from the perspective of NGOs. From 2022 to 2024, the organization held over eight training sessions with more than 150 participants, lasting from 2 to 5 days each. All participants were healthcare professionals. The training included situational awareness, basic battlefield injury management, and advanced damage-control resuscitation, combined with highly realistic, scenario-based exercises to enhance situational awareness and response capabilities.
In post-training interviews, all participants reported that the training helped them develop new logical thinking and perspectives. The scenario-based exercises enhanced their response speed and adaptability. The skills acquired were applicable not only in high-risk environments but also in their daily work settings. High-risk environments are not limited to humanitarian conflicts; they can also occur in everyday settings. Given the current global instability, similar training courses conducted by NGOs can effectively improve the situational awareness and response abilities of healthcare professionals.
The occurrence of disasters often has a tremendous impact on communities. In large-scale disasters, affected residents often need to rely on self-rescue before emergency response resources arrive. Therefore, enhancing the disaster response capability of community members is increasingly important, especially in light of the current extreme weather conditions.
From 2020 to 2024, the organization conducted 15 training sessions for frontline community responders, with over 1,000 participants in total. The training included classroom lectures, hands-on practice, and scenario-based drills to increase familiarity. A post-training assessment was conducted to ensure that participants understood and were proficient in the skills and knowledge taught in the course.
In the final assessment, all participants passed, achieving a 100% success rate. In the technical skills section, participants were able to independently complete all tasks. During the lecture sessions, instructors engaged with participants in comprehensive drills to confirm their retention of the course content.
Building community resilience is not a short-term endeavor with immediate results. Starting from basic first aid education and gradually expanding to all-hazard response training, the long-term planning and implementation of frontline community responder training can strengthen the community’s comprehensive response capabilities, equipping them to effectively handle both natural and human-made disasters in the future.
Sexual dimorphism, a widespread phenomenon, has been extensively researched in extant and fossil crustaceans. However, identifying sexual dimorphism in phyllocarid fossils preserved as isolated parts is often challenging, except in cases where the specimens are exceptionally well preserved, including those with soft tissues. This study proposes a novel approach by introducing the use of geometric morphometric techniques to identify sexual dimorphism in phyllocarid fossils based on carapace morphology. It presents a comprehensive re-analysis of Soomicaris ordosensis Liu et al., 2023a, carapaces from the Upper Ordovician in North China and Tarim Plates. Elliptic Fourier analysis was applied to quantify the size and shape variation in nearly 100 specimens. The results demonstrate the presence of significant sexual dimorphism in the length and shape of the S. ordosensis carapace. The carapace shape exhibited variation between the sexes: the posterodorsal margin of one group of carapaces gradually extends backward to form a posterodorsal spine; the carapaces of the other group have a convex posterior margin and lack a posterodorsal spine. Additionally, both types manifest an overall allometric growth pattern, albeit with distinct growth coefficients. Furthermore, the observed approximately 1:1 ratio between the two forms suggests that the population of S. ordosensis may have exhibited a dioecious mating system. Geometric morphometrics are a highly effective method for elucidating the subtle variations in the carapace morphology of S. ordosensis, thereby underscoring the cryptic dimorphism characteristics of fossil animals. This finding offers the first indirect evidence for egg-brooding behavior within the extinct order Archaeostraca.
We report an experimental study on the effects of polymer additives in the dissipative-scale flow field properties in turbulent Rayleigh–Bénard convection. The experiments were conducted in a cylindrical convection cell with a minute amount of polyacrylamide long-chain polymer. The local velocity gradient tensor was measured using an integrated home-made measurement system (J. Fluid Mech., 2024, vol. 984, p. A8). Although the single-roll large-scale circulation persists (owing to the slight tilt of the convection cell), polymers induce an anisotropic suppression of the dissipative-scale flow properties. The normal velocity gradient components are suppressed more than the shear components. The mean energy dissipation rate in both centre and side regions decreases, then levels off with increasing polymer concentration and the final reduction ratio exceeds 50 % in each region. In the side region, adding polymers has a stronger stabilising effect on the strain rate than the rotation. The anisotropic suppression of the velocity gradient tensor affects dissipation-rotation co-occurrence probability, velocity gradient triple decomposition and local streamline topology. Adding polymers also induces a deceleration effect and increases the contribution of local buoyancy in driving the flow. These results reveal that the addition of polymers can non-trivially manipulate dissipative-scale turbulence fields and energy cascades.
One-degree-of-freedom flow-induced vibration (FIV) and energy harvesting through FIV of an elastically mounted circular cylinder with mechanically coupled rotation were investigated numerically for low Reynolds number 100, mass ratio 8 and a wide range of reduced velocities. The aims of this study are to investigate the effect of the flow direction angle $\beta$ on the vibration and energy harvesting through FIV. Two types of lock-in are found: vortex-induced vibration (VIV) and galloping. The response amplitude increases with the increase of $\beta$ in both regimes. Both VIV response and galloping regimes are found for $\beta$ = 45° to $\beta$ = 90°. For $\beta$ = −90° to $\beta$ = 0°, only VIV response regimes are found. The fluid force and fluid torque play different roles in exciting/damping the vibration. In the high-amplitude gallop regime, the fluid force excites the vibration, and the torque damps the vibration. Energy harvesting at flow direction angle 90° is investigated as this flow direction has the maximum galloping amplitude. The energy harvesting is achieved by a linear electric damping coefficient in the numerical model. The maximum harvestable power in the galloping regime is significantly greater than that in the VIV regime, and it increases with the increase of the reduced velocity. When the reduced velocity is 20, the harvested power is over 20 times that in the VIV regime, and can further increase if reduced velocity further increases. The maximum efficiency over all simulated parameters is 0.424, occurring when the reduced velocity is 20, and electric damping factor is 0.04.
