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The National Institutes of Health (NIH) Executive Abilities: Measures and Instruments for Neurobehavioral Evaluation and Research (EXAMINER) is a validated laptop-based battery of executive functioning tests. A modified tablet version of the EXAMINER was developed on the UCSF Tablet-based Cognitive Assessment Tool (TabCAT-EXAMINER). Here we describe the battery and investigate the reliability and validity of a composite score.
Methods:
A diagnostically heterogeneous sample of 2135 individuals (mean age = 65.58, SD = 16.07), including controls and participants with a variety of neurodegenerative syndromes, completed the TabCAT-EXAMINER. A composite score was developed using confirmatory factor analysis and item response theory. Validity was evaluated via linear regressions that tested associations with neuropsychological tests, demographics, clinical diagnosis, and disease severity. Replicability of cross-sectional results was tested in a separate sample of participants (n = 342) recruited from a frontotemporal dementia study. As this separate sample also collected longitudinal TabCAT-EXAMINER measures, we additionally assessed test-retest reliability and associations between baseline disease severity and changes in TabCAT-EXAMINER scores.
Results:
The TabCAT-EXAMINER score was normally distributed, demonstrated high test-retest reliability, and was associated in the expected directions with independent tests of executive functioning, demographics, disease severity, and diagnosis. Greater baseline disease severity was associated with more rapid longitudinal TabCAT-EXAMINER decline.
Conclusions:
The TabCAT-EXAMINER is a tablet-based executive functioning battery developed for observational research and clinical trials. Performance can be summarized as a single composite score, and results of this study support its reliability and validity in cognitive aging and neurodegenerative disease cohorts.
We present the discovery of two extended, low surface-brightness radio continuum sources, each consisting of a near-circular body and an extended tail of emission, nicknamed Stingray 1 (ASKAP J0129–5350) and Stingray 2 (ASKAP J0245–5642). Both are found in the direction of the Magellanic Stream (MS) and were discovered in the Australian Square Kilometre Array Pathfinder (ASKAP) Evolutionary Map of the Universe (EMU) survey at 944 MHz. We combine the ASKAP data with low-frequency radio observations from the GaLactic and Extragalactic All-sky MWA Survey (GLEAM) to conduct a radio continuum analysis. galaxy pairs or groups, and Odd Radio Circles (ORCs). We explore both Galactic/near Galactic scenarios, including runaway or circumgalactic supernova remnants (SNRs) and parentless pulsar-wind nebulae (PWNe), and extragalactic scenarios including radio active galactic nuclei (AGNs), dying radio galaxies, galaxy clusters, galaxy pairs or groups, head-tail radio galaxies, and ORCs, as well as the possibility that the morphology is due to a chance alignment. The Stingrays exhibit non-thermal emission with spectral indices of $\alpha=-0.89\pm0.09$ for Stingray 1 and $\alpha=-1.77\pm0.06$ for Stingray 2. We find that none of the proposed scenarios can explain all of the observed properties, however we determine it most likely that their shape is caused by some kind of complex environmental interaction. The most likely scenario from the available data is that of a head-tail radio galaxy, but more data is required for a definitive classification.
We present the serendipitous radio-continuum discovery of a likely Galactic supernova remnant (SNR) G305.4–2.2. This object displays a remarkable circular symmetry in shape, making it one of the most circular Galactic SNRs known. Nicknamed Teleios due to its symmetry, it was detected in the new Australian Square Kilometre Array Pathfinder (ASKAP) Evolutionary Map of the Universe (EMU) radio–continuum images with an angular size of 1 320$^{\prime\prime}$$\times$1 260$^{\prime\prime}$ and PA = 0$^\circ$. While there is a hint of possible H$\alpha$ and gamma-ray emission, Teleios is exclusively seen at radio–continuum frequencies. Interestingly, Teleios is not only almost perfectly symmetric, but it also has one of the lowest surface brightnesses discovered among Galactic SNRs and a steep spectral index of $\alpha$=–0.6$\pm$0.3. Our best estimates from Hi studies and the $\Sigma$–D relation place Teleios as a type Ia SNR at a distance of either $\sim$2.2 kpc (near-side) or $\sim$7.7 kpc (far-side). This indicates two possible scenarios, either a young (under 1 000 yr) or a somewhat older SNR (over 10 000 yr). With a corresponding diameter of 14/48 pc, our evolutionary studies place Teleios at the either early or late Sedov phase, depending on the distance/diameter estimate. However, our modelling also predicts X-ray emission, which we do not see in the present generation of eROSITA images. We also explored a type Iax explosion scenario that would point to a much closer distance of $\lt$1 kpc and Teleios size of only $\sim$3.3 pc, which would be similar to the only known type Iax remnant SN1181. Unfortunately, all examined scenarios have their challenges, and no definitive Supernova (SN) origin type can be established at this stage. Remarkably, Teleios has retained its symmetrical shape as it aged even to such a diameter, suggesting expansion into a rarefied and isotropic ambient medium. The low radio surface brightness and the lack of pronounced polarisation can be explained by a high level of ambient rotation measure (RM), with the largest RM being observed at Teleios’s centre.
