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Caring for children with solid tumors (STs) can impact caregiver’s physical and mental health. Caregiver mastery, which influences psychological well-being, is vital in improving outcomes for both caregivers and children. The study aimed to investigate the relationship between caregiver mastery, anxiety, depression, fear of disease progression (FoP), caregiver burden, and the quality of life (QOL) of children with ST.
Methods
This cross-sectional study was conducted from June 2022 to April 2023 at a Grade A tertiary hospital in Shandong. Family caregivers of children with ST completed several validated measures, including the Pediatric Quality of Life Inventory (PedsQL) 3.0 Cancer Module, the Fear of Progression Questionnaire-parent version (FoP-Q-SF/PR), the Zarit Burden Interview Scale (ZBI), the hospital anxiety and depression scale (HADS), and the Caregiver Mastery Scale. Multiple linear regression analyses assessed the relationships between FoP, caregiver burden, anxiety, depression, caregiver mastery, and children’s QOL. Results were expressed as β and 95% confidence intervals (CIs).
Results
A total of 454 caregivers participated. Caregiver mastery was positively correlated with children’s QOL (β = 0.80, 95% CI: 0.20 to 1.39). Depression (β = −0.64, 95% CI: −0.83 to −0.45), anxiety (β = −0.67, 95% CI: −0.85 to −0.49), caregiver burden (β = −1.20, 95% CI: −1.60 to −0.80), and FoP (β = −0.04, 95% CI: −0.05 to −0.03) were negatively related to children’s QOL. Caregiver mastery moderated the associations between depression, caregiver burden, FoP, and children’s QOL, while also improving the effect of mild anxiety on QOL.
Significance of results
The study underscores the importance of fostering caregiver mastery to mitigate the negative impact of caregiver distress on children’s QOL and improve outcomes for both caregivers and children with solid tumors.
Conclusion
Caregiver mastery moderates the effects of anxiety, depression, FoP, and caregiver burdenon children’s QOL. Supporting caregiver mastery can alleviate caregiver burden and enhance both caregiver and child well-being.
Slender Russian thistle (Salsola collina Pall.) is a troublesome weed distributed mainly in the cropping regions of northern China that produces heteromorphic seeds in the same plant. However, limited information is available on the germination ecology of heteromorphic seeds in S. collina. Thus, the present study was conducted to verify the effect of alternating temperature conditions, light conditions, winged perianth, salt concentrations, water stress, and burial depths on the seed germination or seedling emergence of S. collina. The results showed that S. collina produced two different types of fruits/seeds that significantly differed in seed size, seed color, external structure, and germination/dormancy behavior. The type A seeds (green seeds) were nondormant, and the germination percentage was >96% at all alternating day/night temperatures and light conditions; whereas type B seeds (yellow seeds) exhibited dormancy characteristics and poor germination (≤1%). Moreover, the winged perianth did not inhibit the germination of S. collina green seeds. The germination of green seeds declined rapidly when NaCl concentration exceeded 100 mM, and only 2.22% germination was observed at 600 mM NaCl. About 62.00% of green seeds germinated at −0.6 MPa, and 8.00% germination was obtained at −1.2 MPa. The seedling emergence declined with an increase of burial depth, and decreased sharply when the burial depth exceeded 1.0 cm. Only 8.33% seedling emergence occurred at a burial depth of 4.0 cm. The results gathered from present study will help to illustrate the ecological adaptation strategy of S. collina and indicate that shallow tillage can effectively minimize the seedling emergence of S. collina.
Escherichia albertii is an emerging foodborne enteropathogen associated with infectious diarrhoea in humans. In February 2023, an outbreak of acute gastroenteric cases was reported in a junior high school located in Hangzhou, Zhejiang province, China. Twenty-two investigated patients presented diarrhoea (22/22, 100%), abdominal pain (21/22, 95.5%), nausea (6/22, 27.3%), and vomiting (3/22, 13.6%). E. albertii strains were successfully isolated from anal swabs collected from six patients. Each isolate was classified as sequence type ST2686, harboured eae-β gene, and carried both cdtB-I and cdtB-II subtypes, being serotyped as EAOg32:EAHg4 serotype. A comprehensive whole-genome phylogenetic analysis revealed that the six isolates formed a distinct cluster, separate from other strains. These isolates exhibited minimal genetic variation, differing from one another by 0 to 1 single nucleotide polymorphism, suggesting a common origin from a single clone. To the best of our knowledge, this represented the first reported outbreak of gastroenteritis attributed to E. albertii outside of Japan on a global scale.
