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This study investigates the heating issue associated with a V-shaped blunt leading edge (VBLE) in a hypersonic flow. The heat flux generation on the VBLE is highly correlated with the shock interaction configurations in the crotch region, determined by the relative position of the triple point T and the curved shock (CS). The primary Mach reflection (MR), accompanied by a series of secondary shock–shock interactions and shock wave–boundary layer interactions, can produce extremely high heating peaks on the crotch. To configure the shock wave structures and reduce the heat flux, a shock-controllable design approach is developed based on the simplified continuity method. The strategy involves the inverse design of the crotch sweep path, according to the location of the triple point and the contour of the CS. The comparisons between the pre-designed shock configurations and the numerical results demonstrate the reliability of the design approach across various free stream Mach numbers ranging from 6 to 10. A VBLE model designed with the shock configuration of regular reflection from the same family (sRR) at a free stream Mach number of 8 is examined. Under the design conditions, the outermost heat flux peak is reduced by 80 % compared with the baseline case. The heating reduction capabilities of the model under varying free stream Mach numbers and sideslip angles are also evaluated, confirming its robustness under undesigned operating scenarios.
In this paper, curved detonation equations with gradients for the pre-wave and post-wave are constructed followed by analysis, verification and applications. The study focuses on shock induced chemical reaction such as detonation, with the energy effect for the main attention. Equations consider both planar and transverse curvature to accommodate both planar and axisymmetric flow problems. Influence coefficients are derived and used to analyse the effect of energy and curvature on the post-wave gradient. Good agreement with the simulation results demonstrates that the equations presented in this paper can calculate various post-wave gradients accurately. After verification, the equations can be applied to applications, including not only solution and analysis but also in the inverse design. First, the method can be applied with polar analysis to provide a new perspective and higher order parameters for the study of detonation. Second, the equations can be used for the capture of detonation waves, where both planar and axisymmetric examples show better performance. Furthermore, the equations can be used in the inverse design of detonation waves in combination with the method of characteristics, which is one of the unique benefits of the present equations.
The discovery that blazars dominate the extra-galactic $\gamma$-ray sky is a triumph in the Fermi era. However, the exact location of $\gamma$-ray emission region still remains in debate. Low-synchrotron-peaked blazars (LSPs) are estimated to produce high-energy radiation through the external Compton process, thus their emission regions are closely related to the external photon fields. We employed the seed factor approach proposed by Georganopoulos et al. It directly matches the observed seed factor of each LSP with the characteristic seed factors of external photon fields to locate the $\gamma$-ray emission region. A sample of 1 138 LSPs with peak frequencies and peak luminosities was adopted to plot a histogram distribution of observed seed factors. We also collected some spectral energy distributions (SEDs) of historical flare states to investigate the variation of $\gamma$-ray emission region. Those SEDs were fitted by both quadratic and cubic functions using the Markov-chain Monte Carlo method. Furthermore, we derived some physical parameters of blazars and compared them with the constraint of internal $\gamma\gamma$-absorption. We find that dusty torus dominates the soft photon fields of LSPs and most $\gamma$-ray emission regions of LSPs are located at 1–10 pc. The soft photon fields could also transition from dusty torus to broad line region and cosmic microwave background in different flare states. Our results suggest that the cubic function is better than the quadratic function to fit the SEDs.
This paper investigates the effect of curvature on curved detonation and its reflections. Specifically, the study focuses on two aspects: the effect of curvature on the postwave parameters and their gradients, and the stabilization of Mach reflection. Relationships are established between the curvature and the gradients of the postwave parameters, thus providing a basis for examining detonation reflections and obtaining a comprehensive understanding of curved detonation. In particular, these relationships offer a valuable analytical tool to predict the postwave gradients, as well as providing a fresh perspective to understand the transformation from Mach reflection to regular reflection in curved detonation. The validity of these relationships is confirmed by comparison with simulation results. Two mechanisms by which curvature influences the stationarity of Mach reflection are identified. An increase in wave angle and interference between wave systems leading to the generation and integration of subsonic zones are the reasons for the non-stationarity of the Mach reflection in curved detonation. Besides, the effect mechanisms of choked flow which is considered to be the root cause are analysed in detail. On the basis of a theoretical model, the development of a quantitative criterion for the stability of detonation reflection is proposed, and its validity is confirmed by simulations. This criterion is used in a comprehensive investigation of the primary factors affecting the stability of detonation wave reflections, providing insights that will be of great value for the further development of detonation engines.
