We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Plotinus' Enneads is a work which is central to the history of philosophy in late antiquity. This is the second edition of the first English translation of the complete works of Plotinus in one volume in seventy years, which also includes Porphyry's Life of Plotinus. Led by Lloyd P. Gerson, a team of experts present up-to-date translations which are based on the best available text, the edition minor of Henry and Schwyzer and its corrections. The translations are consistent in their vocabulary, making the volume ideal for the study of Plotinus' philosophical arguments. This second edition includes a number of corrections, as well as additional cross-references to enrich the reader's understanding of Plotinus' sometimes very difficult presentation of his ideas. It will be invaluable for scholars of Plotinus with or without ancient Greek, as well as for students of the Platonic tradition.
The COVID-19 pandemic resulted in a mental health crisis in adolescents. To evaluate resource needs, we attempted to collect data from Children’s Health Fund’s national network of pediatric practices working in resource-limited settings.
Methods
Data could not be collected largely due to other disaster response priorities for our network. Using a STROBE flowchart, we characterize the inability to collect data, provide insight into network challenges, and offer this report as a case example for the limitations in collecting data during disaster response.
Results
Only 2 of 24 programs had the capacity and the data to participate. Causes of non-participation included shifting work toward other aspects of disaster response, limiting collection of data, or lack of human resources to extract it.
Conclusions
Disaster disproportionately affects under-resourced communities. The lack of resources impairs disaster response due to conflicting priorities in those working within these communities.
This study explored junior mental health workers’ experiences of conducting assessments involving traumatic events. Semi-structured interviews with 11 junior mental health workers from a UK primary care mental health service were analysed using reflexive thematic analysis. Participants discussed themes of ambiguity in distinguishing trauma and PTSD, high levels of pressure, management of personal distress, appropriate training, and personal support in-service. Findings corroborate previous research regarding challenges experienced by junior mental health workers and offer novel insight into the challenges faced when assessing service-users’ experiences of traumatic events. Recommendations regarding future training, service design and emotional outlets for junior mental health workers are offered.
Key learning aims
(1) Following reading this paper, readers will better understand the diagnostic and practice-based complexities involved in assessing traumatic events as a Psychological Wellbeing Practitioner (PWP) in an NHS Talking Therapies service.
(2) Readers will also be aware of the emotional challenges PWPs in this service have reported experiencing as a result of assessing service users that report having experienced traumatic events.
(3) The reader will also learn about PWPs’ perspectives on what could improve this NHS Talking Therapies service’s processes involved in assessing traumatic events and reflect on whether this might be generalisable across other, similar services.
Online platforms and activities, including smartphones, computers, social media, video games and applications involving artificial intelligence, have become a regular part of daily life and offer individuals a wide range of benefits. The purpose of this document is to increase psychiatrists’ awareness of the frequency and potential risks associated with excessive internet use, and to emphasise the need for psychiatrists to routinely question patients about their online activities. Internet use may become excessive and result in both psychological distress and physical impairments. Treatments and countermeasures may be required to address the harmful consequences of excessive internet use. Psychiatrists should be aware of patient online activities. Understanding of a patient’s online behaviour should now be a routine part of a psychiatric interview.
It remains unclear which individuals with subthreshold depression benefit most from psychological intervention, and what long-term effects this has on symptom deterioration, response and remission.
Aims
To synthesise psychological intervention benefits in adults with subthreshold depression up to 2 years, and explore participant-level effect-modifiers.
Method
Randomised trials comparing psychological intervention with inactive control were identified via systematic search. Authors were contacted to obtain individual participant data (IPD), analysed using Bayesian one-stage meta-analysis. Treatment–covariate interactions were added to examine moderators. Hierarchical-additive models were used to explore treatment benefits conditional on baseline Patient Health Questionnaire 9 (PHQ-9) values.
Results
IPD of 10 671 individuals (50 studies) could be included. We found significant effects on depressive symptom severity up to 12 months (standardised mean-difference [s.m.d.] = −0.48 to −0.27). Effects could not be ascertained up to 24 months (s.m.d. = −0.18). Similar findings emerged for 50% symptom reduction (relative risk = 1.27–2.79), reliable improvement (relative risk = 1.38–3.17), deterioration (relative risk = 0.67–0.54) and close-to-symptom-free status (relative risk = 1.41–2.80). Among participant-level moderators, only initial depression and anxiety severity were highly credible (P > 0.99). Predicted treatment benefits decreased with lower symptom severity but remained minimally important even for very mild symptoms (s.m.d. = −0.33 for PHQ-9 = 5).
