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Loess, a geologic record of dust, is an optimal archive for exploring paleoclimate and the paleo-dust path from source to sink. The dust path for the Songnen Plain, NE China, during the last glacial period has not been established. To address this, 63 surface sediment samples from the Northeast China Sandy Lands, i.e., Onqin Daga Sandy Land (OD), Horqin Sandy Land (HQ), Hulun Buir Sandy Land (HL), and Songnen Sandy Land (SN), and six samples from the last glacial loess in the Harbin area were collected for elemental geochemical analysis of the <10 μm fraction to quantitatively reconstruct the dust pathway using a frequentist model. The results show that these sandy lands have a distinct geochemical composition due to a control from markedly different provenances. The quantitative results indicate that the dust contribution of the southwestern SN to the Harbin loess is as high as 50.4–77.2%, followed by the OD and HQ (3.3–34.8%), the northwestern SN (0–36.8%), and the HL (0–8%). Notably, the dust contribution to the Harbin loess began to change considerably after ~46–41 ka BP, with a significant increase from 1.1% to 41.2% from the northwestern direction. Some ecological safety strategies are proposed to address dust pollution in the Harbin area.
There is a lack of longitudinal data on the relationship between upward social comparison on social network sites (SNSs) and depression and its underlying mechanisms. Therefore, this study aimed to examine the relationship between upward social comparison on social network sites and depression and analyze the mediating effects of self-concept clarity and self-esteem in this relationship. We employed a two-wave longitudinal design among 1179 Chinese middle school students. The results indicated that : upward social comparison on SNSs predicted middle school students’ depression; Self-concept clarity and self-esteem sequentially mediated the relationship between upward social comparison on SNSs and middle school students’ subsequent depression. These results suggested that three types of interventions could be effectively used to decrease the risk of depression among middle school students.
The focus of cognitive diagnosis (CD) is on evaluating an examinee’s strengths and weaknesses in terms of cognitive skills learned and skills that need study. Current methods for fitting CD models (CDMs) work well for large-scale assessments, where the data of hundreds or thousands of examinees are available. However, the development of CD-based assessment tools that can be used in small-scale test settings, say, for monitoring the instruction and learning process at the classroom level has not kept up with the rapid pace at which research and development proceeded for large-scale assessments. The main reason is that the sample sizes of the small-scale test settings are simply too small to guarantee the reliable estimation of item parameters and examinees’ proficiency class membership. In this article, a general nonparametric classification (GNPC) method that allows for assigning examinees to the correct proficiency classes with a high rate when sample sizes are at the classroom level is proposed as an extension of the nonparametric classification (NPC) method (Chiu and Douglas in J Classif 30:225–250, 2013). The proposed method remedies the shortcomings of the NPC method and can accommodate any CDM. The theoretical justification and the empirical studies are presented based on the saturated general CDMs, supporting the legitimacy of using the GNPC method with any CDM. The results from the simulation studies and real data analysis show that the GNPC method outperforms the general CDMs when samples are small.
A recent study published in Oryx proposed that the extinct Javan tiger Panthera tigris sondaica may still survive on the Island of Java, Indonesia, based on mitochondrial DNA analysis of a single hair sample collected from a location where a tiger was reportedly encountered. However, upon reanalysing the genetic data presented in that study, we conclude that there is little support for this claim. The sequences of the putative tiger hair and Javan tiger museum specimens generated are not from tiger cytoplasmic mitochondrial DNA but more likely the nuclear pseudogene copies of mitochondrial DNA. In addition, the number of mismatches between the two Javan tiger sequences is unusually high for homologous sequences that are both from tigers, suggesting potential issues with data reliability. The paper provides insufficient details on quality control measures, making it impossible to rule out the possibility that errors were introduced during the analysis. Consequently, it is inappropriate to use the sequences presented in that study to infer the existence of the Javan tiger.