Xiaonanshan is an archaeological site dated to 16.5–13.5 cal kyr BP, situated beside the Ussuri River in China. The lithic assemblages feature microblade debitage, bifacial points and stone adzes, which provide important new materials for this project to explore Neolithisation in the Amur River basin of northeast Asia.
Theoretical investigation of the primary Mach reflection (MR) configuration on V-shaped blunt leading edges (VBLEs) forms the focus of this study. By ignoring the secondary interactions, a theoretical method based on a simplified form of the continuity relation is developed to predict the shock configurations, including the detached shock, the Mach stem, the transmitted shock and the triple point. The comparison of the theoretical results with both numerical and previous experimental results shows the reliability of the theoretical approach in predicting shock structures across a wide range of free stream and geometric parameters. The theoretical model provides a detailed comprehension of the occurrence mechanism of inverse MRs on VBLEs and the influence of the free stream and geometric parameters on primary MR configurations. Along with the primary MR configuration, the curved shock or compression waves generated by the crotch are solved and offer insight into the transition from the MR to the regular reflection from the same family (sRR). The increase of the ratio $R/r$ and the free stream Mach number $M_0$ appears to facilitate the transition, while the effect of the half-span angle $\beta$ is non-monotonic. The predicted shock positions allow for the identification of the transition boundary between the primary MR and sRR. It is found that $R/r$ below a threshold (for a set $M_0$ value) produces MR, irrespective of $\beta$. If this threshold is exceeded, the configuration can transition from the primary MR to sRR and then back to the primary MR as $\beta$ increases.
In this paper, the reflection of curved shock waves over a symmetry plane in planar supersonic flow is studied. This includes stable Mach reflection (MR) and the regular reflection (RR) to MR transition process. Curved shock theory (CST) is applied to derive the high-order parameters in front of and behind the shock wave. The method of curved shock characteristics is used to establish an analytical model to predict the wave configurations. The shock structures provided by the proposed model agree well with the numerical results. Flow structures, such as the height of the Mach stem and the shape of the shock wave and slip line, are studied by applying the analytical model. Isentropic waves generated from a curved wall are found to significantly influence the flow patterns. It appears that the compression waves obstruct the formation of the sonic throat and increase the Mach-stem height. The expansion waves have the opposite effect. The evolution mechanism of the Mach stem is found in conjunction with the RR-to-MR transition process. The CST is extended to a moving frame and used to model the transition. The time history of the moving triple point illustrates the effects of the incident shock angle and isentropic waves on the transition process.
Homeostasis of gut microbiota is a critical contributor to growth and health in weaned piglets. Fish oil is widely reported to benefit health of mammals including preventing intestinal dysfunction, yet its protective effect during suckling-to-weaning transition in piglets remains undetermined. Low (30 g/d) and high (60 g/d) doses of n-3-rich fish oil were supplemented in sows from late gestation to lactation. Serum indicators and gut microbiota were determined to evaluate the effects of maternal fish oil on growth performance, immunity and diarrhea of piglets. DHA and EPA in the colostrum as well as serum of suckling and 1-week post-wean piglets were significantly and linearly increased by maternal supplementation of fish oil (P < 0.05). IGF1 and T3 in nursing and weaned piglets were significantly elevated by maternal fish oil (P < 0.05), and the increase of IGF1 was concerning the dosage of fish oil. Colostrum IgG, plasma IgG, IgM in suckling piglets, IgG, IgM and IgA in weaned piglets were significantly increase as maternal replenishment of fish oil increased (P < 0.05). Additionally, cortisol was significantly reduced in weaned pigs (P < 0.05), regardless of dosage. 16S rRNA sequencing revealed that α-diversity of fecal microbiota in nursery piglets, and fecal Lactobacillus genus, positively correlated with post-weaning IgA, was significantly increased by high dosage. Collectively, maternal fish oil during late pregnancy and lactation significantly promoted growth, enhanced immunity, and reduced post-weaning diarrhea in piglets, therefore facilitated suckling-to-weaning transition in piglets, which may be partially due to the altered gut microbial community.
