The glutamatergic system is implicated in the pathogenesis of Treatment Resistant Depression (TRD), evidenced by the efficacy of ketamine, a N-methyl-D-aspartate receptor (NMDAR) antagonist. This hypothesis suggests that NMDAR inhibition promotes glutamate release via suppression of NMDAR GABAergic interneurons (1). Studies report reduced plasmatic Gamma AminoButiric Acid (pGABA) (2) and altered plasmatic glutamate (pGlu) levels in depressed patients vs. healthy controls (HC) (3). Single nucleotide polymorphisms (SNPs) in the GRIN2B gene, encoding the NMDAR 2B subunit (rs1806201, rs890, rs1805502) have been associated with TRD (4).

1. To evaluate the distribution of GRIN2B haplotypes formed by these SNPs (rs1806201-rs890-rs1805502) in TRD and HC. 2. To analyze the relationship between pGABA or pGlu levels and haplotypes in all participants as well as differences by diagnosis.

38 TRD patients (non-responders to 3 different antidepressants including potentiation strategies) prior to esketamine initiation and 55 HCs were recruited. pGABA and pGLu levels were analysed by HPLC. Haplotypes were inferred using PLINK toolset. Associations with diagnosis were assessed by PLINK toolset and Fisher’s test. General Linear models (GLM) were used to evaluate haplotype effects on pGABA or pGlu levels in all participants as well as differences by diagnosis, considering age and sex were covariates.

No differences in GRIN2B haplotype distribution between TRD and HC were observed. In GLM analysis, only ACG haplotype (rs1806201-rs890-rs1805502) showed effect on pGABA (Wald’s X2 = 11.77, df:5 p = 0.038). While no overall association was found between AGC-haplotype presence and pGABA levels (B = 0.153, p = 0.166), a diagnosis-haplotype interaction was observed (B = -0.110, p = 0.033). Among TRD patients, AGC carriers had higher pGABA levels than non-AGC carriers, whereas no difference was observed in HCs. Moreover, TRD patients had lower pGABA levels than HCs (B = 0.125, p = 0.006) and pGABA levels increase with age in the study population (B = 0.002, p = 0.043). Sex had no effect. In pGlu no relevant findings were observed

While GRIN2B haplotypes seemed to be not associated with TRD diagnosis, the pGABA levels are related to TRD and are influenced by ACG-haplotype in TRD. Our findings suggest a potential role of the AGC-haplotype (rs1806201-rs890-rs1805502) modulating pGABA levels among TRD patients. These results could improve treatment selection in these patients. Nonetheless, given our limited sample size, larger samples are necessary to confirm these results.

1. Zanos P, Gould TD. Mol Psychiatry. 2018;23(4):801-11.

2. Gammoh O, et al. XCLI J. 2024 Jan 4;23:62–78.

3. Romeo B, et al. J Psychiatry Neurosci JPN. 2018;43(1):58-66.

4. Zhang C, et al. Psychopharmacology. 2014; 231: 685-693.

Supported by the Basque Government Health Department, 2023111045

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High fuinctioning autism spectrum disorder (ASD) in women frequently goes unrecognized, with many receiving diagnosis after years of social camouflaging and misattributed symptoms. Midlife introduces new challenges that can unmask long compensated autistic traits. This review aims to explore whether midlife and aging act as critical periods that unmask high functioning ASD in women. We hypothesize that hormonal shifts, compounded by life stressors, exacerbate underlying autistic traits that lead to new clinical presentations.

This review aims to explore whether midlife and aging act as critical periods that unmask high functioning ASD in women. We hypothesize that hormonal shifts, compounded by life stressors, exacerbate underlying autiostic traits that lead to new clinical presentations.

A narrative literature review by searching MEDLINE (vía PubMed), EMBASE, PsychINFO, and Cochrane Library for articles published from 2010 to 2025. We used controlled vocabulary and key words including MeSH terms (“Autistic Disorder”, “Asperger Syndrome”, “Women”, “Menopause”, “Aging”) and EMtree terms (“autistic sprectrum disorder”, “female”, “midlife crisis!, “camouflaging behaviour”. We combined these terms with Boolean operators AND and OR. We prioritsed studies published in English or Spanish, involving adult women with high functionin ASD and addressing diagnostic features, psychosocial outmcomes, or health impacts during midlife.

