We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The association between cannabis and psychosis is established, but the role of underlying genetics is unclear. We used data from the EU-GEI case-control study and UK Biobank to examine the independent and combined effect of heavy cannabis use and schizophrenia polygenic risk score (PRS) on risk for psychosis.
Methods
Genome-wide association study summary statistics from the Psychiatric Genomics Consortium and the Genomic Psychiatry Cohort were used to calculate schizophrenia and cannabis use disorder (CUD) PRS for 1098 participants from the EU-GEI study and 143600 from the UK Biobank. Both datasets had information on cannabis use.
Results
In both samples, schizophrenia PRS and cannabis use independently increased risk of psychosis. Schizophrenia PRS was not associated with patterns of cannabis use in the EU-GEI cases or controls or UK Biobank cases. It was associated with lifetime and daily cannabis use among UK Biobank participants without psychosis, but the effect was substantially reduced when CUD PRS was included in the model. In the EU-GEI sample, regular users of high-potency cannabis had the highest odds of being a case independently of schizophrenia PRS (OR daily use high-potency cannabis adjusted for PRS = 5.09, 95% CI 3.08–8.43, p = 3.21 × 10−10). We found no evidence of interaction between schizophrenia PRS and patterns of cannabis use.
Conclusions
Regular use of high-potency cannabis remains a strong predictor of psychotic disorder independently of schizophrenia PRS, which does not seem to be associated with heavy cannabis use. These are important findings at a time of increasing use and potency of cannabis worldwide.
Fast and efficient identification is critical for reducing the likelihood of weed establishment and for appropriately managing established weeds. Traditional identification tools require either knowledge of technical morphological terminology or time-consuming image matching by the user. In recent years, deep learning computer vision models have become mature enough to enable automatic identification. The major remaining bottlenecks are the availability of a sufficient number of high-quality, reliably identified training images and the user-friendly, mobile operationalization of the technology. Here, we present the first weed identification and reporting app and website for all of Australia. It includes an image classification model covering more than 400 species of weeds and some Australian native relatives, with a focus on emerging biosecurity threats and spreading weeds that can still be eradicated or contained. It links the user to additional information provided by state and territory governments, flags species that are locally reportable or notifiable, and allows the creation of observation records in a central database. State and local weed officers can create notification profiles to be alerted of relevant weed observations in their area. We discuss the background of the WeedScan project, the approach taken in design and software development, the photo library used for training the WeedScan image classifier, the model itself and its accuracy, and technical challenges and how these were overcome.
Depression is an independent risk factor for cardiovascular disease (CVD), but it is unknown if successful depression treatment reduces CVD risk.
Methods
Using eIMPACT trial data, we examined the effect of modernized collaborative care for depression on indicators of CVD risk. A total of 216 primary care patients with depression and elevated CVD risk were randomized to 12 months of the eIMPACT intervention (internet cognitive-behavioral therapy [CBT], telephonic CBT, and select antidepressant medications) or usual primary care. CVD-relevant health behaviors (self-reported CVD prevention medication adherence, sedentary behavior, and sleep quality) and traditional CVD risk factors (blood pressure and lipid fractions) were assessed over 12 months. Incident CVD events were tracked over four years using a statewide health information exchange.
Results
The intervention group exhibited greater improvement in depressive symptoms (p < 0.01) and sleep quality (p < 0.01) than the usual care group, but there was no intervention effect on systolic blood pressure (p = 0.36), low-density lipoprotein cholesterol (p = 0.38), high-density lipoprotein cholesterol (p = 0.79), triglycerides (p = 0.76), CVD prevention medication adherence (p = 0.64), or sedentary behavior (p = 0.57). There was an intervention effect on diastolic blood pressure that favored the usual care group (p = 0.02). The likelihood of an incident CVD event did not differ between the intervention (13/107, 12.1%) and usual care (9/109, 8.3%) groups (p = 0.39).
Conclusions
Successful depression treatment alone is not sufficient to lower the heightened CVD risk of people with depression. Alternative approaches are needed.
