This article emerged as the human species collectively have been experiencing the worst global pandemic in a century. With a long view of the ecological, economic, social, and political factors that promote the emergence and spread of infectious disease, archaeologists are well positioned to examine the antecedents of the present crisis. In this article, we bring together a variety of perspectives on the issues surrounding the emergence, spread, and effects of disease in both the Americas and Afro-Eurasian contexts. Recognizing that human populations most severely impacted by COVID-19 are typically descendants of marginalized groups, we investigate pre- and postcontact disease vectors among Indigenous and Black communities in North America, outlining the systemic impacts of diseases and the conditions that exacerbate their spread. We look at how material culture both reflects and changes as a result of social transformations brought about by disease, the insights that paleopathology provides about the ancient human condition, and the impacts of ancient globalization on the spread of disease worldwide. By understanding the differential effects of past epidemics on diverse communities and contributing to more equitable sociopolitical agendas, archaeology can play a key role in helping to pursue a more just future.

In this paper we test the hypothesis that an intensification of maize production preceded the development of a regional Moche political economy in the Moche Valley of north coastal Peru during the Early Intermediate period (400 B.C.—A.D. 600). To do so we analyze stable isotopic signatures of 48 bone apatite and 17 tooth enamel samples from human remains recovered from the site of Cerro Oreja, a large urban and ceremonial center in the Moche Valley. These remains date to the Guañape, Salinar, or Gallinazo phases and provide a diachronic picture of subsistence before the appearance of the Southern Moche state. The most notable patterns identified in the study include a lack of significant change in δ13 Capatite values from the Guañape to Satinar phases, followed by a significant enrichment in δ13 Capatite values from the Salinar to Gallinazo phases. Several lines of evidence, including archaeological context, dental data, and comparative carbon stable isotope data from experimental animal studies and studies of archaeological human remains support the interpretation that the observed 13C enrichment in stable isotope values in the Gallinazo phase primarily reflects maize intensification. The stable isotope data from Cerro Oreja thus suggest that a shift in subsistence toward a highly productive and storable crop may have served as an important precursor to state development during the Early Intermediate period in the Moche Valley.

The original authors of Billman et al. (2000) are joined by three other analysts from the Cowboy Wash research team to respond to the critique of this article by Dongoske et al. (2000). Dongoske and his coauthors state that Billman et al. (2000) failed to test alternative hypotheses or to consider alternative explanations for the findings at 5MT10010 and similar sites. The original authors point out that alternative hypotheses were examined and rejected, leaving a violent episode of cannibalism as the most plausible explanation for the remains found at 5MT10010. Dongoske et al. also question many aspects of the osteological, archaeological, coprolite, and biochemical analyses that were presented in the 5MT10010 study. Our response addresses issues of data collection, procedure, and interpretation, and attempts to clarify some points that were not fully developed in the original text due to length restrictions.

The existence of cannibalism has emerged as one of the most controversial issues in the archaeology of the American Southwest. In this paper, we examine this issue by presenting the results of our investigation at 5MT10010, a small early Pueblo III habitation site in southwestern Colorado. Battered, broken bones from seven individuals were discovered in two adjacent pithouses at 5MT10010. Mixed and incomplete remains of four adults and an adolescent were recovered from the floor and ventilator shaft of one pithouse; the remains of two subadults were found on the floor and in various subfeatures of the second. Cut marks and percussion scars implicate humans in the disarticulation and reduction of these bodies. Evidence of heat exposure on some bone fragments and laboratory analyses of a human coprolite recovered from one of the pithouses support the interpretation that people prepared and consumed human body parts. The discovery of disarticulated human remains at 5MT10010 is one of a number of similar finds in the northern Southwest. Analysis of cases from the Mesa Verde region indicates a sharp increase in cannibalism around A.D. 1150, a time of drought and the collapse of the Chaco system. The causes, consequences, and nature of this apparent outbreak of cannibalism are examined in light of 5MT10010 and other recent finds.

Skeletal remains from the Santa Barbara Channel Islands, California were analyzed to evaluate the health consequences of an economic shift from a generalized maritime hunting-and-gathering adaptation to one focused increasingly on fishing. Changes in stature and in the frequency of inflammatory bone lesions suggest that health generally declined during this economic shift. This occurred despite an increase in the protein content of the diet. These data provide a basis for evaluating the significance of protein deficiency as a cause of the deterioration in health seen with the development of intensive agriculture.

In this paper we use osteological data to evaluate theories about the rise of chiefdoms in southern California. To do this, we examine skeletal evidence for changes in diet, disease and violence in Santa Barbara Channel area populations. These collections date from before and after the development of large, sedentary coastal villages and a political system that facilitated inter-village economic interaction. Our data show that the health consequences of the development of these chiefdoms are comparable to those seen with the development of complex agricultural societies. They also provide insights into the causes of social complexity in non-agricultural societies.