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Depression is highly prevalent in haemodialysis patients, and diet might play an important role. Therefore, we conducted this cross-sectional study to determine the association between dietary fatty acids (FA) consumption and the prevalence of depression in maintenance haemodialysis (MHD) patients. Dietary intake was assessed using a validated FFQ between December 2021 and January 2022. The daily intake of dietary FA was categorised into three groups, and the lowest tertile was used as the reference category. Depression was assessed using the Patient Health Questionnaire-9. Logistic regression and restricted cubic spline (RCS) models were applied to assess the relationship between dietary FA intake and the prevalence of depression. As a result, after adjustment for potential confounders, a higher intake of total FA [odds ratio (OR)T3 vs. T1 = 1·59, 95 % confidence interval (CI) = 1·04, 2·46] and saturated fatty acids (SFA) (ORT3 vs. T1 = 1·83, 95 % CI = 1·19, 2·84) was associated with a higher prevalence of depressive symptoms. Significant positive linear trends were also observed (P < 0·05) except for SFA intake. Similarly, the prevalence of depression in MHD patients increased by 20% (OR = 1.20, 95% CI = 1.01–1.43) for each standard deviation increment in SFA intake. RCS analysis indicated an inverse U-shaped correlation between SFA and depression (Pnonlinear > 0·05). Additionally, the sensitivity analysis produced similar results. Furthermore, no statistically significant association was observed in the subgroup analysis with significant interaction. In conclusion, higher total dietary FA and SFA were positively associated with depressive symptoms among MHD patients. These findings inform future research exploring potential mechanism underlying the association between dietary FA and depressive symptoms in MHD patients.
Although numerous neuroimaging studies have depicted neural alterations in individuals with obsessive–compulsive disorder (OCD), a psychiatric disorder characterized by intrusive cognitions and repetitive behaviors, the molecular mechanisms connecting brain structural changes and gene expression remain poorly understood.
Methods
This study combined the Allen Human Brain Atlas dataset with neuroimaging data from the Meta-Analysis (ENIGMA) consortium and independent cohorts. Later, partial least squares regression and enrichment analysis were performed to probe the correlation between transcription and cortical thickness variation among adults with OCD.
Results
The cortical map of case-control differences in cortical thickness was spatially correlated with cortical expression of a weighted combination of genes enriched for neurobiologically relevant ontology terms preferentially expressed across different cell types and cortical layers. These genes were specifically expressed in brain tissue, spanning all cortical developmental stages. Protein–protein interaction analysis revealed that these genes coded a network of proteins encompassing various highly interactive hubs.
Conclusions
The study findings bridge the gap between neural structure and transcriptome data in OCD, fostering an integrative understanding of the potential biological mechanisms.
To overcome Yb lasing, a kilowatt-level 1535 nm fiber laser is utilized to in-band pump an Er:Yb co-doped fiber (EYDF) amplifier. The output power of a 301 W narrow-linewidth EYDF amplifier operating at 1585 nm, with 3 dB bandwidth of 150 pm and ${M}^2$< 1.4, is experimentally demonstrated. To the best of our knowledge, it is the highest output power achieved in L-band narrow-linewidth fiber amplifiers with good beam quality. Theoretically, a new ion transition behavior among energy levels for in-band pumping EYDF is uncovered, and a spatial-mode-resolved nonlinearity-assisted theoretical model is developed to understand its internal dynamics. Numerical simulations reveal that the reduction in slope efficiency is significantly related to excited-state absorption (ESA). ESA has a nonlinear hindering effect on power scaling. It can drastically lower the pump absorption and slope efficiency with increasing pump power for in-band pumped EYDF amplifiers. Meanwhile, optimized approaches are proposed to improve its power to the kilowatt level via in-band pumping.
A comprehensive direct numerical simulation of electroconvection (EC) turbulence caused by strong unipolar charge injection in a two-dimensional cavity is performed. The EC turbulence has strong fluctuations and intermittency in the closed cavity. Several dominant large-scale structures are found, including two vertical main rolls and a single primary roll. The flow mode significantly influences the charge transport efficiency. A nearly $Ne \sim T^{1/2}$ scaling stage is observed, and the optimal $Ne$ increment is related to the mode with two vertical rolls, while the single roll mode decreases the charge transport efficiency. As the flow strength increases, EC turbulence transitions from an electric force-dominated mode to an inertia-dominated mode. The former utilizes the Coulomb force more effectively and allocates more energy to convection. The vertical mean profiles of charge, electric field and energy budget provide intuitive information on the spatial energy distribution. With the aid of the energy-box technique, a detailed energy transport evolution is illustrated with changing electric Rayleigh numbers. This exploration of EC turbulence can help explain more complicated electrokinetic turbulence mechanisms and the successful utilization of Fourier mode decomposition and energy-box techniques is expected to benefit future EC studies.
