We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Acute renal failure (ARF) in the critically ill, almost always, develops as part of multiple organ dysfunction (or failure) syndrome.
ARF in the critically ill has high mortality.
Understanding renal physiology and pathophysiology of ARF in the critically ill (especially those with sepsis-associated ARF or SAARF) provides logical guidelines for prevention and/or management of patients at risk.
To date there are no proven pharmacological therapies that “prevent” ARF.
Our understanding of ARF in the critically ill is far from complete.
ARF in the critically ill is distinctly different from “medical” ARF; and management of these patients is often challenging.
Critically ill patients with ARF have higher mortality than a similar cohort of patients without ARF.
Incidence and definition
ARF in the critically ill is not properly defined.
In the literature, definitions for ARF, populations studied and timing of interventions seem to be different in different studies.
This creates problems in interpreting the available literature.
Besides that, defining points at which interventions like renal replacement therapy (RRT) should begin or stop also becomes difficult.
Lack of definition also means that it is difficult to estimate accurate incidence of this disease in our intensive care unit (ICU) patients.
In the literature, the incidence of ARF is quoted as 0.14% (community acquired or “medical” ARF) to 33% in the critically ill. In some recent studies, ARF complicating critical illness has been estimated to be of the order of 4–8%. Based on unpublished data (1997–2001), the incidence of ARF in author's ICU is about 15–20% (a tertiary referral unit).
[…]
Recommend this
Email your librarian or administrator to recommend adding this to your organisation's collection.