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1 results

  • Impact of phenotypic rapid diagnostic assay on duration of empiric antibiotics for gram-negative bacteremia

  • Sana M. Mohayya, Mohammad Arsalan, Navaneeth Narayanan, Purvi Patel, Christin G. Hong, Thomas J. Kirn, Pinki J. Bhatt, Tanaya Bhowmick
  • Journal:
    Antimicrobial Stewardship & Healthcare Epidemiology / Volume 3 / Issue 1 / 2023
    Published online by Cambridge University Press:
    30 January 2023, e22
    • Article
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  • Objective:

    Rapid diagnostic tests (RDTs) are increasingly being implemented as antimicrobial stewardship tools to facilitate antibiotic modification and reduce complications related to their overutilization. We measured the clinical impact of a phenotypic RDT with antimicrobial stewardship (AMS) in the setting of gram-negative bacteremia.

    Setting and participants:

    In this single-center retrospective cohort study, we evaluated adult patients with gram-negative bacteremia who received at least 72 hours of an antibiotic.

    Methods:

    The primary outcome was the duration of empiric antibiotic therapy for gram-negative bacteremia. Secondary outcomes included time-to-directed therapy, proportion of modifications, hospital length of stay (LOS), and subsequent infection with a multidrug-resistant organism (MDRO) or C. difficile infection (CDI).

    Results:

    The duration of empiric antibiotics decreased in the RDT+AMS group (4 days vs 2 days; P < .01). Time to directed therapy decreased from 75.0 to 27.9 hours (P < .01).

    Conclusions:

    The clinical outcomes of LOS, MDRO, and CDI were reduced. The phenotypic RDT demonstrated an improvement in stewardship measures and clinical outcomes.