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This study presents new (n=32) and previously published (n=35) human bone 14C AMS dates from 54 individuals interred in 50 burials in the Plinkaigalis cemetery (3rd–7th century AD, Lithuania). The aim of this study is to establish duration of use and identify temporal subgroups within the cemetery. Individuals in group burials were assessed for temporal agreement across individuals and the dates for individuals with multiple dates were combined using OxCal. The Sum command, Interval command, and two Bayesian models (overlapping and abutting periods of use) were used to approximate the use of the site over time and evaluate the chronology of dated burials. An IDW (inverse distance weighted) model was employed to visualize median radiocarbon dates across the cemetery for comparison to earlier IDW interpolations of time at Plinkaigalis. While the two models cannot be distinguished at this time, it can be determined that the site was likely in continuous use from 200–600 cal AD (Sum), 230–560 cal AD (Model 1), 220–550 cal AD (Model 2), or cal 283–508 AD (IDW). The area of the cemetery associated with earliest use shifted east when the IDW model was compared to original data. There was also poor agreement in some group burials and burials with multiple dates. The models generally agree on assignment of burials to phases, but disparate phase assignment was noted across the IDW and Bayesian models. Temporal subgroups cannot be confidently reclassified beyond early/later periods of use based on these models without additional sampling and refinement of the IDW modeling method.
Understanding how youth perceive household economic hardship and how it relates to their behavior is vital given associations between hardship and behavioral development. Yet, most studies ignore youth’s own perceptions of economic hardship, instead relying solely on caregiver reports. Moreover, the literature has tended to treat economic hardship as a stable force over time, rather than a volatile one that varies month-to-month. This study addressed extant limitations by collecting monthly measures of economic hardship, specifically caregiver- and youth-reported material deprivation and youth-reported financial stress, and youth internalizing and externalizing problems from 104 youth–caregiver dyads (youth: 14–16 years, 55% female, 37% Black, 43% White) over nine months. We examined month-to-month variability of these constructs and how youth-reports of material deprivation and financial stress predicted their behavior problems, controlling for caregiver-reports of material deprivation. We found that hardship measures varied month-to-month (ICCs = 0.69–0.73), and youth-reported material deprivation positively predicted internalizing when examining both within- and between-individual variability (β = .19–.47). Youth-reported financial stress positively predicted within-individual variation in externalizing (β = .18), while youth reports of material deprivation predicted externalizing when looking between families (β = .41). Caregiver-reported material deprivation was unrelated to youth behavior when accounting for youth perceptions of economic hardship.
One of the most important aspects of genetic evaluation (GE) is the definition of contemporary groups (CG), commonly defined as animals of the same sex born in the same herd, year and season. The objective of this study was to use an aridity index (AI) to classify season and evaluate the implications on the GE of Braunvieh cattle. A data set with 32 777 and 22 448 birth weight (BW) and weaning weight adjusted to 240 days (WW) records, respectively, was used to compare two methods of classification of climatic seasons to be used in the definition of CG for GE models. The first method considered rain season criterion (RC), and the second method is a proposed classification using an AI. Both methods were compared using two approaches. The first approach examined differences in mixed models using the RC and AI season to select the best model for BW and WW, evaluated by different goodness of fit measures. The second approach considered fitting a GE model including the season classifications into the CG structure. Lower probability values for season effect and better goodness of fit measures were obtained when the season was classified according to the AI. Results showed that although differences are small, the AI allows a better model fitting for live-weight traits than RC and revealed a re-ranking effect on expected progeny differences data. Further analysis with other traits would demonstrate the extended utility of AI indicators to be considered for fitting models under a climatic change environment.
