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Outlining the economic significance of the role of global supply chains (GSCs) in the organisation of the global economy, this paper initially presents some indications of health and safety outcomes in low- and middle-income counties (LMICs) where GSCs source much of the production destined for use in advanced economies. It goes on to discuss the operational dynamics of these chains and the corporate priorities that they reflect, which, it argues, do little to improve the poor work health and safety (WHS) outcomes in LMICs. It then examines evidence for the effectiveness of various private and public regulatory strategies that are claimed to bring about improved health and safety practices and outcomes among GSC suppliers in these countries. The paper critically evaluates this evidence and argues that, while there may be some examples of effective strategies and regulatory practices in particular contexts, their overall influence remains limited. It identifies and discusses the principal reasons for these limitations and concludes that the global regulation of conditions of labour – including WHS – at the end of GSCs falls well short of universal best practice and is, more generally, insufficient to counter the economic forces working against the maintenance of adequate standards of worker protection.
Early studies of common mental disorders (CMDs) during the COVID-19 pandemic mainly report increases; however, more recent findings have been mixed. Also, studies assessing the effects of restriction measures on CMDs show varied results. The aim of this meta-analysis was to assess changes in levels of CMDs from pre-/early to during the pandemic and the effects of restriction policies in the European population.
Methods
We searched for studies assessing both pre-pandemic and peri-pandemic self-reported emotional distress and symptoms of depression or anxiety among nationally/regionally representative samples in Europe and collected microdata from those studies. Estimates of corona containment index were related to changes in CMDs using random-effects meta-regression.
Results
Our search strategy resulted in findings from 15 datasets drawn from 8 European countries being included in the meta-analysis. There was no evidence of change in the prevalence of emotional distress, anxiety, or depression from before to during the pandemic; but from early pandemic periods to later periods, there were significant decreases in emotional distress and anxiety. Increased school restrictions and social distancing were associated with small increases in self-reported emotional distress.
Conclusions
Despite initial concerns of increased emotional distress and mental illness due to the COVID-19 pandemic, the results from this meta-analysis indicate that there was a decrease in emotional distress and no change in anxiety or depression in the general population in Europe. Overall, our findings support the importance of strong governance when implementing periodic and robust restriction measures to combat the spread of COVID-19.
Previous studies using resting-state functional neuroimaging have revealed alterations in whole-brain images, connectome-wide functional connectivity and graph-based metrics in groups of patients with schizophrenia relative to groups of healthy controls. However, it is unclear which of these measures best captures the neural correlates of this disorder at the level of the individual patient.
Methods
Here we investigated the relative diagnostic value of these measures. A total of 295 patients with schizophrenia and 452 healthy controls were investigated using resting-state functional Magnetic Resonance Imaging at five research centres. Connectome-wide functional networks were constructed by thresholding correlation matrices of 90 brain regions, and their topological properties were analyzed using graph theory-based methods. Single-subject classification was performed using three machine learning (ML) approaches associated with varying degrees of complexity and abstraction, namely logistic regression, support vector machine and deep learning technology.
Results
Connectome-wide functional connectivity allowed single-subject classification of patients and controls with higher accuracy (average: 81%) than both whole-brain images (average: 53%) and graph-based metrics (average: 69%). Classification based on connectome-wide functional connectivity was driven by a distributed bilateral network including the thalamus and temporal regions.
Conclusion
These results were replicated across the three employed ML approaches. Connectome-wide functional connectivity permits differentiation of patients with schizophrenia from healthy controls at single-subject level with greater accuracy; this pattern of results is consistent with the ‘dysconnectivity hypothesis’ of schizophrenia, which states that the neural basis of the disorder is best understood in terms of system-level functional connectivity alterations.
The 1997 Russian law on religion recognizes Orthodoxy, Islam, Judaism, and Buddhism as the “traditional religions” of Russia. These religions see themselves as having an important role to play in achieving social stability, and particularly in overcoming religious “extremism” and the perceived threat it poses to society. “Traditional'” religions stand shoulder to shoulder, explaining that the values they champion tend towards the creation and preservation of peace and reconciliation in society, and that, moreover, these are shared values, common to all “traditional'‘ religions. Indeed, the primary criterion for identifying a “traditional'” religion in Russia today may be that it is “noncompetitive” with other religions. The Moscow Patriarchate rejects the idea, for example, that Orthodox Christians should proselytize among Muslims. The fact that each religion sees itself as having possession of the “truth” does not endanger the cooperation, harmony and mutual respect among the traditional religions in Russia at the level of official and institutional interaction. Regarding the controversy over the school textbook, Foundations of Orthodox Culture, which human rights activists accused of constituting pro-Orthodox propaganda, an Orthodox priest and a Muslim chief mufti filed a joint claim against those who initiated the case, and a Protestant leader came out in support of the use of the textbook in the public schools.
