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4 Evaluating Plasma GFAP for the Detection of Alzheimer’s Disease Dementia
- Madeline Ally, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Thomas K. Karikari, Hugo Aparicio, Michael A. Sugarman, Brandon Frank, Yorghos Tripodis, Ann C. McKee, Thor D. Stein, Brett Martin, Joseph N. Palmisano, Eric G. Steinberg, Irene Simkina, Lindsay Farrer, Gyungah Jun, Katherine W. Turk, Andrew E. Budson, Maureen K. O’Connor, Rhoda Au, Wei Qiao Qiu, Lee E. Goldstein, Ronald Killiany, Neil W. Kowall, Robert A. Stern, Jesse Mez, Michael L. Alosco
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- Journal:
- Journal of the International Neuropsychological Society / Volume 29 / Issue s1 / November 2023
- Published online by Cambridge University Press:
- 21 December 2023, pp. 408-409
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Objective:
Blood-based biomarkers represent a scalable and accessible approach for the detection and monitoring of Alzheimer’s disease (AD). Plasma phosphorylated tau (p-tau) and neurofilament light (NfL) are validated biomarkers for the detection of tau and neurodegenerative brain changes in AD, respectively. There is now emphasis to expand beyond these markers to detect and provide insight into the pathophysiological processes of AD. To this end, a reactive astrocytic marker, namely plasma glial fibrillary acidic protein (GFAP), has been of interest. Yet, little is known about the relationship between plasma GFAP and AD. Here, we examined the association between plasma GFAP, diagnostic status, and neuropsychological test performance. Diagnostic accuracy of plasma GFAP was compared with plasma measures of p-tau181 and NfL.
Participants and Methods:This sample included 567 participants from the Boston University (BU) Alzheimer’s Disease Research Center (ADRC) Longitudinal Clinical Core Registry, including individuals with normal cognition (n=234), mild cognitive impairment (MCI) (n=180), and AD dementia (n=153). The sample included all participants who had a blood draw. Participants completed a comprehensive neuropsychological battery (sample sizes across tests varied due to missingness). Diagnoses were adjudicated during multidisciplinary diagnostic consensus conferences. Plasma samples were analyzed using the Simoa platform. Binary logistic regression analyses tested the association between GFAP levels and diagnostic status (i.e., cognitively impaired due to AD versus unimpaired), controlling for age, sex, race, education, and APOE e4 status. Area under the curve (AUC) statistics from receiver operating characteristics (ROC) using predicted probabilities from binary logistic regression examined the ability of plasma GFAP to discriminate diagnostic groups compared with plasma p-tau181 and NfL. Linear regression models tested the association between plasma GFAP and neuropsychological test performance, accounting for the above covariates.
Results:The mean (SD) age of the sample was 74.34 (7.54), 319 (56.3%) were female, 75 (13.2%) were Black, and 223 (39.3%) were APOE e4 carriers. Higher GFAP concentrations were associated with increased odds for having cognitive impairment (GFAP z-score transformed: OR=2.233, 95% CI [1.609, 3.099], p<0.001; non-z-transformed: OR=1.004, 95% CI [1.002, 1.006], p<0.001). ROC analyses, comprising of GFAP and the above covariates, showed plasma GFAP discriminated the cognitively impaired from unimpaired (AUC=0.75) and was similar, but slightly superior, to plasma p-tau181 (AUC=0.74) and plasma NfL (AUC=0.74). A joint panel of the plasma markers had greatest discrimination accuracy (AUC=0.76). Linear regression analyses showed that higher GFAP levels were associated with worse performance on neuropsychological tests assessing global cognition, attention, executive functioning, episodic memory, and language abilities (ps<0.001) as well as higher CDR Sum of Boxes (p<0.001).
Conclusions:Higher plasma GFAP levels differentiated participants with cognitive impairment from those with normal cognition and were associated with worse performance on all neuropsychological tests assessed. GFAP had similar accuracy in detecting those with cognitive impairment compared with p-tau181 and NfL, however, a panel of all three biomarkers was optimal. These results support the utility of plasma GFAP in AD detection and suggest the pathological processes it represents might play an integral role in the pathogenesis of AD.
5 Antemortem Plasma GFAP Predicts Alzheimer’s Disease Neuropathological Changes
- Madeline Ally, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Thomas K. Karikari, Hugo Aparicio, Michael A. Sugarman, Brandon Frank, Yorghos Tripodis, Brett Martin, Joseph N. Palmisano, Eric G. Steinberg, Irene Simkina, Lindsay Farrer, Gyungah Jun, Katherine W. Turk, Andrew E. Budson, Maureen K. O’Connor, Rhoda Au, Wei Qiao Qiu, Lee E. Goldstein, Ronald Killiany, Neil W. Kowall, Robert A. Stern, Jesse Mez, Bertran R. Huber, Ann C. McKee, Thor D. Stein, Michael L. Alosco
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- Journal:
- Journal of the International Neuropsychological Society / Volume 29 / Issue s1 / November 2023
- Published online by Cambridge University Press:
- 21 December 2023, pp. 409-410
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Objective:
Blood-based biomarkers offer a more feasible alternative to Alzheimer’s disease (AD) detection, management, and study of disease mechanisms than current in vivo measures. Given their novelty, these plasma biomarkers must be assessed against postmortem neuropathological outcomes for validation. Research has shown utility in plasma markers of the proposed AT(N) framework, however recent studies have stressed the importance of expanding this framework to include other pathways. There is promising data supporting the usefulness of plasma glial fibrillary acidic protein (GFAP) in AD, but GFAP-to-autopsy studies are limited. Here, we tested the association between plasma GFAP and AD-related neuropathological outcomes in participants from the Boston University (BU) Alzheimer’s Disease Research Center (ADRC).