The construction of organic-inorganic hybrid ferroelectric materials with larger, high-polarity guest molecules intercalated in kaolinite (K) faces difficulties in terms of synthesis and uncertainty of structure-property relationships. The purpose of the present study was to optimize the synthesis method and to determine the mechanism of ferroelectric behavior of kaolinite intercalated with p-aminobenzamide (PABA), with an eye to improving the design of intercalation methods and better utilization of clay-based ferroelectric materials. The K-PABA intercalation compound (chemical formula Al2Si2O5(OH)4∙(PABA)0.7) was synthesized in an autoclave and then characterized using X-ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). The experimental results showed that PABA expanded the kaolinite interlayer from 7.2 Å to 14.5 Å, and the orientation of the PABA molecule was ~70° from the plane of the kaolinite layers. The amino group of the PABA molecule was close to the Si sheet. The presence of intermolecular hydrogen bonds between kaolinite and PABA and among PABA molecules caused macro polarization of K-PABA and dipole inversion under the external electric field, resulting in K-PABA ferroelectricity. Simulation calculations using the Cambridge Sequential Total Energy Package (CASTEP) and the ferroelectricity test revealed the optimized intercalation model and possible ferroelectric mechanism.
In spite of many studies of laterite origins in various parts of the world, the origin of laterite in the middle to lower reaches of the Yangtze River is still a topic of debate, thus leaving doubts about the prevailing environmental and climatic conditions at the time. The purpose of this study was to provide greater understanding of this subject by examining in more detail the associated mineralogical evolution, i.e. clay mineral composition, structural characteristics of clays in various beds with different degrees of weathering along the laterite profile, and the alteration mechanisms during the pedogenic process in tropical to semitropical climate conditions. High-resolution transmission electron microscopy (HTEM), X-ray diffraction, and wavelength dispersive X-ray fluorescence spectrometry were used to characterize the samples in order to link clay mineralogy in various beds with different degrees of weathering along the laterite profile to the formation and origin of laterites in the region. The laterite profile displayed a distinct layered structure and was divided into a saprolite (B4), a light colored net-like clay bed (B3), a brown-red gravelly clay bed (B2), and a dark-brown topsoil (B1), respectively, from bottom to top. The clay mineral assemblage of beds B1 and B2 was illite, kaolinite, and chlorite, while that of beds B3 and B4 was mainly kaolinite with minor illite. The bimodal particle-size distribution of clay minerals in the laterite profile indicated that fine-grained particles could have been produced by partial dissolution and decomposition of coarse-grained ones. Examination by HRTEM revealed that fine-grained particles usually occurred as X-ray amorphous materials in the upper soil beds, but with euhedral morphology in the lower portions, suggesting that the fine-grained particles in the lower soil beds might be partially neoformed during the weathering process. Amorphous spots occurred frequently in kaolinite crystals in the upper soil beds, while the structure of kaolinite was well preserved, with a well defined lattice-fringe image. The illite crystallinity index exhibited a trend of downward decrease, while the values of the chemical index of alteration (CIA = Al2O3/(Al2O3+ CaO+ K2O+ Na2O) × 100%) of the soil profile showed a trend of downward increase. Samples of the upper soil beds, B1 and B2, had comparable SiO2/Al2O3 ratios of 5.37–6.22, while those of the lower beds, B3 and B4, had significantly smaller SiO2/Al2O3 ratios of 1.92–3.98, suggesting that the latter had a greater degree of weathering than the former, in reasonable agreement with the results of the illite crystallinity and CIA index. In addition, samples from B1 and B2 had similar TiO2/Al2O3 ratios of 0.042–0.053, while those from B3 and B4 had comparable TiO2/Al2O3 ratios of 0.021–0.033, comparable to the value 0.020 of the bedrock, and were notably smaller than the upper soil beds, indicating that materials of the upper soil beds, B1 and B2, had a different origin from the lower soil beds. The upper bed was probably derived from eolian accumulation due to intensification of the winter monsoon and aridity in central Asia and was modified by intense chemical weathering since the late Pleistocene, while the lower bed originated from an in situ weathering of the underlying argillaceous limestone.