Findings indicate that many autistic women enter midlife with profound fatigue from years of masking, high susceptibility to anxiety and depression. Menopausal changes and shrinking social networks further exacerbate isolation. While diagnosis at this stage often provides explanatory value and guides supportive interventions, it also raises questions about the thesholds for labeling lifelong neurodevelopmental patterns in the absence of functioning impairment.

• - Bargiela S et al.The expriences of late- diagnosed women with autism spectrum conditions: An investigation of the female autism phenotype. J Autism Dev Disord. 2016; 46 (19): 3281-94

• - Lai MC et al. Sex/gender differences and autism: setting the scne for future research. J Am Acad Child Adolec Psychiatry. 2015; 54(1(: 11-24

• - Hull L, et al. Autism spectrum disorder ad social camouflaging. Austism. 2017; 21(&): 702-717.

• - Moseley RL, et al. Brain and hormonal changes in autistic women. J Neurodev Disord. 2021; 13(1):9.

Recognizing ASD in women during midlife requires a refined, gender-sensitive approach. The decision to pursue or communicate a formal diagnosis should weight the potential for empowerment and targeted psychoeducation against the risks of unnecessary medicalization. Future research should refine diagnostic criteria and develop specific supports that acknowledge the unique trajectories of autistic women across the lifespan.

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Despite strong evidence for group psychotherapy, its implementation in adolescent mental health services remains limited. Barriers include lack of professional training, insufficient supervision, and rigid adherence to specific theoretical schools.

• - To identify barriers in the training and implementation of adolescent group therapy.

• - To present insights from the Toledo Transition Program on overcoming these barriers.

• - To propose recommendations for professional development and service design.

Qualitative descriptive study based on clinical experience. Observation of group sessions, supervision dynamics, and training needs of psychiatry residents and staff were analyzed.

• - Residents were often relegated to observer roles in groups, limiting active learning.

• - Lack of supervision spaces hindered skill acquisition and confidence.

• - Rigid theoretical frameworks discouraged flexible, integrative approaches.

• - Program experience showed that transdisciplinary teamwork and integrative use of dynamic, systemic, and cognitive tools improved training outcomes.

Expanding group therapy training requires supervision, active participation, and theoretical flexibility. Addressing these gaps can strengthen workforce capacity and facilitate the integration of group interventions as a standard tool in adolescent psychiatry.

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An increasing number of adolescents present to mental health services with anxiety, depression, or self-harming behaviors. In a significant subset, these symptoms conceal undiagnosed neurodevelopmental conditions—such as borderline intellectual functioning (BIF), mild intellectual disability (ID), or autism spectrum disorder (ASD)—that were not identified during childhood. Many of these youths advanced academically and socially despite substantial effort, which delayed recognition by pediatricians and schools. Without acknowledging these hidden developmental profiles, clinicians risk applying symptom-focused therapies that are ill-suited to the adolescent’s cognitive and adaptive capacities.

(1) To highlight the impact of missed childhood diagnosis of BIF, mild ID, or ASD in adolescents presenting with emotional or behavioral symptoms. (2) To demonstrate how undetected neurodevelopmental conditions undermine standard psychotherapeutic approaches. (3)To propose systematic neurodevelopmental screening prior to intervention initiation in adolescent mental health care.

We conducted a narrative review (2023–2025) of recent meta-analyses on adapted psychotherapy in ASD and ID, conceptual reviews of BIF, and major international guidelines (NICE, NHS England). We analyzed recommendations on neurodevelopmental screening and psychotherapeutic adaptations for adolescents.

1. (1) Missed in childhood: Many adolescents with low IQ or autistic traits escaped earlier detection, progressing academically at the cost of hidden distress.

2. (2) Secondary presentations: In adolescence, they present with anxiety, depression, or self-harm, symptoms that overshadow the underlying condition.

3. (3) Therapy works—when adapted: Evidence supports the efficacy of adapted psychotherapies (simplified CBT, visual supports, structured pacing, family involvement) when neurodevelopmental conditions are recognized.

4. (4) Guideline gap: Although guidelines recommend adaptations, they rarely require clinicians to systematically rule out neurodevelopmental conditions prior to starting standard therapy.

