We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
We present the third data release from the Parkes Pulsar Timing Array (PPTA) project. The release contains observations of 32 pulsars obtained using the 64-m Parkes ‘Murriyang’ radio telescope. The data span is up to 18 yr with a typical cadence of 3 weeks. This data release is formed by combining an updated version of our second data release with $\sim$3 yr of more recent data primarily obtained using an ultra-wide-bandwidth receiver system that operates between 704 and 4032 MHz. We provide calibrated pulse profiles, flux density dynamic spectra, pulse times of arrival, and initial pulsar timing models. We describe methods for processing such wide-bandwidth observations and compare this data release with our previous release.
While oral antidepressants reach efficacy after weeks, single-dose intravenous (i.v.) ketamine has rapid, yet time-limited antidepressant effects. We aimed to determine the efficacy and safety of single-dose i.v. ketamine augmentation of escitalopram in major depressive disorder (MDD).
Method
Thirty outpatients with severe MDD (17-item Hamilton Rating Scale for Depression total score ⩾24) were randomized to 4 weeks double-blind treatment with escitalopram 10 mg/day+single-dose i.v. ketamine (0.5 mg/kg over 40 min) or escitalopram 10 mg/day + placebo (0.9% i.v. saline). Depressive symptoms were measured using the Montgomery–Asberg Depression Rating Scale (MADRS) and the Quick Inventory of Depressive Symptomatology – Self-Report (QIDS-SR). Suicidal ideation was evaluated with the QIDS-SR item 12. Adverse psychopathological effects were measured with the Brief Psychiatric Rating Scale (BPRS)-positive symptoms, Young Mania Rating Scale (YMRS) and Clinician Administered Dissociative States Scale (CADSS). Patients were assessed at baseline, 1, 2, 4, 24 and 72 h and 7, 14, 21 and 28 days. Time to response (⩾50% MADRS score reduction) was the primary outcome.
Results
By 4 weeks, more escitalopram + ketamine-treated than escitalopram + placebo-treated patients responded (92.3% v. 57.1%, p = 0.04) and remitted (76.9% v. 14.3%, p = 0.001), with significantly shorter time to response [hazard ratio (HR) 0.04, 95% confidence interval (CI) 0.01–0.22, p < 0.001] and remission (HR 0.11, 95% CI 0.02–0.63, p = 0.01). Compared to escitalopram + placebo, escitalopram + ketamine was associated with significantly lower MADRS scores from 2 h to 2 weeks [(peak = 3 days–2 weeks; effect size (ES) = 1.08–1.18)], QIDS-SR scores from 2 h to 2 weeks (maximum ES = 1.27), and QIDS-SR suicidality from 2 to 72 h (maximum ES = 2.24). Only YMRS scores increased significantly with ketamine augmentation (1 and 2 h), without significant BPRS or CADSS elevation.
Conclusions
Single-dose i.v. ketamine augmentation of escitalopram was safe and effective in severe MDD, holding promise for speeding up early oral antidepressant efficacy.
A wide class of materials that were discovered to carry a topologically protected phase order has led to a highly active area of research called topological insulators (TIs). This phenomenon has radically changed our thinking because of the robust quantum coherent behavior showing two-dimensional Dirac-type metallic surface states (SSs) and simultaneously insulating bulk states. The Dirac SSs are induced by the strong spin–orbit coupling as well as protected by time reversal symmetry (TRS). Breaking TRS in a TI with ferromagnetic perturbation can lead to many exotic quantum phenomena, such as the quantum anomalous Hall effect, topological magnetoelectric effect, as well as image magnetic monopole. This article presents an overview of the current status of TRS breaking in TIs and outlines the prospects for future studies.
Interconnected microstructural ZnO:Al thin films with low doping concentration (Al/Zn ≤1%) were deposited on (0001) sapphire substrates by the sol-gel technique. The effects of low doping concentration on the structural, optical and electrical properties of the films were investigated. Scanning electron microscope (SEM), X-ray diffraction (XRD), photoluminescence (PL), and four-point probe method were used to characterize the structural, optical and electrical properties. We found that with increasing the dopant concentration the interconnected thread becomes thinner, the (002) diffraction peak and the near band edge (NBE) emission are enhanced while the deep level emission (DLE) and the resistivity are decreased.
Finite-difference solutions of the equations of motion for steady incompressible flow around a circular cylinder have been obtained for a range of Reynolds numbers from R = 5 to R = 100. The object is to extend the Reynolds number range for reliable data on the steady flow, particularly with regard to the growth of the wake. The wake length is found to increase approximately linearly with R over the whole range from the value, just below R = 7, at which it first appears. Calculated values of the drag coefficient, the angle of separation, and the pressure and vorticity distributions over the cylinder surface are presented. The development of these properties with Reynolds number is consistent, but it does not seem possible to predict with any certainty their tendency as R → ∞. The first attempt to obtain the present results was made by integrating the time-dependent equations, but the approach to steady flow was so slow at higher Reynolds numbers that the method was abandoned.
