Patients with ‘secondary’ affective disorder differ from those with ‘primary’ affective disorder in that there are additional symptoms of their pre-existing illness among the former. Hysteria, anxiety neurosis, antisocial personality, alcoholism, and drug dependency are the psychiatric conditions most frequently associated with ‘secondary’ affective disorders. There are other differences which may also be related to the presence of pre-existing illness. These differences include the findings that patients with ‘secondary’ affective disorder are younger, more often male, and are rarely manic; they suggest that it is appropriate to distinguish between ‘primary’ and ‘secondary’ affective disorder for research purposes.

A multiple-scale perturbation expansion is applied to extract a closed system of two equations governing the scalar descriptors of the turbulence energy spectrum from a spectral closure model. The result applies when the length scale and total energy input of a force that maintains a steady state of homogeneous isotropic turbulence are perturbed slowly and the energy spectrum consequently evolves slowly compared to the time scales of the turbulence itself.

The high contrast (typically $10^{10}$) and small angular separation between a planet and its parent star are the main challenges that need to be overcome to detect and characterize Earth-like planets around the nearest stars. Therefore, exoplanet imaging requires the use of a coronagraph, that ideally efficiently cancels the light from the star and has minimal influence on the planet image. The Phase Induced Amplitude Apodization Coronagraph relies on pupil apodization by geometrical remapping of the flux in the pupil plane. This method combines the advantages of classical pupil apodization with high throughput ($\approx$100%) and high angular resolution (${\approx}\lambda/D$), and has some unique advantages over most coronagraphs, such as low chromaticity, low sensitivity to stellar angular size and to small pointing errors. As a result, planet detection time is about 50–100 times shorter in comparison with classical coronagraphic techniques (Martinache et al. 2005).

Both the advantages of the PIAAC and the main factors affecting the performance of the coronograph will be examined in our laboratory experiment in which high quality PIAA optics wilkl be combined with wavefront control to demonstrate achromatic high contrast imaging ($10^6$ or more) at small angular separation (less than $2\lambda/D$). We present here a description and current status of this experiment together with a short analyses of the main factors affecting the performance of the coronograph.

The Phase-Induced Amplitude Coronagraph (PIAAC) uses a lossless beam apodization, performed by aspheric mirrors, to produce a high contrast PSF. Thanks to the lossless apodization, this concept offers a unique combination of high theoretical throughput ($\approx$100%), high angular resolution ($\lambda/d$), small inner working angle (${\approx} 1.5 \lambda/d$), low chromaticity and low sensitivity to pointing errors or angular star diameter. Together, these characteristics make the PRC an ideal choice for direct imaging of extrasolar terrestrial planets (ETPs) from space. We show that a visible telescope smaller than 4m would then achieve the goals of the TPF mission, while other coronagraphs considered for TPF require telescope diameters typically 2 to 3 times larger. On a large size (8m) space telescope, ETPs can be searched for around a significantly larger sample of stars, thus enabling a much higher scientific return.

SAO has set up a testbed to study coronagraphic techniques, starting with Labeyrie's multi-step speckle reduction technique. This technique expands the general concept of a coronagraph by incorporating a speckle corrector (phase and/or amplitude) in combination with a second occulter for speckle light suppression. The correction function is derived applying the phase diversity method on images taken in focus and slightly out-of-focus. The occulter masks for the testbed will initially be produced lithographically. However, in a parallel program we are studying a new manufacturing method. This method utilizes focussed ion beams and will directly mill the mask shape into absorbing material deposited on a transparent substrate.

Visible Nulling Coronagraphy (VNC) is the proposed method of detecting and characterizing exo-solar Jovian planets (null depth $10^{-9}$) for the proposed NASA's Extrasolar Planetary Imaging Coronagraph (EPIC) Clampin & Lyon 2004 and is an approach under evaluation for NASA's Terrestrial Planet Finder (TPF) mission. The VNC approach uses a single unobscured filled-aperture telescope and splits, via a 50:50 beamsplitter, its re-imaged pupil into two paths within a Mach-Zender interferometer. An achromatic PI phase shift is imposed onto one beam path and the two paths are laterally sheared with respect to each other. The two beams are recombined at a second 50:50 beamsplitter. The net effect is that the on axis (stellar) light is transmitted out of the bright interferometer arm while the off-axis (planetary) light is transmitted out of the nulled interferometer arm. The bright output is used for fine pointing control and coarse wavefront control. The nulled output is relayed to the science camera for science imagery and fine wavefront control. The actual transmission pattern, projected on the sky, follows a $\theta^2$ pattern for a single shear, $\theta^4$ for a double shear, with the spacing of the successive maxima proportional to the inverse of the relative lateral shear. Combinations of shears and spacecraft rolls build up the spatial frequency content of the sky transmission pattern in the same manner as imaging interferometer builds up the spatial frequency content of the image.

