OBJECTIVES/GOALS: Our objective is to develop a Telenephrology dashboard for the 150,000 Veterans that obtain care through the Iowa City Veterans Affairs Health Care System. Our goal is to create a comprehensive and user-friendly tool for monitoring kidney health and facilitating remote nephrology consultations. METHODS/STUDY POPULATION: We structured our intervention according to the five stages of human-centered design: (1) Empathize, (2) Define, (3) Ideate, (4) Prototype and (5) Test. During the empathy stage, the principal investigator spent 10 hours immersed in the clinical setting observing how nephrologists approach a remote nephrology consultation. These observations were augmented by unstructured interviews with clinicians and patients to better understand the process and dynamics. Following this, a rapid ideation workshop was convened to generate creative solutions that balance technical requirements with the needs of clinicians and patients. These led to rapid prototyping and testing to identify what elements of the prototypes worked and which needed improvement. RESULTS/ANTICIPATED RESULTS: Through the empathy and define stages, three needs were identified: (1) clarity in visualizing data, (2) accuracy of information, and (3) balancing standardization with individualization. During the rapid ideation workshop, the concept of a four-frame dashboard was settled upon. This led to the creation of five prototypes, which were tested. These were reconciled and modified to make a final product. This final product, the Telenephrology Dashboard, contains 5 elements that support nephrologists and supporting staff: (1) a graph of kidney function over time, (2) tables synthesizing lab data, (3) options to drill down events to specific times, (4) customization of views, and (5) integration of kidney disease progression models. DISCUSSION/SIGNIFICANCE: A Telenephrology dashboard was created to facilitate remote nephrology consultations through a Human-Centered Design process. Our next steps include determining if this dashboard may improve end-user satisfaction, referring clinician satisfaction, access to specialist care, and patient outcomes.

The provisioning of foraging opportunities to primates has been shown to be an effective means of enriching the laboratory environment. In this study artificial turf was used as the substrate for a particulate food given to the subjects as an environmental enrichment technique. Eight rhesus monkeys exhibited a significant reduction in behavioural pathology when allowed to extend the amount of time they spent in consummatory activities. An increasing trend in time spent foraging with a concomitant decline in aberrant behaviour over a period of six months was particularly noteworthy. No significant difference in preference for particulate monkey chow or more flavourful particulate food treats was expressed by the primates.

The onset of magnetic reconnection in space, astrophysical and laboratory plasmas is reviewed discussing results from theory, numerical simulations and observations. After a brief introduction on magnetic reconnection and approach to the question of onset, we first discuss recent theoretical models and numerical simulations, followed by observations of reconnection and its effects in space and astrophysical plasmas from satellites and ground-based detectors, as well as measurements of reconnection in laboratory plasma experiments. Mechanisms allowing reconnection spanning from collisional resistivity to kinetic effects as well as partial ionization are described, providing a description valid over a wide range of plasma parameters, and therefore applicable in principle to many different astrophysical and laboratory environments. Finally, we summarize the implications of reconnection onset physics for plasma dynamics throughout the Universe and illustrate how capturing the dynamics correctly is important to understanding particle acceleration. The goal of this review is to give a view on the present status of this topic and future interesting investigations, offering a unified approach.

The basal ganglia represents a key component of the pathophysiological model for obsessive-compulsive disorder (OCD). This brain region is part of several neural circuits, including the orbitofronto-striatal circuit and dorsolateral prefronto-striatal circuit. There are, however, no published studies investigating those circuits at a network level in non-medicated patients with OCD. Resting state functional magnetic resonance imaging scans were obtained from 20 non-medicated patients with OCD and 23 matched healthy volunteers. Voxelwise statistical parametric maps testing strength of functional connectivity of three striatal seed regions of interest (ROIs) with remaining brain regions were calculated and compared between groups. We performed additional correlation analyses between strength of connectivity and the severity scores for obsessive-compulsive symptoms, depression, and anxiety in the OCD group. Positive functional connectivity with the ventral striatum was significantly increased (Pcorrected <.05) in the orbitofrontal cortex, ventral medial prefrontal cortex and dorsal lateral prefrontal cortex of subjects with OCD. There was no significant correlation between measures of symptom severity and the strength of connectivity (Puncorrected <.001). This is the first study to investigate the corticostriatal connectivity in non-medicated patients with OCD. These findings provide the first direct evidence supporting a pathophysiological model involving basal ganglia circuitry in OCD.