The elimination of Pb2+ and recovery of lead metal during the treatment of industrial sewage is an important research topic. Montmorillonite (Mnt) is a promising material in this regard. The purpose of the present study was to improve the Pb2+ adsorption ability of Na-containing Mnt (Na-Mnt) by pillaring titania (anatase) into its interlayer spaces using a sol-gel method. The samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The ratio of Ti to Mnt affected the crystal phase of titania-pillared Na-Mnt (Ti-Mnt), and changed the interlayer spacing of the (001) plane of Ti-Mnt and the growth of anatase. The Pb2+-adsorption capabilities of Ti-Mnt were tested using an aqueous solution of lead nitrate as a wastewater model. The Ti-Mnt prepared adsorbed >99.99% of the Pb2+; leached and activated Ti-Mnt adsorbed >95.7% of the Pb2+, indicating that Ti-Mnt could be recycled effectively. Furthermore, the Pb2+-adsorption capability of Ti- Mnt was related to the interlayer spacing of Mnt, the distribution of anatase particles pillared in Mnt, and the specific surface area, especially with respect to the relationship between the anatase particles and the interlayer spacing of the (001) plane.
Numerous Late Carboniferous – Early Permian dykes are found in West Junggar and represent an important part of the Central Asian Orogenic Belt. In this contribution, we use these dykes to assess the tectonic regime and stress state in the Late Carboniferous – Early Permian. The West Junggar dykes are mainly diorite/dioritic porphyrite with minor diabase and were formed in 324–310 Ma. They have been divided into two groups based on their orientation, petrology and geochronology. Group 1 dykes mostly comprise WNW-striking dioritic porphyrite and NE-striking diorite with minor diabase and resemble the Karamay-Baogutu sanukitoid. They were probably formed from depleted mantle at a relatively high temperature and pressure with the addition of 1–2% sediment/sedimental partial melt and 0–5% trapped oceanic crust-derived melts. Group 2 dykes are ENE-striking and are similar to sanukite in the Setouchi Volcanic Belt. These dykes were also derived from depleted mantle at a shallow depth but high temperature with the addition of 2–3.5% sediment/sedimental partial melt. Magma banding and injection folds in dykes and host granitoids indicate magma flow. Paleostress analysis reveals that both groups of dykes were formed in a tensile stress field. Their emplacement is favoured by presence of pre-existing joints or fractures in the host granitoids and strata. We conclude that large-scale asthenosphere mantle upwelling induced by trapped oceanic slab-off can explain the magmatism and significant continental crustal growth of West Junggar during Late Carboniferous to Early Permian.
In this note, we bound the metric dimension of the circulant graphs $C_n(1,2,\ldots ,t)$. We shall prove that if $n=2tk+t$ and if t is odd, then $\dim (C_n(1,2,\ldots ,t))=t+1$, which confirms Conjecture 4.1.1 in Chau and Gosselin (2017, Opuscula Mathematica 37, 509–534). In Vetrík (2017, Canadian Mathematical Bulletin 60, 206–216; 2020, Discussiones Mathematicae. Graph Theory 40, 67–76), the author has shown that $\dim (C_n(1,2,\ldots ,t))\leq t+\left \lceil \frac {p}{2}\right \rceil $ for $n=2tk+t+p$, where $t\geq 4$ is even, $1\leq p\leq t+1$, and $k\geq 1$. Inspired by his work, we show that $\dim (C_n(1,2,\ldots ,t))\leq t+\left \lfloor \frac {p}{2}\right \rfloor $ for $n=2tk+t+p$, where $t\geq 5$ is odd, $2\leq p\leq t+1$, and $k\geq 2$.
Dynamic interpersonal therapy (DIT) is a brief, structured psychodynamic psychotherapy with demonstrated efficacy in treating major depressive disorder (MDD). The aim of the study was to determine whether DIT is an acceptable and efficacious treatment for MDD patients in China.
Method
Patients were randomized to 16-week treatments with either DIT plus antidepressant medication (DIT + ADM; n = 66), general supportive therapy plus antidepressant medication (GST + ADM; n = 75) or antidepressant medication alone (ADM; n = 70). The Hamilton Depression Rating Scale (HAMD) administered by blind raters was the primary efficacy measure. Assessments were completed during the acute 16-week treatment and up to 12-month posttreatment.