We study the dynamics of atomization of a liquid column by a coaxial gas flow with varying gas pressures. Specifically, we analyse how the gas density increase associated with elevated gas pressures in the ambient and co-flowing gas jet influences the liquid destabilization and breakup process, as well as the resulting droplet formation and dispersion. We present new experimental results for a coaxial liquid–gas atomizer operating in a high-pressure environment, with gas–liquid momentum ratio in the range $M = 5\unicode{x2013}56$ and pressurized gas densities $\rho _g/\rho _0 = 1\unicode{x2013}5$, where $\rho _0$ is the ambient gas density at standard conditions. High-speed shadowgraphy images are used to quantify the spatially and temporally varying liquid–gas interface in the spray near-field. Liquid core lengths, spreading angles and other spray metrics are presented, and the influence of gas density is identified from the comparison with atomization at atmospheric conditions. In the spray mid-field, phase Doppler interferometry is used in conjunction with laser Doppler velocimetry to quantify the droplet size and velocities, as well as their radial variations across the spray. Results show an increase in droplet size at elevated ambient pressures, when keeping the gas–liquid momentum ratio constant. Finally, we show that these observations are in line with predictions from the Kelvin–Helmholtz and Rayleigh–Taylor instabilities, both of which are relevant to the gas–liquid atomization process.
The aim of the present study was to develop and validate a test to evaluate dietitian's clinical competence (CC) about nutritional care in patients with early chronic kidney disease (CKD). The study was conducted through five steps: (1) CC and its dimensions were defined; (2) test items were elaborated, and choice of response format and scoring system was selected; (3) content and face validity were established; (4) test was subjected to a pilot test and those items with inadequate performance were removed; (5) criterion validity and internal consistency for final validation were established. A 120-items test was developed and applied to 207 dietitians for validation. Dietitians with previous CKD training obtained higher scores than those with no training, confirming the test validity criterion. According to item analysis, Cronbach's α was 0⋅85, difficulty index 0⋅61 ± 0⋅22, discrimination index 0⋅26 ± 0⋅15 and inter-item correlation 0⋅19 ± 0⋅11, displaying adequate internal consistency.
A canonical co-axial round-jet two-fluid atomizer where atomization occurs over a wide range of momentum ratios: $M=1.9 - 376.4$ is studied. The near field of the spray, where the droplet formation process takes place, is characterized and linked to droplet dispersion in the far field of the jet. Counterintuitively, our results indicate that in the low-momentum regime, increasing the momentum in the gas phase leads to less droplet dispersion. A critical momentum ratio of the order of $M_c=50$, that separates this regime from a high-momentum one with less dispersion, is found in both the near and far fields. A phenomenological model is proposed that determines the susceptibility of droplets to disperse beyond the nominal extent of the gas phase based on a critical Stokes number, $St=\tau _p/T_E=1.9$, formulated based on the local Eulerian large scale eddy turnover time, $T_E$, and the droplets’ response time, $\tau _p$. A two-dimensional phase space summarizes the extent of these different regimes in the context of spray characteristics found in the literature.
Epidemiological studies indicate that individuals with one type of mental disorder have an increased risk of subsequently developing other types of mental disorders. This study aimed to undertake a comprehensive analysis of pair-wise lifetime comorbidity across a range of common mental disorders based on a diverse range of population-based surveys.
Methods
The WHO World Mental Health (WMH) surveys assessed 145 990 adult respondents from 27 countries. Based on retrospectively-reported age-of-onset for 24 DSM-IV mental disorders, associations were examined between all 548 logically possible temporally-ordered disorder pairs. Overall and time-dependent hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards models. Absolute risks were estimated using the product-limit method. Estimates were generated separately for men and women.
Results
Each prior lifetime mental disorder was associated with an increased risk of subsequent first onset of each other disorder. The median HR was 12.1 (mean = 14.4; range 5.2–110.8, interquartile range = 6.0–19.4). The HRs were most prominent between closely-related mental disorder types and in the first 1–2 years after the onset of the prior disorder. Although HRs declined with time since prior disorder, significantly elevated risk of subsequent comorbidity persisted for at least 15 years. Appreciable absolute risks of secondary disorders were found over time for many pairs.
Conclusions
Survey data from a range of sites confirms that comorbidity between mental disorders is common. Understanding the risks of temporally secondary disorders may help design practical programs for primary prevention of secondary disorders.
Interest in the premorbid personality of schizophrenic patients is well established in the psychiatric literature. The relationship between personality disorders and acute phase proteins (APP) in schizophrenia is not well known.
Aim:
Investigating the relationship among acute phase proteins and personality disorders in schizophrenic patients in a sample of adult schizophrenic patients under psychiatric treatment in a general hospital health setting.