The self-generated magnetic field in three-dimensional (3-D) single-mode ablative Rayleigh–Taylor instability (ARTI) relevant to the acceleration phase of a direct-drive inertial confinement fusion (ICF) implosion is investigated. It is found that stronger magnetic fields up to a few thousand teslas can be generated by 3-D ARTI rather than by its two-dimensional (2-D) counterpart. The Nernst effects significantly alter the magnetic field convection and amplify the magnetic fields. The magnetic field of thousands of teslas yields the Hall parameter of the order of unity, leading to profound magnetized heat flux modification. While the magnetic field significantly accelerates the bubble growth in the short-wavelength 2-D modes through modifying the heat fluxes, the magnetic field mostly accelerates the spike growth but has little influence on the bubble growth in 3-D ARTI. The accelerated growth of spikes in 3-D ARTI is expected to enhance material mixing and degrade ICF implosion performance. This work is focused on a regime relevant to direct-drive ICF parameters at the National Ignition Facility, and it also covers a range of key parameters that are relevant to other ICF designs and hydrodynamic/astrophysical scenarios.
To understand the dietary patterns of adults and explore their association with iodine nutritional levels and thyroid function in adults.
Design:
We randomly collected 5 ml of adult urine samples and measured urinary iodine concentration (UIC) by cerium arsenate-catalysed spectrophotometry. A serum sample of 5 ml was collected for the determination of free triiodothyronine, free thyroxine and thyrotropin, and diet-related information was collected through a FFQ. Dietary patterns were extracted by principal component analysis, and the relationship between dietary patterns and iodine nutrition levels and thyroid function was explored.
Settings:
A cross-sectional study involving adults in Xinjiang, China, was conducted.
Participants:
A total of 435 adults were enrolled in the study.
Results:
The overall median urinary iodine of the 435 respondents was 219·73 μg/l. The dietary patterns were PCA1 (staple food pattern), PCA2 (fruit, vegetable and meat pattern), PCA3 (fish, shrimp and legume pattern) and PCA4 (dairy-based protein pattern). The correlation analyses showed that PCA1 and PCA3 were positively correlated with the UIC. The results of the multivariable analysis showed that PCA1, Q1, Q2 and Q3 were associated with an increased risk of iodine deficiency compared with Q4 ((OR): 260·41 (95 % CI: 20·16, 663·70)), 59·89 (5·64, 335·81), and 2·01 (0·15, 26·16), respectively). In PCA2, Q3 was associated with an increased risk of iodine deficiency compared with Q4 (OR: 0·16 (0·05, 0·53)). In PCA3, Q3 was associated with an increased risk of iodine deficiency compared with Q4 (OR: 0·23 (0·06, 0·90)). In PCA4, Q1 was associated with an increased risk of iodine deficiency compared with Q4 (OR: 31·30 (4·88, 200·64)).
Conclusion:
This study demonstrated that of the four dietary patterns, the least dependent staple food pattern (Q1) had a higher risk of iodine deficiency compared with the most dependent staple food pattern (Q4). However, the current evidence on the effect of dietary patterns on thyroid function needs to be validated by further longitudinal studies that include long-term follow-up, larger sample sizes and repeated measures.