The oxidation state of structural Fe greatly alters surface chemistry, which may have a large influence on clay-organic interactions. The effect of structural-iron oxidation state on chlorinated hydrocarbons at the clay-water interface was examined. Pentachloroethane (5CA) was reacted with oxidized, reduced, and reoxidized forms of three different smectites: montmorillonite, ferruginous smectite, and nontronite in aqueous suspension under controlled-atmosphere conditions. Pentachloroethane was found to adsorb at different rates for the three smectites. A series of 5CA-adsorption rate constants in the presence of these clays showed a strong correlation with the Fe(II) content of the clay (r2 = 0.98). The clay surface behaves as a Brønsted base and promotes 5CA dehydrochlorination. The adsorption kinetics at the clay-water interface were described by the formation of a precursor complex prior to 5CA dehydrochlorination.
Heart rate variability (HRV) can be an indicator of the flexibility of the central and autonomic nervous systems. Heart rate variability biofeedback (HRV-BF) has been shown to validate the neuro-peripheral relationship and enhance the interaction between top-down and bottom-up processes. Few previous studies have focused on the treatment outcomes of HRV-BF in traumatic brain injury, and such studies have been mostly limited to pilot studies or case reports. The purpose of this study is to investigate the efficacy of HRV-BF for neuropsychological functioning in patients with mild traumatic brain injury (mTBI).
Participants and Methods:
Forty-one patients with mTBI were referred from the neurosurgery outpatient program and randomly assigned to a psychoeducation group or a HRV-BF intervention group. The psychoeducation group received standard medical care and one 60-minute psychoeducation session after brain injury. The HRV-BF group received standard medical care and one 60-minute session of the HRV-BF intervention weekly for 10 weeks. All participants received performance-based and self-reported neuropsychological measures of memory, executive function, mood, and information processing at week 1 of injury (pretest) and week 12 (posttest).
Results:
Participants in HRV-BF improved significantly after the intervention compared with the psychoeducation group on the Verbal Learning Test, Frontal Assessment Battery, Verbal Fluency Test, Paced Auditory Serial Addition Test, Trail Making Test, Dysexecutive Questionnaire, Depression Inventory, and Checklist of Post-concussion Symptoms.
Conclusions:
HRV-BF was found to be an efficacious and efficient intervention for improving neuropsychological functioning in patients with mTBI and a potential candidate for mTBI rehabilitation.
Though diet quality is widely recognised as linked to risk of chronic disease, health systems have been challenged to find a user-friendly, efficient way to obtain information about diet. The Penn Healthy Diet (PHD) survey was designed to fill this void. The purposes of this pilot project were to assess the patient experience with the PHD, to validate the accuracy of the PHD against related items in a diet recall and to explore scoring algorithms with relationship to the Healthy Eating Index (HEI)-2015 computed from the recall data. A convenience sample of participants in the Penn Health BioBank was surveyed with the PHD, the Automated Self-Administered 24-hour recall (ASA24) and experience questions. Kappa scores and Spearman correlations were used to compare related questions in the PHD to the ASA24. Numerical scoring, regression tree and weighted regressions were computed for scoring. Participants assessed the PHD as easy to use and were willing to repeat the survey at least annually. The three scoring algorithms were strongly associated with HEI-2015 scores using National Health and Nutrition Examination Survey 2017–2018 data from which the PHD was developed and moderately associated with the pilot replication data. The PHD is acceptable to participants and at least moderately correlated with the HEI-2015. Further validation in a larger sample will enable the selection of the strongest scoring approach.
The Wood Snipe Gallinago nemoricola is one of the least known shorebird species, and its habitat associations are very poorly understood. Here we provide the first assessment of the habitat use of the Wood Snipe during the breeding season. Between May and July 2021 at a 4-km2 alpine meadow in Sichuan province, China, we conducted population surveys and behavioural observations to identify sites where breeding Wood Snipe occurred and foraged. We quantified the habitat characteristics and food resource availability of these sites and compared them with randomly selected “background” sites. Comparison between 34 occurrence sites and 25 background sites indicated that during the breeding season, Wood Snipes are not distributed evenly across alpine meadow habitats, but preferred habitats in the lower part (3,378–3,624 m) of the alpine meadow with intermediate levels of soil moisture. In addition, comparison between 17 foraging sites and 24 background sites showed that the Wood Snipe tended to forage at sites with higher soil fauna abundance. We found weak evidence for denser vegetation cover at its height and no evidence for other biotic habitat variables such as vegetation composition or other abiotic habitat variables such as slope, soil penetrability, or disturbance level to influence Wood Snipe habitat associations. Our results suggest that the actual distribution range of the Wood Snipe during the breeding season may be smaller than expected from the extent of apparently suitable habitat. We advise caution in evaluating the potential habitat availability and distribution of the Wood Snipe, and call for further research to better understand the ecology of this rare species to inform its conservation.