The failure to detect neurodevelopmental disorders early partly explains why many adolescents show poor response to conventional, symptom-focused treatments. Unless mental health services incorporate routine cognitive and adaptive screening before pychotherapy or pharmacotherapy, treatments risk addressing symptoms while ignoring root causes. This raises a necessary debate: should adolescent mental health care continue to apply one-size-fits-all protocols, or move toward precision psychotherapy tailored to each individual’s neurodevelopmental profile?

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Theory of Mind (ToM) - the capacity to infer others’ mental states – is consistently impaired in patients with schizophrenia (SZ), and is a well-established predictor of social dysfunction and poor functional outcomes. While numerous functional imaging studies have examined ToM in SZ, few have employed videos, which may be important for ecological validity and a more nuanced understanding of social cognitive deficits in the disorder.

This pilot study aimed to: 1) validate a novel video-based task for engaging the core ToM neural network, and 2) analyse differences in brain activation between SZ patients and healthy controls (HC).

15 HC and 6 SZ patients matched for sex, age and estimated premorbid IQ underwent fMRI while performing a video-based ToM task adapted from the Battery for Theory of Mind Assessment (BAT). The task included 16 videos, 8 showing social situations with a ToM component, and 8 control videos featuring people performing various non-social activities, each followed by a question (either ToM-related or related to a concrete aspect of the scene) (Figure 1). Data were analysed using FSL’s FEAT with a GLM approach (cluster-based threshold: z > 2.6, p < .05) to compare brain activity while responding to ToM relative to control questions.

Behavioral performance was significantly worse in the SZ group compared to HCs on the ToM questions (p < .05). Both groups activated the canonical ToM network during the task, including the medial prefrontal cortex (mPFC) and the precuneus (both nodes of the default mode network), and the temporoparietal junction (TPJ). The comparison between patients and controls revealed four clusters of significant hyperactivation in the dorsomedial prefrontal cortex (dmPFC), precuneus/posterior cingulate cortex, the right inferior parietal lobule and the cerebellum (Figure 2).Image 1:

This video-based task robustly engaged the canonical ToM network in both healthy subjects and SZ patients, supporting its utility for studying the neural correlates of ToM. Our results for the comparison between patients and controls are preliminary, but point to potential hyperactivation in parts of the default mode network in SZ patients.

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Methadone is a synthetic opioid with slow-onset activity, acting as an agonist at μ-opioid receptors (MOR) and as an antagonist at N-methyl-D-aspartate (NMDA) receptors. Its biotransformation is primarily mediated by cytochrome P450 enzymes, including CYP3A4, CYP2C19, CYP2D6, and particularly CYP2B6, which exhibits preferential metabolism of the R-enantiomer. Single nucleotide polymorphisms (SNPs) have been shown to influence methadone pharmacokinetics and contribute to interindividual variability. Owing to this metabolic variability, a consistent correlation between dose, plasma concentration, and clinical effect has not been established, thereby necessitating individualized dose titration guided by clinical response.

This study aims to elucidate the relationship between plasma methadone concentrations and patient-specific variables, including body weight, sex, and metabolizer phenotypes of the principal genes implicated in methadone biotransformation.

This descriptive study involved genotyping and phenotyping a cohort of 80 patients enrolled in methadone substitution programs in the Galician community. Two blood samples were collected from each participant: one to determine the metabolizer phenotype for the previously mentioned enzymes, and another to isolate plasma for quantification of methadone concentrations.

Following pharmacogenetic and pharmacokinetic analyses, significant differences were observed between normal and intermediate CYP3A4 metabolizers (p = 0.0327), whereas no significant associations were found for the other enzymes, supporting the hypothesis that the enzyme encoded by this gene is the predominant contributor.

Although no correlation was detected between methadone metabolism and BMI, body weight, or sex, the observed association between CYP3A4 metabolizer status and plasma methadone concentrations highlights the potential for precision medicine approaches in guiding the prescription of methadone for opioid use disorder.

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Depression is a chronic and recurrent mental condition, causing a high burden of disease, functional impairment, and significant economic costs worldwide.

To compare the neuropsychological profile, inflammation, and functionality in patients with a major depressive episode before and after treatment.