The article studies an initial boundary valueproblem (ibvp) for the radial solutions of the nonlinear Schrödinger (NLS) equation in a radially symmetric region $\Omega\in \mathbb R^n$ with boundaries. All such regions can be classified into three types: a ball Ω0 centred at origin, a region Ω1 outside a ball, and an n-dimensional annulus Ω2. To study the well-posedness of those ibvps, the function spaces for the boundary data must be specified in terms of the solutions in appropriate Sobolev spaces. It is shown that when $\Omega = \Omega_1$, the ibvp for the NLS equation is locally well-posed in $ C( [0, T^*]; H^s(\Omega_1))$ if the initial data is in $H^s(\Omega_1)$ and boundary data is in $ H^{\frac{2s+1}{4}}(0, T)$ with $s \geq 0$. This is the optimal regularity for the boundary data and cannot be improved. When $\Omega = \Omega_2$, the ibvp is locally well-posed in $ C( [0, T^*]; H^s(\Omega_2))$ if the initial data is in $ H^s(\Omega_2)$ and boundary data is in $ H^{\frac{s+1}{2}}(0, T)$ with $s \geq 0$. In this case, the boundary data requires $1/4$ more derivative compared to the case when $\Omega = \Omega_1$. When $\Omega = \Omega_0$ with n = 2 (the case with n > 2 can be discussed similarly), the ibvp is locally well-posed in $ C( [0, T^*]; H^s(\Omega_0))$ if the initial data is in $ H^s(\Omega_0)$ and boundary data is in $ H^{\frac{s+1}{2}}(0, T)$ with s > 1 (or $s \gt n/2$). Due to the lack of Strichartz estimates for the corresponding boundary integral operator with $ 0 \leq s \leq 1$, the local well-posedness can only be achieved for s > 1. It is noted that the well-posedness results on Ω0 and Ω2 are the first ones for the ibvp of NLS equations in bounded regions of higher dimension.
This study investigates the flow structures and combustion regimes in an axisymmetric cavity-based scramjet combustor with a total temperature of 1800 K and a high Reynolds number of approximately 1 × 107. The hydroxyl planar laser-induced fluorescence technique, along with the broadband flame emission and CH* chemiluminescence, is employed to visualize the instantaneous flame structure in the optically accessible cavity. The jet-wake flame stabilization mode is observed, with intense heat release occurring in the jet wake upstream of the cavity. A hybrid Reynolds-averaged Navier–Stokes/large-eddy simulation approach is performed for the 0.18-equivalent-ratio case with a pressure-corrected flamelet/progress variable model. The combustion regime is identified mainly in the corrugated or wrinkled flamelet regime (approximately 102 < Da < 104, 103 < Ret < 105 where $Da$ is the Damköhler number and $Re_t$ is the turbulent Reynolds number). The combustion process is jointly dominated by supersonic combustion (which accounts for approximately 58 %) and subsonic combustion, although subsonic combustion has a higher heat release rate (peak value exceeding 1 × 109 J (m3s)−1). A partially premixed flame is observed, where the diffusion flame packages a considerable quantity of twisted premixed flame. The shockwave plays a critical role in generating vorticity by strengthening the volumetric expansion and baroclinic torque term, and it can facilitate the chemical reaction rates through the pressure and temperature surges, thereby enhancing the combustion. Combustion also shows a remarkable effect on the overall flow structures, and it drives alterations in the vorticity of the flow field. In turn, the turbulent flow facilitates the combustion and improves the flame stabilization by enhancing the reactant mixing and increasing the flame surface area.
Timing of food intake is an emerging aspect of nutrition; however, there is a lack of research accurately assessing food timing in the context of the circadian system. The study aimed to investigate the relation between food timing relative to clock time and endogenous circadian timing with adiposity and further explore sex differences in these associations among 151 young adults aged 18–25 years. Participants wore wrist actigraphy and documented sleep and food schedules in real time for 7 consecutive days. Circadian timing was determined by dim-light melatonin onset (DLMO). The duration between last eating occasion and DLMO (last EO-DLMO) was used to calculate the circadian timing of food intake. Adiposity was assessed using bioelectrical impedance analysis. Of the 151 participants, 133 were included in the statistical analysis finally. The results demonstrated that associations of adiposity with food timing relative to circadian timing rather than clock time among young adults living in real-world settings. Sex-stratified analyses revealed that associations between last EO-DLMO and adiposity were significant in females but not males. For females, each hour increase in last EO-DLMO was associated with higher BMI by 0·51 kg/m2 (P = 0·01), higher percent body fat by 1·05 % (P = 0·007), higher fat mass by 0·99 kg (P = 0·01) and higher visceral fat area by 4·75 cm2 (P = 0·02), whereas non-significant associations were present among males. The findings highlight the importance of considering the timing of food intake relative to endogenous circadian timing instead of only as clock time.
