Diamondback moth, Plutella xylostella (Linnaeus) (Lepidoptera: Plutellidae), a globally important pest of Brassicaceae crops, migrates into all provinces of Canada annually. Life tables were used to determine the mortality levels contributed by the parasitoid complexes associated with diamondback moth in British Columbia, Ontario, Prince Edward Island, and insular Newfoundland. Overall, diamondback moth populations showed high generational mortality (> 90%) in all provinces, although parasitism levels were generally low. The net reproductive rate of increase in diamondback moth was less than 1.0 (populations declined) in both years in British Columbia and in each of two years in Newfoundland and Ontario, but it was greater than 1.0 in all three years in Prince Edward Island. Lower parasitism levels were found in Prince Edward Island (3.0–6.3%) compared with other provinces (8.4–17.6%, except one year in British Columbia). Diadegma insulare was the main larval parasitoid found; it was present in all provinces. Microplitis plutellae was present in all provinces except British Columbia. Oomyzus sokolowskii was found in British Columbia and Ontario. The parasitoid community documented from sentinel sampling was less diverse than that found through destructive sampling. Hypotheses are provided to explain the presence of major parasitoids. Increasing larval parasitism would have the largest effect on diamondback moth population growth in Canada.

Maternal adversity and prenatal stress confer risk for child behavioral health problems. Few studies have examined this intergenerational process across multiple dimensions of stress; fewer have explored potential protective factors. Using a large, diverse sample of mother–child dyads, we examined associations between maternal childhood trauma, prenatal stressors, and offspring socioemotional-behavioral development, while also examining potential resilience-promoting factors. The Conditions Affecting Neurocognitive Development and Learning and Early Childhood (CANDLE) study prospectively followed 1503 mother–child dyads (65% Black, 32% White) from pregnancy. Exposures included maternal childhood trauma, socioeconomic risk, intimate partner violence, and geocode-linked neighborhood violent crime during pregnancy. Child socioemotional-behavioral functioning was measured via the Brief Infant Toddler Social Emotional Assessment (mean age = 1.1 years). Maternal social support and parenting knowledge during pregnancy were tested as potential moderators. Multiple linear regressions (N = 1127) revealed that maternal childhood trauma, socioeconomic risk, and intimate partner violence were independently, positively associated with child socioemotional-behavioral problems at age one in fully adjusted models. Maternal parenting knowledge moderated associations between both maternal childhood trauma and prenatal socioeconomic risk on child problems: greater knowledge was protective against the effects of socioeconomic risk and was promotive in the context of low maternal history of childhood trauma. Findings indicate that multiple dimensions of maternal stress and adversity are independently associated with child socioemotional-behavioral problems. Further, modifiable environmental factors, including knowledge regarding child development, can mitigate these risks. Both findings support the importance of parental screening and early intervention to promote child socioemotional-behavioral health.

We report on the successful demonstration of a 150 J nanosecond pulsed cryogenic gas cooled, diode-pumped multi-slab Yb:YAG laser operating at 1 Hz. To the best of our knowledge, this is the highest energy ever recorded for a diode-pumped laser system.

In this paper we review the design and development of a 100 J, 10 Hz nanosecond pulsed laser, codenamed DiPOLE100X, being built at the Central Laser Facility (CLF). This 1 kW average power diode-pumped solid-state laser (DPSSL) is based on a master oscillator power amplifier (MOPA) design, which includes two cryogenic gas cooled amplifier stages based on DiPOLE multi-slab ceramic Yb:YAG amplifier technology developed at the CLF. The laser will produce pulses between 2 and 15 ns in duration with precise, arbitrarily selectable shapes, at pulse repetition rates up to 10 Hz, allowing real-time shape optimization for compression experiments. Once completed, the laser will be delivered to the European X-ray Free Electron Laser (XFEL) facility in Germany as a UK-funded contribution in kind, where it will be used to study extreme states of matter at the High Energy Density (HED) instrument.

Objectives: Glioblastoma is a lethal disease in the elderly population. We aimed to evaluate disease and treatment outcomes in the oldest-old patients. Methods: Patients >80 years old with histologically confirmed glioblastoma treated between 2004 and 2009 were identified. We included patients managed with best supportive care (BSC), temozolomide (TMZ) alone, radiotherapy (RT) alone, or concomitantly with TMZ (CRT). Survival outcomes were analyzed using the Kaplan–Meier method. Results: Ultimately, 48 patients were analyzed. Median age and Eastern Cooperative Oncology Group (ECOG) Performance Status were 82 years and 2, respectively. The median Age-Adjusted Charlson Index (AAC) was 6. Gross total and subtotal resections were performed in 16.7% and 18.8% of patients, respectively. Biopsy followed by RT alone was the treatment modality for 23/48 (47.9%), while 17/48 (35.4%) received surgery followed by RT alone or CRT. A total of 8 (16.7%) were managed with BSC after biopsy. Median overall survival (OS) and progression-free survival (PFS) were 4.1 (95% confidence interval [95% CI] 3.3-4.9) and 2.7 (95% CI 1.5-3.9) months, respectively. Improved median OS was observed in those treated with surgical resection followed by RT alone or CRT (7.1 months), compared to biopsy followed by RT alone (4.2 months) or BSC (2.0 months; p=0.002). Surgical resection, age≤85, and AAC<6 were associated with better OS (p=0.032, p=0.031, and p=0.02, respectively). Cause of death was neurological progression in 56% of cases. RT was well-tolerated. Conclusions: PFS and OS outcomes remain poor in the oldest-old patients (>80 years old). Younger age, lower AAC, surgical resection, and adjuvant treatment were associated with improved OS.