The aims of the study were to investigate the burden for health care workers (HCWs) who suffer from occupational-related adverse events (ORAEs) while working in contaminated areas in a specialized hospital for novel coronavirus pneumonia, to explore related risk factors, to evaluate the effectiveness of bundled interventions, as well as to provide scientific evidence regarding the reduction of risks concerning ORAEs and occupational exposure events.
Methods:
The study was completed using a special team of 138 HCWs assembled for a specialized hospital for novel coronavirus pneumonia in Wuhan, dated from February 16 to March 26, 2020. The incidence of occupational exposure was determined by data reported from the hospital, while the prevalence of ORAEs was derived from questionnaire results. The relation coefficients of ORAEs and the variable potential risk factors are analyzed by logistic regression. After the risk factors were identified, targeted organized intervention was implemented and chi-square tests were performed to compare the incidence of occupational exposure and the prevalence of ORAEs in contaminated areas before and after the interventions.
Results:
Ninety one out of 138 (65.94%) had reported ORAEs with 300 (27.96%) cases of ORAEs being recorded in a total of 1073 entries into contaminated areas. The prevalence of different ORAEs include 205 tenderness (24.73%), 182 headache/dizziness (21.95%), 138 dyspnea (16.65%), 130 blurred vision (15.68%), and 95 nausea/vomiting (11.46%). Personal protective equipment (PPE) is significantly associated with ORAEs in contaminated areas (P < 0.05). Among non-PPE-related factors, insomnia is associated with the majority of ORAEs in contaminated areas. Significant differences were achieved after organized interventions in the incidence of occupational exposure of HCWs (χ2 = 39.07, P < 0.001) and the prevalence of ORAEs in contaminated areas (χ2 = 22.95, P < 0.001).
Conclusion:
During the epidemic period of novel severe respiratory infectious disease, the burden of the ORAEs in contaminated areas and the risk of occupational exposure of HCWs were relatively high. In time, comprehensive and multi-level bundled interventions may help decrease the risk of both ORAEs and occupational exposure.
This paper describes the development of a method of curved-shock characteristics based on curved shock theory. The proposed method is applied to supersonic flowfield calculations and inverse design in planar/axisymmetric, external/internal and uniform/non-uniform flows. The main idea is to determine the gradients of the pressure and flow deflection angle in the streamline-characteristic coordinates. With the acquired derivatives, the flow parameters of the post-shock flowfield can be quickly identified. Compared with the method of characteristics, the gradient information enhances the computational efficiency and accuracy of the method of curved-shock characteristics. This makes the method of curved-shock characteristics more effective, accurate and robust than the conventional method of characteristics. Explicit equations in the form of gradients are derived along the streamlines and characteristics. Several supersonic flowfields are solved using the method of curved-shock characteristics, and the results show that the proposed method requires less computational resources, by an order of magnitude, than the method of characteristics while achieving superior accuracy. Additionally, the proposed method is applied to the inverse design of internal flows. A series of planar and axisymmetric flowfields with centre-bodies are solved under the condition that the shock curves are given. The accuracy and efficiency of the method of curved-shock characteristics make it a good candidate for the inverse design of planar/axisymmetric supersonic flowfields.