We consider linear-fractional branching processes (one-type and two-type) with immigration in varying environments. For $n\ge0$, let $Z_n$ count the number of individuals of the nth generation, which excludes the immigrant who enters the system at time n. We call n a regeneration time if $Z_n=0$. For both the one-type and two-type cases, we give criteria for the finiteness or infiniteness of the number of regeneration times. We then construct some concrete examples to exhibit the strange phenomena caused by the so-called varying environments. For example, it may happen that the process is extinct, but there are only finitely many regeneration times. We also study the asymptotics of the number of regeneration times of the model in the example.
To assess whether isolated very low QRS voltage of ≤0.3 mV in the frontal leads might be a marker for diagnosing paediatric vasovagal syncope and the risk of recurrence.
Methods:
We included 118 children with vasovagal syncope, comprising 70 males and 48 females in our retrospective analysis. All patients underwent head-up tilt test and supine 12-lead electrocardiography. Furthermore, the QRS voltage was measured from each one of the 12 leads on basal electrocardiography. Patients were followed up for 6–24 months (average, 16 months).
Results:
Eighty-six patients (73%) patients displayed isolated very low QRS voltage in frontal leads. Furthermore, the patients were classified into two groups based on the presence or absence of isolated very low QRS voltage. Enhanced syncopic spells over the past 6 months, and the positive rates of head-up tilt test were observed in patients having isolated very low QRS voltage in the frontal leads than those without isolated very low QRS voltage (p < 0.05). The single factor and time-to-event analyses also showed an increased syncope recurrence rate in patients with isolated very low QRS voltage in frontal leads when compared with those without isolated very low QRS voltage (p < 0.01).
Conclusions:
Isolated very low QRS voltage in frontal leads is correlated with the positive response of the head-up tilt test in children who experience syncope and its recurrence post-treatment. Hence, isolated very low QRS voltage in frontal leads might become a novel diagnostic indicator and a risk factor for syncope recurrence in children with vasovagal syncope.
To explore the associations between nutrition literacy (NL) and possible sarcopenia in older Chinese adults. A cross-sectional study was conducted. NL was assessed using a twelve-item short-form NL scale. Possible sarcopenia was identified using SARC-CALF. Logistic regression was used to calculate OR and 95 % CI for NL and the incidence of possible sarcopenia. A total of 1338 older individuals, aged 71·41 (sd 6·84) years, were enrolled in this study. After confounders were adjusted for, older adults in the upper quartile of NL were found to be 52 % less likely to have possible sarcopenia than those in the lower quartile of NL (OR = 0·48, 95 % CI: 0·29, 0·77). The associations between NL and possible sarcopenia were present only in those who lived in rural areas (OR: 0·38, 95 % CI: 0·19, 0·77), had a primary school education or less (OR: 0·21, 95 % CI: 0·09, 0·48), had a monthly income < 3000 RMB (OR: 0·39, 95 % CI: 0·22, 0·70) and had chronic diseases (OR: 0·37, 95 % CI: 0·22, 0·63). Moreover, an interaction effect was observed between having a chronic disease and junior high school education and being in the upper quartile of NL. The prevalence of possible sarcopenia in older Chinese adults is substantial, with prevalence decreasing with increasing NL. Moreover, the association between NL and possible sarcopenia varies by residence type, education level, monthly income and chronic disease experience. Targeted NL interventions are required to prevent and manage sarcopenia in older adults, particularly those with low socio-economic status and chronic diseases.