A longitudinal study was conducted, recruiting a total of 39 subjects, with a mean age of 42 years (12 men - 30.8% and 27 women - 69.2%) diagnosed with major depressive disorder (MDD). The neuropsychological profile was measured using the Screening of Cognitive Impairment in Psychiatry (SCIP) and the level of functionality with the Brief Assessment of Functioning (FAST) test. Both total scores and subscales were used, along with inflammatory biomarkers (IL-6, IL-1ß, TNF-α, PGE2) and oxidative stress markers (TAS, GSHtot, GSHfree, GSSG, CAT, SOD, GPx, and BDNF).

The paired t-test was used through the statistical program SPSS. A unilateral p-value less than 0.05 was considered statistically significant.

Significant differences were observed in both the Hamilton Depression Rating Scale (p < 0.001) and in the biomarkers total GSH (p < 0.15), GSH free (p < 0.029), and GSSG (p < 0.027) of patients at three months from the start of pharmacological treatment compared to baseline (Table 1). Differences were also observed at 3 months of treatment in the SCIP scale (p < 0.001) as well as in its subscales: Immediate verbal learning (p < 0.001), Working memory (p < 0.001), Verbal fluency (p = 0.007), and Delayed verbal learning (p < 0.001), and in the FAST scale (p < 0.001) and its subscales: Autonomy (p = 0.002), Cognitive (p = 0.004), Finances (p = 0.004), and Relationships (p < 0.001) (Table 2).

Image 1:

Image 2:

Our results indicate that there are improvements at the cognitive and functional level in subjects taking antidepressant treatment. Changes in GSH and GSSG biomarkers were also observed, whose antioxidant function is crucial for protecting cells from oxidative damage. The findings suggest that oxidative stress is a crucial factor in the pathophysiology of MDD. The study highlights the potential of these biomarkers to guide therapeutic strategies and improve the management of depression.

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In high-income countries, Coordinated Specialized Care for First Psychotic Episode (FEP) programs have been shown to be effective in reducing symptoms and disability. Chile guarantees universal access to these services through a national policy, but previous research indicates that evidence-based approaches are not used. Our team adapted the OnTrackNY (OTNY) program to the Chilean context, called OnTrackChile (OTCH), to evaluate its effectiveness and implementation. This summary presents preliminary results on model fidelity, one of the primary outcomes of the study.

To evaluate the fidelity of the implementation of the OTCH program in comparison with usual care services for FEP, analyzing its compliance in 18 key domains of care and its alignment with the National Mental Health Plan.

A fidelity scale was designed to guide data collection on OTCH implementation. The scale included the name and definition of each domain, along with a set of expectations. The scale assessed 18 key domains, such as staffing, team integration, communication, burden of care, service flexibility, crisis, treatment planning, prescribing, care management, working with families, and education and employment support, among others. The scale was applied in the 5 OTCH intervention sites and 8 control sites that maintained usual care included in the cluster-randomized controlled clinical trial.

OTCH sites met more than 80% of the criteria for the domains assessed in the fidelity scale, which is more than twice the compliance observed in the control sites. In domains related to the usual functioning of the centers coincident with those established in the National Mental Health Plan, OTCH intervention sites exceeded compliance standards to control sites (p<0.001). In situations where the frequency of problems was similar between both types of centers, such as suicidal risk and risky substance use, OTCH centers showed significantly better performance (p<0.001) compared to control centers.

The implementation of the OTCH model has not only allowed the introduction of specific aspects of the program, but has also improved the overall performance of the centers in key areas defined by the National Mental Health Plan. This suggests that the implementation of OTCH in the Chilean context is not only feasible, but can also improve the quality of community mental health care.

OnTrack Chile is funded by the U.S. National Institute of Mental Health (R01MH115502).

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Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by systemic inflammation and high prevalence of neuropsychiatric symptoms. Among these, suicidal ideation represents a significant concern, with reported higher rates than in the general population. The etiology of suicidal ideation in SLE is multifaceted, encompassing both disease-specific factors and psychosocial variables. Recent research has highlighted the intricate interplay between SLE and psychiatric symptoms, suggesting a bidirectional relationship mediated by inflammatory processes, neurological involvement, and psychosocial stressors. However, the specific contributions of these factors remain unclear.