Conclusions
Psychological intervention reduces the symptom burden in individuals with subthreshold depression up to 1 year, and protects against symptom deterioration. Benefits up to 2 years are less certain. We find strong support for intervention in subthreshold depression, particularly with PHQ-9 scores ≥ 10. For very mild symptoms, scalable treatments could be an attractive option.
Aquinas presents his argument for the existence of an uncaused cause of all effects in his Second Way in the Summa theologiae as a deductively valid argument from premises known with certainty. This seems unwarranted, since the argument gives no reason for there being only one uncaused cause, and the reasons it gives for rejecting an endless causal regress seem unconvincing. These apparent shortcomings can be better understood by examining Aquinas’s metaphysics of causation, which is presupposed by the argument. He uses a form of composition argument to justify the claim that endless per se causal series cannot exist. He does not argue against the possibility of a multiplicity of uncaused causes because he sees no rational grounds for entertaining this possibility. Given Aquinas’s metaphysical assumptions, it is correct to take the Second Way to be a deductively sound argument.
Domestic cats have lived alongside human communities for thousands of years, hunting rats, mice, and other pests and serving as pets and a source of pelts and meat. Cats have received limited archaeological attention because their independence limits direct insight into human societies. An adult and juvenile cat recovered from the Emanuel Point wreck 2 (EP2) reflect what are, most likely, the earliest cats in what is now the United States. Zooarchaeological analyses of these and other archaeological cats in the Americas demonstrate that cats ranged substantially in size: some were comparable to modern house cats, and others were much smaller. Isotopic analyses of the adult cat from EP2 provides insight into early shipboard cat behavior and their diet, which appears to have focused on consumption of fish and possibly domestic meat. Cats accompanied sailors on ships where they were relied on to hunt rats and mice that were infesting ships’ holds. Interestingly, based on these isotopic results, the adult cat from EP2 does not seem to have relied heavily on rats as a source of food. These pests were unintentionally introduced to the New World, and cats would have followed, hunting both native and invasive pests.
Double-diffusive convection can arise when the fluid density is set by multiple species which diffuse at different rates. Different flow regimes are possible depending on the distribution of the diffusing species, including salt fingering and diffusive convection. Flows arising from diffusive convection commonly exhibit step-like density profiles with sharp density interfaces separated by well-mixed layers. The formation of density layers is also seen in stratified turbulence, where a framework based on sorted density coordinates (Winters & D’Asaro 1996 J. Fluid Mech.317, 179–193) has been used to diagnose layer formation (Zhou et al. 2017 J. Fluid Mech.823, 198–229; Taylor & Zhou 2017 J. Fluid Mech.823, R5). In this framework, the evolution of the sorted density profile can be expressed solely in terms of the eddy diffusivity, $\kappa _e$. Here, we use the same framework to diagnose layer formation in two-dimensional simulations of double-diffusive convection. We show that $\kappa _e$ is negative everywhere, with the antidiffusive effect strongest in ‘well-mixed’ layers where a positive diffusion coefficient may be expected. By considering a decomposition of the budget of the square of the Brunt-Väisälä frequency $\partial N^2_*/\partial t$, we demonstrate that the density layers are maintained by fundamentally different processes than in single-component stratified turbulence. In more complicated flows where stratified turbulence and double-diffusive convection can coexist, this framework could provide a method to distinguish between the mechanisms responsible for generating density layers.