This paper retrospectively analysed the prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) in some parts of China. Between January 2013 and December 2019, we collected 4,145 respiratory samples, including pharyngeal swabs and alveolar lavage fluid. The highest PCR-positive rate of M. pneumoniae was 74.5% in Beijing, the highest resistance rate was 100% in Shanghai, and Gansu was the lowest with 20%. The highest PCR-positive rate of M. pneumoniae was 74.5% in 2013, and the highest MRMP was 97.4% in 2019; the PCR-positive rate of M. pneumoniae for adults in Beijing was 17.9% and the MRMP was 10.48%. Among the children diagnosed with community-acquired pneumonia (CAP), the PCR-positive and macrolide-resistant rates of M. pneumoniae were both higher in the severe ones. A2063G in domain V of 23S rRNA was the major macrolide-resistant mutation, accounting for more than 90%. The MIC values of all MRMP to erythromycin and azithromycin were ≥ 64 μg/ml, and the MICs of tetracycline and levofloxacin were ≤ 0.5 μg/ml and ≤ 1 μg/ml, respectively. The macrolide resistance varied in different regions and years. Among inpatients, the macrolide-resistant rate was higher in severe pneumonia. A2063G was the common mutation, and we found no resistance to tetracycline and levofloxacin.
China's cattle trade before 1949 is effectively invisible to historians. With no geographic center, few dominant firms, and little government oversight, cattle trade left behind no clear archive of sources, leaving scholars to the mercy of conjecture and episodic evidence. Combining insights from business and social history, we focused our attention on trade intermediation as the key to understanding the operations of a diffuse trade system. In the absence of a top–down archive, we composited hundreds of local sources on intermediation in cattle trade and remotely interviewed 80 former brokers. These sources revealed large numbers of individuated trade routes, which we break into three types: persistent supply, specialized demand, and resource circulation. Each type of trade called for distinct forms of intermediation with relatively little overlap between specialized networks. This recreation of China's cattle trade reveals a sophisticated market for animal labor that calls into question the direct causal link between imperialist resource extraction and rural immiseration, and suggests the utility of applying tools and perspectives of social history to other sorts of decentered commercial systems.
Contra-posing panel data on the incidence of pulmonary tuberculosis (PTB) at the provincial level in China through the years of 2004–2021 and introducing a geographically and temporally weighted regression (GTWR) model were used to explore the effect of various factors on the incidence of PTB from the perspective of spatial heterogeneity. The principal component analysis (PCA) was used to extract the main information from twenty-two indexes under six macro-factors. The main influencing factors were determined by the Spearman correlation and multi-collinearity tests. After fitting different models, the GTWR model was used to analyse and obtain the distribution changes of regression coefficients. Six macro-factors and incidence of PTB were both correlated, and there was no collinearity between the variables. The fitting effect of the GTWR model was better than ordinary least-squares (OLS) and geographically weighted regression (GWR) models. The incidence of PTB in China was mainly affected by six macro-factors, namely medicine and health, transportation, environment, economy, disease, and educational quality. The influence degree showed an unbalanced trend in the spatial and temporal distribution.
Tuberculosis (TB) infection prevention and control (IPC) in healthcare facilities is key to reducing transmission risk. A framework for systematically improving TB IPC through training and mentorship was implemented in 9 healthcare facilities in China from 2017 to 2019.
Methods:
Facilities conducted standardized TB IPC assessments at baseline and quarterly thereafter for 18 months. Facility-based performance was assessed using quantifiable indicators for IPC core components and administrative, environmental, and respiratory protection controls, and as a composite of all control types We calculated the percentage changes in scores over time and differences by IPC control type and facility characteristics.
Results:
Scores for IPC core components increased by 72% during follow-up when averaged across facilities. The percentage changes for administrative, environmental, and respiratory protection controls were 39%, 46%, and 30%, respectively. Composite scores were 45% higher after the intervention. Overall, scores increased most during the first 6 months. There was no association between IPC implementation and provincial economic development or volume of TB services.
Conclusions:
TB IPC policies and practices showed most improvement early during implementation and did not differ consistently by facility characteristics. The training component of the project helped increase the capacity of healthcare professionals to manage TB transmission risks. Lessons learned here will inform national TB IPC guidance.
