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We describe Swauka ypresiana n. gen. n. sp., the second fossil gossamerwing damselfly (Odonata, Zygoptera, Epallagidae, Epallaginae) and its oldest occurrence. It is the first fossil insect reported from the Swauk Formation of central Washington State, U.S.A. It was recovered from the “Sandstone facies of Swauk Pass,” a fluvial unit, immediately below the Silver Pass Volcanic Member of the Swauk Formation, which has a U–Pb zircon CA-ID-TIMS age of 51.364 ± 0.029 Ma. The host deposits probably represent mud-dominated floodplain lake or oxbow lake environments.
Selig Harrison originally visited North Korea in 1972, when he and Harrison Salisbury were the first independent or non-communist American journalists to visit since the Korean War. Mr. Harrison was also one of the first American experts to understand the strong grip of nationalism in North Korea, which he elucidated in his excellent 1978 book, The Widening Gulf: Asian Nationalism and American Policy. He now has more than 20 visits to Pyongyang under his belt, and his most recent book, Korean Endgame is a provocative call for American disengagement with Korea.
It also contains perhaps the best informed treatment that we have of the issues that have animated the confrontation between Washington and Pyongyang over the latter's nuclear program. With that stymied conflict now in its eighteenth year, it is no wonder that Mr. Harrison returned from his most recent visit with a suggestion that “benign neglect” of the nuclear issue might be the best among a narrowing list of American options.
Most species exhibit morphological stasis following speciation, and this is a key feature of the concept of punctuated equilibria. Stasis results in species often having long durations on geological timescales. Durational data are fundamental to many types of paleobiological analyses and are ideally based on occurrence data represented by specimens in museum collections. Often, however, durational data are presented without supporting information about voucher specimens that document stratigraphic ranges, including first and last appearances. We use the iconic Devonian trilobite Eldredgeops rana to demonstrate that durational data can be challenging to determine at multiple taxonomic levels. Further, we show that different datasets—including Sepkoski’s published databases, the Paleobiology Database, and iDigBio—give discordant results concerning first and last occurrences. We argue that paleontologists should adopt two general best practices to help address these problems. First, systematists should clearly identify voucher specimens that represent stratigraphic occurrences of species. Second, we recommend that high-quality photographs of occurrence vouchers be placed in open access websites and be assigned public domain licensing before being paywalled by journals. Such voucher images also have a role to play in training artificial intelligence (AI) systems that will be applied to future paleobiological questions.
To date, the NIH Helping to End Addiction Long-term (HEAL) Initiative has funded over 1,000 projects that aim to identify new therapeutic targets for pain and substance use disorder (SUD), develop nonpharmacological strategies for pain management, and improve overdose and addiction treatment across settings. This study conducted a portfolio analysis of HEAL’s research to assess opportunities to advance translation and implementation.
Methods:
HEAL projects (FY 2018–2022) were classified into early (T0–T1) and later (T2–T4) translational stages. Eleven coders used a 54-item data collection tool based on the Consolidated Framework for Implementation Research (CFIR) to extract project characteristics (e.g., population, research setting) relevant to translation and implementation. Descriptive statistics and visualization techniques were employed to analyze and map aggregate characteristics onto CFIR’s domains (e.g., outer setting).
Results:
HEAL’s portfolio comprised 923 projects (33.7% T0–T1; 67.3% T2–T4), ranging from basic science (27.1%) and preclinical research (21.4%) to clinical (36.8%), implementation (27.1%), and dissemination research (13.1%). Most projects primarily addressed either addiction (46.3%) or pain (37.4%). Implementation-related gaps included the underrepresentation of certain populations (e.g., sexual/gender minorities: 0.5%). T0–T1 projects occurred primarily in laboratory settings (35.1%), while T2–T4 projects were concentrated in healthcare settings (e.g., hospitals: 21.6%) with limited transferability to other contexts (e.g., community: 12.9%).