A total of eight foxhound packs in England and Wales were screened for Echinococcus species using a genus-specific coproantigen ELISA and for Echinococcus granulosus sensu lato and Echinococcus equinus by coproPCR. Main screening (n = 364 hounds) occurred during 2010–2011 wherein a quarter (25.6%) of the foxhound fecal samples tested were Echinococcus coproantigen-positive (93/364). In total, five of eight (62.5%) hunts screened had coproantigen-positive hounds; coproantigen prevalence for individual foxhound packs ranged from 0 to 61.2% and was shown to be >30% in three hunts (in counties of Powys, Wales and Northumberland, England). Foxhound fecal samples from six of the eight tested hunts (four Welsh and two English hunts) were positive by coproPCR for E. granulosus s.l (including one sequence confirmation of E. granulosus sensu stricto) and E. equinus DNA. Analysis of hunt questionnaire data suggested that there was an association between poor foxhound husbandry, especially feeding practices and Echinococcus coproantigen prevalence. Clearer guidelines regarding the risk of canine echinococcosis are required for safe management of foxhound hunts in England and Wales.
Conodonts were mostly small, elongate, eel-shaped marine animals that inhabited a variety of environments in Paleozoic and Triassic seas. Although long enigmatic, conodonts are now regarded as vertebrates and their closely controlled fossil record is not only the most extensive of all vertebrates, but it also makes conodonts the fossils of choice in upper Cambrian through Triassic biostratigraphy. Conodonts were soft-bodied except for a variety of phosphatic elements that formed a distinctive feeding apparatus. Post-mortal dissociation of the apparatus and subsequent jumbling of its elements on the sea floor led, from 1856 to about 1966, to development of an artificial, form-based taxonomy that was utilitarian, but clearly unsatisfactory as a vehicle for understanding the group in biologic terms. Natural assemblages of elements, discovered between 1879 and 1952, have been interpreted as undisturbed skeletal apparatuses, and in the mid-1960s it was determined that original composition of the apparatuses of many species could be reconstructed and statistically evaluated from collections of disjunct elements by various grouping procedures. These determinations led to an emphasis on multielement taxonomy by most (but not all) students of conodonts. Even so, only about a third of the approximately 550 valid conodont genera, have been established (or re-interpreted) in multielement terms and this makes any of the several extant schemes of suprageneric classification phylogenetically suspect. We comment on a recent scheme that recognizes 41 families assigned to some 7 orders, and suggest how it might be modified so as to square with principles of phylogenetic systematics.
Mass losses originating from supraglacial ice cliffs at the lower tongues of debris-covered glaciers are a potentially large component of the mass balance, but have rarely been quantified. In this study, we develop a method to estimate ice cliff volume losses based on high-resolution topographic data derived from terrestrial and aerial photogrammetry. We apply our method to six cliffs monitored in May and October 2013 and 2014 using four different topographic datasets collected over the debris-covered Lirung Glacier of the Nepalese Himalayas. During the monsoon, the cliff mean backwasting rate was relatively consistent in 2013 (3.8 ± 0.3 cm w.e. d−1) and more heterogeneous among cliffs in 2014 (3.1 ± 0.7 cm w.e. d−1), and the geometric variations between cliffs are larger. Their mean backwasting rate is significantly lower in winter (October 2013–May 2014), at 1.0 ± 0.3 cm w.e. d−1. These results are consistent with estimates of cliff ablation from an energy-balance model developed in a previous study. The ice cliffs lose mass at rates six times higher than estimates of glacier-wide melt under debris, which seems to confirm that ice cliffs provide a large contribution to total glacier melt.