The Good Chinese Lawyer explores the ethical and professional challenges that will confront a law student, and will help them to prepare for life as a lawyer. The book offers principled and pragmatic advice about how to overcome such challenges. It urges readers to examine motives for seeking a career in law, to foster a deep understanding of what it means to be 'good' lawyer, and how to draw on virtue and judgment when difficult choices arise, rather than simply relying on rushed compliance with rules or codes. The Good Chinese Lawyer analyses four important areas of legal ethics – truth and deception, professional secrets, conflicts of interest, and professional competence – and explains the choices that are available when determining a course of moral action. It links theory to practice, and includes many diagrams and scenarios to illustrate ethical concepts and good decision-making.
Adaptation by
Adrian Evans, Monash University, Victoria,Richard Wu, The University of Hong Kong,Shenjian Xu, China University of Political Science and Law, Beijing
Adaptation by
Adrian Evans, Monash University, Victoria,Richard Wu, The University of Hong Kong,Shenjian Xu, China University of Political Science and Law, Beijing
Adaptation by
Adrian Evans, Monash University, Victoria,Richard Wu, The University of Hong Kong,Shenjian Xu, China University of Political Science and Law, Beijing
Adaptation by
Adrian Evans, Monash University, Victoria,Richard Wu, The University of Hong Kong,Shenjian Xu, China University of Political Science and Law, Beijing
Adaptation by
Adrian Evans, Monash University, Victoria,Richard Wu, The University of Hong Kong,Shenjian Xu, China University of Political Science and Law, Beijing
We owe our first duty to the law and to the stability of society and our second to the courts. Only then can we consider our clients and others. But some lawyers put their clients first (out of concern for their fees), and the rule of law suffers. Key issues include hiding documents, defending apparently ‘guilty’ people and evading tax. Lawyers can ignore their own character development and try to draw distinctions between active and passivedeceit, especially in relation to taxation. We analyse several unethical scenarios, for example, lawyers who encourage some clients to evade tax by characterising it as avoidance and ‘arguably legal’. General morality – that is, consequentialism, Kantian ethics, virtue ethics and Confucian teaching – and the three sets of conduct rules that apply in the PRC, Hong Kong SAR and Taiwan, suggest that good tax lawyers’ efforts to assist their clients to pay less tax within the law will be evident from the transparency of their advice and their accountability in their keeping of proper records. These virtues operate in the context of a wider loyalty to clients: to keep them out of the hands of state authorities investigating taxation infringements.
Adaptation by
Adrian Evans, Monash University, Victoria,Richard Wu, The University of Hong Kong,Shenjian Xu, China University of Political Science and Law, Beijing
‘Negligence’ is frightening to think about, but accepting the possibility of making mistakes as lawyers does not mean we ought to give up on a desire to perform to the best of our ability, and at the peak of our moral consciousness. This chapter applies morality to our technical competence. In the hothouse atmosphere of competitive law firms, the underlying conflict between commercialism and professionalism leads to moral as well as financial risk. Only true professionalism – which emphasizes the dual virtues of integrity and competence – will sustainably support your future. Too much concentration on the business of law and profit can and does lead to the temptation to ‘borrow’ clients’ money and to carelessness. There are extensive conduct and accounting rules that focus on accounting honestly for clients’ money, especially for lawyers who practise across international borders, and we should back that up by arranging professional indemnity (malpractice) insurance against any negligence. In addition, risk management, continuing legal education and specialist accreditation courses are all available through the internet to support you, even if not available through a bar association
Adaptation by
Adrian Evans, Monash University, Victoria,Richard Wu, The University of Hong Kong,Shenjian Xu, China University of Political Science and Law, Beijing
Technical challenges for lawyers impact on our ethics. Some predict that singularity technologies will progressively merge human and machine intelligences. These may become evident in knowledge processing and therefore affect litigation, with potential for such merged intelligences to minimize moral accountability. Perhaps machine intelligences will progressively calculate which actions are ‘better’ in rigid consequentialist terms, ignoring competing moral frameworks described in this book, and government authority will be challenged. Speculation, of course, but there is unlikely to be a lessening in the need for moral leadership from law school deans, bar association presidents and leading practitioners, as Greater China strives for overall sustainability. Arguably, with our lawyers’ sensitivity to virtue and Confucian teaching we might conclude that narrow role morality is no longer enough. Our final social utility (and the reason for any social and economic privileges we retain as lawyers) may lie in our willingness to help whole communities access practical justice: that is, genuine equality of access to health, food, housing and education.