Firn can store glacial meltwater and delay contribution to sea level rise, but ice layers and ice slabs within the shallow firn layer can impede the downward percolation of melt. Here we report firn conditions along a transect on southwest Devon Ice Cap (DIC), Nunavut, and explore its response to air temperature variability over a decadal period. We present results from two field campaigns, during which six shallow firn cores were extracted along the same transect in spring 2012 and 2022. At all sites, the ice fraction (IF) was less in 2022 than in 2012, and the firn content increased. Between 2012 and 2022, the IF of the firn layer changed by −30% at the lowest elevation site (1400 m a.s.l.) and by −11% at the highest elevation site (1800 m a.s.l.) and by an average of −26% across all sites. Despite higher annual positive degree day sums during 2012–22 compared to 2002–12, cooler summers in 2013, 2018 and 2021 resulted in less ice content in the shallow firn layer. This demonstrates that the shallow firn layer can regenerate from several cooler years and highlights the nuanced response of the DIC shallow firn layer to climate warming.
Ultrasound-guided wire localisation may improve intra-operative identification and outcomes of non-palpable cervical lymphadenopathy in a previously treated neck. We undertook a literature search and present our case series to determine the safety and efficacy of ultrasound-guided wire localisation.
Methods
A search of databases up to 29 April 2024 was performed. At our tertiary centre, ultrasound-guided wire localisation was utilised for 20 patients with cervical lymphadenopathy between February 2021 and April 2024.
Results
Seventeen studies with a combined total of 92 patients were identified, with one complication reported. Within our case series, all 20 patients had accurate lesion localisation using ultrasound-guided wire localisation and none required repeat operations.
Conclusion
Ultrasound-guided wire localisation is a safe and cost-effective technique for lesions in an otherwise difficult area to operate, providing confidence to the multidisciplinary team, particularly where histopathology indicates benignity. Surgical outcomes do not appear worse than outcomes without ultrasound-guided wire localisation. We advocate its use provided appropriate patient selection is considered.
Foliar-applied postemergence applications of glufosinate are often applied to glufosinate-resistant crops to provide nonselective weed control without significant crop injury. Rainfall, air temperature, solar radiation, and relative humidity near the time of application have been reported to affect glufosinate efficacy. However, previous research may have not captured the full range of weather variability to which glufosinate may be exposed before or following application. Additionally, climate models suggest more extreme weather will become the norm, further expanding the weather range to which glufosinate can be exposed. The objective of this research was to quantify the probability of successful weed control (efficacy ≥85%) with glufosinate applied to some key weed species across a broad range of weather conditions. A database of >10,000 North American herbicide evaluation trials was used in this study. The database was filtered to include treatments with a single postemergence application of glufosinate applied to waterhemp [Amaranthus tuberculatus (Moq.) Sauer], morningglory species (Ipomoea spp.), and/or giant foxtail (Setaria faberi Herrm.) <15 cm in height. These species were chosen because they are well represented in the database and listed as common and troublesome weed species in both corn (Zea mays L.) and soybean [Glycine max (L.) Merr.] (Van Wychen 2020, 2022). Individual random forest models were created. Low rainfall (≤20 mm) over the 5 d before glufosinate application was detrimental to the probability of successful control of A. tuberculatus and S. faberi. Lower relative humidity (≤70%) and solar radiation (≤23 MJ m−1 d−1) on the day of application reduced the probability of successful weed control in most cases. Additionally, the probability of successful control decreased for all species when average air temperature over the first 5 d after application was ≤25 C. As climate continues to change and become more variable, the risk of unacceptable control of several common species with glufosinate is likely to increase.
Foliar-applied postemergence herbicides are a critical component of corn (Zea mays L.) and soybean [Glycine max (L.) Merr.] weed management programs in North America. Rainfall and air temperature around the time of application may affect the efficacy of herbicides applied postemergence in corn or soybean production fields. However, previous research utilized a limited number of site-years and may not capture the range of rainfall and air temperatures that these herbicides are exposed to throughout North America. The objective of this research was to model the probability of achieving successful weed control (≥85%) with commonly applied postemergence herbicides across a broad range of environments. A large database of more than 10,000 individual herbicide evaluation field trials conducted throughout North America was used in this study. The database was filtered to include only trials with a single postemergence application of fomesafen, glyphosate, mesotrione, or fomesafen + glyphosate. Waterhemp [Amaranthus tuberculatus (Moq.) Sauer], morningglory species (Ipomoea spp.), and giant foxtail (Setaria faberi Herrm.) were the weeds of focus. Separate random forest models were created for each weed species by herbicide combination. The probability of successful weed control deteriorated when the average air temperature within the first 10 d after application was <19 or >25 C for most of the herbicide by weed species models. Additionally, drier conditions before postemergence herbicide application reduced the probability of successful control for several of the herbicide by weed species models. As air temperatures increase and rainfall becomes more variable, weed control with many of the commonly used postemergence herbicides is likely to become less reliable.