This study aims to elucidate the primary predictors of suicidal ideation in a cohort of SLE patients.

A cross-sectional study was conducted with a cohort of SLE patients from the Autoimmune Diseases Unit at Cruces University Hospital (Biscay, Spain). Each patient underwent a thorough clinical evaluation by a psychiatrist, and relevant clinical and sociodemographic data were collected. Suicidal ideation was assessed using the Plutchik scale, while predictor variables included autoimmune factors such as cumulative corticosteroid dose, disease activity, and accumulated organ damage. Psychiatric symptoms were assessed using various psychometric scales. A multiple linear regression model was employed to examine the associations between these variables and suicidal ideation.

A total of 92 SLE patients in active follow-up were included, with a female predominance (91%). Most patients were in an inactive disease state, receiving low-dose prednisone and antimalarial therapy according to our clinical protocol; the majority were in remission, as reflected by a mean SLEDAI-2K score of 1.59(±2.44). Despite a median disease duration of over 10 years, cumulative organ damage was low (mean SDI score 0.33 ± 0.84). In a multiple linear regression analysis, the model showed a strong fit (R=0.732, R²=0.535, p<.001), explaining approximately 53.5% of the variability in suicidal ideation. Suicidal ideation was significantly associated with cumulative corticosteroid dose (β=0.172, p=0.011), total anxiety score (β=0.248, p<.001), and frequency of traumatic experiences (β=0.118, p<.001). Collinearity statistics (VIF 1.03–1.07) indicated no significant multicollinearity issues.

Suicidal ideation in our SLE cohort was associated with corticosteroid use, anxiety, and traumatic experiences, highlighting the importance of addressing these factors in suicide risk management. The relationship between corticosteroid dose and suicidal ideation may be linked to the neuropsychiatric effects of these drugs, while anxiety and traumatic experiences contribute to the emotional burden of the patient. Notably, disease activity was not linked to suicidal ideation in this cohort.

None Declared

Autoimmune encephalitis is a new and increasingly well-described entity. The most common is encephalitis caused by antibodies against the N-methyl-D-aspartate receptor on the surface of neurons (NMDAR encephalitis). It is a predominant entity in women and young patients and it is often associated with ovarian teratomas, neuroblastomas, Hodgkin’s lymphomas and others.

NMDAR encephalitis can manifest with a diverse range of neurological and psychiatric symptoms (personality change, anxiety, insomnia, confusion, attentional and short-term memory deficits, emotional lability, psychotic symptoms, language impairment, fluctuations in the level of consciousness, seizures and dysautonomia).

Clinical review of Anti-NMDAR Encephalitis for differential diagnosis with Functional Neurologic Disorder.

Clinical case and literature review.

We present the clinical case of a 27-year-old woman with a history of depression and anancastic personality disorder. The patient went to the Emergency Department different days presenting both neurological (facial paresthesias, hypoesthesia, weakness, high-intensity occipital headache, dizziness, loss of consciousness and anterograde amnesia) and psychiatric symptoms (obsessive thoughts, anxiety, visual and auditory hallucinations). She was admitted to the Neurology Unit. Complementary tests were performed: EEG, cranial CT scan, MRI, lumbar puncture, blood tests (including tumour markers) and urinalysis, founding no alterations suggestive of encephalitis or other systemic pathologies. She was also evaluated by the Psychiatry service. The patient described that as a result of a recent change in her job she presented emotional lability, obsessive ruminative ideas and anxiety. Treatment with Sertraline 100mg/day and Lorazepam 1mg/8 hours was started.

After ruling out autoimmune encephalitis, the patient was diagnosed with Functional Neurologic Disorder, given the temporal relationship of the symptoms with the stressful history at work.

Given their growing prevalence autoimmune causes, such as NMDA anti-receptor antibody encephalitis, should always be considered in the cases of neuropsychiatric alterations. It is very important to carry out a correct organic screening prior to the diagnosis of psychiatric pathology. It is also essential an adequate coordination between different medical departments for an accurate and comprehensive approach to the patient.

None Declared

Maniform symptoms for the first time after the age of 50 are not common, although we can find it in our clinical practice due to the increasing aging of the world’s population.