Measurements in the infrared wavelength domain allow direct assessment of the physical state and energy balance of cool matter in space, enabling the detailed study of the processes that govern the formation and evolution of stars and planetary systems in galaxies over cosmic time. Previous infrared missions revealed a great deal about the obscured Universe, but were hampered by limited sensitivity.

SPICA takes the next step in infrared observational capability by combining a large 2.5-meter diameter telescope, cooled to below 8 K, with instruments employing ultra-sensitive detectors. A combination of passive cooling and mechanical coolers will be used to cool both the telescope and the instruments. With mechanical coolers the mission lifetime is not limited by the supply of cryogen. With the combination of low telescope background and instruments with state-of-the-art detectors SPICA provides a huge advance on the capabilities of previous missions.

SPICA instruments offer spectral resolving power ranging from R ~50 through 11 000 in the 17–230 μm domain and R ~28.000 spectroscopy between 12 and 18 μm. SPICA will provide efficient 30–37 μm broad band mapping, and small field spectroscopic and polarimetric imaging at 100, 200 and 350 μm. SPICA will provide infrared spectroscopy with an unprecedented sensitivity of ~5 × 10−20 W m−2 (5σ/1 h)—over two orders of magnitude improvement over what earlier missions. This exceptional performance leap, will open entirely new domains in infrared astronomy; galaxy evolution and metal production over cosmic time, dust formation and evolution from very early epochs onwards, the formation history of planetary systems.

Montmorillonites ion-exchanged with Li+, Na+, K+ Ca2+, Mg2+ and Ni2+ and acidic clay were used as catalysts for the polymerization of a cyclic siloxane monomer, 2,4,6,8- tetramethylcyclotetrasiloxane. Montmorillonites with Ni2+ and Mg2+ in the interlayer, and acidic clay exhibit a greater ability for siloxane polymerization in both yield and mean molecular weight of products than those containing Li+, Na+ and K+. The difference in catalytic ability of the ionexchanged montmorillonites is caused by the number of Brmasted acid sites due to the polarization of H2O. This was confirmed experimentally by FTIR analysis of pyridine-treated samples. Therefore, it may be possible to design a catalyst for controlling siloxane polymerization (i.e. mean molecular weight of product) by changing the number of Bronsted acid sites through exchange of the interlayer cations of montmorillonites.

Aspidolite, the Na analogue of phlogopite, ideally NaMg3AlSi3O10(OH)2, occurring in hornfels from a contact aureole in Kasuga-mura, central Japan, has been approved as a mica species by the Commission on New Minerals and Mineral Names of the International Mineralogical Association. Aspidolite is interleaved with and surrounded by phlogopite. Based on its mode of occurrence, phlogopite is classified into two types; (1) phlogopite interleaved with aspidolite (= interleaved phlogopite) and (2) phlogopite rim. The aspidolite-phlogopite assemblage is associated with amphibole (pargasite-magnesiosadanagaite), titanite, calcite, scapolite, apatite, pyrrhotite and chalcopyrite. A representative chemical formula of aspidolite is (Na0.90K0.10)∑1.00(Mg2.27Al0.41Fe0.232+Ti0.05)∑2.96 (Al1.44Si2.56)∑4.00O10(OH1.97F0.03)∑2.00. Aspidolite has almost fully occupied the interlayer site; its Na/(Na+K) ratio ranges from 0.67 to 0.95. It has more tetrahedral Al (1.38—1.48 a.p.f.u. for O = 11) than the ideal aspidolite end-member showing progression of tschermakite-type substitution. The alternation of aspidolite and phlogopite parallel to the (001) plane may indicate a miscibility gap between these two phases. The phlogopite rim is interpreted as a later product, probably formed metasomatically. Aspidolite is optically biaxial negative with elongation positive and Z ‖ cleavage. Two polytypes (1M and 1A) of aspidolite were identified in X-ray powder diffraction patterns. Aspidolite-1M is monoclinic, space group C2/m, with refined unit-cell parameters a = 5.291(8), b = 9.16(2), c = 10.12(2) Å, β = 105.1(1)°, V = 473(1) Å3, Z = 2. Aspidolite-1A is triclinic, space group C, with a = 5.289(6), b = 9.16(1), c = 9.892(9) Å, α = 94.45(9), β = 97.74(9), γ = 90.0(1)°, V = 473.4(9) Å3, Z = 2.