In patients with remitted psychosis, the dosage of antipsychotics can be lowered without increased risk of relapse. Whether dose tapering can lead to improved cognition is unclear. We compared changes in cognitive performance between patients undergoing dose tapering and those receiving a fixed maintenance dose.
Methods
A 2-year prospective trial of patients with stable schizophrenia-related psychotic disorders was conducted: one group received guided dose reduction (GDR) and one group received maintenance treatment. Cognitive function was assessed using the Wechsler Adult Intelligence Scale-Third Edition, Mandarin Chinese version, at baseline, 1, and 2 years. The relations between the ratio of reduced dose and the extent of cognitive improvement were examined by Spearman’s correlation coefficient. We also examined cognitive performance between aripiprazole (ARI) users and non-ARI users.
Results
GDR patients exhibited significantly greater improvements in total intellectual quotient (IQ), particularly working memory, and information and arithmetic subtest scores, with no significant difference in relapse rates between groups. Statistically significant dose–response correlations were found between the degree of dose reduction and improvements in total IQ (n = 72, r = 0.242, p = 0.041), Working Memory Index (n = 72, r = 0.284, p = 0.016), and Arithmetic subtest (n = 72, r = 0.295, p = 0.012). There were no differences in cognitive changes between ARI users and non-users.
Conclusions
Lowering antipsychotic dosage may ameliorate patient performance in several cognitive domains. This finding is worthy of consideration while evaluating the risk-to-benefit ratio of tapering antipsychotics in patients with remitted psychosis.
This study employs a direct numerical simulation method to investigate the wake pattern evolutions of flows past an insulated spheroid and provides expressions of force and torque coefficients influenced by a streamwise magnetic field in an incompressible, conducting, viscous fluid. A total of 1150 cases are examined covering a parameter range of Reynolds number $50 \leqslant \textit{Re} \leqslant 250$, aspect ratio $1.5 \leqslant \beta \leqslant 6$, inclination angle $0^\circ \leqslant \theta \leqslant 90^\circ$, and interaction parameter $0 \leqslant N \leqslant 10$, where $\beta$ and $N$, respectively, reflect the anisotropy of the spheroid and the strength of magnetic field. Nine wake patterns are classified based on wake structure features and summarised in three maps of regimes according to the inclination angle. The transition mechanisms among these wake patterns are also investigated under the influence of a streamwise magnetic field. Furthermore, expressions for drag, lift and torque coefficients are derived with the help of three fundamental physical criteria. Results indicate that the force and torque expressions give a good prediction within the present parameter space $\{\textit{Re}, \beta , \theta , N\}$.
Some cadres receive promotions, whereas others do not. This study explores the Chinese Communist Party’s (CCP) personnel control over the central state-owned enterprise (SOE) leaders from the Hu era to the Xi era. An analysis of the résumés and careers of SOE leaders reveals that the CCP has established a dual-track system to manage enterprises with different functions. This system employs two types of incentives: promotion incentives for leaders of eldest-son enterprises associated with national security, and salary incentives for leaders of other enterprises. Through the dual-track system, the CCP aims to influence the career trajectories of SOE leaders and address conflicts of interest in the principal-agent relationship. This study also investigates the individual characteristics of SOE leaders, including their political qualifications, professional qualifications and ages. The results indicate a tendency towards specialization and institutionalization in central-enterprise leaders, even during the Xi era.
Depression and anxiety are prevalent mental health disorders. While sleep duration has been extensively studied, sleep regularity may play a critical role. We aimed to examine associations between objectively measured sleep regularity and incident depression and anxiety and to investigate whether meeting recommended sleep duration modifies these associations.
Methods
In 79,666 UK Biobank participants without baseline depression or anxiety, wrist accelerometers worn for 7 days yielded a sleep regularity index (SRI) and average sleep duration. SRI was categorized as irregular (≤51), moderately irregular (52–70), or regular (≥71). Sleep duration was classified by age-specific recommendations (7–9 hours for ages 18–64 years; 7–8 hours for over 65 years). Cox regression models assessed associations between sleep parameters and mental health outcomes.
Results
During a median follow-up of 7.5 years, 1,646 participants developed depression, and 2,097 developed anxiety. Compared to irregular sleepers, regular sleepers had a 38% lower depression risk (hazard ratio [HR], 0.62; 95% confidence interval [CI], 0.52–0.73) and a 33% lower anxiety risk (HR, 0.67; 95%CI, 0.58–0.77). Participants with both irregular sleep and nonrecommended duration exhibited the highest risks (depression HR, 1.91; 95%CI, 1.55–2.35; anxiety HR, 1.61; 95%CI, 1.35–1.93). Notably, irregular sleepers who met duration guidelines still faced elevated risks (depression HR, 1.48; 95%CI, 1.18–1.86; anxiety HR, 1.35; 95%CI, 1.11–1.64).
Conclusions
Greater sleep regularity is independently associated with lower depression and anxiety risk regardless of sleep duration, suggesting that sleep–wake consistency should be considered in mental health promotion strategies alongside traditional sleep duration recommendations.