Since Schiavone and Kaldor (16) reported the incidental finding of increased creatine Phosphokinase (CPK) in patients with schizophrenia a number of studies of the enzyme have appeared in the literature. Bengzon et al. (2), reported among a group of 30 schizophrenics, CPK elevations, which returned to normal during the course of treatment with phenothiazines. These authors investigated a second group of 60 untreated patients who were ‘acutely psychotic’ and found abnormally high CPK levels in half of them. However no mention was made of diagnostic criteria, nor of attempts to control for extraneous circumstances known to elevate the enzyme.

Though divorce is frequent among psychiatric patients, its relative frequency among persons with various psychiatric disorders remains unclear. In addition, it is unclear to what extent family history variables, variables of the sexual history or marital history, or environmental deprivation are associated with divorce.

The classification of affective disorders has been a topic of controversy for years. The literature is filled with tentative attempts to order this large group of patients. Such attempts have brought surprisingly little resolution of the issues involved. There are those who would make numerous subdivisions within the affective disorders, and others who see affective illness as a unitary disorder.

In 1962, Perley and Guze introduced specific criteria for the diagnosis of hysteria based on clinical observations made in 1951 by Purtell, Robins and Cohen. A number of reports have been published since 1962 evaluating the limits and usefulness of these criteria. A recent paper by Guze (1967) summarizes a large part of this work and explores various problems of definition and methodology. In 1968, two papers appeared in this journal evaluating the criteria for hysteria by applying them to women with chronic medical illnesses (Woodruff) and to normal women (Farley, Woodruff and Guze). The present study is an extension of the method used in those reports.

In 1962, Perley and Guze introduced objective criteria for the diagnosis of hysteria (Perley and Guze, 1962). These criteria were essentially a quantification of clinical observations which had appeared in the literature previously, notably in the work of Purtell, Robins and Cohen (1951). The Perley and Guze criteria for the diagnosis of hysteria offered several important advantages. First, they were derived from observations of the natural history of hysteria. They were straightforward and objective, suggesting that they could be used reliably by different clinicians in different places. Second, the criteria were accompanied by a follow-up study which indicated that diagnoses of hysteria made by means of the Perley-Guze criteria would be stable over a six to eight year period in 90 per cent. of cases. Put another way, these criteria selected a population homogeneous in prognosis. The stability of such a population over time is of particular importance. The original Perley-Guze paper and a further study by Gatfield and Guze (1962) both described the prognosis of patients selected by looser criteria. When conversion (pseudoneurologic) symptoms alone were the criteria of diagnosis, patients developed a bewildering array of psychiatric, medical and neurological illnesses within a few short years. In contrast, the Perley-Guze criteria for the diagnosis of hysteria predict prognosis accurately and represent a significant advance in descriptive, clinical psychiatry.

Since 1962, a series of studies have appeared in the psychiatric literature which define hysteria with increasing precision, differentiating that syndrome from the presence of conversion symptoms alone. Hysteria was described in a recognizable fashion more than a century ago by Briquet (1859). Some fifty years later, the syndrome was redescribed by Savill (1909). After a further period of nearly fifty years, Purtell, Robins and Cohen described hysteria as it occurred in a controlled series of patients (1951). Working from Purtell's clinical data, Perley and Guze introduced specific checklist criteria for the diagnosis of hysteria in 1962. These criteria defined a female population homogeneous in prognosis, a population to be distinguished from that defined by conversion symptoms alone. Conversion symptoms are seen in a variety of medical and psychiatric illnesses, and by themselves, conversion symptoms are of little prognostic value (Gatfield and Guze, 1962; Perley and Guze, 1962; Slater and Glithero, 1965).

Since 1932 the amylobarbitone (amobarbital sodium, Amytal) interview has been used as a technique for diagnostic evaluation of patients with psychiatric illnesses (Lindemann, 1932). Amytal has also been used to make mute patients talk, as a sedative, a mood elevator, and as an agent in various other types of psychiatric treatment such as sleep therapy, abreaction, narcoanalysis (Horsley, 1936), narcosynthesis (Grinker et al., 1945), narcosuggestion, and narcoplexis (Brickner et al., 1950).