Dinitroaniline and amide herbicides have been continually applied in garlic in China, leading to the change of weed community and dominant weed species. Catchweed bedstraw, shepherd's-purse, and flixweed have become major troublesome weeds. Crop safety of fluorochloridone to 18 crops (at rates of 500 and 1,000 g ai ha−1) and weed efficacy against 35 weeds (at rates of 125 and 250 g ha−1) were determined in greenhouse studies. Visual estimate indicated that fluorochloridone was not safe to many crops, especially cruciferous crops. Among all of the trial crops, garlic was the only crop which was not injured in both PRE and POST application at rate of 500 g ha−1, even when treated with 1,000 g ha−1. Fluorochloridone showed high efficacy against most weeds tested in this experiment when applied PRE, but could not offer a satisfactory control when applied POST. Further rate-response study of fluorochloridone to garlic and six weeds was also investigated. PRE application of fluorochloridone to garlic was safer than POST, and the rates for 10% growth reductions (GR10s) were 1,959 g ha−1 for PRE and 537 g ha−1 for POST. When applied PRE, GR90s of shepherd's-purse and flixweed were 19.2 and 70.3 g ha−1, respectively. Though GR90 of catchweed bedstraw was 541 g ha−1, it could be totally controlled without injuring garlic. On the basis of these results, fluorochloridone has an excellent prospect for weed control in garlic fields.