Participants and Methods:This sample included 45 participants from the BU ADRC who had a plasma sample within 5 years of death and donated their brain for neuropathological examination. Most recent plasma samples were analyzed using the Simoa platform. Neuropathological examinations followed the National Alzheimer’s Coordinating Center procedures and diagnostic criteria. The NIA-Reagan Institute criteria were used for the neuropathological diagnosis of AD. Measures of GFAP were log-transformed. Binary logistic regression analyses tested the association between GFAP and autopsy-confirmed AD status, as well as with semi-quantitative ratings of regional atrophy (none/mild versus moderate/severe) using binary logistic regression. Ordinal logistic regression analyses tested the association between plasma GFAP and Braak stage and CERAD neuritic plaque score. Area under the curve (AUC) statistics from receiver operating characteristics (ROC) using predicted probabilities from binary logistic regression examined the ability of plasma GFAP to discriminate autopsy-confirmed AD status. All analyses controlled for sex, age at death, years between last blood draw and death, and APOE e4 status.
Results:Of the 45 brain donors, 29 (64.4%) had autopsy-confirmed AD. The mean (SD) age of the sample at the time of blood draw was 80.76 (8.58) and there were 2.80 (1.16) years between the last blood draw and death. The sample included 20 (44.4%) females, 41 (91.1%) were White, and 20 (44.4%) were APOE e4 carriers. Higher GFAP concentrations were associated with increased odds for having autopsy-confirmed AD (OR=14.12, 95% CI [2.00, 99.88], p=0.008). ROC analysis showed plasma GFAP accurately discriminated those with and without autopsy-confirmed AD on its own (AUC=0.75) and strengthened as the above covariates were added to the model (AUC=0.81). Increases in GFAP levels corresponded to increases in Braak stage (OR=2.39, 95% CI [0.71-4.07], p=0.005), but not CERAD ratings (OR=1.24, 95% CI [0.004, 2.49], p=0.051). Higher GFAP levels were associated with greater temporal lobe atrophy (OR=10.27, 95% CI [1.53,69.15], p=0.017), but this was not observed with any other regions.
Conclusions:The current results show that antemortem plasma GFAP is associated with non-specific AD neuropathological changes at autopsy. Plasma GFAP could be a useful and practical biomarker for assisting in the detection of AD-related changes, as well as for study of disease mechanisms.
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. 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Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- The Cambridge Dictionary of Philosophy
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- 05 August 2015
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- 27 April 2015, pp ix-xxx
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- By Christopher Ames, Cathy W. Barks, Ronald Berman, Anthony J. Berret, Robert Beuka, William Blazek, Elisabeth Bouzonviller, Jackson R. Bryer, Deborah Clarke, Gretchen Comba, Kirk Curnutt, Linda De Roche, Suzanne Del Gizzo, Kathleen Drowne, Richard Fine, Edward Gillin, Michael K. Glenday, Richard Godden, Steven Goldleaf, Peter L. Hays, Pearl James, Joel Kabot, Heidi M. Kunz, Jarom Lyle McDonald, Philip McGowan, Bonnie Shannon McMullen, Bryant Mangum, Lauren Rule Maxwell, James H. Meredith, Linda Patterson Miller, James Nagel, Michael Nowlin, Ruth Prigozy, Laura Rattray, Walter Raubicheck, Deborah Davis Schlacks, Gail D. Sinclair, Robert Sklar, Linda Wagner-Martin, James L. W. West, Doni M. Wilson
- Edited by Bryant Mangum, Virginia Commonwealth University
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- F. Scott Fitzgerald in Context
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- 05 February 2013
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- 18 March 2013, pp xi-xx
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- By Alfredo Aguilar, Klaus Ammann, Tina Barsby, David Baulcombe, Roger Beachy, David J. Bennett, Jack A. Bobo, Graham Brookes, Samuel Burckhardt, Claudia Canales Holzeis, Mark F. Cantley, Eugenio J. Cap, Danuta Cichocka, Gordon Conway, Adrian Dubock, Jim M. Dunwell, Ioannis Economidis, Claude Fischler, George Gaskell, Ian Graham, Julian Gray, Jonathan Gressel, Brian Heap, T. J. V. Higgins, Jens Högel, Richard C. Jennings, Drew L. Kershen, Christopher J. Leaver, Lu Bao-rong, Diran Makinde, Carel du Marchie Sarvaas, Nathalie Moll, Larry Murdock, Martin Porter, Wayne Powell, Tim Radford, Chavali Kameswara Rao, Pamela Ronald, Piet Schenkelaars, Idah Sithole-Niang, Sally Stares, Eduardo J. Trigo, Piero Venturi, Katy Wilson
- Edited by David J. Bennett, St Edmund's College, Cambridge, Richard C. Jennings, University of Cambridge
