We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
We experimentally study optional costly communication in Stag-Hunt games. Prior research demonstrates that efficient coordination is difficult without a communication option but obtains regularly with mandatory costless pre-play messages. We find that even small communication costs dramatically reduce message use when communication is optional, but efficient coordination can occur with similar frequency as under costless communication. These findings can be accounted for by formalizations of forward induction that take Nash equilibrium as a reference point (such as Kohlberg and Mertens in Econometrica 54: 1003–1037, 1986; Govindan and Wilson in Econometrica 77: 1–28, 2009), while formalizations that only appeal to (higher-order) knowledge of rationality remain silent in this environment.
In Germany, the utility model is a type of intellectual property right that provides protection for novel and useful inventions. It is governed by the German Utility Model Act (“Gebrauchsmustergesetz” – GebrMG) which was enacted in 1891, making it the oldest still-existing utility model system in the world. Utility models grant the right holder exclusive control over the use and commercialisation of an invention for a period of ten years from the date of filing, subject to the payment of annual renewal fees. In a way, the utility model is the “little sister” of a full-fledged patent (also called a “petty patent”), protecting the same type of subject matter (technical inventions) with a more limited scope.
Declining labor force participation of older men throughout the 20th century and recent increases in participation have generated substantial interest in understanding the effect of public pensions on retirement. The National Bureau of Economic Research's International Social Security (ISS) Project, a long-term collaboration among researchers in a dozen developed countries, has explored this and related questions. The project employs a harmonized approach to conduct within-country analyses that are combined for meaningful cross-country comparisons. The key lesson is that the choices of policy makers affect the incentive to work at older ages and these incentives have important effects on retirement behavior.
Eustachian tube dysfunction is prevalent in both paediatric and adult populations. Current clinical guidelines recommend observation over topical intranasal corticosteroids for Eustachian tube dysfunction management, which remains controversial. This study aimed to systematically review randomised, controlled trials assessing topical intranasal corticosteroid efficacy in Eustachian tube dysfunction, and analyse effect through tympanometric normalisation.
Methods
PubMed, EMBASE, Web of Science and Cochrane Library databases were searched. All randomised, controlled trials assessing intranasal corticosteroids in adult or paediatric Eustachian tube dysfunction patients were included. A meta-analysis of proportions was used to evaluate tympanogram normalisation.
Results
Of 330 results, eight randomised, controlled trials met inclusion criteria and underwent qualitative data synthesis and risk-of-bias analysis. Meta-analysis of tympanometry data from four eligible trials (n = 512 ears) revealed no significant difference in tympanometric normalisation between intranasal corticosteroids and control (odds ratio 1.21, 95% confidence interval 0.65–2.24).
Conclusion
Study results do not strongly support intranasal corticosteroids for Eustachian tube dysfunction. Data were limited, emphasising the need for larger, higher quality, randomised, controlled trials.
Viruses are the most numerically abundant biological entities on Earth. As ubiquitous replicators of molecular information and agents of community change, viruses have potent effects on the life on Earth, and may play a critical role in human spaceflight, for life-detection missions to other planetary bodies and planetary protection. However, major knowledge gaps constrain our understanding of the Earth's virosphere: (1) the role viruses play in biogeochemical cycles, (2) the origin(s) of viruses and (3) the involvement of viruses in the evolution, distribution and persistence of life. As viruses are the only replicators that span all known types of nucleic acids, an expanded experimental and theoretical toolbox built for Earth's viruses will be pivotal for detecting and understanding life on Earth and beyond. Only by filling in these knowledge and technical gaps we will obtain an inclusive assessment of how to distinguish and detect life on other planetary surfaces. Meanwhile, space exploration requires life-support systems for the needs of humans, plants and their microbial inhabitants. Viral effects on microbes and plants are essential for Earth's biosphere and human health, but virus–host interactions in spaceflight are poorly understood. Viral relationships with their hosts respond to environmental changes in complex ways which are difficult to predict by extrapolating from Earth-based proxies. These relationships should be studied in space to fully understand how spaceflight will modulate viral impacts on human health and life-support systems, including microbiomes. In this review, we address key questions that must be examined to incorporate viruses into Earth system models, life-support systems and life detection. Tackling these questions will benefit our efforts to develop planetary protection protocols and further our understanding of viruses in astrobiology.
