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71 results

Page 1 of 4

  • Live Cell Imaging: The past, The Present and Future Opportunities

  • Simon C. Watkins
  • Journal:
    / Volume 28 / Issue S1 / August 2022
    Published online by Cambridge University Press:
    22 July 2022, p. 1544
    Print publication:
    August 2022
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  • The contribution of depressive ‘disorder characteristics’ to determinations of prognosis for adults with depression: an individual patient data meta-analysis

  • Joshua E. J. Buckman, Rob Saunders, Zachary D. Cohen, Phoebe Barnett, Katherine Clarke, Gareth Ambler, Robert J. DeRubeis, Simon Gilbody, Steven D. Hollon, Tony Kendrick, Edward Watkins, Nicola Wiles, David Kessler, David Richards, Deborah Sharp, Sally Brabyn, Elizabeth Littlewood, Chris Salisbury, Ian R. White, Glyn Lewis, Stephen Pilling
  • Journal:
    Psychological Medicine / Volume 51 / Issue 7 / May 2021
    Published online by Cambridge University Press:
    14 April 2021, pp. 1068-1081
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  • Background

    This study aimed to investigate general factors associated with prognosis regardless of the type of treatment received, for adults with depression in primary care.

    Methods

    We searched Medline, Embase, PsycINFO and Cochrane Central (inception to 12/01/2020) for RCTs that included the most commonly used comprehensive measure of depressive and anxiety disorder symptoms and diagnoses, in primary care depression RCTs (the Revised Clinical Interview Schedule: CIS-R). Two-stage random-effects meta-analyses were conducted.

    Results

    Twelve (n = 6024) of thirteen eligible studies (n = 6175) provided individual patient data. There was a 31% (95%CI: 25 to 37) difference in depressive symptoms at 3–4 months per standard deviation increase in baseline depressive symptoms. Four additional factors: the duration of anxiety; duration of depression; comorbid panic disorder; and a history of antidepressant treatment were also independently associated with poorer prognosis. There was evidence that the difference in prognosis when these factors were combined could be of clinical importance. Adding these variables improved the amount of variance explained in 3–4 month depressive symptoms from 16% using depressive symptom severity alone to 27%. Risk of bias (assessed with QUIPS) was low in all studies and quality (assessed with GRADE) was high. Sensitivity analyses did not alter our conclusions.

    Conclusions

    When adults seek treatment for depression clinicians should routinely assess for the duration of anxiety, duration of depression, comorbid panic disorder, and a history of antidepressant treatment alongside depressive symptom severity. This could provide clinicians and patients with useful and desired information to elucidate prognosis and aid the clinical management of depression.

Urban Planet
  • Knowledge towards Sustainable Cities
  • Edited by Thomas Elmqvist, Xuemei Bai, Niki Frantzeskaki, Corrie Griffith, David Maddox, Timon McPhearson, Susan Parnell, Patricia Romero-Lankao, David Simon, Mark Watkins
  • Published online:
    27 April 2018
    Print publication:
    26 April 2018
  • Global urbanization promises better services, stronger economies, and more connections; it also carries risks and unforeseeable consequences. To deepen our understanding of this complex process and its importance for global sustainability, we need to build interdisciplinary knowledge around a systems approach. Urban Planet takes an integrative look at our urban environment, bringing together scholars from a diverse range of disciplines: from sociology and political science to evolutionary biology, geography, economics and engineering. It includes the perspectives of often neglected voices: architects, journalists, artists and activists. The book provides a much needed cross-scale perspective, connecting challenges and solutions on a local scale with drivers and policy frameworks on a regional and global scale. The authors argue that to overcome the major challenges we are facing, we must embark on a large-scale reinvention of how we live together, grounded in inclusiveness and sustainability. This title is also available Open Access.