Conclusion:
Opportunities to advance translational and implementation efforts include fostering interdisciplinary collaboration, prioritizing underserved populations, engaging with community leaders and policy stakeholders, and targeting evidence-based practices in nonclinical settings. Ongoing analyses can guide strategic investments to maximize HEAL’s impact on substance use and pain crises.
We measured brain activity using a functional magnetic resonance imaging (fMRI) paradigm and conducted a whole-brain analysis while healthy adult Democrats and Republicans made non-hypothetical food choices. While the food purchase decisions were not significantly different, we found that brain activation during decision-making differs according to the participant’s party affiliation. Models of partisanship based on left insula, ventromedial prefrontal cortex, precuneus, superior frontal gyrus, or premotor/supplementary motor area activations achieve better than expected accuracy. Understanding the differential function of neural systems that lead to indistinguishable choices may provide leverage in explaining the broader mechanisms of partisanship.
The recent expansion of cross-cultural research in the social sciences has led to increased discourse on methodological issues involved when studying culturally diverse populations. However, discussions have largely overlooked the challenges of construct validity- ensuring instruments are measuring what they are intended to- in diverse cultural contexts, particularly in developmental research. We contend that cross-cultural developmental research poses distinct problems for ensuring high construct validity, owing to the nuances of working with children and that the standard approach of transporting protocols designed and validated in one population to another risks low construct validity. Drawing upon our own and others’ work, we highlight several challenges to construct validity in the field of cross-cultural developmental research, including 1) lack of cultural and contextual knowledge, 2) dissociating developmental and cultural theory and methods, 3) lack of causal frameworks, 4) superficial and short- term partnerships and collaborations, and 5) culturally inappropriate tools and tests. We provide guidelines to address these challenges, including 1) using ethnographic and observational approaches, 2) developing evidence-based causal frameworks, 3) conducting community-engaged and collaborative research, and 4) culture-specific refinements and training. We discuss the need to balance methodological consistency with culture-specific refinements to improve construct validity in cross-cultural developmental research.
This paper presents an analysis, based on simulation, of the stability of principal components. Stability is measured by the expectation of the absolute inner product of the sample principal component with the corresponding population component. A multiple regression model to predict stability is devised, calibrated, and tested using simulated Normal data. Results show that the model can provide useful predictions of individual principal component stability when working with correlation matrices. Further, the predictive validity of the model is tested against data simulated from three non-Normal distributions. The model predicted very well even when the data departed from normality, thus giving robustness to the proposed measure. Used in conjunction with other existing rules this measure will help the user in determining interpretability of principal components.
Three new species of Ypresian (early Eocene) Odonata are described: Paradysagrion sosbyaegen. and sp. nov. from the Klondike Mountain Formation at Republic, Washington, United States of America, and Dysagrionites allenbyensissp. nov. and Allenby gen. and sp. A from the Allenby Formation near Princeton, British Columbia, Canada. All three are assigned to the Dysagrionidae and Cephalozygoptera but only tentatively, as key diagnostic morphology is missing from their incomplete fossils. The definition of the collective genus Dysagrionites is broadened to include odonates tentatively assigned to the Dysagrioninae (Dysagrionidae) that are distinct as species but have unclear nominal genus affinity.
In response to the COVID-19 pandemic, we rapidly implemented a plasma coordination center, within two months, to support transfusion for two outpatient randomized controlled trials. The center design was based on an investigational drug services model and a Food and Drug Administration-compliant database to manage blood product inventory and trial safety.
Methods:
A core investigational team adapted a cloud-based platform to randomize patient assignments and track inventory distribution of control plasma and high-titer COVID-19 convalescent plasma of different blood groups from 29 donor collection centers directly to blood banks serving 26 transfusion sites.
Results:
We performed 1,351 transfusions in 16 months. The transparency of the digital inventory at each site was critical to facilitate qualification, randomization, and overnight shipments of blood group-compatible plasma for transfusions into trial participants. While inventory challenges were heightened with COVID-19 convalescent plasma, the cloud-based system, and the flexible approach of the plasma coordination center staff across the blood bank network enabled decentralized procurement and distribution of investigational products to maintain inventory thresholds and overcome local supply chain restraints at the sites.