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- Successful Agricultural Innovation in Emerging Economies
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- 05 March 2013
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- 07 March 2013, pp viii-xxviii
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Recommendations for Nanomedicine Human Subjects Research Oversight: An Evolutionary Approach for an Emerging Field
- Leili Fatehi, Susan M. Wolf, Jeffrey McCullough, Ralph Hall, Frances Lawrenz, Jeffrey P. Kahn, Cortney Jones, Stephen A. Campbell, Rebecca S. Dresser, Arthur G. Erdman, Christy L. Haynes, Robert A. Hoerr, Linda F. Hogle, Moira A. Keane, George Khushf, Nancy M. P. King, Efrosini Kokkoli, Gary Marchant, Andrew D. Maynard, Martin Philbert, Gurumurthy Ramachandran, Ronald A. Siegel, Samuel Wickline
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- Journal:
- Journal of Law, Medicine & Ethics / Volume 40 / Issue 4 / Winter 2012
- Published online by Cambridge University Press:
- 01 January 2021, pp. 716-750
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- Winter 2012
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Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions (often defined as 1-100 nm, but sometimes defined to include dimensions up to 1000 nm, as discussed further below) where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products (biologics), implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. Nanotherapeutics and in vivo nanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes (including the bloodbrain barrier) and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents.
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- By Lee R. Berger, Fred L. Bookstein, Günter Bräuer, Michel Brunet, Steven E. Churchill, Ronald J. Clarke, M. Christopher Dean, Michelle S. M. Drapeau, Sarah Elton, Dean Falk, Andrew Gallagher, John A. J. Gowlett, Colin Groves, Philipp Gunz, Adam Hartstone-Rose, Jason Hemingway, Ralph L. Holloway, Vance T. Hutchinson, William L. Jungers, Ivor Janković, Kevin L. Kuykendall, Sang-Hee Lee, Julia Lee-Thorp, Paul R. Manger, Emma Mbua, Henry M. McHenry, Philipp Mitteroecker, Simon Neubauer, Osbjorn M. Pearson, Travis R. Pickering, Martin Pickford, Sally C. Reynolds, Brian G. Richmond, Avraham Ronen, Darryl J. de Ruiter, Brigitte Senut, Fred H. Smith, Muhammad A. Spocter, Matt Sponheimer, J. Francis Thackeray, Phillip V. Tobias, Peter S. Ungar, Lyn Wadley, Gerhard W. Weber, Milford H. Wolpoff, B. Headman Zondo
- Edited by Sally C. Reynolds, University of the Witwatersrand, Johannesburg, Andrew Gallagher, University of Johannesburg
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- African Genesis
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- 05 April 2012
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- 29 March 2012, pp viii-xii
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DIVISION IX / COMMISSION 25 / WORKING GROUP INFRARED ASTRONOMY
- Eugene F. Milone, Andrew T. Young, Roger A. Bell, Michael Bessell, Richard P. Boyl, Brian Carter, T. Alan Clark, Martin Cohen, David J.I. Fry, Robert Garrison, Ian S. Glass, John Graham, Anahi Granada, Lynn Hillenbrand, Robert L. Kurucz, Ian McLean, Matthew Mountain, George Riecke, Rogerio Riffel, Ronald G. Samec, Stephen J. Schiller, Douglas Simons, Michael Skrutskie, C. Russell Stagg, Christiaan L. Sterken, Roger I. Thompson, Alan Tokunaga, Kevin Volk, Robert Wing
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- Proceedings of the International Astronomical Union / Volume 7 / Issue T28A / December 2011
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- 04 April 2012, pp. 297-302
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- December 2011
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The formal commissioning of the IRWG occurred at the 1991 Buenos Aires General Assembly, following a Joint Commission meeting at the IAU GA in Baltimore in 1988 that identified the problems with ground-based infrared photometry. The meeting justification, papers, and conclusions, can be found in Milone (1989). In summary, the challenges involved how to explain the failure to achieve the milli-magnitude precision expected of infrared photometry and an apparent 3% limit on system transformability. The proposed solution was to redefine the broadband Johnson system, the passbands of which had proven so unsatisfactory that over time effectively different systems proliferated, although bearing the same “JHKLMNQ” designations; the new system needed to be better positioned and centered in the spectral windows of the Earth's atmosphere, and the variable water vapour content of the atmosphere needed to be measured in real time to better correct for atmospheric extinction.