Slowing climate change will almost certainly require a reduction in greenhouse gas emissions, but agreement on who should reduce emissions by how much is difficult, in part because of the self-serving bias—the tendency to believe that what is beneficial to oneself is also fair. Conducting surveys among college students in the United States and China, we show that each of these groups displays a nationalistic self-serving bias in judgments of a fair distribution of economic burdens resulting from mitigation. Yet, we also show, by disguising the problem and the identity of the parties, that it is possible to elicit perceptions of fairness that are not influenced by national interests. Our research reveals that the self-serving bias plays a major role in the difficulty of obtaining agreement on how to implement emissions reductions. That is, the disagreement over what constitutes fair climate policy does not appear to be due to cross-national differences in what constitutes a fair distribution of burdens. Interventions to mitigate the self-serving bias may facilitate agreement.
Despite the availability of more than 20 antiseizure drugs (ASDs) for the treatment of epilepsy, up to 30% of patients continue to experience disabling seizures and are classified as having medically refractory epilepsy (MRE).1 Some patients with MRE are candidates for resective surgery or other palliative interventions, such as disconnection therapies (callosotomy or subpial transections).2 Unfortunately, the majority of refractory patients are not candidates for these surgical options due to having multifocal epileptogenic foci, foci localized to an eloquent brain area or because the focus cannot be adequately localized.3,4 For some of these patients, stimulation therapy (also known as neuromodulation) is an alternative palliative treatment option. This chapter will review the different neuromodulation modalities that are available as adjunctive treatment of MRE. The impact of neuromodulation on sudden unexplained death in epilepsy (SUDEP) will be explored in the final section.
Surgical site infections (SSIs) are common surgical complications that lead to increased costs. Depending on payer type, however, they do not necessarily translate into deficits for every hospital.
Objective:
We investigated how surgical site infections (SSIs) influence the contribution margin in 2 reimbursement systems based on diagnosis-related groups (DRGs).
Methods:
This preplanned observational health cost analysis was nested within a Swiss multicenter randomized controlled trial on the timing of preoperative antibiotic prophylaxis in general surgery between February 2013 and August 2015. A simulation of cost and income in the National Health Service (NHS) England reimbursement system was conducted.
Results:
Of 5,175 patients initially enrolled, 4,556 had complete cost and income data as well as SSI status available for analysis. SSI occurred in 228 of 4,556 of patients (5%). Patients with SSIs were older, more often male, had higher BMIs, compulsory insurance, longer operations, and more frequent ICU admissions. SSIs led to higher hospital cost and income. The median contribution margin was negative in cases of SSI. In SSI cases, median contribution margin was Swiss francs (CHF) −2045 (IQR, −12,800 to 4,848) versus CHF 895 (IQR, −2,190 to 4,158) in non-SSI cases. Higher ASA class and private insurance were associated with higher contribution margins in SSI cases, and ICU admission led to greater deficits. Private insurance had a strong increasing effect on contribution margin at the 10th, 50th (median), and 90th percentiles of its distribution, leading to overall positive contribution margins for SSIs in Switzerland. The NHS England simulation with 3,893 patients revealed similar but less pronounced effects of SSI on contribution margin.
Conclusions:
Depending on payer type, reimbursement systems with DRGs offer only minor financial incentives to the prevention of SSI.
In interwar Germany, internationalism and nationalism coexisted in a public sphere that often transcended national borders. This seeming contradiction helps explain the mindset of an era, which simultaneously recognized interconnectedness while privileging national identity. Historians’ interest in internationalism has primarily focused on liberal and cooperative actors and on some selected examples demonstrating the dark sides of internationalism. Fewer historians, however, have analyzed the ambiguities and contradictions of liberal internationalism and the perseverance of the national as a frame of reference in internationalist discourses. Ernst Jäckh, best known as the founder of the Deutsche Hochschule für Politik, perhaps best represented this collision of values while simultaneously being one of the biggest proponents of such a view. Jäckh's internationalism permeated all his endeavors and served the goal of reintegrating Germany in the international community.