Material and Methods:
37 adult paranoid schizophrenics undergoing treatment in the University Hospital of the Canary Islands with DSM-IV diagnosis of paranoid schizophrenia are included. Years from onset 9.20 s.d. 6.29, age at onset 19.75 s.d. 4.73. The record of personality disorders as a secondary diagnosis in the medical chart was taking into account. A blood sample as routine standard analysis was carried out in each patient.
Results:
In 21 patients (56.7%) a personality disorder, mainly with paranoid and schizotypal traits, was registered. The percentage of each personality disorder is as follows, Schizotypal (16.2%), Paranoid (13.5%), Schizoid (2.7%), Paranoid and Schizotypal (24.3%). The results point to no significant correlation according to APP (C3, C4, alpha2-macroglobulin, alpha1-glicoprotein, ceruloplasmin) in the different diagnostic groups.
Discussion and conclusions:
In our study there is no evidence to support a significant correlation among APP and the different personality disorders in our sample of schizophrenics in spite of a positive correlation of APP and some psychopathology dimensions that has been communicated earlier elsewhere. In order to set some possible specificity of acute phase proteins and other clinical features in schizophrenia further research is required.
Malondialdehyde (MDA) is a common biologic marker of oxidative stress used in psychiatric research. Data regarding MDA levels in healthy subjects are controversial. One factor affecting MDA levels may stem from the existence of a circadian rhythm of MDA formation. The objective of this study consists of investigating whether MDA formation has a circadian rhythm of formation in healthy human subjects.
Methods:
The sample was comprised by 9 healthy male subjects. None of them had a history of medical or neurological disease and routine laboratory parameters were normal. The study was carried out in accordance with the Helsinki Declaration and all subjects gave written informed consent before their inclusion. Blood samples were extracted at 12:00 and 2:00 in December 2004. The same routine was followed during the two experimental sessions. Serum MDA was determined by the thiobarbituric acid reactive substance (TBARS) according to the method of Ohkaba et al (1979).
Results:
The sample was comprised by 9 male healthy subjects (age 33.0±11.7). There were significant differences in MDA levels between 12:00 and 2:00 (2.33±1.01 vs. 1.58±0.48, p<0.015).
Conclusions:
MDA has a circadian rhythm of formation with higher levels at 12:00 than 2:00. This variation in circadian MDA levels of formation should be accounted when researching in this field.
Despite the well-known relevance of twin studies in the medical and social sciences and the growing number of twin registries throughout the world, Latin America has not fully incorporated into the twin research community. We describe the first steps taken toward developing a twin registry in Mexico: its aim, organization, recruiting potential and main short-term objectives.
To provide cross-national data for selected countries of the Americas on service utilization for psychiatric and substance use disorders, the distribution of these services among treatment sectors, treatment adequacy and factors associated with mental health treatment and adequacy of treatment.
Methods
Data come from data collected from 6710 adults with 12 month mental disorder surveys across seven surveys in six countries in North (USA), Central (Mexico) and South (Argentina, Brazil, Colombia, Peru) America who were interviewed 2001–2015 as part of the World Health Organization (WHO) World Mental Health (WMH) Surveys. DSM-IV diagnoses were made with the WHO Composite International Diagnostic Interview (CIDI). Interviews also assessed service utilization by the treatment sector, adequacy of treatment received and socio-demographic correlates of treatment.
Results
Little over one in four of respondents with any 12 month DSM-IV/CIDI disorder received any treatment. Although the vast majority (87.1%) of this treatment was minimally adequate, only 35.3% of cases received treatment that met acceptable quality guidelines. Indicators of social-advantage (high education and income) were associated with higher rates of service use and adequacy, but a number of other correlates varied across survey sites.
Conclusions
These results shed light on an enormous public health problem involving under-treatment of common mental disorders, although the problem is most extreme among people with social disadvantage. Promoting services that are more accessible, especially for those with few resources, is urgently needed.
To assess counts of α4 and α7 nicotinic acetylcholine receptors in nasal polyps of adults with or without long-term exposure to cigarette tobacco smoke.
Methods
Twenty-two patients with and 22 patients without exposure to cigarette tobacco smoke participated in the study. After endoscopic polypectomy, the fragments of the nasal polyps were analysed by immunohistochemistry.