  • Part II - Global Urban Sustainable Development

  • Edited by Thomas Elmqvist, Stockholm Resilience Centre, Xuemei Bai, Australian National University, Canberra, Niki Frantzeskaki, Corrie Griffith, Arizona State University, David Maddox, Timon McPhearson, New School University, New York, Susan Parnell, University of Cape Town, Patricia Romero-Lankao, National Center for Atmospheric Research, Boulder, Colorado, David Simon, Chalmers University of Technology, Gothenberg, Mark Watkins, Arizona State University
  • Book:
    Urban Planet
    Published online:
    27 April 2018
    Print publication:
    26 April 2018, pp 147-260
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  • Contents

  • Edited by Thomas Elmqvist, Stockholm Resilience Centre, Xuemei Bai, Australian National University, Canberra, Niki Frantzeskaki, Corrie Griffith, Arizona State University, David Maddox, Timon McPhearson, New School University, New York, Susan Parnell, University of Cape Town, Patricia Romero-Lankao, National Center for Atmospheric Research, Boulder, Colorado, David Simon, Chalmers University of Technology, Gothenberg, Mark Watkins, Arizona State University
  • Book:
    Urban Planet
    Published online:
    27 April 2018
    Print publication:
    26 April 2018, pp v-ix
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  • Tables

  • Edited by Thomas Elmqvist, Stockholm Resilience Centre, Xuemei Bai, Australian National University, Canberra, Niki Frantzeskaki, Corrie Griffith, Arizona State University, David Maddox, Timon McPhearson, New School University, New York, Susan Parnell, University of Cape Town, Patricia Romero-Lankao, National Center for Atmospheric Research, Boulder, Colorado, David Simon, Chalmers University of Technology, Gothenberg, Mark Watkins, Arizona State University
  • Book:
    Urban Planet
    Published online:
    27 April 2018
    Print publication:
    26 April 2018, pp xv-xv
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  • Preface

  • Edited by Thomas Elmqvist, Stockholm Resilience Centre, Xuemei Bai, Australian National University, Canberra, Niki Frantzeskaki, Corrie Griffith, Arizona State University, David Maddox, Timon McPhearson, New School University, New York, Susan Parnell, University of Cape Town, Patricia Romero-Lankao, National Center for Atmospheric Research, Boulder, Colorado, David Simon, Chalmers University of Technology, Gothenberg, Mark Watkins, Arizona State University
  • Book:
    Urban Planet
    Published online:
    27 April 2018
    Print publication:
    26 April 2018, pp xxi-xxx
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  • Figures

  • Edited by Thomas Elmqvist, Stockholm Resilience Centre, Xuemei Bai, Australian National University, Canberra, Niki Frantzeskaki, Corrie Griffith, Arizona State University, David Maddox, Timon McPhearson, New School University, New York, Susan Parnell, University of Cape Town, Patricia Romero-Lankao, National Center for Atmospheric Research, Boulder, Colorado, David Simon, Chalmers University of Technology, Gothenberg, Mark Watkins, Arizona State University
  • Book:
    Urban Planet
    Published online:
    27 April 2018
    Print publication:
    26 April 2018, pp x-xiv
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  • Part I - Dynamic Urban Planet

  • Edited by Thomas Elmqvist, Stockholm Resilience Centre, Xuemei Bai, Australian National University, Canberra, Niki Frantzeskaki, Corrie Griffith, Arizona State University, David Maddox, Timon McPhearson, New School University, New York, Susan Parnell, University of Cape Town, Patricia Romero-Lankao, National Center for Atmospheric Research, Boulder, Colorado, David Simon, Chalmers University of Technology, Gothenberg, Mark Watkins, Arizona State University
  • Book:
    Urban Planet
    Published online:
    27 April 2018
    Print publication:
    26 April 2018, pp 17-146
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  • Contributors

  • Edited by Thomas Elmqvist, Stockholm Resilience Centre, Xuemei Bai, Australian National University, Canberra, Niki Frantzeskaki, Corrie Griffith, Arizona State University, David Maddox, Timon McPhearson, New School University, New York, Susan Parnell, University of Cape Town, Patricia Romero-Lankao, National Center for Atmospheric Research, Boulder, Colorado, David Simon, Chalmers University of Technology, Gothenberg, Mark Watkins, Arizona State University
  • Book:
    Urban Planet
    Published online:
    27 April 2018
    Print publication:
    26 April 2018, pp xvi-xx
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  • Part III - Urban Transformations to Sustainability