Adaptation by
Adrian Evans, Monash University, Victoria,Richard Wu, The University of Hong Kong,Shenjian Xu, China University of Political Science and Law, Beijing
Client confidentiality expresses the duty of loyalty to our clients, but our secrets are shrinking. Social media, hacking and surveillance are increasingly modern realities. Globally, concern about leaky ‘cloud’ storage, terrorism, corruption, organised crime and money laundering, as well as economic and trading challenges to state and public security, are reportable and create an environment in which lawyers cannot guarantee clients’ privacy. Nevertheless, professional secrecy remains important for lawyers to observe, because clients will not trust us if they think their affairs will be disclosed. We tabulate the confidentiality conduct rules across Greater China and analyze several scenarios according to the four frameworks of general morality. Deciding to keep a secret for good reasons can be a moral act that increases the stability of society. In the mainstream of cases where there are no state secrecy issues, lawyers need to re-legitimize support for client confidentiality because keeping secrets is still important to our communities, so that filial and personal relationships are respected and the common privacy we all need is retained.
Adaptation by
Adrian Evans, Monash University, Victoria,Richard Wu, The University of Hong Kong,Shenjian Xu, China University of Political Science and Law, Beijing
Legal ethics challenges us to do the right thing when no one is looking. Beware the lawyer who tells you that something is ‘arguably legal’. Clinical legal education in your law school helps with the answer, because it places you in contact with real clients and teaches how to be a moral lawyer. But do we choose the right thing according to law only, or law and something else? Here, we use a detailed table to examine how Chinese relational ethics are strengthened by comparisons with Western duty-based and virtue ethics frameworks, in contexts including: understanding duty versus (v) knowing your values; education through law or through character development?; asking what should I do v who should I be, v to whom do I owe respect and obedience?; action v character v harmony; rightness v excellence v social cohesion; absolute duties v judgment in choosing virtues v the Confucian balance between all; general principles v particular circumstances v loyalty in pursuit of harmony; reason v emotion v respect in relationships; rule logic v caring perspectives v appropriate role relationships; and the contrasts between universal values, cultural relativity and the political community.
Adaptation by
Adrian Evans, Monash University, Victoria,Richard Wu, The University of Hong Kong,Shenjian Xu, China University of Political Science and Law, Beijing
Adaptation by
Adrian Evans, Monash University, Victoria,Richard Wu, The University of Hong Kong,Shenjian Xu, China University of Political Science and Law, Beijing
We should act for only one client at a time, to avoid a conflict of interest (or a conflict of loyalty). So what happens when your law firm as a whole has two commercial clients trying to negotiate a merger and one lawyer in one team ‒ yourself ‒ suddenly learns something damaging about the other client that could derail the merger? Traditional role morality, virtue ethics and Confucian teaching require us to avoid situations where interests conflict. Loyalty is not contentious for most of us, except when we are setting our fees. However, the professional conduct rules that apply to current (concurrent) client conflicts and current–former (successive) client conflicts are some of the most complex in Greater China. Utilising scenarios around Big Pharma patents’ disputes, competing airlines and competing steelmakers, our diagrams set out the conduct rules of Greater China and suggest solutions according to general morality. Avoid joint representation in commercially competitive areas – regardless of an information barrier – and where a conflict emerges due to a firm merger, cease acting for both parties.