TiNi shape memory alloy (SMA) has potential applications for nuclear reactors and its phase stability under irradiation is becoming an important topic. Some irradiation-induced diffusion-dependent phase transformations, such as amorphization, have been reported before. In the present work, the behavior of diffusion-independent phase transformation in TiNi SMA was studied by electron irradiation at room temperature. The effect of irradiation on the martensitic transformation of TiNi shape memory alloys was studied by Transmission Electron Microscopy (TEM) with in-situ observation and differential scanning calorimeter (DSC). The results of TEM and DSC measurements show that the microstructure of samples is R phase at room temperature. Electron irradiations were carried out using several different TEM with accelerating voltage of 200 kV, 300 kV, 400 kV and 1000 kV. Also the accelerating voltage in the same TEM was changed to investigate the critical voltage for the effect of irradiation on phase transformation. It was found that a phase transformation occurred under electron irradiation above 320 kV, but never appeared at 300 kV or lower accelerating voltage. Such phase transformation took place in a few seconds of irradiation and was independent of atom diffusion. The mechanism of Electron-irradiation-induced the martensitic transformation due to displacements of atoms from their lattice sites produced by the accelerated electrons.
TiNi shape memory alloy samples were irradiated within R-phase by 1.7 MeV electrons with different doses. The martensitic transformation temperatures were measured by Differential Scanning Calorimeter (DSC). The results indicated that the temperature Ms of the onset of R-phase-to-martensite transformation decreased with increasing the dose. The electron irradiation had a slight effect on the other transformation temperatures. The second lifetime of positrons determined by Positron Annihilation Technology were lowered with an increment of the irradiated dose. Relaxation of the elastic stress fields around the Ti3Ni4 precipitates was the cause of the observed change of the transformation characteristics because of the migration and accumulation of electron irradiation-induced point defects.
64-keV Ni ion implantation was performed at room temperature up to a dose of 1×1017 cm-2 in α-Al2O3 single crystals. The charge states, structure and optical properties of metallic embedded Ni nanoparticles were studied by using X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM) and optical spectroscopy, respectively. XPS analysis showed that implanted Ni ions are mainly in charge state of metallic Ni0. Nanoparticles distributed from the surface to 30 nm below the surface were observed in a bright-field cross-sectional image. The size of nanoparticles ranges from 1 to 5 nm in diameter. A selected area electron diffraction (SAED) pattern shows Ni nanoparticles with lattice parameter a = 0.352 nm. A high-resolution electron microscopy (HREM) image indicated the Ni-implanted area had been entirely amorphized. A new broad absorption band centered at 400 nm appeared in the optical absorption spectrum of the as-implanted crystal, due to surface plasma resonance (SPR) of Ni nanoparticles.
YSZ and MgAl2O4-YSZ composite are two promising materials as in the inert matrix nuclear fuel for the incineration of plutonium. In this study, 400 keV Cs ions were implanted to a fluence of 1×1017 ions/m2 in both materials in order to investigate the retention behavior of fission product at elevated temperature. The implantations were completed at room temperature for the YSZ and 973 K for MgAl2O4-YSZ, respectively. Subsequent annealing at 1273 K was performed after a room temperature implantation of YSZ. After annealing, a high density of gas bubbles formed with diameter from 3 to 40 nm from the surface to a depth of 150 nm in the YSZ matrix. The swelling due to bubbles formation was estimated to be 2.5%. In situ TEM was employed during high temperature ion implantation of the MgAl2O4-YSZ composite. A high density of small bubbles with 5 nm in diameter formed in the MgAl2O4 and YSZ grains after an ion dose of 1×1017 ions/cm2. There was no preferential precipitation along grain boundaries. Electron Paramagnetic resonance (EPR) spectroscopy was used to investigate the type of defects that formed in the YSZ matrix.
Ion backscattering and channeling techniques have been employed to measure the etching rate of amorphous and single crystal Si by XeF2 under similar conditions.Both (100) Si on sapphire and (111) Si on spinel showed higher etching rates compared to amorphous Si.However, measurements of the etching rate using a Si cell aligned to the axis and along the planes under similar conditions did not show appreciable difference in the etching rate compared to the etching rate with random orientation of the cell.Presence of the analyzing 4He+ beam during etching enhances the etching rate to twice the value when compared to post etching analysis with the same beam.The enhancement of the etching rate due to ion induced decomposition of XeF2 have been considered in the explanation of the experimental results.
Recommend this
Email your librarian or administrator to recommend adding this to your organisation's collection.