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16 results

  • Genetic variants in folate metabolism-related genes, serum folate and hepatocellular carcinoma survival: the Guangdong Liver Cancer Cohort study

  • Yunshan Li, Jing Shu, Peishan Tan, Xiaocong Dong, Mingjie Zhang, Tongtong He, Zhijun Yang, Xuehong Zhang, Edward L. Giovannucci, Zhaoyan Liu, Zhongguo Zhou, Qijiong Li, Yanjun Xu, Xiaojun Xu, Tianyou Peng, Jialin Lu, Yaojun Zhang, Huilian Zhu, Aiping Fang
  • Journal:
    British Journal of Nutrition / Volume 132 / Issue 11 / 14 December 2024
    Published online by Cambridge University Press:
    07 November 2024, pp. 1411-1422
    Print publication:
    14 December 2024
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  • Folate metabolism is involved in the development and progression of various cancers. We investigated the association of single nucleotide polymorphisms (SNP) in folate-metabolising genes and their interactions with serum folate concentrations with overall survival (OS) and liver cancer-specific survival (LCSS) of newly diagnosed hepatocellular carcinoma (HCC) patients. We detected the genotypes of six SNP in three genes related to folate metabolism: methylenetetrahydrofolate reductase (MTHFR), 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR). Cox proportional hazard models were used to calculate multivariable-adjusted hazard ratios (HR) and 95 % CI. This analysis included 970 HCC patients with genotypes of six SNP, and 864 of them had serum folate measurements. During a median follow-up of 722 d, 393 deaths occurred, with 360 attributed to HCC. In the fully-adjusted models, the MTRR rs1801394 polymorphism was significantly associated with OS in additive (per G allele: HR = 0·84, 95 % CI: 0·71, 0·99), co-dominant (AG v. AA: HR = 0·77; 95 % CI: 0·62, 0·96) and dominant (AG + GG v. AA: HR = 0·78; 95 % CI: 0·63, 0·96) models. Carrying increasing numbers of protective alleles was linked to better LCSS (HR10–12 v. 2–6 = 0·70; 95 % CI: 0·49, 1·00) and OS (HR10–12 v. 2–6 = 0·67; 95 % CI: 0·47, 0·95). Furthermore, we observed significant interactions on both multiplicative and additive scales between serum folate levels and MTRR rs1801394 polymorphism. Carrying the variant G allele of the MTRR rs1801394 is associated with better HCC prognosis and may enhance the favourable association between higher serum folate levels and improved survival among HCC patients.

  • Directly Probing Local Coordination, Charge State and Stability of Single Atom Catalysts

  • Xiaoqing Pan, Xingxu Yan, Sheng Dai, Mingjie Xu, George Graham
  • Journal:
    / Volume 26 / Issue S2 / August 2020
    Published online by Cambridge University Press:
    30 July 2020, pp. 2468-2469
    Print publication:
    August 2020
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  • Developing Multifunctional and High Resolution In-situ TEM Holders

  • Songhua Cai, Mingjie Xu, Sheng Dai, Peng Wang, Xiaoqing Pan
  • Journal:
    / Volume 25 / Issue S2 / August 2019
    Published online by Cambridge University Press:
    05 August 2019, pp. 1854-1855
    Print publication:
    August 2019
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  • Characterization of Iron-Containing Nanoparticle Catalyst Using STEM Techniques

  • Mingjie Xu, Yang Yu, Jian-Guo Zheng
  • Journal:
    / Volume 25 / Issue S2 / August 2019
    Published online by Cambridge University Press:
    05 August 2019, pp. 2342-2343
    Print publication:
    August 2019
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  • Double-tilt in situ TEM Holder with Ultra-high Stability

  • Mingjie Xu, Sheng Dai, Thomas Blum, Linze Li, Xiaoqing Pan
  • Journal:
    / Volume 24 / Issue S1 / August 2018
    Published online by Cambridge University Press:
    01 August 2018, pp. 1890-1891
    Print publication:
    August 2018
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  • In Situ TEM Probing of Ferroelectric Switching under Electrical Bias

  • Xiaoqing Pan, Lin-Ze Li, Mingjie Xu, Sheng Dai, Thomas Blum
  • Journal:
    / Volume 24 / Issue S1 / August 2018
    Published online by Cambridge University Press:
    01 August 2018, pp. 1812-1813
    Print publication:
    August 2018
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