We present a clinical case of a patient with manifest behavioral symptoms where a differential diagnosis is made between Late-onset bipolar disorder vs Frontotemporal dementia with a behavioral profile (FTD)

62-year-old male with a history of type II diabetes, hypertension and L4-L5 disc herniation. Psychiatric history of recurrent depressive disorder and dysfunctional personality. Treated with venlafaxine 150 mg and gabapentin 600 mg DMD. He was on sick leave from his company due to lower back pain. Married with two children, dysfunctional relationship with them. He was admitted to Psychiatry for the first time in February 2024 due to behavioral disturbances of 5 days’ duration. He was verbose, irritable and described “being better than ever”. A few days earlier he took a Tadalafil tablet, an event that he related to the onset of the condition. Since then, there has been an increase in psychomotor activity, disinhibition and exalted mood. He reported having contact with high-ranking political figures. Upon discharge from hospital, he was diagnosed with an Unspecified Manic Episode and was prescribed Lithium 800mg DMD and Risperidone extended release 75 mg monthly. The symptoms did not improve, he abandoned the treatment and was admitted for the second time in April 2024 where Valproic 1000 mg DMD, Olanzapine 20mg DMD and Risperidone 6 DMD were prescribed.

He has a poor outpatient evolution with loss of autonomy, physical deterioration, hyperfamiliarity, behavioral disinhibition and no awareness of the disease. Given the suspicion of an organic condition, he was referred to Neurology consultations where a cranial magnetic resonance imaging was performed. with results of punctate and hyperintense images in T2 localized in subcortical white matter of nonspecific character and Mini-ACEII test: 22/30. Waiting for PET-CT and with a diagnosis of possible Frontal Release Syndrome to rule out behavioral variant FTD.

Within the differential diagnosis of the condition we find Late-onset bipolar affective disorder and behavioral variant FTD. The first presents with inappropriate, repetitive and stereotyped behavior, as well as a progressive and gradual deterioration. While late bipolar disorder presents with self-limiting episodes and more manifest symptoms. In a PET-CT suggestive of FTD it is likely to find areas of hypoperfusion in frontal and temporal regions. The differential diagnosis between both is a challenge in clinical practice.

None Declared

Eating disorders (EDS) have become in recent decades an important focus of interest for basic and clinical research due to the increase in prevalence and incidence observed and, therefore, the evident need to prevent and provide a therapeutic response to situations that affect important sectors of the population. Normal eating behavior and its pathological deviations can only be understood if they are studied under the biopsychosocial approach, since, attending only to the eating aspect, we are ignoring a series of determining factors in the development of this process. Within these factors, important changes have been observed in recent times in relation to the demographic profile, going from being a disease studied predominantly in women, to extending to men and non-binary people or with other sexual and/or gender options.

The aim of this study is to propose a new model for the representation of Eating Disorders (EDS) using nursing care languages, which allows us to approach the description of people affected by this pathology and their environment, implementing the perspective of gender, and that facilitates the realization of better diagnoses.

A systematic bibliographic review on EDS was carried out using databases from the different areas involved. The information was ordered and summarized in tables and concept maps. Next, a comparison was made between the traditional EDS model, described using medical language, and the new model proposed by the nursing discipline, where all the information previously obtained is codified in languages proposed by the North American Nursing Diagnosis Association (NANDA) and the Nursing Development Foundation (FUDEN) in the manual on Standardized Nursing Knowledge (CENES).

The results obtained indicate that, after coding and organizing the existing information through nursing languages, the diagnostic view can be broadened by incorporating a greater number of variables to carry out a more complete approach to EDs. This would make it possible to propose a new conceptual model of these disorders, addressing them not only as a disease, but as a product of the failure of a healthy individualization that leads people who suffer from them to not carry out their self-care adequately, exerting on their person a act of anti-self care.

The energetic representation of care, characteristic of nursing, could be useful in care practice, so that the description of the phenomenology of care for each individual could be established, and it would also provide a series of action algorithms that would favor its implementation for health prevention.

None Declared

The proposed research work aims to carry out a review of the data of the Assertive Community Treatment Program of Segovia, analyzing its importance in certain profiles of psychiatric patients.

Review of data from the Segovia Assertive Community Treatment Program from 2020-2024: age, sex, nationality, marital status, level of education, diagnosis, family history, substance use, population, socio-family situation, economic situation, follow-up and admissions in Mental health, social health coordination and disability.