Results
The group × time interaction was significant for the primary outcome HAMD (F = 2.900, df1 = 10, df2 = 774.72, p = 0.001) in the acute treatment phase. Pairwise comparisons showed a benefit of DIT + ADM over ADM at weeks 12 [least-squares (LS) mean difference = −3.161, p = 0.007] and 16 (LS mean difference = −3.237, p = 0.004). Because of the unexpected high attrition during the posttreatment follow-up phase, analyses of follow-up data were considered exploratory. Differences between DIT + ADM and ADM remained significant at the 1-, 6-, and 12-month follow-up (ps range from 0.001 to 0.027). DIT + ADM had no advantage over GST + ADM during the acute treatment phase. However, at the 12-month follow-up, patients who received DIT remained less depressed.
Conclusions
Acute treatment with DIT or GST in combination with ADM was similarly efficacious in reducing depressive symptoms and yielded a better outcome than ADM alone. DIT may provide MDD patients with long-term benefits in symptom improvement but results must be viewed with caution.
The G protein-coupled receptors (GPCR) sensing nutritional signals (amino acids, fatty acids, glucose, etc.) are not fully understood. In this research, we used transcriptome sequencing to analyse differentially expressed genes (DEG) in mouse mammary gland tissues at puberty, lactation and involution stages, in which eight GPCR were selected out and verified by qRT-PCR assay. It was further identified the role of GPR110-mediating nutrients including palmitic acid (PA) and methionine (Met) to improve milk synthesis using mouse mammary epithelial cell line HC11. PA but not Met affected GPR110 expression in a dose-dependent manner. GPR110 knockdown decreased milk protein and fat synthesis and cell proliferation and blocked the stimulation of PA on mechanistic target of rapamycin (mTOR) phosphorylation and sterol-regulatory element binding protein 1c (SREBP-1c) expression. In summary, these experimental results disclose DEG related to lactation and reveal that GPR110 mediates PA to activate the mTOR and SREBP-1c pathways to promote milk protein and fat synthesis.
The grey wolf optimizer (GWO) as a new intelligent optimization algorithm has been successfully applied in many fields because of its simple structure, few adjustment parameters and easy implementation. This paper mainly aims at the defects of GWO in path planning application, such as easily falling into local optimization, poor convergence and poor accuracy, and turn point grey wolf optimization (TPGWO) algorithm is proposed. First, the idea of cross-mutation and roulette is used to increase the initial population of GWO and improve the search range. At the same time, the convergence factor function is improved to become a nonlinear update. In the early stage, the search range is expanded, and in the later stage, the convergence speed is increased, while the parameters in the convergence factor function can be adjusted according to the number of obstacles and the map area to change the turning point of the function to improve the convergence speed and accuracy of the algorithm. The turning times and turning angles of the obtained path are added to the fitness function as penalty values to improve the path accuracy. The optimization test is carried out through 16 test functions, and the test results prove the convergence and robustness of TPGWO algorithm. Finally, the TPGWO algorithm is applied to the path planning of patrol robot for simulation experiments. Compared with the GWO algorithm and Particle Swarm Optimization, the simulation results show that the TPGWO algorithm has better convergence, stability and accuracy in the path planning of patrol robot.
It has been acknowledged that the Doppler is beneficial to the GNSS positioning of smartphones. However, analysis of Doppler precision on smartphones is insufficient. In this paper, we focus on the characteristic analysis of the raw Doppler measurement from Android smartphones. A comprehensive investigation of the Doppler was conducted. The results illustrate that the availability of Doppler is stable and higher than that of carrier measurements, which means that the Doppler-smoothed code (DSC) method is more effective. However, there is a constant bias between the Doppler and the code rate in Xiaomi MI8, which indicates that extra processing of the DSC method is necessary for this phone. Additionally, it is demonstrated that the relationship between the Doppler and C/N0 can be expressed as an exponential function, and the fitting parameters are provided. The numerical experiment in car-borne and hand-held scenes was conducted for evaluating the performance of the Doppler-aided positioning algorithm. For positioning, the improvement reaches 37 ⋅ 69%/37 ⋅ 14%/26 ⋅ 61% in the east, north and up components, respectively, after applying the Doppler aiding. For velocity estimation, the improvement reaches 29 ⋅ 62%/39 ⋅ 63%/29 ⋅ 37% in the three components, respectively.