Results
Compared to patients with no exposure, patients with exposure showed higher counts of α4 and α7 nicotinic acetylcholine receptors (t-test, p < 0.05). However, in patients with no exposure, multivariate analysis showed gender dimorphism, with lower counts in males than in females, and no influence from other variables (analysis of covariance, p > 0.05).
Conclusion
Exposure to cigarette tobacco smoke may induce increased counts of α4 and α7 nicotinic acetylcholine receptors in nasal polyps of adults, with lower counts in males than females without exposure to tobacco smoke.
Priming has proved to enhance seed germination, but most of the research dealing with this topic has been carried out with cultivated species. The potential applications that this process has on wild species, which can be useful for restoration, are usually overlooked. This study analyses the germination response after natural priming and hydropriming of Penstemon roseus and Castilleja tenuiflora, two perennial herbs growing in a protected area known as ‘Parque Ecológico de la Ciudad de México’. Photoblastism was evaluated for both species. Seeds were exposed to a hydration/dehydration cycle and then placed in germination chambers to determine responses to hydropriming. To identify the effects of natural priming, seeds were buried in natural conditions and then recovered every two months and placed in germination chambers. Germination percentages and rates were then quantified. Both species proved to have permeable seed coats. Penstemon roseus seeds are positive photoblastic whereas C. tenuiflora seeds are indifferent to light. Priming methods increased C. tenuiflora germination rates, but they did not affect germination capacity. For P. roseus, priming methods did not improve germination rates, and germination capacity of recovered seeds decreased after the rainy season, suggesting that P. roseus forms a short-term, transient, seed bank. The germination strategies of these two species allow them to occupy suitable microsites for germination and establishment. These responses can be helpful in developing restoration programmes based on the accelerated establishment of native and characteristic successional species.
By using electrochemical tests, small signal variations were study by digital signal processing techniques. Electrochemical noise and electrochemical polarization curves were very useful to obtained electrochemical behavior of alloys, but the low signal levels of measurements obtained showed that some of the information was not likely to be measured and, therefore, not being able to identify. Graphene oxides (GO) samples were prepared by ball milling procedure adding Lithium. SIGVIEW software was used for Digital Signal studies. Comparing, the signals obtained by electrochemical techniques and the research by computational tools; it was possible to find out a behavior path of samples. Display devices made by graphene were observed to provide new information about the structure of samples and how nanotechnology area can be improved. The current investigation aimed at maintaining electrochemical stability, since different deformations, as twisting and bending are quite relevant in portable electronics devices.
This work shows the electrochemical study of nickel (Ni) and TiC/Ni composite immersed in synthetic seawater. In order to characterize the corrosion process, polarization curves (PC) were carried out. All electrochemical measures were made under static conditions, room temperature, atmospheric pressure and 24 hours exposure time. An electrochemical cell with a typical three-electrode array was used. Effect of TiC as reinforcement into the Ni matrix was evaluated. According PC results, it is possible to point out that the corrosion rate (CR) of the TiC/Ni composite was higher than Ni corrosion rate. The obtained results indicate that the corrosion process of both materials is of mixed type, that is to say a process of transfer of load influenced by a mechanism of mass transfer. Observations through scanning electron microscopy (SEM) revealed that mechanism of corrosion was cells of differential aeration (difference of concentration of oxygen). The corrosion morphology was localized type (pits and crevice).
No review has used a meta-analytic approach to estimate common odds ratios (ORs) for the effect of acute use of alcohol (AUA) on suicide attempts. We aim to report the results of the first meta-analysis of controlled epidemiological studies on AUA and suicide attempt.
Method
The English-language literature on Medline, PsycINFO and Google Scholar was searched for original articles and critical review on AUA and suicide attempt (period 1996–2015). Studies had to report an OR estimate for this association. Common ORs and 95% confidence intervals (CIs) from random effects in meta-analyses for any AUA and two levels of alcohol use on suicide attempt were calculated.
Results
In all, seven studies provided OR estimates for the likelihood of suicide attempt by AUA, compared with those who did not drink alcohol. Studies used case–control (n 3) and case–crossover designs (n 4). Meta-analysis revealed a common OR of 6.97 (95% CI 4.77–10.17) for any AUA. Using four studies, ‘low levels of acute drinking’ resulted in an OR of 2.71 (95% CI 1.56–4.71) and ‘high levels’ had an OR of 37.18 (95% CI 17.38–79.53).