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- By Eric Adler, Anoushka Afonso, Dean B. Andropoulos, Adel Bassily-Marcus, Yaakov Beilin, Elliott Bennett-Guerrero, Howard H. Bernstein, Marc J. Bloom, David Bronheim, Albert T. Cheung, Samuel DeMaria, Deborah Dubensky, James B. Eisenkraft, Jonathan Elmer, Liza J. Enriquez, Jonathan Epstein, Jeffrey M. Feldman, Gregory W. Fischer, Brigid Flynn, Jennifer A. Frontera, Richard S. Gist, Glenn P. Gravlee, Christina L. Jeng, Ronald A. Kahn, Jenny Kam, Mukul Kapoor, Jung Kim, Roopa Kohli-Seth, Aaron F. Kopman, Tuula S. O. Kurki, Andrew B. Leibowitz, Matthew Levin, Adam I. Levine, Michael S. Lewis, Justin Lipper, Martin London, Michael L. McGarvey, Alexander J. C. Mittnacht, Timothy Mooney, Diana Mungall, Yasuharu Okuda, Peter J. Papadakos, Jayashree Raikhelkar, Lakshmi V. Ramanathan, David L. Reich, Meg A. Rosenblatt, Corey Scurlock, Tamas Seres, Linda Shore-Lesserson, Marc E. Stone, Daniel M. Thys, Judit Tolnai, David Wax, Nathaen Weitzel
- David L. Reich, Mount Sinai School of Medicine, New York
- Edited by Ronald A. Kahn, Mount Sinai School of Medicine, New York, Alexander J. C. Mittnacht, Mount Sinai School of Medicine, New York, Andrew B. Leibowitz, Mount Sinai School of Medicine, New York, Marc E. Stone, Mount Sinai School of Medicine, New York, James B. Eisenkraft, Mount Sinai School of Medicine, New York
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- Book:
- Monitoring in Anesthesia and Perioperative Care
- Published online:
- 05 July 2011
- Print publication:
- 08 August 2011, pp vii-ix
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. 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Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. Rubenstein, Rosemary Radford Ruether, Markku Ruotsila, John E. Rybolt, Risto Saarinen, John Saillant, Juan Sanchez, Wagner Lopes Sanchez, Hugo N. Santos, Gerhard Sauter, Gloria L. Schaab, Sandra M. Schneiders, Quentin J. Schultze, Fernando F. Segovia, Turid Karlsen Seim, Carsten Selch Jensen, Alan P. F. Sell, Frank C. Senn, Kent Davis Sensenig, Damían Setton, Bal Krishna Sharma, Carolyn J. Sharp, Thomas Sheehan, N. Gerald Shenk, Christian Sheppard, Charles Sherlock, Tabona Shoko, Walter B. Shurden, Marguerite Shuster, B. Mark Sietsema, Batara Sihombing, Neil Silberman, Clodomiro Siller, Samuel Silva-Gotay, Heikki Silvet, John K. Simmons, Hagith Sivan, James C. Skedros, Abraham Smith, Ashley A. Smith, Ted A. Smith, Daud Soesilo, Pia Søltoft, Choan-Seng (C. S.) Song, Kathryn Spink, Bryan Spinks, Eric O. Springsted, Nicolas Standaert, Brian Stanley, Glen H. Stassen, Karel Steenbrink, Stephen J. Stein, Andrea Sterk, Gregory E. Sterling, Columba Stewart, Jacques Stewart, Robert B. Stewart, Cynthia Stokes Brown, Ken Stone, Anne Stott, Elizabeth Stuart, Monya Stubbs, Marjorie Hewitt Suchocki, David Kwang-sun Suh, Scott W. Sunquist, Keith Suter, Douglas Sweeney, Charles H. Talbert, Shawqi N. Talia, Elsa Tamez, Joseph B. Tamney, Jonathan Y. Tan, Yak-Hwee Tan, Kathryn Tanner, Feiya Tao, Elizabeth S. Tapia, Aquiline Tarimo, Claire Taylor, Mark Lewis Taylor, Bishop Abba Samuel Wolde Tekestebirhan, Eugene TeSelle, M. Thomas Thangaraj, David R. Thomas, Andrew Thornley, Scott Thumma, Marcelo Timotheo da Costa, George E. “Tink” Tinker, Ola Tjørhom, Karen Jo Torjesen, Iain R. Torrance, Fernando Torres-Londoño, Archbishop Demetrios [Trakatellis], Marit Trelstad, Christine Trevett, Phyllis Trible, Johannes Tromp, Paul Turner, Robert G. Tuttle, Archbishop Desmond Tutu, Peter Tyler, Anders Tyrberg, Justin Ukpong, Javier Ulloa, Camillus Umoh, Kristi Upson-Saia, Martina Urban, Monica Uribe, Elochukwu Eugene Uzukwu, Richard Vaggione, Gabriel Vahanian, Paul Valliere, T. J. 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Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
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- 05 August 2012
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- 20 September 2010, pp xi-xliv
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DIVISION IX / COMMISSION 25 / WORKING GROUP: INFRARED ASTRONOMY
- Eugene F. Milone, Andrew T. Young, Roger A. Bell, Michael Bessell, Richard P. Boyl, Martin Cohen, David J.I. Fry, Robert Garrison, Robert Garrison, Ian S. Glass, John Graham, Anahi Granada, Lynn Hillenbrand, Robert L. Kurucz, Ian McLean, Matthew Mountain, George Riecke, Rogerio Riffel, Ronald G. Samec, Stephen J. Schiller, Douglas Simons, Michael Skrutskie, C. Russell Stagg, Christiaan L. Sterken, Roger I. Thompson, Alan Tokunaga, Kevin Volk, Robert Wing
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- Journal:
- Proceedings of the International Astronomical Union / Volume 6 / Issue T27B / December 2010
- Published online by Cambridge University Press:
- 14 May 2010, pp. 229-232
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- December 2010
