We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Hand, foot, and mouth disease (HFMD) shows spatiotemporal heterogeneity in China. A spatiotemporal filtering model was constructed and applied to HFMD data to explore the underlying spatiotemporal structure of the disease and determine the impact of different spatiotemporal weight matrices on the results. HFMD cases and covariate data in East China were collected between 2009 and 2015. The different spatiotemporal weight matrices formed by Rook, K-nearest neighbour (KNN; K = 1), distance, and second-order spatial weight matrices (SO-SWM) with first-order temporal weight matrices in contemporaneous and lagged forms were decomposed, and spatiotemporal filtering model was constructed by selecting eigenvectors according to MC and the AIC. We used MI, standard deviation of the regression coefficients, and five indices (AIC, BIC, DIC, R2, and MSE) to compare the spatiotemporal filtering model with a Bayesian spatiotemporal model. The eigenvectors effectively removed spatial correlation in the model residuals (Moran’s I < 0.2, p > 0.05). The Bayesian spatiotemporal model’s Rook weight matrix outperformed others. The spatiotemporal filtering model with SO-SWM was superior, as shown by lower AIC (92,029.60), BIC (92,681.20), and MSE (418,022.7) values, and higher R2 (0.56) value. All spatiotemporal contemporaneous structures outperformed the lagged structures. Additionally, eigenvector maps from the Rook and SO-SWM closely resembled incidence patterns of HFMD.
Despite previous observational studies suggesting that malnutrition could be involved in venous thromboembolism (VTE), definitive causality still lacks high-quality research evidence. This study aims to explore the genetic causal association between malnutrition and VTE. The study was performed using summary statistics from genome-wide association studies for VTE (cases = 23 367; controls = 430 366). SNP associated with exposure was selected based on quality control steps. The primary analysis employed the inverse variance weighted (IVW) method, with additional support from Mendelian randomisation (MR)-Egger, weighted median and weighted mode approaches. MR-Egger, leave-one-SNP-out analysis and MR pleiotropy residual sum and outlier (MR-PRESSO) were used for sensitivity analysis. Cochran’s Q test was used to assess heterogeneity between instrumental variables (IV). IVW suggested that overweight has a positive genetic causal effect on VTE (OR = 1·1344, 95 % CI = 1·056, 1·2186, P < 0·001). No genetic causal effect of malnutrition (IVW: OR = 0·9983, 95 % CI = 0·9593, 1·0388, P = 0·9333) was found on VTE. Cochran’s Q test suggests no possible heterogeneity in both related exposures. The results of the MR-Egger regression suggest that the analysis is not affected by horizontal pleiotropy. The results of the MR-PRESSO suggest that there are no outliers. The results revealed a statistical genetic association where overweight correlates with an increased risk of VTE. Meanwhile, no genetic causal link was observed between malnutrition and VTE. Further research is warranted to deepen our understanding of these associations.
Patients with chronic insomnia are characterized by alterations in default mode network and alpha oscillations, for which the medial parietal cortex (MPC) is a key node and thus a potential target for interventions.
Methods
Fifty-six adults with chronic insomnia were randomly assigned to 2 mA, alpha-frequency (10 Hz), 30 min active or sham transcranial alternating current stimulation (tACS) applied over the MPC for 10 sessions completed within two weeks, followed by 4- and 6-week visits. The connectivity of the dorsal and ventral posterior cingulate cortex (vPCC) was calculated based on resting functional MRI.
Results
For the primary outcome, the active group showed a higher response rate (≥ 50% reduction in Pittsburgh Sleep Quality Index (PSQI)) at week 6 than that of the sham group (71.4% versus 3.6%) (risk ratio 20.0, 95% confidence interval 2.9 to 139.0, p = 0.0025). For the secondary outcomes, the active therapy induced greater and sustained improvements (versus sham) in the PSQI, depression (17-item Hamilton Depression Rating Scale), anxiety (Hamilton Anxiety Rating Scale), and cognitive deficits (Perceived Deficits Questionnaire-Depression) scores. The response rates in the active group decreased at weeks 8–14 (42.9%–57.1%). Improvement in sleep was associated with connectivity between the vPCC and the superior frontal gyrus and the inferior parietal lobe, whereas vPCC-to-middle frontal gyrus connectivity was associated with cognitive benefits and vPCC-to-ventromedial prefrontal cortex connectivity was associated with alleviation in rumination.