The Deep Ice Sheet Coring (DISC) drill developed by Ice Coring and Drilling Services under contract with the US National Science Foundation is an electromechanical ice-drill system designed to take 122mm ice cores to depths of 4000 m. The new drill system was field-tested near Summit camp in central Greenland during the spring/summer of 2006. Testing was conducted to verify the performance of the DISC drill system and its individual components and to determine the modifications required prior to the system’s planned deployment for coring at the WAIS Divide site in Antarctica in the following year. The experiments, results and the drill crew’s experiences with the DISC drill during testing are described and discussed.

This paper reexamines the stratigraphy, sources, and paleoclimatic significance of Holocene Bignell Loess in the central Great Plains. A broadly similar sequence of loess depositional units and paleosols was observed in thick Bignell Loess sections up to 300 km apart, suggesting that these sections record major regional changes in the balance between dust deposition and pedogenesis. New optical ages, together with previously reported radiocarbon ages, indicate Bignell Loess deposition began 9000–11,000 yr ago and continued into the late Holocene; some Bignell Loess is <1000 yr old. There is little evidence that Holocene Loess was derived from flood plain sources, as previously proposed. Instead, thick Bignell Loess occurs mainly near the downwind margins of inactive dune fields, particularly atop escarpments facing the dunes. Thus, the immediate loess source was dust produced when the dunes were active. Previous work indicates that widespread episodes of dune activity are likely to have resulted from drier-than-present climatic conditions. The regionally coherent stratigraphy of Bignell Loess can be interpreted as a near-continuous record of climatically driven variation in dune field activity throughout the Holocene.

The Palisades Site is an extensive silt-loam bluff complex on the central Yukon River preserving a nearly continuous record of the last 2 myr. Volcanic ash deposits present include the Old Crow (OCt; 140,000 yr), Sheep Creek (SCt; 190,000 yr), PA (2.02 myr), EC (ca. 2 myr), and Mining Camp (ca. 2 myr) tephras. Two new tephras, PAL and PAU, are geochemically similar to the PA and EC tephras and appear to be comagmatic. The PA tephra occurs in ice-wedge casts and solifluction deposits, marking the oldest occurrence of permafrost in central Alaska. Three buried forest horizons are present in association with dated tephras. The uppermost forest bed occurs immediately above the OCt; the middle forest horizon occurs below the SCt. The lowest forest bed occurs between the EC and the PA tephras, and correlates with the Dawson Cut Forest Bed. Plant taxa in all three peats are common elements of moist taiga forest found in lowlands of central Alaska today. Large mammal fossils are all from common late Pleistocene taxa. Those recovered in situ came from a single horizon radiocarbon dated to ca. 27,000 14C yr B.P. The incongruous small mammal assemblage in that horizon reflects a diverse landscape with both wet and mesic environments.

Loess has been recognized on the glacial land surface of the Green Bay Lobe for over 100 yr, but no systematic explanation of the source of the loess has been advanced. Intriguingly, the loess on the Green Bay Lobe land surface is thicker than predicted by regional thinning trends from the Mississippi Valley and is geographically separated from much loess of southwest Wisconsin by a sandy region devoid of loess. Mapping based on soil survey interpretation indicates that the loess occurs above an escarpment marking the eastern end of the sandy loess-free region. Particle size fining trends demonstrate that the loess was transported by northwesterly winds. Clay mineralogy of the Green Bay Lobe loess is distinctly different than glaciogenic sediments and matches loess of the Mississippi Valley, indicating a regional source and long distance transport of the loess. We propose the loess was transported from the regional source along a surface of transport produced by migration of eolian sand through low-relief landscapes including the glacial Lake Wisconsin basin. Eolian sand migration caused repeated entrainment of dust leading to east-southeastward transport. The loess accumulated above an escarpment that limited sand mobility and re-entrainment of loess beyond this topographic barrier.

Discrete dune fields are found throughout much of the Great Plains of North America, and the timing of past dune activity is often used as a proxy for paleoclimate because of the intuitive link between dune activity and a more arid climate. This research suggests that feedbacks in the soil-geomorphic system create a relationship between dune activity and climate that varies both spatially and temporally. Older eolian landforms are more resistant to activation because of the long-term accumulation of finer soil particles in a Bt horizon which retain moisture and anchor the deposit even during more arid times. Conversely, younger deposits lack these fines and are more easily reactivated. This spatially variable relationship is supported by soil stratigraphy, particle size analysis, and optical age control. Additionally, the water retention of the Bt horizons is quantifiably greater than that of the soils found in the younger dunes of the area. This complication in the relationship between eolian activity and climate is important because it suggests that caution is needed when using past dune activity as the lone proxy for paleoclimate.

Tuberculosis (TB) researchers and clinicians, by virtue of the social disease they study, are drawn into an engagement with ways of understanding illness that extend beyond the strictly biomedical model. Primers on social science concepts directly relevant to TB, however, are lacking. The particularities of TB disease mean that certain social science concepts are more relevant than others. Concepts such as structural violence can seem complicated and off-putting. Other concepts, such as gender, can seem so familiar that they are left relatively unexplored. An intimate familiarity with the social dimensions of disease is valuable, particularly for infectious diseases, because the social model is an important complement to the biomedical model. This review article offers an important introduction to a selection of concepts directly relevant to TB from health sociology, medical anthropology and social cognitive theory. The article has pedagogical utility and also serves as a useful refresher for those researchers already engaged in this genre of work. The conceptual tools of health sociology, medical anthropology and social cognitive theory offer insightful ways to examine the social, historical and cultural dimensions of public health. By recognizing cultural experience as a central force shaping human interactions with the world, TB researchers and clinicians develop a more nuanced consideration of how health, illness and medical treatment are understood, interpreted and confronted.