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The formal origin of the IRWG occured at the Buenos Aires General Assembly, following a Joint Commission meeting at the IAU GA in Baltimore in 1988 that identified the problems with ground-based infrared photometry. The situation is summarized in Milone (1989). In short, the challenges involved how to explain the failure to achieve the milli-magnitude precision expected of infrared photometry and an apparent 3% limit on system transformability. The proposed solution was to redefine the broadband Johnson system, the passbands of which had proven so unsatisfactory that over time effectively different systems proliferated, although bearing the same JHKLMNQ designations; the new system needed to be better positioned and centered in the atmospheric windows of the Earth's atmosphere, and the variable water vapour content of the atmosphere needed to be measured in real time to better correct for atmospheric extinction.
21 - Hemoglobin SC Disease and Hemoglobin C Disorders
- from SECTION FIVE - SICKLE CELL DISEASE
- Martin H. Steinberg, Boston University, Bernard G. Forget, Yale University, Connecticut, Douglas R. Higgs, David J. Weatherall, Albert Einstein College of Medicine, New York
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- Disorders of Hemoglobin
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- 03 May 2010
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- 17 August 2009, pp 525-548
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Summary
INTRODUCTION
HbC (HBB glu6lys), along with HbS (HBB glu6val) and HbE (HBB glu26lys), is one of the three most common hemoglobin variants in humankind. Its positive charge that allows it to bind the erythrocyte membrane, and perhaps other unique features of this variant, lead to loss of cell K+ and water, thereby increasing erythrocyte density. HbC disease, defined as homozygosity for the HbC gene, causes mild hemolytic anemia; simple heterozygosity for HbC (HbC trait, HbAC) is innocuous. In HbSC disease, in which the erythrocyte concentration of HbS and HbC is nearly equal, the dehydrated, dense erythrocyte accentuates the deleterious properties of HbS by producing a milieu favoring HbS polymerization. HbSC disease causes vasoocclusive disease and hemolytic anemia, albeit on average both less severe than found in sickle cell anemia (homozygosity for HbS). Like sickle cell anemia, the hematological and clinical features of HbSC disease are heterogeneous, but all of the complications that make sickle cell anemia notorious can be present; some even appear more often in HbSC disease.
HbC and HbC Disease
Origins, Selection, and Distribution of HbC
HbC, the second hemoglobin variant discovered, was described in 1950, and the first homozygous case was reported in 1953. The βC-globin gene contains a GAG→AAG transition and codes for lysine instead of glutamic acid. Shortly after its description in African Americans, HbC was found to be common in Africa.
24 - Unstable Hemoglobins, Hemoglobins with Altered Oxygen Affinity, Hemoglobin M, and Other Variants of Clinical and Biological Interest
- from SECTION SIX - OTHER CLINICALLY IMPORTANT DISORDERS OF HEMOGLOBIN
- Martin H. Steinberg, Boston University, Bernard G. Forget, Yale University, Connecticut, Douglas R. Higgs, David J. Weatherall, Albert Einstein College of Medicine, New York
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- Disorders of Hemoglobin
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- 03 May 2010
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- 17 August 2009, pp 589-606
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Summary
INTRODUCTION
Mutations of hemoglobin can be polymorphic (>1% of a population), like HbS, HbE, HbC, and the thalassemias, or rare. Our first edition listed 750 unique hemoglobin variants; this number is now more than 1,000. In this chapter we address rare mutations. Some are associated with clinical disease; others are interesting solely for the biological principles they illustrate. A current listing of variant human hemoglobins is maintained in the HbVar database at http://globin.cse.psu.edu/, and the journal Hemoglobin (Taylor & Francis, Philadelphia) is a rich source for reports of new variants. Both are invaluable resources for clinicians and investigators with interests in unusual hemoglobin disorders.
Globin gene mutations, which include nearly every class of mutation so far described, except trinucleotide repeats and other nucleotide expansions associated with neuromuscular disorders, provided an early catalog of the mutations that can cause genetic disease. Clinically important but rare mutants affect hemoglobin stability causing premature red cell destruction; interfere with normal oxygen binding kinetics producing erythrocytosis; and permit heme iron oxidation, causing cyanosis. Most rare variants have no phenotype and are of biological and diagnostic interest only.