Environmental scientists and managers increasingly recognize that socio-cultural evaluations expand the understanding of human–nature relationships. Here, user groups’ perceptions of the benefits from and threats to nature were analysed in Tierra del Fuego National Park, Argentina. We hypothesized that the different relationships of users to this place would lead to significantly different valuations among local Ushuaia residents (n = 122), Argentine nationals (n = 147) and international tourists (n = 294). All users perceived a broad spectrum of benefits. The three groups assessed intrinsic and relational values more highly than instrumental benefits, and significant differences included a higher mean valuation of benefits by Argentine visitors. Overall, threats were less perceived than benefits, and significant differences included a higher mean threat assessment by Ushuaia residents. To explain these relationships, we found that mean valuations of benefits and threats were weakly related to increased biodiversity knowledge for residents and international tourists, but not for Argentine visitors. These findings can orient environmental management in Patagonia and elsewhere by identifying areas where information can improve user experiences and by contributing a more pluralistic understanding of nature from multiple stakeholders.
Max Weber (1864–1920), generally known as a founder of modern social science, was concerned with political affairs throughout his life. The texts in this edition span his career and include his early inaugural lecture The Nation State and Economic Policy, Suffrage and Democracy in Germany, Parliament and Government in Germany under a New Political Order, Socialism, The Profession and Vocation of Politics, and an excerpt from his essay The Situation of Constitutional Democracy in Russia, as well as other shorter writings. Together they illustrate the development of his thinking on the fate of Germany and the nature of politics in the modern western state in an age of cultural 'disenchantment'. The introduction discusses the central themes of Weber's political thought, and a chronology, notes and an annotated bibliography place him in his political and intellectual context.
We agree with Lake and colleagues on their list of “key ingredients” for building human-like intelligence, including the idea that model-based reasoning is essential. However, we favor an approach that centers on one additional ingredient: autonomy. In particular, we aim toward agents that can both build and exploit their own internal models, with minimal human hand engineering. We believe an approach centered on autonomous learning has the greatest chance of success as we scale toward real-world complexity, tackling domains for which ready-made formal models are not available. Here, we survey several important examples of the progress that has been made toward building autonomous agents with human-like abilities, and highlight some outstanding challenges.
Alachlor [2-chloro-2′,6′-diethyl-N-(methoxymethyl) acetanilide], acetochlor [2-chloro-N-(ethoxymethyl)-6′-ethyl-o-acetotoluidide] and metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide] were adsorbed in similar amounts, approximately one-third that of the reference compound prometryn [2,4-bis(isopropylamino)-6-(methylthio)-s-triazine] by Ca-organic matter and seven soils. Adsorption isotherms for the four herbicides by Ca-montmorillonite were of the same shape, but different bonding mechanisms were involved. Adsorption and bioactivity of the acetanilide herbicides were correlated with organic matter, clay content, and other soil parameters as determined by two different soil- testing laboratories.
The effect of various soil parameters on metribuzin [4-amino-6-(1,1-dimethylethyl)-3-(methylthio)-1,2,4-triazin-5(4H)-one] efficacy was studied on seven soils and metribuzin adsorption was investigated in nine soils. Soil organic-matter and clay contents were correlated with metribuzin activity. Specific surface area, as measured by ethylene glycol monoethyl ether (EGME) was highly correlated with metribuzin activity. Soil organic-matter content and EGME surface area measurements were also highly correlated with metribuzin adsorption in soils. Since metribuzin is highly water soluble (water solubility greater than 1000 ppm), it was probably adsorbed at the hydrophilic sites on the soil surfaces that were measured by EGME. Metribuzin was much more mobile than atrazine [6-chloro-N-ethyl-N′-(1-methylethyl)-1,3,5-triazine-2,4-diamine] in a leaching study.
Alachlor [2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide] and metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide] adsorption was positively correlated with soil organic-matter content, clay content, and surface area as measured by ethylene glycol monoethyl ether (EGME) or benzyl ethyl ether (BEE) and inversely correlated with herbicidal activity. Alachlor was adsorbed in slightly greater amounts by soil than metolachlor. Metolachlor had slightly greater bioactivity than alachlor on grass weeds, but the herbicides had similar activity on broadleaf weeds. Slightly greater amounts of metolachlor than alachlor were leached through a Norfolk soil and slightly greater amounts of alachlor were retained in the upper soil zones, compared with metolachlor.