Conclusion:
The rapid creation of a plasma coordination center for outpatient transfusions is infrequent in the academic setting. Distributing more than 3,100 plasma units to blood banks charged with managing investigational inventory across the U.S. in a decentralized manner posed operational and regulatory challenges while providing opportunities for the plasma coordination center to contribute to research of global importance. This program can serve as a template in subsequent public health emergencies.
This paper presents a comprehensive evaluation of reduced-order models (ROMs) for the determination of pressure coefficient distributions on supersonic and hypersonic bodies. The study investigates the limitations, aerodynamic precision and computational performance associated with various methodologies, ranging from simplistic Newtonian theory-based approaches to more advanced first and second-order shock-expansion theories. Validation is performed by comparing computed results with experimental and computational data for pressure distributions, drag and lift coefficients and centres of pressure for fundamental geometries and authentic vehicle design over a wide range of freestream conditions. The study also includes a comprehensive computational complexity analysis, demonstrating the superiority of finite-element ROM approaches over traditional finite-volume computational fluid dynamics (CFD) simulations. The primary objective of this paper is to scrutinise the extension of these methodological classes to the low supersonic regime. Hence, thermo-chemical reactions within the flow are disregarded, and the ideal gas law is adopted. A value of $\gamma = 1.4$ is chosen for consistency and comparability across the analyses. The proposed ROMs show remarkable potential for reducing high-speed simulation execution times by four orders of magnitude, maintaining accuracy within 20 per cent and as low as 1 per cent. The study unveils three key findings: first, the accuracy degradation of Newtonian-based theories for inclined elements, particularly around 45 degrees, and their reduced dependency on Mach number at large inclination. Secondly, the study presents novel insights into the impact of shock-wave-Mach-wave interactions on pressure distribution calculations, emphasising the Mach number as a crucial metric governing recompression effects. Lastly, the study demonstrates the exceptional accuracy of DeJarnette’s method, providing ${C_P}$ results within 2 per cent for a wide range of conditions, offering an attractive alternative to the Taylor-Maccoll equation.
Operationalizing multi-site Community Engagement (CE) Studios to inform a research program is valuable for researchers. We describe the process and outcomes of hosting three CE Studios with Community Experts aged 65 years or older with chronic conditions and care partners of older adults. Experts gave feedback about processes for testing the feasibility, efficacy, effectiveness, and implementation of audio recording clinic visits and sharing recordings with patients who have multimorbidity and their care partners.
Methods:
The CE Cores of the Clinical and Translational Science Awards Programs at three academic health science centers created a joint CE Studio guide. Studios were conducted iteratively by site. Following receipt of the final reports, responses were compared to find themes, similarities, and differences on four topics in addition to overall commentary: Recruitment and Retention, Study Protocol, Study Reminders and Frequency, and Recording Technology.
Results:
Eighteen older adults and care partners in three states provided valuable feedback to inform multi-site trials. Feedback influenced multiple aspects of trials in process or subsequently funded. Experts provided critique on the wording of study invitations, information sheets, and reminders to engage in study procedures. Experts were concerned for participants being disappointed by randomization to a control arm and advised how investigators should prepare to address that.
Conclusions:
Multi-site CE Studios should be consecutive, so each team can learn from the previous teams. Using the CES Toolkit ensures that final reports were easily comparable and utilized to develop a research program that now includes three federally funded clinical trials.