Comparatively few globin residues are critical for maintaining the structural integrity and functional performance of the molecule (Chapter 6). Hemoglobin gene mutations are, as a rule, not associated with hematological or clinical abnormalities and escape detection, especially when they are chromatographically silent.
Large-scale population screening programs have defined the worldwide prevalence of medically important hemoglobinopathies and thalassemias.
7 - Hemoglobins of the Embryo, Fetus, and Adult
- from SECTION ONE - THE MOLECULAR, CELLULAR, AND GENETIC BASIS OF HEMOGLOBIN DISORDERS
- Martin H. Steinberg, Boston University, Bernard G. Forget, Yale University, Connecticut, Douglas R. Higgs, David J. Weatherall, Albert Einstein College of Medicine, New York
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- Disorders of Hemoglobin
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- 03 May 2010
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- 17 August 2009, pp 119-136
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Summary
INTRODUCTION
During development, humans express six different hemoglobin types, the products of eight different globin genes (Fig. 3.1, Chapter 3). Hb Gower I (ς2ε2), Gower II (α2ε2), and Portland (ς2γ2) are found in the embryo, fetal hemoglobin (HbF; α2γ2) is present mainly in the fetus but also in the embryo and adult, whereas HbA (α2β2) and HbA2 (α2δ2) are seen primarily in adults. All hemoglobins undergo posttranslational modifications forming minor hemoglobins. Globin genes are discussed in Chapter 3, hemoglobin switching in Chapter 5, and the structure and function of hemoglobin in Chapter 6 and. In this chapter we discuss the clinical and physiological attributes of HbF, HbA2, embryonic hemoglobins, and their posttranslational modifications.
HEMOGLOBIN F
The observation that hemoglobin in newborns' erythrocytes was resistant to alkaline denaturation provided the first suggestion that a hemoglobin existed that differed from normal HbA.
Structure of the γ-Globin Genes and γ-Globin
γ-Globin chains differ from β-globin chains in either 39 or 40 amino acid residues, depending on whether a glycine or alanine residue is present at γ136. γ-Globin is the product of two nearly identical γ-globin genes. A glycine codon is present in the 5′ or Gγ gene (HBG2) and an alanine codon characterizes the 3′, or Aγ gene (HBG1). Also, a common polymorphism is found in the Aγ gene, where threonine (AγT) replaces isoleucine (AγI) at codon γ75 (HbF-Sardinia). This striking similarity in protein sequence and structure of the γ-globin genes reflect their concerted evolution from gene duplication and gene conversion.
27 - Genetic Modulation of Sickle Cell Disease and Thalassemia
- from SECTION SEVEN - SPECIAL TOPICS IN HEMOGLOBINOPATHIES
- Martin H. Steinberg, Boston University, Bernard G. Forget, Yale University, Connecticut, Douglas R. Higgs, David J. Weatherall, Albert Einstein College of Medicine, New York
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- Disorders of Hemoglobin
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- 03 May 2010
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- 17 August 2009, pp 638-657
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INTRODUCTION
Sickle cell anemia is a typical mendelian, single gene disease. Nevertheless, because of its characteristic phenotypic heterogeneity it resembles a multigenic trait. That is, the mutation in HBB is necessary, but alone insufficient to account for the phenotypic differences among patients, and other genes and the environment are likely to modulate its phenotype. In β thalassemia, and even in HbH disease, genotype–phenotype correlations are also often difficult to establish. Modulation of the phenotypes of these disorders by epistatic and other modifying genes has been a subject of increasing interest. Although studies based on candidate-modulating genes – genes chosen for study on the basis of their possible affects on a phenotype – have started to suggest genes and pathways that might modulate the phenotype of sickle cell anemia, a complete picture of genetic modulators should emerge as genome-wide association studies mature.
It is likely that fetal hemoglobin (HbF) concentration, and its distribution among erythrocytes is the major genetic modulator of both sickle cell disease and the β thalassemias. The coincidence of α thalassemia with sickle cell anemia or β thalassemia is another powerful modulatory influence. Individually, other genetic modulators are likely to have small effects, yet together the interactions of modulatory genes (and environmental factors) might have an important influence on morbidity and mortality.
In this chapter we will first discuss HbF and the genetic elements and genes that might modulate its levels and then the effects of α thalassemia in sickle cell disease and β thalassemia.
SWAS Observations of Comet 9P/Tempel 1 and Deep Impact
- Frank Bensch, Gary J. Melnick, David A. Neufeld, Martin Harwit, Ronald L. Snell, Brian M. Patten
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- Proceedings of the International Astronomical Union / Volume 1 / Issue S231 / August 2005
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- 21 March 2006, pp. 489-490
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- August 2005
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On 4 July 2005 at 5:52 UT the Deep Impact mission successfully completed its goal to hit the nucleus of 9P/Tempel 1 with an impactor, forming a crater on the nucleus and ejecting material into the coma of the comet (A'Hearn et al. 2005). The 370 kg impactor collided with the sunlit side of the nucleus with a relative velocity of 10.2 km s$^{-1}$. NASA's Submillimeter Wave Astronomy Satellite (SWAS) observed the $1_{10}-1_{01}$ ortho-water ground-state rotational transition in comet 9P/Tempel 1 before, during, and after the impact. No excess emission from the impact was detected by SWAS. However, the water production rate of the comet showed large natural variations of more than a factor of three during the weeks before the impact.
