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1 results

  • Social and cognitive functioning, urbanicity and risk for schizophrenia

  • Mark Weiser, Jim van Os, Abraham Reichenberg, Jonathan Rabinowitz, Daniella Nahon, Efrat Kravitz, Gad Lubin, Moti Shmushkevitz, Haim Y. Knobler, Shlomo Noy, Michael Davidson
  • Journal:
    The British Journal of Psychiatry / Volume 191 / Issue 4 / October 2007
    Published online by Cambridge University Press:
    02 January 2018, pp. 320-324
    Print publication:
    October 2007
    • Article
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  • Background

    Previous work suggests that the association between urbanicity and schizophrenia may be greatest in those with pre-existing vulnerability.

    Aims

    To test for synergism in risk of schizophrenia between population density and a combined exposure of poor premorbid social and cognitive functioning.

    Method

    For 371 603 adolescent males examined by the Israeli Draft Board on social and cognitive functioning, data on population density of place of residence and later hospitalisation for schizophrenia were obtained from population-based registries.

    Results

    There was an interaction between population density (five levels) and poor premorbid social and cognitive functioning (interaction χ2=4.6, P=0.032). The adjusted increase in cumulative incidence associated with one unit change in population density was 0.10% in the vulnerable group (95% CI 0.019–0.18, P=0.015), nine times larger than that in the non-vulnerable group (0.011%, 95% CI 0.0017–0.020, P=0.021).

    Conclusions

    Risk of schizophrenia may increase when people with a genetic liability to the disorder, expressed as poor social and cognitive functioning, need to cope with city life.