Policy specialization in the U.S. Congress benefits the institution collectively and members individually. Yet members of Congress (MCs) are insufficiently specialized to optimize lawmaking success (Volden and Wiseman 2020). In this paper, we demonstrate the increasing propensity of MCs to generalize legislatively is driven largely by an expansion of MC legislative agendas in business domains. We then offer and test an explanation for this trend whereby business’s increasing demand for congressional attention (Drutman 2015) has outpaced the supply of congressional capacity to serve business needs (Crossen, Furnas, LaPira, and Burgat 2020; McKay 2022). This unmet demand incentivizes MCs to expand their business portfolio, which results in increased campaign contributions from business political action committees (PACs). We provide evidence consistent with this theory, showing that under conditions of access scarcity, MCs benefit financially (in terms of increased business PAC contributions) by broadening the number of business domains they are active in legislatively.
Postural orthostatic tachycardia syndrome is a debilitating disorder. We compared paediatric patients with this dysautonomia presenting with and without peak upright heart rate > 100 beats per minute.
Materials and Methods:
Subjects were drawn from the Postural Orthostatic Tachycardia Syndrome Program database of the Children’s Hospital of Philadelphia diagnosed between 2007 and 2018. Subjects were aged 12–18 years at diagnosis with demographic data, supine and peak heart rate from 10-minute stand, symptoms, and family history. Patients were divided into “low heart rate” (peak less than 100 beats/minute) and “high heart rate” (peak at least 100 beats/minute) groups.
Results:
In total, 729 subjects were included (low heart rate group: 131 patients, high heart rate group: 598 patients). The low heart rate group had later age at diagnosis (16.1 versus 15.7, p = 0.0027). Median heart rate increase was 32 beats/minute in the low heart rate group versus 40 beats/minute in the high heart rate group (p < 0.00001). Excluding palpitations and tachypalpitations, there were no differences in symptom type or frequency between groups.
Discussion:
Paediatric patients meeting heart rate criteria for postural orthostatic tachycardia syndrome but without peak heart rate > 100 demonstrate no difference in symptom type or frequency versus those who meet both criteria. Differences observed reached statistical significance due to population size but are not clinically meaningful. This suggests that increased heart rate, but not necessarily tachycardia, is seen in these patients, supporting previous findings suggesting maximal heart rate is not a major determinant of symptom prevalence in paediatric postural orthostatic tachycardia syndrome.
Diagnosis of acute ischemia typically relies on evidence of ischemic lesions on magnetic resonance imaging (MRI), a limited diagnostic resource. We aimed to determine associations of clinical variables and acute infarcts on MRI in patients with suspected low-risk transient ischemic attack (TIA) and minor stroke and to assess their predictive ability.
Methods:
We conducted a post-hoc analysis of the Diagnosis of Uncertain-Origin Benign Transient Neurological Symptoms (DOUBT) study, a prospective, multicenter cohort study investigating the frequency of acute infarcts in patients with low-risk neurological symptoms. Primary outcome parameter was defined as diffusion-weighted imaging (DWI)-positive lesions on MRI. Logistic regression analysis was performed to evaluate associations of clinical characteristics with MRI-DWI-positivity. Model performance was evaluated by Harrel’s c-statistic.
Results:
In 1028 patients, age (Odds Ratio (OR) 1.03, 95% Confidence Interval (CI) 1.01–1.05), motor (OR 2.18, 95%CI 1.27–3.65) or speech symptoms (OR 2.53, 95%CI 1.28–4.80), and no previous identical event (OR 1.75, 95%CI 1.07–2.99) were positively associated with MRI-DWI-positivity. Female sex (OR 0.47, 95%CI 0.32–0.68), dizziness and gait instability (OR 0.34, 95%CI 0.14–0.69), normal exam (OR 0.55, 95%CI 0.35–0.85) and resolved symptoms (OR 0.49, 95%CI 0.30–0.78) were negatively associated. Symptom duration and any additional symptoms/symptom combinations were not associated. Predictive ability of the model was moderate (c-statistic 0.72, 95%CI 0.69–0.77).
Conclusion:
Detailed clinical information is helpful in assessing the risk of ischemia in patients with low-risk neurological events, but a predictive model had only moderate discriminative ability. Patients with clinically suspected low-risk TIA or minor stroke require MRI to confirm the diagnosis of cerebral ischemia.