2 - The contemporary debate over the North–South divide: images and realities of regional inequality in late-twentieth-century Britain
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- By Ronald L. Martin, Professor of Geography, University of Cambridge; Fellow of St Catharine's College, Cambridge
- Edited by Alan R. H. Baker, Emmanuel College, Cambridge, Mark Billinge, Magdalene College, Cambridge
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- Geographies of England
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- 10 December 2009
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- 24 June 2004, pp 15-43
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Summary
Introduction
In the period since the Second World War, and especially since the 1970s, the unity and meaning of the United Kingdom, virtually unchallenged for two hundred years, has come increasingly into question. One by one, the very forces and assumptions that helped to forge a sense of national identity and common unity, have disappeared. The spell was broken by the Suez debacle in 1956, which compelled the British people at last to begin the painful task of reassessing their sense of themselves and their position in the world. From the mid-1960s onwards, a growing awareness of national relative economic decline – of a progressive slippage of the nation down the international league table of living standards – fuelled the process, and stimulated a flood of jeremiads on the causes and consequences of Britain's economic failure (Manser 1971; Barnett 1972; Kramnick 1975; Allen 1976; Eatwell 1982; Pollard 1982; Roderick and Stephens 1982; Smith 1984), a literary genre that continued into the 1990s (Coates 1994; Hutton 1996; Clarke and Trebilcock 1997). A surge of Scottish and Welsh nationalism in the early 1970s, and the public debate on federalism and devolution this activated, merely compounded the sense of gloom surrounding the state and unity of the nation. Little wonder that political commentators talked of the ‘break up of Britain’ (Nairn 1981).
Working Group on Infrared Astronomy: (Groupe De Travail Pour Astronomie Infrarouge)
- Eugene F. Milone, Ronald Angione, Roger A. Bell, Michael Bessell, T. Alan Clark, Robert Garrison, Martin Cohen, Ian S. Glass, Robert L. Kurucz, Arlo Landolt, Matthew Mountain, George Riecke, Stephen J. Schiller, Douglas A. Simons, Michael Skrutskie, Christopher R. Stagg, Christiaan Sterken, Roger I. Thompson, Alan Tokunaga, Andrew T. Young, Kevin Volk
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- Journal:
- Transactions of the International Astronomical Union / Volume 25 / Issue 1 / 2002
- Published online by Cambridge University Press:
- 25 April 2016, pp. 340-342
- Print publication:
- 2002
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Looking Backward, Looking Forward: MLA Members Speak
- April Alliston, Elizabeth Ammons, Jean Arnold, Nina Baym, Sandra L. Beckett, Peter G. Beidler, Roger A. Berger, Sandra Bermann, J.J. Wilson, Troy Boone, Alison Booth, Wayne C. Booth, James Phelan, Marie Borroff, Ihab Hassan, Ulrich Weisstein, Zack Bowen, Jill Campbell, Dan Campion, Jay Caplan, Maurice Charney, Beverly Lyon Clark, Robert A. Colby, Thomas C. Coleman III, Nicole Cooley, Richard Dellamora, Morris Dickstein, Terrell Dixon, Emory Elliott, Caryl Emerson, Ann W. Engar, Lars Engle, Kai Hammermeister, N. N. Feltes, Mary Anne Ferguson, Annie Finch, Shelley Fisher Fishkin, Jerry Aline Flieger, Norman Friedman, Rosemarie Garland-Thomson, Sandra M. Gilbert, Laurie Grobman, George Guida, Liselotte Gumpel, R. K. Gupta, Florence Howe, Cathy L. Jrade, Richard A. Kaye, Calhoun Winton, Murray Krieger, Robert Langbaum, Richard A. Lanham, Marilee Lindemann, Paul Michael Lützeler, Thomas J. Lynn, Juliet Flower MacCannell, Michelle A. Massé, Irving Massey, Georges May, Christian W. Hallstein, Gita May, Lucy McDiarmid, Ellen Messer-Davidow, Koritha Mitchell, Robin Smiles, Kenyatta Albeny, George Monteiro, Joel Myerson, Alan Nadel, Ashton Nichols, Jeffrey Nishimura, Neal Oxenhandler, David Palumbo-Liu, Vincent P. Pecora, David Porter, Nancy Potter, Ronald C. Rosbottom, Elias L. Rivers, Gerhard F. Strasser, J. L. Styan, Marianna De Marco Torgovnick, Gary Totten, David van Leer, Asha Varadharajan, Orrin N. C. Wang, Sharon Willis, Louise E. Wright, Donald A. Yates, Takayuki Yokota-Murakami, Richard E. Zeikowitz, Angelika Bammer, Dale Bauer, Karl Beckson, Betsy A. Bowen, Stacey Donohue, Sheila