The objective of this study was to investigate the effects of different levels of seminal plasma (SP) on boar sperm quality, antioxidant capacity and bacterial concentrations during liquid storage at 17°C. Boar sperm was diluted with Beltsville Thawing Solution (BTS) consisting of 0, 25, 50 and 75% (v/v) of SP. Total motility, progressive motility and dynamic parameters were assessed by the computer assisted sperm analysis (CASA) system. Acrosome and plasma membrane integrity were measured by FITC-PNA/DAPI and SYBR-14/PI staining, respectively. In addition, total antioxidant capacity (T-AOC), malondialdehyde (MDA) content, and reactive oxygen species (ROS) levels were detected using commercial assay kits. Bacterial concentrations were assessed by turbidimetric assay. Our results showed that 25% SP markedly improved total motility, progressive motility, sperm dynamic parameters, acrosome integrity compared with 0, 50 and 75% SP (P < 0.05). In addition, 25% SP significantly increased T-AOC but decreased MDA content and ROS levels compared with 0, and 75% SP (P < 0.05). Moreover, 25% SP significantly decreased the bacterial concentrations in extended semen compared with 50% and 75% SP, however, which was higher than with 0% SP (P < 0.05). These results suggest that 25% SP can promote boar sperm quality through enhancing its antioxidant capacity during liquid storage.
In this short and elementary note, we study some ergodic optimization problems for circle expanding maps. We first make an observation that if a function is not far from being convex, then its calibrated sub-actions are closer to convex functions in a certain effective way. As an application of this simple observation, for a circle doubling map, we generalize a result of Bousch saying that translations of the cosine function are uniquely optimized by Sturmian measures. Our argument follows the mainline of Bousch’s original proof, while some technical part is simplified by the observation mentioned above, and no numerical calculation is needed.
Non-alcoholic fatty liver disease (NAFLD) was defined in 1980 and has the same histological characteristics as alcoholic liver disease except for alcohol consumption. After 40 years, the understanding of this disease is still imperfect. Without specific drugs available for treatment, the number of patients with NAFLD is increasing rapidly, and NAFLD currently affects more than one-quarter of the global population. NAFLD is mostly caused by a sedentary lifestyle and excessive energy intake of fat and sugar. To ameliorate or avoid NAFLD, people commonly replace high-fat foods with high-carbohydrate foods (especially starchy carbohydrates) as a way to reduce caloric intake and reach satiety. However, there are few studies that concentrate on the effect of carbohydrate intake on liver metabolism in patients with NAFLD, much fewer than the studies on fat intake. Besides, most of these studies are not systematic, which has made identification of the mechanism difficult. In this review, we collected and analysed data from studies on human and animal models and, surprisingly, found that carbohydrates and liver steatosis could be linked by inflammation. This review not only describes the effects of carbohydrates on NAFLD and body lipid metabolism but also analyses and predicts possible molecular pathways of carbohydrates in liver lipid synthesis that involve inflammation. Furthermore, the limitations of recent research and possible targets for regulating inflammation and lipogenesis are discussed. This review describes the effects of starchy carbohydrates, a nutrient signal, on NAFLD from the perspective of inflammation.
A fever clinic within a hospital plays a vital role in pandemic control because it serves as an outpost for pandemic discovery, monitoring and handling. As the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan was gradually brought under control, the fever clinic in the West Campus of Wuhan Union Hospital introduced a new model for construction and management of temporary mobile isolation wards. A traditional battlefield hospital model was combined with pandemic control regulations, to build a complex of mobile isolation wards that used adaptive design and construction for medical operational, medical waste management and water drainage systems. The mobile isolation wards allowed for the sharing of medical resources with the fever clinic. This increased the capacity and efficiency of receiving, screening, triaging and isolation and observation of patients with fever. The innovative mobile isolation wards also controlled new sudden outbreaks of COVID-19. We document the adaptive design and construction model of the novel complex of mobile isolation wards and explain its characteristics, functions and use.
The docking simulators are significant ground test equipment for aerospace projects. The fidelity of docking simulation highly depends on the accuracy performance. This paper investigates the kinematic accuracy for the developed docking simulator. A novel kinematic calibration method which can reduce the number of parameters for error modeling is presented. The principle of parameters separation is studied. A simplified error model is derived based on Taylor series. This method can contribute to the simplification of the error model, fewer measurements, and easier convergence during the parameters identification. The calibration experiment validates this method for further accuracy enhancement.