Gravitational waves from coalescing neutron stars encode information about nuclear matter at extreme densities, inaccessible by laboratory experiments. The late inspiral is influenced by the presence of tides, which depend on the neutron star equation of state. Neutron star mergers are expected to often produce rapidly rotating remnant neutron stars that emit gravitational waves. These will provide clues to the extremely hot post-merger environment. This signature of nuclear matter in gravitational waves contains most information in the 2–4 kHz frequency band, which is outside of the most sensitive band of current detectors. We present the design concept and science case for a Neutron Star Extreme Matter Observatory (NEMO): a gravitational-wave interferometer optimised to study nuclear physics with merging neutron stars. The concept uses high-circulating laser power, quantum squeezing, and a detector topology specifically designed to achieve the high-frequency sensitivity necessary to probe nuclear matter using gravitational waves. Above 1 kHz, the proposed strain sensitivity is comparable to full third-generation detectors at a fraction of the cost. Such sensitivity changes expected event rates for detection of post-merger remnants from approximately one per few decades with two A+ detectors to a few per year and potentially allow for the first gravitational-wave observations of supernovae, isolated neutron stars, and other exotica.
Second-order curved shock theory is developed and applied to planar and axisymmetric curved shock flow fields. Explicit equations are given in an influence coefficient format, relating the second-order gradients of pre-shock and post-shock flow parameters to shock curvature gradients. Two types of applications are demonstrated. First, the post-shock flow fields behind known curved shocks are solved using the second-order curved shock equations. Compared with the first-order curved shock equations, the second-order equations give better agreement with solutions obtained using the method of characteristics. Second, the second-order theory is applied to capture the curved shock shape with limited flow field information. In terms of the residual sum of squares of the curved shock, the second-order curved shock equations give a value one order of magnitude better than those given by the Rankine–Hugoniot equations and the first-order equations. This improved accuracy makes the second-order theory a good candidate for solving shock capture problems in computational fluid dynamics algorithms.
Facilitated by the establishment of terrestrial networks and satellite constellations of Automatic Identification System (AIS) receivers, large quantities of spatial and temporal information that trace ships' paths have been collected. The exponential increase in the amount of AIS data has caused expensive and time-consuming transmission, calculation and storage problems. Using appropriate trajectory simplification methods in a timely manner to compress redundant information while minimising the loss of importation information is important. To minimise the simplification error, this paper proposes an online multi-dimensional simplification algorithm for AIS trajectory streaming data. The simplification algorithm takes into account position, direction and speed preservation. Finally, a comparison experiment with other algorithms is made to examine the effectiveness of this algorithm. The results indicate that the proposed online multi-dimensional simplification algorithm can effectively preserve a ship's motion state, including its position, speed and course.
North-east China occupies an important geographic position for understanding the process of Neolithisation in East Asia. Although archaeologists have long debated the trajectory of change in this region, a lack of intensive survey and excavation has precluded convincing interpretations. This article presents research on the newly excavated sites of Huayang and Taoshan in the southern Lesser Khingan Mountains, with a particular focus on the lithic assemblages. Comparative and environmental analyses demonstrate the largely uniform trajectory of lithic technologies across north-east China and close correspondence with Late Glacial palaeoclimatic and palaeoenvironmental changes.
In this paper a one-dimensional numerical study on the nonlinear behaviour of an electrically charged jet of Oldroyd-B viscoelastic, Taylor–Melcher leaky dielectric liquid is carried out. The effect of surface charge level, axial wavenumber and finite conductivity on the nonlinear evolution of the jet is investigated. Different structures including beads-on-a-string with/without satellite droplets, quasi-spikes and spikes are detected, and their domains in the plane of the non-dimensional axial wavenumber and the electrical Bond number are illustrated. The underlying mechanisms in the formation of the structures are examined. It is found that tangential electrostatic force plays a key role in the formation of a quasi-spike structure. Decreasing liquid conductivity may lead to a decrease in the size of satellite droplets or even the complete removal of them from a beads-on-a-string structure, induce the transition from a beads-on-a-string to a quasi-spike structure or postpone the appearance of a spike. On the other hand, finite conductivity has little influence on filament thinning in a beads-on-a-string structure, owing to the fact that the electrostatic forces are of secondary importance compared with the capillary force. The difference between the finite conductivity, large conductivity and other cases is elucidated. An experiment is carried out to observe spike structures.