The strong coupling interactions of non-equilibrium flow, microscopic particle collisions and radiative transitions within the shock layer of hypersonic atmospheric re-entry vehicles makes accurate prediction of the aerothermodynamics challenging. Therefore, in this study a self-consistent non-equilibrium flow, collisional–radiative reactions and radiative transfer fully coupled model are established to study the non-equilibrium characteristics of the flow field and radiation of vehicle atmospheric re-entry. The comparison of the present calculation results with flight data of FIRE II and previous results in the literature shows a reasonable agreement. The thermal, chemical and excited energy level non-equilibrium phenomena are obtained and analysed for the different FIRE II trajectory points, which form the critical basis for studying the heat transfer and radiation. The non-equilibrium distribution of excited energy levels significantly exists in the post-shock and near-wall regions due to the rapid vibrational dissociation and electronic under-excitation, as well as the wall catalytic reactions. The analysis of stagnation-point heating of FIRE II illustrates that the translational–rotational convection and the dissociation component diffusion play key roles in the aerodynamic heating of the wall region. The spectrally resolved radiative intensity in the entire flow field indicates that the vacuum ultraviolet radiation caused by the high-energy nitrogen atomic spectral lines makes the main contribution to the radiative transfer. Finally, it is found that the non-equilibrium flow–radiation coupling effect can exacerbate the excited energy level non-equilibrium, and further affect the gas radiative properties and radiative transfer. This fully coupled study provides an effective method for reasonable prediction of atmospheric re-entry flow and radiation fields.
This study aimed to compare changes in the level of health technology assessment (HTA) development from 2016 to 2021, and to inform policies and decisions to promote further development of HTA in China.
Methods
We conducted a cross-sectional and anonymous web-based survey to relevant stakeholders in China in 2016 and 2021 respectively. The mapping of the HTA instrument was used to reflect the HTA development from eight domains. To reduce the influence of confounders and to compare the mapping outcomes between 2016 and 2021 groups, we performed 1:1 propensity score matching methodology in this study. Univariate analysis was performed to compare the differences in these two groups. We also compared the overall results with that of a mapping study that included ten countries.
Results
A total of 212 and 255 respondents completed the survey in 2016 and 2021 respectively. After propensity score matching methodology, 183 cases from the 2016 group and 2021 group were matched. Overall, the mean score of 2021 in most of the domains was higher than in 2016 in China (p < 0.05), matching the level of HTA institutionalization and dissemination strategy, except for the assessment domain. Although China scored significantly lower among the three developed countries, the overall HTA development score for China was comparable among the ten countries.
Conclusions
Our study suggested the level of HTA development in China has made great progress from 2016 to 2021. Prior to HTA activities, the researcher or policy makers should first formulate an explicit assessment goal and scope, and during the assessment process, more attention should be paid to the clinical effectiveness and cost-effectiveness indicator to ensure a higher quality of HTA evidence.
Multilayer dielectric gratings (MLDGs) are crucial for pulse compression in picosecond–petawatt laser systems. Bulged nodular defects, embedded in coating stacks during multilayer deposition, influence the lithographic process and performance of the final MLDG products. In this study, the integration of nanosecond laser conditioning (NLC) into different manufacturing stages of MLDGs was proposed for the first time on multilayer dielectric films (MLDFs) and final grating products to improve laser-induced damage performance. The results suggest that the remaining nodular ejection pits introduced by the two protocols exhibit a high nanosecond laser damage resistance, which remains stable when the irradiated laser fluence is more than twice the nanosecond-laser-induced damage threshold (nanosecond-LIDT) of the unconditioned MLDGs. Furthermore, the picosecond-LIDT of the nodular ejection pit conditioned on the MLDFs was approximately 40% higher than that of the nodular defects, and the loss of the grating structure surrounding the nodular defects was avoided. Therefore, NLC is an effective strategy for improving the laser damage resistance of MLDGs.