Objectives/Goals: Digital recruitment can improve participant engagement in medical research, but its potential to introduce demographic and socioeconomic biases is unclear. This study investigates pathways participants took during a digital recruitment workflow in neurology, examining potential associations with socioeconomic and demographic factors. Methods/Study Population: As part of an ongoing study aiming to remotely capture speech from patients with neurologic disease, most participants seen in neurology on our campus are invited to complete a self-administered speech examination. We exported participant data from Epic (semi-automated identification and invitation), Qualtrics (eligibility screening), the participant tracking database (consent), and the recording platform (completion) for March to July 2024. Data visualization was performed using a Sankey diagram. Socioeconomic status was assessed using the housing-based socioeconomic status (HOUSES) index and area deprivation index (ADI) national rank. Kruskal–Wallis and Wilcoxon rank-sum tests were used to compare the median age, socioeconomic indices, and time taken to reach different steps of the study. Results/Anticipated Results: Of the 5846 invited participants, 57% were from urban areas, 23% from rural areas, and 20% from urban clusters. Most did not read/respond (2739) or declined (1749) the initial invitation via Epic. Of the 1358 interested participants, 415 completed the study. Participants from urban areas completed enrollment steps faster than those from rural areas and urban clusters, though the variance was large (42.6 ± 41.4 days vs. 50.6 ± 42.2 days and 50 ± 43.9 days, respectively; p = 0.030). Female participants took longer to complete enrollment than males (48.7 ± 44 days vs. 40.5 ± 38.8 days; p = 0.026). Participants who successfully finished the study had significantly lower ADI national ranks compared to other common pathways (40.6 ± 19; p = 0.0021). No associations were found with the HOUSES indices. Discussion/Significance of Impact: Our findings support differences in participant engagement, with urban participants and males more likely to complete enrollment steps. Those who finished the study were less disadvantaged suggesting potential bias in digital recruitment. These findings can inform strategies to improve digital recruitment in neurology research.
Japanese stiltgrass is one of the most troublesome invasive weed species in the eastern United States. Strategies for controlling the weed in managed lawns are limited because most previous research was conducted in forest understories or on golf course natural areas. Eight field experiments were conducted in Virginia from 2014 to 2019 to evaluate the response of Kentucky bluegrass, tall fescue, and Japanese stiltgrass to selective herbicides traditionally marketed for use on cool-season turfgrass. Only treatments that contained mesotrione caused transient injury to tall fescue of 15% to 25% at 2 wk after treatment (WAT). When fenoxaprop was applied at a rate of 35 g ha−1 or higher, at 8 WAT Japanese stiltgrass was controlled by ≥90%, relative cover was reduced to <15% compared with a nontreated control, and shoot density was reduced to ≤6 shoots m−2. Sequential applications of topramezone at 27 g ha−1 at 3-wk intervals, or a single application of topramezone at 54 g ha−1 alone or with triclopyr, resulted in ≥80% control of Japanese stiltgrass and a reduction in relative weed cover and shoot density to ≤22% and <35 shoots m−2, respectively. Fenoxaprop applied at 0.25× of the labeled rate and herbicide combinations that contained topramezone selectively controlled Japanese stiltgrass without injuring tall fescue. Fluazifop applied at 53 g ha− 1 resulted in 25% injury to Kentucky bluegrass and digitally assessed turf cover was reduced by 20% at 4 WAT, but turfgrass recovered by 6 WAT. Reduced rates of fluazifop provided 85% control of Japanese stiltgrass, and a reduction in weed shoot density to <20 shoots m−2, and relative cover to <20% at 8 WAT. Kentucky bluegrass did not appear to be injured with premixed applications of dicamba, fenoxaprop, and fluroxypyr, but Japanese stiltgrass was controlled by ≥92%, the relative weed cover was reduced to ≤7%, and shoot density was reduced to ≤5 shoots m−2 at 8 WAT. Our research provides herbicide options for turf managers for controlling Japanese stiltgrass in lawns of Kentucky bluegrass and tall fescue.
The linear stability of miscible displacement for radial source flow at infinite Péclet number in a Hele-Shaw cell is calculated theoretically. The axisymmetric self-similar flow is shown to be unstable to viscous fingering if the viscosity ratio $m$ between ambient and injected fluids exceeds $3/2$, and to be stable if $m\lt {3/2}$. If $1\lt m\lt {3/2}$, then small disturbances decay at rates between $t^{-3/4}$ and $t^{-1}$ (the exact range depending on $m$) relative to the $t^{1/2}$ radius of the axisymmetric base-state similarity solution; if $m\lt 1$, then they decay faster than $t^{-1}$. Asymptotic analysis confirms these results and gives physical insight into various features of the numerically determined relationship between the growth rate and the azimuthal wavenumber and viscosity ratio.
The gift-exchange game is a form of sequential prisoner's dilemma, developed by Fehr et al. (1993), and popularized in a series of papers by Ernst Fehr and co-authors. While the European studies typically feature a high degree of gift exchange, the few U.S. studies provide some conflicting results. We find that the degree of gift exchange is surprisingly sensitive to an apparently innocuous change—whether or not a comprehensive payoff table is provided in the instructions. We also find significant and substantial time trends in responder behavior.