Conclusions
Targeting the MPC with alpha-tACS appears to be an effective treatment for chronic insomnia, and vPCC connectivity represents a prognostic marker of treatment outcome.
Recent studies have increasingly utilized gradient metrics to investigate the spatial transitions of brain organization, enabling the conversion of macroscale brain features into low-dimensional manifold representations. However, it remains unclear whether alterations exist in the cortical morphometric similarity (MS) network gradient in patients with schizophrenia (SCZ). This study aims to examine potential differences in the principal MS gradient between individuals with SCZ and healthy controls and to explore how these differences relate to transcriptional profiles and clinical phenomenology.
Methods
MS network was constructed in this study, and its gradient of the network was computed in 203 patients with SCZ and 201 healthy controls, who shared the same demographics in terms of age and gender. To examine irregularities in the MS network gradient, between-group comparisons were carried out, and partial least squares regression analysis was used to study the relationships between the MS network gradient-based variations in SCZ, and gene expression patterns and clinical phenotype.
Results
In contrast to healthy controls, the principal MS gradient of patients with SCZ was primarily significantly lower in sensorimotor areas, and higher in more areas. In addition, the aberrant gradient pattern was spatially linked with the genes enriched for neurobiologically significant pathways and preferential expression in various brain regions and cortical layers. Furthermore, there were strong positive connections between the principal MS gradient and the symptomatologic score in SCZ.
Conclusions
These findings showed changes in the principal MS network gradient in SCZ and offered potential molecular explanations for the structural changes underpinning SCZ.
The sulfur microbial diet (SMD), a dietary pattern associated with 43 sulfur-metabolizing bacteria, may influence gut microbiota composition and contribute to aging process through gut-produced hydrogen sulfide (H2S). We aimed to explore the association between SMD and biological age acceleration, using the cross-sectional study included 71,579 individuals from the UK Biobank. The SMD score was calculated by multiplying β-coefficients by corresponding serving sizes and summing them, based on dietary data collected using the Oxford WebQ, a 24-hour dietary assessment tool. Biological age (BA) was assessed using Klemerae-Doubal (KDM) and PhenoAge methods. The difference between BA and chronological age refers to the age acceleration (AgeAccel), termed “KDMAccel” and “PhenoAgeAccel”. Generalized linear regression was performed. Mediation analyses were used to investigate underlying mediators including body mass index (BMI) and serum aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio. Following adjustment for multiple variables, a positive association was observed between consuming a dietary pattern with a higher SMD score and both KDMAccel (βQ4vsQ1 = 0.35, 95%CI = 0.27 to 0.44, P<0.001) and PhenoAgeAccel (βQ4vsQ1 = 0.32, 95%CI = 0.23 to 0.41, P<0.001). Each 1-standard deviation increase in SMD score was positively associated with the acceleration of biological age by 7.90% for KDMAccel (P<0.001) and 7.80% for PhenoAgeAccel (P<0.001). BMI and AST/ALT mediated the association. The stratified analysis revealed stronger accelerated aging impacts in males and smokers. Our study indicated a higher SMD score is associated with elevated markers of biological aging, supporting the potential utility of gut microbiota-targeted dietary interventions in attenuating the aging process.
Random effects meta-analysis model is an important tool for integrating results from multiple independent studies. However, the standard model is based on the assumption of normal distributions for both random effects and within-study errors, making it susceptible to outlying studies. Although robust modeling using the t distribution is an appealing idea, the existing work, that explores the use of the t distribution only for random effects, involves complicated numerical integration and numerical optimization. In this article, a novel robust meta-analysis model using the t distribution is proposed (tMeta). The novelty is that the marginal distribution of the effect size in tMeta follows the t distribution, enabling that tMeta can simultaneously accommodate and detect outlying studies in a simple and adaptive manner. A simple and fast EM-type algorithm is developed for maximum likelihood estimation. Due to the mathematical tractability of the t distribution, tMeta frees from numerical integration and allows for efficient optimization. Experiments on real data demonstrate that tMeta is compared favorably with related competitors in situations involving mild outliers. Moreover, in the presence of gross outliers, while related competitors may fail, tMeta continues to perform consistently and robustly.
This chapter reviews alternative methods for estimating the integrated covariance matrix (ICM) using high-frequency data and their properties. The high-frequency data are assumed to come from a continuous-time model. The alternative estimators are justified by their asymptotic properties under the infill asymptotic scheme, which requires that the time interval Δ between any two consecutive observations go to zero. When reviewing the methods, we separate the methods that assume the dimension of the ICM is fixed and those that assume the dimension of the ICM goes to infinity with the sample size. Comparisons of the performances of alternative ICM estimators in portfolio choice are discussed.
