Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

3 results

  • Author's reply

  • Ragy R. Girgis, Naihua Duan, Jeffrey A. Lieberman
  • Journal:
    The British Journal of Psychiatry / Volume 200 / Issue 2 / February 2012
    Published online by Cambridge University Press:
    02 January 2018, pp. 165-166
    Print publication:
    February 2012
    • Article
      • You have access
    • PDF
    • HTML
    • Export citation

  • Clozapine v. chlorpromazine in treatment-naive, first-episode schizophrenia: 9-year outcomes of a randomised clinical trial

  • Ragy R. Girgis, Michael R. Phillips, Xiaodong Li, Kejin Li, Huiping Jiang, Chengjing Wu, Naihua Duan, Yajuan Niu, Jeffrey A. Lieberman
  • Journal:
    The British Journal of Psychiatry / Volume 199 / Issue 4 / October 2011
    Published online by Cambridge University Press:
    02 January 2018, pp. 281-288
    Print publication:
    October 2011
    • Article
      • You have access
    • PDF
    • HTML
    • Export citation
  • Background

    The differential effects of so-called ‘first- and second-generation’ antipsychotic medications, when given in the first episode, on the long-term outcome of schizophrenia remain to be elucidated.

    Aims

    We compared the 9-year outcomes of individuals initially randomised to clozapine or chlorpromazine.

    Method

    One-hundred and sixty individuals with treatment-naive, first-episode schizophrenia or schizophreniform disorder in a mental health centre in Beijing, China were randomised to clozapine or chlorpromazine treatment for up to 2 years, followed by up to an additional 7 years of naturalistic treatment. The primary outcome was remission status for individuals in each group.

    Results

    Individuals in both groups spent essentially equal amounts of time in each clinical state over the follow-up time period (remission, 78%; intermediate, 8%; relapse, 14%). There were no significant differences on other measures of illness severity. The clozapine group was more likely than the chlorpromazine group to remain on the medication to which they were originally assigned (26% v. 10%, P = 0.01). There were no significant differences between the two groups on other secondary efficacy outcomes.

    Conclusions

    These findings support the comparability in effectiveness between antipsychotic medications but with slightly greater tolerability of clozapine in the treatment of first-episode psychosis.

  • 11 - Anticipatory Guidance: What Information Do Parents Receive? What Information Do They Want?

    • By Mark A. Schuster, Associate Professor of Pediatrics, School of Medicine, and Associate Professor of Health Services, School of Public Health University of California, Los Angeles; Senior Natural Scientist RAND; Director UCLA/RAND Center for Adolescent Health Promotion, Michael Regalado, Associate Professor of Pediatrics and Community Health Sciences UCLA Schools of Medicine and Public Health, Naihua Duan, Professor in Residence Department of Psychiatry and Biobehavioral Sciences, School of Medicine, Department of Biostatistics, School of Public Health, University of California, Los Angeles, David J. Klein, Senior Quantitative Analyst RAND, Santa Monica, California
  • Edited by Neal Halfon, University of California, Los Angeles, Kathryn Taaffe McLearn, Columbia University, New York, Mark A. Schuster, University of California, Los Angeles
  • Book:
    Child Rearing in America
    Published online:
    15 July 2009
    Print publication:
    08 July 2002, pp 320-344

  • Summary

    Our [medical] curriculum covers a certain amount of study of the anatomy and physiology of the child about which mothers never ask us, but the information which they seek has to do with that which cannot be obtained from books, but rather is that sort of knowledge which has passed from mouth to mouth down through the centuries. Instead of asking mother or grandmother what should be done, the doctor is consulted. If her confidence is to be retained, the physician must be as familiar with the proper manner of bathing a baby as he is with the treatment of pneumonia, and he may render the baby as notable a service in one instance as in the other.

    The doctor is taking the place more and more of the ‘advice offering neighbor,’ and it behooves him to be able to advise the mother correctly.

    B. R. Hoobler, “The Desirability of Teaching Students Details Concerning the Care of the Normal Infant,” Transactions of the Association of American Teachers of Diseases of Children, 1917.

    Physicians who take care of children are often called on to provide education and counseling about child rearing. Their advice may be especially important for the parents of young children, who grow and develop rapidly and sometimes seem to change overnight. Although physicians have been playing this role for at least the last century, the medical profession has given it greater attention in recent years in response to several factors: technological advances in medicine, a growing understanding of neuroscience and child development, and evolving systems of health care delivery.