Knowledge of sex differences in risk factors for posttraumatic stress disorder (PTSD) can contribute to the development of refined preventive interventions. Therefore, the aim of this study was to examine if women and men differ in their vulnerability to risk factors for PTSD.
Methods
As part of the longitudinal AURORA study, 2924 patients seeking emergency department (ED) treatment in the acute aftermath of trauma provided self-report assessments of pre- peri- and post-traumatic risk factors, as well as 3-month PTSD severity. We systematically examined sex-dependent effects of 16 risk factors that have previously been hypothesized to show different associations with PTSD severity in women and men.
Results
Women reported higher PTSD severity at 3-months post-trauma. Z-score comparisons indicated that for five of the 16 examined risk factors the association with 3-month PTSD severity was stronger in men than in women. In multivariable models, interaction effects with sex were observed for pre-traumatic anxiety symptoms, and acute dissociative symptoms; both showed stronger associations with PTSD in men than in women. Subgroup analyses suggested trauma type-conditional effects.
Conclusions
Our findings indicate mechanisms to which men might be particularly vulnerable, demonstrating that known PTSD risk factors might behave differently in women and men. Analyses did not identify any risk factors to which women were more vulnerable than men, pointing toward further mechanisms to explain women's higher PTSD risk. Our study illustrates the need for a more systematic examination of sex differences in contributors to PTSD severity after trauma, which may inform refined preventive interventions.
The heat capacities of kaolinite (7 to 380 K) and of dimethyl sulfoxide (DMSO) intercalated kaolinite (20 to 310 K) were measured by adiabatically shielded calorimetry. The third law entropy of kaolinite, S298, is 200.9 ± 0.5 J·mol−1K−1.
The “melting point” of the DMSO in the intercalate, 288.0 ± 0.2 K, is 3.7 K lower than that of pure DMSO, 291.67 K. The heat capacity of DMSO in the intercalate above 290 K is approximately 5.2 J·mol−1·K−1 smaller than that of pure liquid DMSO at the same temperature.
The adsorption of arsenate (As(V)) on kaolinite, montmorillonite and illite was investigated at varying pH and competing anion concentration while holding As(V) concentration (6.7 × 10−7M), clay suspension density (2.5 g L−1) and ionic strength (0.1 M NaCl) constant. The effects of 2 concentrations of phosphate (P) or molybdate (Mo) (6.7 × 10−7 and 6.7 × 10−6M) on As(V) adsorption envelopes (adsorption vs. pH) gave evidence for direct competitive adsorption (in the case of As(V) + P) and possibly site-specific non-competitive adsorption (As(V) + Mo). Distinct As(V) adsorption maxima occurred at approximately pH 5.0 for kaolinite, 6.0 for montmorillonite and 6.5 for illite, and ranged from 0.15 to 0.22 mmol As(V) kg−1. When both As(V) and P were present at equimolar concentrations (6.7 × 10−7M), As(V) adsorption decreased slightly, whereas As(V) adsorption substantially decreased in binary As(V)/P systems when the P concentration was 6.7 × 10−6M, which was 10 times greater than As(V). The presence of Mo at equimolar (6.7 × 10−7 M) and 10 times greater (6.7 × 10−6M) concentrations than As(V) caused only slight decreases in As(V) adsorption because the Mo adsorption maximum occurred at pH < 4. The constant capacitance surface complexation model was applied to As(V) and P adsorption data and was used to predict As(V) adsorption at varying P concentrations. The model gave reasonable descriptions of As(V) adsorption on the 3 clay minerals at varying pH and in the presence of a competing oxyanion (P), indicating that surface complexation modeling may be useful in predicting As(V) adsorption in soils.
Nursing home residents may be particularly vulnerable to coronavirus disease 2019 (COVID-19). Therefore, a question is when and how often nursing homes should test staff for COVID-19 and how this may change as severe acute respiratory coronavirus virus 2 (SARS-CoV-2) evolves.