As optical parametric chirped pulse amplification has been widely adopted for the generation of extreme intensity laser sources, nonlinear crystals of large aperture are demanded for high-energy amplifiers. Yttrium calcium oxyborate (YCa4O(BO3)3, YCOB) is capable of being grown with apertures exceeding 100 mm, which makes it possible for application in systems of petawatt scale. In this paper, we experimentally demonstrated for the first time to our knowledge, an ultra-broadband non-collinear optical parametric amplifier with YCOB for petawatt-scale compressed pulse generation at 800 nm. Based on the SG-II 5 PW facility, amplified signal energy of approximately 40 J was achieved and pump-to-signal conversion efficiency was up to 42.3%. A gain bandwidth of 87 nm was realized and supported a compressed pulse duration of 22.3 fs. The near-field and wavefront aberration represented excellent characteristics, which were comparable with those achieved in lithium triborate-based amplifiers. These results verified the great potential for YCOB utilization in the future.
To investigate the association between folate levels and the risk of gestational diabetes mellitus (GDM) risk during the whole pregnancy.
Design:
In this retrospective cohort study of pregnant women, serum folate levels were measured before 24 gestational weeks (GW). GDM was diagnosed between 24th and 28th GW based on the criteria of the International Association of Diabetes and Pregnancy Study Groups. General linear models were performed to examine the association of serum folate with plasma glucose (i.e. linear regressions) and risk of GDM (i.e. log-binomial regressions) after controlling for confounders. Restricted cubic spline regression was conducted to test the dosage–response relationship between serum folate and the risk of GDM.
Setting:
A sigle, urban hospital in Shanghai, China.
Participants:
A total of 42 478 women who received antenatal care from April 2013 to March 2017 were included.
Results:
Consistent positive associations were observed between serum folate and plasma glucose levels (fasting, 1-h, 2-h). The adjusted relative risks (RR) and 95 % CI of GDM across serum folate quartiles were 1·00 (reference), 1·15 (95 % CI (1·04, 1·26)), 1·40 (95 % CI (1·27, 1·54)) and 1·54 (95 % CI (1·40, 1·69)), respectively (P-for-trend < 0·001). The positive association between serum folate and GDM remained when stratified by vitamin B12 (adequate v. deficient groups) and the GW of serum folate measurement (≤13 GW v. >13 GWs)
Conclusions:
The findings of this study may provide important evidence for the public health and clinical guidelines of pregnancy folate supplementation in terms of GDM prevention.
While the construct of moqi (默契, pronounced ‘mò-chee’) is ubiquitously understood and finds itself in everyday conversations around the home and workplace in China, the theoretical development of moqi has been scarce. In this article, we expand on prior work on moqi and conceptualize moqi as a dyadic level construct that describes a situated state of shared contextualized understanding without saying a word between two counterparties. We further articulate a broader view of moqi as a dyadic communication construct that is both target-specific and situation-specific. We propose a nomological network of moqi that shows how shared contextualized understandings between counterparties are informed by several different layers, including ‘capability’ (a) a generalized proclivity to be able to form such understandings with others, and ‘contributing factors’, (b) how those understandings are formed either (i) through interactions or (ii) without them through overlaps in background characteristics or experiences, and (c) how other factors accentuate the capability and inclination to ultimately achieve moqi. We then discuss several potential consequences of moqi in organizational settings. Finally, we discuss why moqi is a powerful form of effective communication that is meaningful beyond the Chinese cultural context.
Nicotine 2,6-dihydroxybenzoate is a nicotine salt that can be used as the nicotine source in tobacco products. X-ray powder diffraction data, unit-cell parameters, and space group for nicotine 2,6-dihydroxybenzoate, C10H15N2⋅C7H5O4, are reported [a = 7.726(8) Å, b = 11.724(3) Å, c = 9.437(1) Å, α = 90°, β = 109.081(3)°, γ = 90°, unit-cell volume V = 802.902 Å3, Z = 2, ρcal = 1.309 g cm−3, and space group P21] at room temperature. All measured lines were indexed and were consistent with the P21 space group.