The tight combination model improves the positioning accuracy of the Global Navigation Satellite System (GNSS) in complex environments by increasing the redundancy of observation. However, the ambiguity cannot be calculated directly because of the correlation between it and the phase difference inter-system bias (DISB) in the model. This paper proposes a method of DISB estimation based on the principle of maximum ratio. From the data analysis, for the standard deviation of code DISB, the improvement of the method can up to 0·179 m with the poor quality data. In addition, compared to the parameter combination method, the standard deviation of all the phase DISB was deceased with the method in the paper. About the phase DISB of GPS L1/Galileo E1, the standard deviation decreased from 0·014/0·022/0·009/0·051 cycles to 0·006/0·015/0·004/0·029 cycles of four baselines, which represents the improvement of 57·14/31·82/55·56/43·14%. About the phase DISB of GPS L1/BDS B1, the standard deviation decreased from 0·014/0·061/0·010/0·052 cycles to 0·002/0·005/0·009/0·004 cycles of four baselines, which represents the improvement of 85·71/91·80/10·00/92·31%.
Since the outbreak of 2019 novel coronavirus (2019-nCoV) infection in Wuhan City, China, pediatric cases have gradually increased. It is very important to prevent cross-infection in pediatric fever clinics, to identify children with fever in pediatric fever clinics, and to strengthen the management of pediatric fever clinics. According to prevention and control programs, we propose the guidance on the management of pediatric fever clinics during the nCoV pneumonia epidemic period, which outlines in detail how to optimize processes, prevent cross-infection, provide health protection, and prevent disinfection of medical staff. The present consideration statement summarizes current strategies on the pre-diagnosis, triage, diagnosis, treatment, and prevention of 2019-nCoV infection, which provides practical suggestions on strengthening the management of pediatric fever clinics during the nCoV pneumonia epidemic period.
In the process of composing a double-differenced positioning model, it is difficult to separate different frequency signals between code division multiple access (CDMA) systems, the single-difference ambiguity of the pivot satellite and phase differential inter-system biases (PDISBs). Hence it is difficult to calibrate in advance the bias between systems in order to build an inter-system model which only needs one pivot satellite. Based on analysis of the stability of PDISB parameters for non-overlapping frequency CDMA systems, this study adopts a particle filter to estimate the fractional part of the PDISBs (F-PDISBs) between the systems and proposes a particle filter-based inter-system positioning model. Results show that the F-PDISBs and code DISBs for the baselines with the same receiver types and some with different receiver types are rather stable over time and for these baselines it is feasible to use a particle filter to estimate the F-PDISB parameters in the initial stage. Having attained the F-PDISBs, the inter-system model can be constructed to improve positioning accuracy in complex operational environments.
Common seepweed [Suaeda glauca (Bunge) Bunge] is a common salt-tolerant weed species distributed across the agricultural regions of northern China. It produces dimorphic seeds with different phenotypic characteristics and seed sizes. However, there is no information regarding the germination biology of these dimorphic seeds. Studies were conducted to evaluate the effects of ecological factors such as temperature, light, pH, osmotic stress, salt concentration, and planting depth on seed germination and seedling emergence. The results showed that brown seeds were nondormant, whereas black seeds had an intermediate physiological dormancy. The germination percentage of brown seeds was more than 80% at all temperature regimes and light conditions, but the optimum germination occurred at the cold thermoperiod of 20/10 C. In contrast, less than 6% of black seeds germinated at all temperature regimes and light conditions. Eight weeks of cold stratification did not break the dormancy of black seeds, whereas low concentrations of gibberellic acid (0.1 and 1.0 mM) significantly increased seed germination. Removal of the testa of black seeds also promoted germination and produced normal seedlings. Brown seeds showed moderate tolerance to salt stress, with 16% germination percentage at a salt concentration of 600 mM NaCl. The germination of brown seeds was 38% at an osmotic potential stress of −0.8 MPa; above that, no germination was obtained. Brown seeds germinated well in a wide pH range (4 to 10), with a germination percentage higher than 95%. Seedling emergence percentage was higher than 90% at burial depths of 0 to 2 cm, while germination percentage severely decreased for brown seeds with burial depths >2 cm, indicating that shallow tillage could be an effective measure to minimize seed germination. Information gathered from this study will help to develop an effective protocols for controlling S. glauca.