Design:
We developed an agent-based model representing a typical nursing home, COVID-19 spread, and its health and economic outcomes to determine the clinical and economic value of various screening and isolation strategies and how it may change under various circumstances.
Results:
Under winter 2023–2024 SARS-CoV-2 omicron variant conditions, symptom-based antigen testing averted 4.5 COVID-19 cases compared to no testing, saving $191 in direct medical costs. Testing implementation costs far outweighed these savings, resulting in net costs of $990 from the Centers for Medicare & Medicaid Services perspective, $1,545 from the third-party payer perspective, and $57,155 from the societal perspective. Testing did not return sufficient positive health effects to make it cost-effective [$50,000 per quality-adjusted life-year (QALY) threshold], but it exceeded this threshold in ≥59% of simulation trials. Testing remained cost-ineffective when routinely testing staff and varying face mask compliance, vaccine efficacy, and booster coverage. However, all antigen testing strategies became cost-effective (≤$31,906 per QALY) or cost saving (saving ≤$18,372) when the severe outcome risk was ≥3 times higher than that of current omicron variants.
Conclusions:
SARS-CoV-2 testing costs outweighed benefits under winter 2023–2024 conditions; however, testing became cost-effective with increasingly severe clinical outcomes. Cost-effectiveness can change as the epidemic evolves because it depends on clinical severity and other intervention use. Thus, nursing home administrators and policy makers should monitor and evaluate viral virulence and other interventions over time.
While mentors can learn general strategies for effective mentoring, existing mentorship curricula do not comprehensively address how to support marginalized mentees, including LGBTQIA+ mentees. After identifying best mentoring practices and existing evidence-based curricula, we adapted these to create the Harvard Sexual and Gender Minority Health Mentoring Program. The primary goal was to address the needs of underrepresented health professionals in two overlapping groups: (1) LGBTQIA+ mentees and (2) any mentees focused on LGBTQIA+ health. An inaugural cohort (N = 12) of early-, mid-, and late-career faculty piloted this curriculum in spring 2022 during six 90-minute sessions. We evaluated the program using confidential surveys after each session and at the program’s conclusion as well as with focus groups. Faculty were highly satisfied with the program and reported skill gains and behavioral changes. Our findings suggest this novel curriculum can effectively prepare mentors to support mentees with identities different from their own; the whole curriculum, or parts, could be integrated into other trainings to enhance inclusive mentoring. Our adaptations are also a model for how mentorship curricula can be tailored to a particular focus (i.e., LGBTQIA+ health). Ideally, such mentor trainings can help create more inclusive environments throughout academic medicine.
We examine the fossil weaver ants (Formicidae, Formicine, Oecophyllini) of the early Eocene Okanagan Highlands fossil localities of British Columbia, Canada and Washington, United States of America, naming Eoecophylla quilchenensisn. gen.etsp. from Quilchena (British Columbia), formally transferring Camponotites kraussei Dlussky and Rasnitsyn (Republic, Washington) to the genus Oecophylla Smith, F., and describing but not naming a worker (McAbee, British Columbia), treated as Oecophyllinisp. A. These are the oldest known Oecophyllini (Oecophylla + Eoecophylla) and Oecophylla. Forewing vein stubs of E. quilchenensis and its well-developed hind wing vein M are plesiomorphies; this M is unique within the subfamily, suggesting Oecophyllini is sister to other Formicine. The head shape of O. kraussein. comb. indicates a close relationship to Oecophylla longiceps Dlussky from Eocene Messel, Germany. The ant Titanomyrma Archibald et al. is also known from the Okanagan Highlands and Messel, consistent with Late Cretaceous/early Paleogene intercontinental dispersal. We discuss possible host plants and trophobionts of these ants. Although Okanagan Highlands localities were cooler than the Paleotropical range of modern Oecophylla, their presence there might be explained by mild winters without significant frost.