Data from the Segovia Assertive Community Treatment Program from 2020-2024.

The majority of patients participating in the Segovia Assertive Community Treatment Program between 2020-2024 were Spanish men between 20 and 60 years old. All patients were single, except three separated and one married. Approximately half of them lived alone and the other half with their family of origin. Most had basic education and half were employed. Regarding the consumption of toxic substances, most of them smoked tobacco and some also consumed alcohol or cannabis, and a small number cocaine. Many of them received a financial benefit and had social-health coordination.

The most common diagnosis is schizophrenia, followed by schizoaffective disorder and delusional disorder, most with psychiatric family history. Other diagnoses that the patients presented were: bipolar disorder, personality disorder and obsessive-compulsive disorder. Some of them also had disabilities.

It is important to highlight that 94.12% of patients live in rural areas, many of them more than 30 minutes away by car and with faced great difficulties with public transportation. Many of them were more previous admissions to Psychiatry and an irregular follow-up in Mental Health, but very few had readmissions during the Program. The majority of patients had psychopharmacological treatment, and 7.14% of them had injectable antipsychotic treatment.

A large percentage of patients in the Assertive Community Mental Health Treatment Program are people who live in a rural environment, with a long distance from the nearest mental health center and with difficulties using public transportation, which is why this program is very useful. In these patients to achieve clinical stability, since these patients had irregular follow-up in Mental Health consultations and had numerous admissions to Psychiatry.

None Declared

The Choice giving birth by cesarean section when it is not biologically necessary implies a greater risk to the health of the mother and child Toral et al. Eletrônica Estácio Saúde 2018; 95(1) 27-30,refers the psychological relevance to identify perinatal effects of a good medical practice at birth. In this respect Poojari et al. Early Hum Dev 2019;115 93-98, state that a cesarean section as a surgical risk, causes decrease fetal oxygenation and an impairment release of stress-related hormones in the maternal-fetal binomial that does not favor neural connections at birth

Identify the neurodevelopmental lags in infant on children under 24 months of age born by cesarean section and vaginal delivery,

A cross-sectional descriptive correlational; Sample consisted of 100 children of a term gestation, 70 with spontaneous vaginal birth and 30 whose birth was by cesarean section, aged between one and twenty-four months; using the Abbreviated Development Scale, an instrument created and validated for the Colombian population (Cronbach’s alpha, 0.94). All parents signed the informed consent.

All test scales were applied (gross and fine motor, language and social personal), the results showed that children born by cesarean section had better development in areas of fine motor and language, while children born by vaginal delivery had better development of gross motor. See (graphic 1).

Graphic 1: Areas of development according to the type of delivery.

References

The influence of contextual variables such as age and educational level of the mother on language and social areas was also found

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Long-acting injectable antipsychotics (LAIs) offer advantages for schizophrenic patients compared to oral antipsychotics: less frequent dosing, lower relapse rates, better adherence, and lower healthcare costs. LAIs include paliperidone, aripiprazole, olanzapine, risperidone, and zuclopenthixol. Paliperidone palmitate is the only antipsychotic with two formulations with an administration interval longer than one month (3-monthly and 6-monthly), which could be better for the patient and help ensure treatment continuity, especially in cases of limited access to the health care system.

To assess the satisfaction of patients under treatment with 6-month paliperidone palmitate compared to other long-acting injectable antipsychotics with a higher frequency of administration.

We analyzed the satisfaction level of a sample of patients receiving treatment with LAIs at the Mental Health Center of El Escorial. All patients had a diagnosis of schizophrenia or other psychotic disorders (according to DSM-5). Patients who met the inclusion criteria completed the Treatment Satisfaction Questionnaire for Medication (TSQM), a generic questionnaire of treatment satisfaction that measures four dimensions: side effects, treatment efficacy, comfort of use, and overall satisfaction. Other clinical and socio-demographic variables were collected, as well as the type of injectable, dose, and frequency of administration.

Data from approximately 30 patients will be analyzed and discussed later.

Less frequent administration of LAIs may result in greater patient satisfaction and be just as beneficial clinically. Treatment satisfaction is positively associated with an improvement in psychotic symptoms and seems to be related to better adherence.

None Declared