Debris-covered glaciers play an important role in the high-altitude water cycle in the Himalaya, yet their dynamics are poorly understood, partly because of the difficult fieldwork conditions. In this study we therefore deploy an unmanned aerial vehicle (UAV) three times (May 2013, October 2013 and May 2014) over the debris-covered Lirung Glacier in Nepal. The acquired data are processed into orthomosaics and elevation models by a Structure from Motion workflow, and seasonal surface velocity is derived using frequency cross-correlation. In order to obtain optimal surface velocity products, the effects of different input data and correlator configurations are evaluated, which reveals that the orthomosaic as input paired with moderate correlator settings provides the best results. The glacier has considerable spatial and seasonal differences in surface velocity, with maximum summer and winter velocities 6 and 2.5 m a-1, respectively, in the upper part of the tongue, while the lower part is nearly stagnant. It is hypothesized that the higher velocities during summer are caused by basal sliding due to increased lubrication of the bed. We conclude that UAVs have great potential to quantify seasonal and annual variations in flow and can help to further our understanding of debris-covered glaciers.
Turtles have served as a model system for molecular divergence dating studies using fossil calibrations. However, because some parts of the fossil record of turtles are very well known, divergence age estimates from molecular phylogenies often do not differ greatly from those observed directly from the fossil record alone. Also, the phylogenetic position and age of turtle fossil calibrations used in previous studies have not been adequately justified. We provide the first explicitly justified minimum and soft maximum age constraints on 22 clades of turtles following best practice protocols. Using these data we undertook a Bayesian relaxed molecular clock analysis establishing a timescale for the evolution of crown Testudines that we exploit in attempting to address evolutionary questions that cannot be resolved with fossils alone. Some of these questions, such as whether the turtle crown originated in the Triassic or Jurassic, cannot be resolved by our analysis. However, our results generate novel age-of-origination estimates for clades within crown Testudines. Finally, we compare our fossil calibrations and posterior age estimates to those from other studies, revealing substantial differences in results and interpretation.
In this paper, a novel set of macros with line/space width from 128nm/128nm, 64nm/64nm to 32nm/32nm was designed and installed on 20nm technology-node hardware. The pitch-dependent pad erosion post Cu CMP was studied by atomic-force microscopy (AFM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) quantitatively on these macros. Two methods were investigated to reduce the difference between pitch- and density-induced CMP non-uniformity. The first is using new scheme of partial Cu plating process followed by SiCNH insulator deposition and then CMP. The second is through the selection of slurries and pads. Both results are discussed in this paper.
This is a two-year elementary college physics course for students majoring in science and engineering. The intention of the writers has been to present elementary physics as far as possible in the way in which it is used by physicists working on the forefront of their field. We have sought to make a course which would vigorously emphasize the foundations of physics. Our specific objectives were to introduce coherently into an elementary curriculum the ideas of special relativity, of quantum physics, and of statistical physics.
This course is intended for any student who has had a physics course in high school. A mathematics course including the calculus should be taken at the same time as this course.
There are several new college physics courses under development in the United States at this time. The idea of making a new course has come to many physicists, affected by the needs both of the advancement of science and engineering and of the increasing emphasis on science in elementary schools and in high schools. Our own course was conceived in a conversation between Philip Morrison of Cornell University and C. Kittel late in 1961. We were encouraged by John Mays and his colleagues of the National Science Foundation and by Walter C. Michels, then the Chairman of the Commission on College Physics. An informal committee was formed to guide the course through the initial stages.
Supercooling ability is a critical component among the suite of adaptations contributing to subzero temperature-tolerance of insects, whether they follow freeze-tolerance or freeze-avoidance strategies. Supercooling points (SCP, nucleation temperature, or crystallization temperature) of insects and other terrestrial arthropods range tremendously, from −2 °C to −100 °C or lower. Supercooling is affected by a number of factors, including the volume and water content of the organism, and the ability of the body surface to prevent inoculative freezing by external ice. However, the topics of this review, ice nucleators and antifreeze proteins, are often of critical importance. Antifreezes can be both small-molecular-mass solutes, such as polyhydroxyl alcohols that depress the freezing point of water on a strictly colligative basis, and high-molecular-mass molecules such as antifreeze proteins that suppress freezing by a non-colligative mechanism. Freeze-tolerant species often exhibit high SCPs (above −10 °C) and have selected for extracellular ice nucleators, while freeze-avoiding insects generally have selected against ice nucleators and for antifreezes, allowing them to supercool below ambient temperatures to which they are exposed over the winter. This review will attempt to provide a broad update on ice nucleators, antifreeze proteins and related adaptations in insects and other arthropods, primarily from the standpoint of how they function in organisms to promote winter survival.
Protein ice nucleators
Ice nucleators (INs) limit supercooling by organizing water into an ice-like structure, the embryo crystal, that promotes freezing at a temperature higher than that where ice would otherwise form (Knight, 1967).