Significantly higher rates of butralin [4-(1,1-dimethylethyl)-N-(1-methylpropyl)-2,6-dinitrobenzenamine] were required to produce the same level of weed control as trifluralin [2,6-dinitro -N,N-dipropyl-4-(trifluoromethyl) benzenamine] when applied to soybeans [Glycine max (L.) Merr.] on seven different soils in the field. Higher rates of butralin were also required to control barnyardgrass [Echinochloa crus-galli (L.) Beauv. ♯ ECHCG] in growth chamber studies. No differences in the extent of soil adsorption of trifluralin and butralin were apparent; therefore, differences in efficacy could not be attributed to differences in soil adsorption. Herbicide rates required for 80% weed control and Freundlich K-values (adsorption capacity indices) were mostly highly correlated with soil organic-matter content and soil surface area as measured by benzyl ethyl ether (BEE) and ethylene glycol monoethyl ether (EGME) on nine soils. Analysis of the organic-matter content of the nine soils by 10 soil testing laboratories resulted in highly significant differences among laboratories.
By
Roberto Barcellan, Eurostat, Luxembourg,
Peter Bøegh Nielsen, Statistics Denmark, Copenhagen, Denmark,
Caterina Calsamiglia, CEMFI, Madrid, Spain,
Colin Camerer, California Institute of Technology, Pasadena, CA, USA,
Estelle Cantillon, Université Libre de Bruxelles, Brussels, Belgium,
Bruno Crépon, CREST and JPAL, Paris, France,
Bram De Rock, Université Libre de Bruxelles, ECARES, Brussels, Belgium,
László Halpern, Hungarian Academy of Science, Budapest Hungary,
Arie Kapteyn, University of Southern California, Los Angeles, CA, USA,
Asim I. Khwaja, Harvard Kennedy School of Government, Cambridge, MA,
Georg Kirchsteiger, Université Libre de Bruxelles,
Vigdis Kvalheim, Norway Social Science Data Service, Bergen, Norway,
Julia Lane, New York University, New York, USA,
Markus Mobius, Microsoft Research, Cambridge, MA, USA,
Luke Sibieta, Institute for Fiscal Studies, London, UK,
Joseph Tracy, Federal Reserve Bank of New York, New York, USA,
Frederic Udina, Idescat, Barcelona, Spain,
Gugliemo Weber, University of Padua, Padua, Italy,
Lisa Wright, Bureau Van Dijk, Manchester, UK
There has been a steep increase in empirical research in economics in the past 20–30 years. This chapter brings together several actors and stakeholders in these developments to discuss their drivers and implications. All types of data are considered: official data, data collected by researchers, lab experiments, randomized control trials, and proprietary data from private and public sources. When relevant, emphasis is placed on developments specific to Europe. The basic message of the chapter is that there is no single type of data that is superior to all others. We need to promote diversity of data sources for economic research and ensure that researchers are equipped to take advantage of them. All stakeholders – researchers, research institutions, funders, statistical agencies, central banks, journals, data firms, and policy-makers – have a role to play in this.
Introduction
The past 20–30 years have witnessed a steady rise in empirical research in economics. In fact, a majority of articles published by leading journals these days are empirical, in stark contrast with the situation 40 or 50 years ago (Hamermesh, 2013). This change in the distribution of methodologies used in economic research was made possible by improved computing power but, more importantly, thanks to an increase in the quantity, quality and variety of data used in economics.
This chapter brings together several actors and stakeholders in these changes to discuss their drivers and implications. All types of data are considered. When relevant, emphasis is placed on developments specific to Europe. Sections 13.2 and 13.3 deal with official microdata. Section 13.2 focuses on the level of access to microdata in Europe and its determinants. Section 13.3 focuses on cross-country data harmonization. Section 13.4 then switches gears entirely and discusses the benefits and costs of large-scale data collection efforts led by researchers, instead of statistical offices. Section 13.5 discusses data produced by researchers, either in the context of lab experiments or in the context of randomized control trials. Both types of data have led to major advances; for the first one in our understanding of human behaviour and the robustness of economic institutions; for the second in our understanding of the impact of policies and themechanisms underlying them.