This study is the first to attempt to isolate a relationship between cognitive activity and equilibration to a Nash Equilibrium. Subjects, while undergoing fMRI scans of brain activity, participated in second price auctions against a single competitor following predetermined strategy that was unknown to the subject. For this auction there is a unique strategy that will maximize the subjects’ earnings, which is also a Nash equilibrium of the associated game theoretic model of the auction. As is the case with all games, the bidding strategies of subjects participating in second price auctions most often do not reflect the equilibrium bidding strategy at first but with experience, typically exhibit a process of equilibration, or convergence toward the equilibrium. This research is focused on the process of convergence.
In the data reported here subjects participated in sixteen auctions, after which all subjects were told the strategy that will maximize their revenues, the theoretical equilibrium. Following that announcement, sixteen more auctions were performed. The question posed by the research concerns the mental activity that might accompany equilibration as it is observed in the bidding behavior. Does brain activation differ between being equilibrated and non-equilibrated in the sense of a bidding strategy? If so, are their differences in the location of activation during and after equilibration? We found significant activation in the frontal pole especially in Brodmann's area 10, the anterior cingulate cortex, the amygdala and the basal forebrain. There was significantly more activation in the basal forebrain and the anterior cingulate cortex during the first sixteen auctions than in the second sixteen. The activity in the amygdala shifted from the right side to the left after the solution was given.
In this paper we discuss laboratory experiments that address the problem of self-governance in an asymmetric commons dilemma. Small-scale irrigation systems that provide food for hundreds of millions of people around the world are probably the most common example of such dilemmas. Here, we formulate an abstract dilemma in which subjects make both a decision about investment in the provision of infrastructure associated with the use of a resource and about how much to extract from the common-pool resource made available by this infrastructure. The impact of inherent asymmetry in irrigation systems on the provision of a resource and the impact of communication on the capacity of the group to solve the two-level commons dilemma of cooperation and coordination based on the analysis of the experimental data are discussed.
Evaluate Department of Defense (DoD) antimicrobial stewardship programs (ASPs) by assessing the relationship between key clinical outcome metrics (antibiotic use, incidence of resistant pathogens, and incidence of Clostridioides difficile infections) and CDC Core Element (CE) adherence.
Design:
Retrospective, cross-sectional study of DoD hospitals in 2018 and 2021
Methods:
National Healthcare Safety Network Standardized Antimicrobial Administration Ratios (SAARs) were used to measure antibiotic use and microbiology results to evaluate four types of pathogen incidence. A novel CE scoring approach used scores to quantitatively assess relationships with CE adherence and outcome metrics using correlation and regression models. Assessments were repeated with 2021 data for Priority CE adherence and to conduct adjusted regressions for CEs and Priority CEs controlling for categorical bed size.
Results:
Compared to 2022 national data, DoD hospitals in 2021 had a similar proportion of facilities with a SAAR statistically significantly > 1.0. Leadership, Action, and Tracking CEs followed a more normal score distribution, while Reporting and Education were somewhat left-skewed. Unadjusted models often showed a positive relationship with higher CE scores associated with worse outcomes for the SAAR and pathogen incidence. Adjusted models indicated that procedural CEs, particularly Priority Reporting, were associated with better ASP-related outcomes.
Conclusions:
CEs should be more quantitatively assessed. Results provide initial evidence to prioritize procedural CE implementation within the DoD; however, additional investigation for structural CEs is needed. Patient outcome data should be collected as an important indicator of ASP performance.
Inspired by laboratory experiments showing internal waves generated by a plume impinging upon a stratified fluid layer (Ansong & Sutherland. 2010 J. Fluid Mech.648, 405–434), we perform large eddy simulations in three dimensions to examine the structure and source of internal waves emanating from the top of a plume that rises vertically into stratification whose strength ranges over two orders of magnitude between different simulations. Provided the plume is sufficiently energetic to penetrate into the stratified layer, internal waves are generated with frequencies in a relatively narrow band moderately smaller than the buoyancy frequency. Through adaptations of ray theory including viscosity and use of dynamic mode decomposition, we show that the waves originate from within the turbulent flow rather than at the turbulent/non-turbulent interface between the fountain top and the surrounding stratified fluid.