Conclusions
AUA is associated with increased likelihood of a suicide attempt, particularly at high doses. Such data should be incorporated into estimates of the burden of disease associated with alcohol use, which are currently limited by a consideration of only alcohol's chronic effects. Future research should focus on the mechanisms through which AUA confers risk for attempt.
A new generation of solar instruments provides improved spectral, spatial, and temporal resolution, thus facilitating a better understanding of dynamic processes on the Sun. High-resolution observations often reveal multiple-component spectral line profiles, e.g., in the near-infrared He i 10830 Å triplet, which provides information about the chromospheric velocity and magnetic fine structure. We observed an emerging flux region, including two small pores and an arch filament system, on 2015 April 17 with the ‘very fast spectroscopic mode’ of the GREGOR Infrared Spectrograph (GRIS) situated at the 1.5-meter GREGOR solar telescope at Observatorio del Teide, Tenerife, Spain. We discuss this method of obtaining fast (one per minute) spectral scans of the solar surface and its potential to follow dynamic processes on the Sun. We demonstrate the performance of the ‘very fast spectroscopic mode’ by tracking chromospheric high-velocity features in the arch filament system.
Low and middle income countries share a heavy burden of suicide with about three in every four suicides occurring in these countries. Mexico has witnessed a growing trend in suicide deaths; if this trend is not simply a reflection of better reporting of suicide on death certificates, then this increase should logically be accompanied by an increasing trend in suicide ideation, plan and attempts, but we lack information on the trends for suicide ideation, plan and attempt for this period. We therefore aim to report changes for suicidal behaviour for the period 2001–2013 in the Mexico City Metropolitan Area.
Method.
Using two cross-sectional surveys conducted in Mexico in 2001 and 2013, we report the lifetime and 12-month prevalence of suicide ideation, plan and attempt and changes in treatment for these problems among respondents aged 19–26 living in the Mexico City Metropolitan Area 12 years apart. To estimate the changes in prevalence for each outcome, we used generalised linear models to calculate prevalence ratios (PR; the prevalence rate in the exposed (year 2013) divided by the prevalence rate in the unexposed (year 2001–2002), adjusting for sociodemographic variables.
Results.
While increases in the prevalence are noted everywhere, statistical comparisons only found differences for lifetime ideation (PR = 3.1; 95% CI = 1.7–5.8) and a borderline difference for suicide attempt (PR = 2.2; 95% CI = 1.0–4.9). No attempt within the last 12-months was reported in 2001, but the prevalence in 2013 reached 1.5% (18 cases). While PRs for 12-month prevalence were all above the null, none reached statistically significant differences. During this 12-year period, the distribution of mental disorders and the use of services for mental disorders among suicide ideators, planners and attempters did not change in any noticeable way.
Conclusions.
The limitations of our data are the small number of participants in the 2001 survey, the low follow-up rate for the survey in 2013 and that while representative from one city it does not represent the whole country. These findings suggest that suicide ideation and attempt may have increased during this 12-year period in the Mexico City metropolitan area, but this increase did not lead to more use of mental health care services. This information, coupled with the long-term trend of increasing suicide death rates in the country, draw a worrisome and neglected scenario for our youth in this region. Urgent measures, following the recent WHO guidelines for suicide prevention, must not be postponed.
An electrochemical impedance spectroscopy (EIS) corrosion study of API X70 steel was carried out in synthetic seawater with different rotation speeds using a rotating cylinder electrode (RCE) to control the hydrodynamic conditions at room temperature, atmospheric pressure and 24 h of exposure time. A superficial analysis through a scanning electron microscope (SEM) was used to analyze the corrosion type. The rotation speed used was 0 rpm (static condition), 1000, 3000 and 5000 rpm (turbulent flow). The results show that the turbulent flow conditions affect directly the corrosion rate (CR) of the steel, because all values of the CR under turbulent flow conditions are higher than the CR values at static conditions. In addition, it is important to point out that at turbulent flow conditions, the CR increased as the rotation speed also increased. The morphology of the corrosion in all experiments was localized corrosion.