IR spectroscopy in the range 12–230 μm with the SPace IR telescope for Cosmology and Astrophysics (SPICA) will reveal the physical processes governing the formation and evolution of galaxies and black holes through cosmic time, bridging the gap between the James Webb Space Telescope and the upcoming Extremely Large Telescopes at shorter wavelengths and the Atacama Large Millimeter Array at longer wavelengths. The SPICA, with its 2.5-m telescope actively cooled to below 8 K, will obtain the first spectroscopic determination, in the mid-IR rest-frame, of both the star-formation rate and black hole accretion rate histories of galaxies, reaching lookback times of 12 Gyr, for large statistically significant samples. Densities, temperatures, radiation fields, and gas-phase metallicities will be measured in dust-obscured galaxies and active galactic nuclei, sampling a large range in mass and luminosity, from faint local dwarf galaxies to luminous quasars in the distant Universe. Active galactic nuclei and starburst feedback and feeding mechanisms in distant galaxies will be uncovered through detailed measurements of molecular and atomic line profiles. The SPICA’s large-area deep spectrophotometric surveys will provide mid-IR spectra and continuum fluxes for unbiased samples of tens of thousands of galaxies, out to redshifts of z ~ 6.

In order to investigate the distinguishability about the progenitors of FeCCSNe and ECSNe, we calculate the luminosities and spectra of their pre-SN neutrinos and estimate the number of events at neutrino detectors.

The field of Developmental Origins of Health and Disease (DOHaD) seeks to understand the relationships between early-life environmental exposures and long-term health and disease. Until recently, the molecular mechanisms underlying these phenomena were poorly understood; however, epigenetics has been proposed to bridge the gap between the environment and phenotype. Epigenetics involves the study of heritable changes in gene expression, which occur without changes to the underlying DNA sequence. Different types of epigenetic modifications include DNA methylation, post-translational histone modifications and non-coding RNAs. Increasingly, changes to the epigenome have been associated with early-life exposures in both humans and animal models, offering both an explanation for how the environment may programme long-term health, as well as molecular changes that could be developed as biomarkers of exposure and/or future disease. As such, epigenetic studies in DOHaD hold much promise; however, there are a number of factors which should be considered when designing and interpreting such studies. These include the impact of the genome on the epigenome, the tissue-specificity of epigenetic marks, the stability (or lack thereof) of epigenetic changes over time and the importance of associating epigenetic changes with changes in transcription or translation to demonstrate functional consequences. In this review, we discuss each of these key concepts and provide practical strategies to mitigate some common pitfalls with the aim of providing a useful guide for future epigenetic studies in DOHaD.

It is now firmly established that a small anisotropy of the galactic cosmic rays exists, observable from Earth as a variation of intensity in sidereal time. The problem now is to determine more clearly the characteristics of the anisotropy and, in particular, its detailed spatial structure and how it depends upon the energy and composition of the cosmic rays. This is a very difficult task and, in the final analysis, may not be fully achievable from Earth-based observations. The purpose of the present paper is to describe briefly an installation now operating in Tasmania to provide further information on the spatial structure of the anisotropy.