The causes of ill health and death are changing and, as we live longer, new health-preventable problems emerge, bringing new challenges. Improving health (physical, mental or both) and promoting general well-being remain major priorities.
Just as important, the difference in health status between rich and poor continues to grow. At a global level, the picture is even more complex. Although there is some evidence that life expectancy is beginning to plateau in developed countries such as the UK, the biggest potential to improve health still lies in addressing inequality between or within countries.
Therefore, this chapter:
summarizes the models of health improvement that are prevalent today;
introduces a combined conceptual model to describe the factors affecting health in modern times; and
presents some case studies of interventions designed to improve health which offer important insight and learning.
Edited by
Sophie Thomson, World Psychiatric Association,Peter Hughes, Springfield University Hospital, London,Sam Gnanapragasam, South London and Maudsley NHS Foundation Trust
Making diagnoses and understanding the appropriate use of medication in treating mental disorders is just one part of mental health care. The other part is psychosocial treatments. In global volunteering it is important to be skilled in the principles and use of these psychological treatments as well as medication. Some aspects of medication are included here as there is so much interplay of psychosocial and prescribing.
Research on the gut microbiome and mental health among children and adolescents is growing. This umbrella review provides a high-level overview of current evidence syntheses to amalgamate current research and inform future directions. Searches were conducted across seven databases for peer-reviewed pediatric (<18 years) review literature. Studies reporting gut microbiome composition and/or biotic supplementation on depression, bipolar disorder, anxiety, attention deficit hyperactivity disorder, autism spectrum disorder (ASD), or obsessive-compulsive disorder (OCD) were included. Deduplication and screening took place in Covidence. A sensitivity analysis was conducted to assess the degree of primary study overlap. Among the 39 included review studies, 23 (59%) were observational and 16 (41%) were interventional. Most reviews (92%) focused on ASD. Over half (56%) of the observational and interventional reviews scored low or critically low for methodological quality. A higher abundance of Clostridium clusters and a lower abundance of Bifidobacterium were consistently observed in ASD studies. Biotic supplementation was associated with ASD symptom improvement. Gut microbiome-mental health evidence syntheses in child and youth depression, anxiety, bipolar disorder, and OCD are lacking. Preliminary evidence suggests an association between specific microbiota and ASD symptoms, with some evidence supporting a role for probiotic supplementation ASD therapy.
Seismic hazard and risk analyses underpin the loadings prescribed by engineering design codes, the decisions by asset owners to retrofit structures, the pricing of insurance policies, and many other activities. This is a comprehensive overview of the principles and procedures behind seismic hazard and risk analysis. It enables readers to understand best practises and future research directions. Early chapters cover the essential elements and concepts of seismic hazard and risk analysis, while later chapters shift focus to more advanced topics. Each chapter includes worked examples and problem sets for which full solutions are provided online. Appendices provide relevant background in probability and statistics. Computer codes are also available online to help replicate specific calculations and demonstrate the implementation of various methods. This is a valuable reference for upper level students and practitioners in civil engineering, and earth scientists interested in engineering seismology.
Jack Baker, Stanford University, California,Brendon Bradley, University of Canterbury, Christchurch, New Zealand,Peter Stafford, Imperial College of Science, Technology and Medicine, London
Jack Baker, Stanford University, California,Brendon Bradley, University of Canterbury, Christchurch, New Zealand,Peter Stafford, Imperial College of Science, Technology and Medicine, London
Jack Baker, Stanford University, California,Brendon Bradley, University of Canterbury, Christchurch, New Zealand,Peter Stafford, Imperial College of Science, Technology and Medicine, London
Jack Baker, Stanford University, California,Brendon Bradley, University of Canterbury, Christchurch, New Zealand,Peter Stafford, Imperial College of Science, Technology and Medicine, London
Jack Baker, Stanford University, California,Brendon Bradley, University of Canterbury, Christchurch, New Zealand,Peter Stafford, Imperial College of Science, Technology and Medicine, London
Jack Baker, Stanford University, California,Brendon Bradley, University of Canterbury, Christchurch, New Zealand,Peter Stafford, Imperial College of Science, Technology and Medicine, London
Jack Baker, Stanford University, California,Brendon Bradley, University of Canterbury, Christchurch, New Zealand,Peter Stafford, Imperial College of Science, Technology and Medicine, London
Jack Baker, Stanford University, California,Brendon Bradley, University of Canterbury, Christchurch, New Zealand,Peter Stafford, Imperial College of Science, Technology and Medicine, London
Jack Baker, Stanford University, California,Brendon Bradley, University of Canterbury, Christchurch, New Zealand,Peter Stafford, Imperial College of Science, Technology and Medicine, London