  • Edited by Thomas Elmqvist, Stockholm Resilience Centre, Xuemei Bai, Australian National University, Canberra, Niki Frantzeskaki, Corrie Griffith, Arizona State University, David Maddox, Timon McPhearson, New School University, New York, Susan Parnell, University of Cape Town, Patricia Romero-Lankao, National Center for Atmospheric Research, Boulder, Colorado, David Simon, Chalmers University of Technology, Gothenberg, Mark Watkins, Arizona State University
  • Book:
    Urban Planet
    Published online:
    27 April 2018
    Print publication:
    26 April 2018, pp 261-350
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  • Copyright page

  • Edited by Thomas Elmqvist, Stockholm Resilience Centre, Xuemei Bai, Australian National University, Canberra, Niki Frantzeskaki, Corrie Griffith, Arizona State University, David Maddox, Timon McPhearson, New School University, New York, Susan Parnell, University of Cape Town, Patricia Romero-Lankao, National Center for Atmospheric Research, Boulder, Colorado, David Simon, Chalmers University of Technology, Gothenberg, Mark Watkins, Arizona State University
  • Book:
    Urban Planet
    Published online:
    27 April 2018
    Print publication:
    26 April 2018, pp iv-iv
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  • Part IV - Provocations from Practice

  • Edited by Thomas Elmqvist, Stockholm Resilience Centre, Xuemei Bai, Australian National University, Canberra, Niki Frantzeskaki, Corrie Griffith, Arizona State University, David Maddox, Timon McPhearson, New School University, New York, Susan Parnell, University of Cape Town, Patricia Romero-Lankao, National Center for Atmospheric Research, Boulder, Colorado, David Simon, Chalmers University of Technology, Gothenberg, Mark Watkins, Arizona State University
  • Book:
    Urban Planet
    Published online:
    27 April 2018
    Print publication:
    26 April 2018, pp 351-461
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  • A nutrition intervention is effective in improving dietary components linked to cardiometabolic risk in youth with first-episode psychosis

  • Scott B. Teasdale, Philip B. Ward, Simon Rosenbaum, Andrew Watkins, Jackie Curtis, Megan Kalucy, Katherine Samaras
  • Journal:
    British Journal of Nutrition / Volume 115 / Issue 11 / 14 June 2016
    Published online by Cambridge University Press:
    04 April 2016, pp. 1987-1993
    Print publication:
    14 June 2016
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  • Severe mental illness is characterised by a 20-year mortality gap due to cardiometabolic disease. Poor diet in those with severe mental illness is an important and modifiable risk factor. The present study aimed to (i) examine baseline nutritional intake in youth with first-episode psychosis (FEP), (ii) evaluate the feasibility and acceptability of nutritional intervention early in FEP and (iii) to evaluate the effectiveness of early dietary intervention on key nutritional end points. Participants were recruited over a 12-month period from a community-based programme specifically targeting young people aged 15–25 years with newly diagnosed FEP. Individual dietetic consultations and practical group sessions were offered as part of a broader lifestyle programme. Dietary assessments were conducted before and at the end of the 12-week intervention. Participants exceeded recommended energy and Na intakes at baseline. Retention within the nutrition intervention was 67 %, consistent with other interventions offered to FEP clients. There was a 47 % reduction in discretionary food intake (−94 g/d, P<0·001) and reductions in daily energy (−24 %, P<0·001) and Na (−26 %, P<0·001) intakes. Diet quality significantly improved, and the mean change was 3·6 (95 % CI 0·2, 6·9, P<0·05), although this finding was not significant after Bonferroni’s correction. Increased vegetable intake was the main factor contributing to improved diet quality. Nutrition intervention delivered shortly after initiation of antipsychotic medication is feasible, acceptable and effective in youth with FEP. Strategies to prevent weight gain and metabolic decline will contribute to prevent premature cardiometabolic disease in this vulnerable population.

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