Previous neuroimaging studies demonstrated that retinal detachment (RD) subjects were associated with abnormal spontaneous brain activities; however, whether the altered interhemispheric functional connectivity (FC) occurred in RD patients remains unknown. The current study tried to explore the alternations of interhemispheric FC of the whole brain in unilateral RD patients using the voxel-mirrored homotopic connectivity (VMHC) method and their connections to clinical features. Methods: We recruited 30 patients with RD (16 males and 14 females) and 30 healthy controls (HCs) (16 males and 14 females) whose age and sex were closely matched. All subjects underwent the rs-fMRI scans. The VMHC method was applied to directly assess the hemispheres’ functional interaction. The VMHC in these brain areas, which could be used as biomarkers to differentiate RD from HC, was identified by the receiver operating characteristic (ROC) curve analyses. The relations between these patients’ clinical features and their mean VMHC signal values in multiple brain regions were calculated by Pearson correlation analysis. Results: RD patients had significantly lower VMHC values than HCs in the bilateral occipital lobe (Brodmann areas, BA 18), bilateral superior temporal gyrus (BA 39), and bilateral cuneus (BA 19). Moreover, the mean VMHC signal values of the bilateral cuneus were in positive correlation with the duration of the RD (r = 0.446, P = 0.013). Conclusion: Our results provided an evidence of disturbed interhemispheric FC in the visual area occurred in RD patients, which might provide some useful information to understand the neural mechanism of RD patients with acute vision loss. Furthermore, the VMHC values might indicate the progress of the RD.
The processing method applied to the side surface is different from the method applied to the light pass surface in neodymium phosphate glass (Nd:glass), and thus subsurface defects remain after processing. The subsurface defects in the side surface influence the gain uniformity of Nd:glass, which is a key factor to evaluate the performance of amplifiers. The scattering characteristics of side subsurface defects were simulated by finite difference time domain (FDTD) Solutions software. The scattering powers of the glass fabricated by a computer numerical control (CNC) machine without cladding were tested at different incident angles. The trend of the curve was similar to the simulated result, while the smallest point was different with the complex true morphology. The simulation showed that the equivalent residual reflectivity of the cladding glass can be more than 0.1% when the number of defects in a single gridding is greater than 50.
Facilitated by recent establishment of terrestrial networks and satellite constellations of Automatic Identification System (AIS) receivers, ship trajectories are becoming increasingly available and the size of recorded trajectories is getting larger. Large sets of trajectories create problems of storing, transmitting and processing data. Using appropriate methods, an accurate representation of the original trajectories can be obtained by compressing redundant information, while maintaining the main characteristic elements. In this paper, a new scheme and the implementation of the Douglas-Peucker (DP) algorithm are presented, which can simplify AIS trajectories by extracting characteristic points. As for the simplification threshold, the solo parameter of the DP algorithm, a new AIS-based minimum ship domain evaluation method is proposed and acts as criteria for simplification threshold determination. Finally, a validation is made to examine the effectiveness of the DP simplification algorithm and the rationality of the simplification threshold. The result indicates that the DP algorithm can simplify AIS trajectories effectively; the simplification threshold is scientific and reasonable.
Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has been suggested to be associated with major depressive disorder (MDD). There were a few reports of the relationship between the variant and late-onset depression (LOD) in Chinese Han population.
Objective:
To investigate the relationship among BDNF Val66Met gene variants, BDNF plasma level and LOD.
Methods:
Chinese Han patients with LOD (n = 99) and control subjects (n = 110) were assessed for BDNF Val66Met gene polymorphism. BDNF plasma level was tested only in LOD.
Results:
There were no significant differences in genotypes and allele frequencies between cases and controls (p = 0.744 and p = 0.845, respectively). Plasma BDNF level also did not show significant differences in three genotypes in LOD (p = 0.860).
Conclusion:
The Val66Met polymorphism in BDNF gene may not confer susceptibility to LOD in Chinese Han population.