Emerson, Gwendolyn Audrey Foster, Jay L. Halio, Karl Kroeber, Terence Hawkes, William B. Hunter, Mary Jambus, Willard F. King, Nancy K. Miller, Jody Norton, Ann Pellegrini, S. P. Rosenbaum, Lorie Roth, Robert Scholes, Joanne Shattock, Rosemary T. VanArsdel, Alfred Bendixen, Alarma Kathleen Brown, Michael J. Kiskis, Debra A. Castillo, Rey Chow, John F. Crossen, Robert F. Fleissner, Regenia Gagnier, Nicholas Howe, M. Thomas Inge, Frank Mehring, Hyungji Park, Jahan Ramazani, Kenneth M. Roemer, Deborah D. Rogers, A. LaVonne Brown Ruoff, Regina M. Schwartz, John T. Shawcross, Brenda R. Silver, Andrew von Hendy, Virginia Wright Wexman, Britta Zangen, A. Owen Aldridge, Paula R. Backscheider, Roland Bartel, E. M. Forster, Milton Birnbaum, Jonathan Bishop, Crystal Downing, Frank H. Ellis, Roberto Forns-Broggi, James R. Giles, Mary E. Giles, Susan Blair Green, Madelyn Gutwirth, Constance B. Hieatt, Titi Adepitan, Edgar C. Knowlton, Jr., Emanuel Mussman, Sally Todd Nelson, Robert O. Preyer, David Diego Rodriguez, Guy Stern, James Thorpe, Robert J. Wilson, Rebecca S. Beal, Joyce Simutis, Betsy Bowden, Sara Cooper, Wheeler Winston Dixon, Tarek el Ariss, Richard Jewell, John W. Kronik, Wendy Martin, Stuart Y. McDougal, Hugo Méndez-Ramírez, Ivy Schweitzer, Armand E. Singer, G. Thomas Tanselle, Tom Bishop, Mary Ann Caws, Marcel Gutwirth, Christophe Ippolito, Lawrence D. Kritzman, James Longenbach, Tim McCracken, Wolfe S. Molitor, Diane Quantic, Gregory Rabassa, Ellen M. Tsagaris, Anthony C. Yu, Betty Jean Craige, Wendell V. Harris, J. Hillis Miller, Jesse G. Swan, Helene Zimmer-Loew, Peter Berek, James Chandler, Hanna K. Charney, Philip Cohen, Judith Fetterley, Herbert Lindenberger, Julia Reinhard Lupton, Maximillian E. Novak, Richard Ohmann, Marjorie Perloff, Mark Reynolds, James Sledd, Harriet Turner, Marie Umeh, Flavia Aloya, Regina Barreca, Konrad Bieber, Ellis Hanson, William J. Hyde, Holly A. Laird, David Leverenz, Allen Michie, J. Wesley Miller, Marvin Rosenberg, Daniel R. Schwarz, Elizabeth Welt Trahan, Jean Fagan Yellin
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- Journal:
- PMLA / Publications of the Modern Language Association of America / Volume 115 / Issue 7 / December 2000
- Published online by Cambridge University Press:
- 23 October 2020, pp. 1986-2078
- Print publication:
- December 2000
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Affective self-report during the intracarotid sodium amobarbital test: Group differences
- GEOFFREY L. AHERN, ANNE M. HERRING, DAVID M. LABINER, MARTIN E. WEINAND, RONALD HUTZLER
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- Journal:
- Journal of the International Neuropsychological Society / Volume 6 / Issue 6 / September 2000
- Published online by Cambridge University Press:
- 01 September 2000, pp. 659-667
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Emotional reactions are sometimes observed during the intracarotid sodium amobarbital test. For instance, euphoric/indifference reactions can be seen during right hemisphere inactivation and catastrophic reactions may accompany left hemisphere inactivation. Less dramatic changes can also be detected in affective self-report during left and right hemisphere amobarbital tests, with more negative affect reported during left hemisphere inactivation and either neutral or mildly positive affective states reported during right hemisphere inactivation. The current study not only replicated this effect, but in addition, found significant group differences. The first group (right way) showed a pattern of affective self-report during left and right amobarbital tests entirely consistent with prior findings, while a second group (wrong way) showed results that behaved in a diametrically opposite fashion. A third group (no change) showed little, if any, difference in affective self-report during left and right amobarbital tests. The major factor distinguishing the wrong way group from the other two appeared to be an asymmetrical distribution of left and right temporal lobe lesions in the former group. In contrast, the factor differentiating the right way group from the no change group appeared to be the relative degree of left hemisphere inactivation during the left hemisphere amobarbital test. The results are discussed not only in terms of their impact on theories of cerebral lateralization for emotion, but also in terms of methodological issues in this field. (JINS, 2000, 6, 659–667.)