In the presence of bubbles, asset prices consist of a fundamental and a component, with the bubble component following an explosive dynamic. The general idea for bubble identification is to apply explosive root tests to a proxy of the unobservable bubble. This chapter provides a theoretical framework that incorporates several definitions of bubbles (and fundamentals) and offers guidance for selecting proxies. For explosive root tests, we introduce the recursive evolving test of Phillips, Shi, and Yu (2015a,b) along with its asymptotic properties. This procedure can serve as a real-time monitoring device and has been shown to outperform several other tests. Like all other recursive testing procedures, the PSY algorithm faces the issue of multiplicity in testing. We propose a multiple-testing algorithm to determine appropriate test critical values and show its satisfactory performance in finite samples by simulations. To illustrate, we conduct a pseudo real-time bubble monitoring exercise in the S&P 500 stock market from January 1990 to June 2020. The empirical results reveal the importance of using a good proxy for bubbles and addressing the multiplicity issue.
This chapter provides an overview of posterior-based specification testing methods and model selection criteria that have been developed in recent years. For the specification testing methods, the first method is the posterior-based version of IOSA test. The second method is motivated by the power enhancement technique. For the model selection criteria, we first review the deviance information criterion (DIC). We discuss its asymptotic justification and shed light on the circumstances in which DIC fails to work. One practically relevant circumstance is when there are latent variables that are treated as parameters. Another important circumstance is when the candidate model is misspecified. We then review DICL for latent variable models and DICM for misspecified models.
This chapter reviews alternative methods proposed in the literature for estimating discrete-time stochastic volatility models and illustrates the details of their application. The methods reviewed are classified as either frequentist or Bayesian. The methods in the frequentist class include generalized method of moments, quasi-maximum likelihood, empirical characteristic function, efficient method of moments, and simulated maximum likelihood based on Laplace-based importance sampler. The Bayesian methods include single-move Markov chain Monte Carlo, multimove Markov chain Monte Carlo, and sequential Monte Carlo.
Limit theory is developed for least squares regression estimation of a model involving time trend polynomials and a moving average error process with a unit root. Models with these features can arise from data manipulation such as overdifferencing and model features such as the presence of multicointegration. The impact of such features on the asymptotic equivalence of least squares and generalized least squares is considered. Problems of rank deficiency that are induced asymptotically by the presence of time polynomials in the regression are also studied, focusing on the impact that singularities have on hypothesis testing using Wald statistics and matrix normalization. The chapter is largely pedagogical but contains new results, notational innovations, and procedures for dealing with rank deficiency that are useful in cases of wider applicability.
Continuous-time models have found broad applications in many core areas of economics and finance. This chapter first briefly introduces the applications of the continuous-time models for modeling the dynamics of the short-term interest rates. While many estimation methods have been proposed to estimate continuous-time models with discrete samples over the past 40 years, almost all suffer from finite-sample bias. The bias problem is particularly severe for the mean-reversion parameter, which measures the persistence level of the interest-rate process. Moreover, such bias propagates and leads to considerable bias in price calculations of the interest-rate contingent claims, such as bonds and bond options. The focus of this chapter is to give a detailed review of the bias issue. Two bias-correction methods are discussed: the jackknife method and the indirect inference method, which can effectively reduce the estimation bias of the mean-reversion parameter and the bias in pricing contingent claims. Monte Carlo studies are provided to illustrate the characteristics of the bias and investigate the performance of the two bias-correction methods.
Fractional Brownian motion is a continuous-time zero mean Gaussian process with stationary increments. It has gained much attention in empirical finance and asset pricing. For example, it has been used to model the time series of volatility and interest rates. This chapter first introduces the basic properties of fractional Brownian motions and then reviews the statistical models driven by the fractional Brownian motions that have been used in financial econometrics such as the fractional Ornstein–Uhlenbeck model and the fractional stochastic volatility models. We also review the parameter estimation methods proposed in the literature. These methods are based on either continuous-time observations or discrete-time observations.
This chapter discusses the nonstationary continuous-time models, including unit root and explosive regressors. The contents cover estimation methods, inferential theory, and empirical examples demonstrating the use of these models. It starts with a univariate framework and extends to multivariate cases for generality.