Bilingualism delays the onset of dementia symptoms and contributes to cognitive reserve. However, the neural basis of this mechanism remains elusive. The few studies that have investigated neural mechanisms of cognitive reserve and bilingualism have focused on Alzheimer’s disease. This study investigated the neural basis of cognitive reserve among persons with frontotemporal dementia (FTD) using regional brain volumes. Sixty-eight persons with FTD (42 bilinguals and 26 monolinguals) were included. After propensity score matching for age, sex, education, FTD subtype and clinical severity, there were 26 bilinguals and 26 monolinguals. The results showed that bilinguals had reduced thalamic volume compared to monolinguals despite having similar cognitive performance. The results indicate that bilinguals were able to tolerate more severe atrophy compared to monolinguals while maintaining comparable cognitive abilities. Our study therefore suggests that bilingualism contributes to cognitive reserve in persons with FTD.

The mass balance of lake-terminating glaciers responds to annual atmospheric variations, while calving-induced ice loss at the front is driven by local ice–water interactions. The current glaciological studies underestimate glacier response by neglecting the significant annual ice loss at the terminus through calving processes. This study integrates field measurements with remote sensing data to investigate the glaciological characteristics and proglacial lake evolution of the Gepang Gath glacier in the Chandra basin, Western Himalaya, India. Long-term observations reveal a continuous expansion of the proglacial lake from 0.21 ± 0.06 km2 (1962) to 1.21 ± 0.05 km2 (2023), along with terminus retreat of ∼2.76 km, attributed to calving at the ice–water interface. The glacier’s surface exhibits complex debris cover, with thicknesses up to 35 cm, creating significant spatial variations in surface mass balance. In-situ, glaciological measurements reveal a highly negative glacier-wide mass balance of −0.90 ± 0.30 m w.e. a−1 between the years 2014 and 2023. The geodetic estimates also reveal a negative mass balance of −0.61 ± 0.1 m w.e. a−1 over the past decade (2013–2023). The frontal area change (0.42 km2) and geodetic mass balance show a total volumetric ice loss of −21.77 × 106 m3 w.e. during the same period. Overall, the yearly frontal ice loss exacerbates the mass loss by 17–22%. These findings suggest that the presence of proglacial lakes plays a significant role in intensifying ice mass loss from Himalayan glaciers, strongly regulating their overall evolution.

The minimal faithful permutation degree $\mu (G)$ of a finite group G is the least integer n such that G is isomorphic to a subgroup of the symmetric group $S_n$. If G has a normal subgroup N such that $\mu (G/N)> \mu (G)$, then G is exceptional. We prove that the proportion of exceptional groups of order $p^6$ for primes $p \geq 5$ is asymptotically zero. We identify $(11p+107)/2$ such groups and conjecture that there are no others.

Glacier and snow melt are the primary sources of water for streams, and rivers in upper Indus region of the western Himalaya. However, the magnitude of runoff from this glacierized basin is expected to vary with the available energy in the catchment. Here, we used a physically based energy balance model to estimate the surface energy and surface mass balance (SMB) of the upper Chandra Basin glaciers for 7 hydrological years from 2015 to 2022. A strong seasonality is observed, with net radiation being the dominant energy flux in the summer, while latent and sensible heat flux dominated in the winter. The estimated mean annual SMB of the upper Chandra Basin glaciers is −0.51 ± 0.28 m w.e. a−1, with a cumulative SMB of −3.54 m w.e during 7 years from 2015 to 2022. We find that the geographical factors like aspect, slope, size and elevation of the glacier contribute towards the spatial variability of SMB within the study region. The findings reveal that a 42% increase in precipitation is necessary to counteract the additional mass loss resulting from a 1°C increase in air temperature for the upper Chandra Basin glaciers.

Aortopulmonary window is a rare CHD, which comprises a communication between the ascending aorta and the pulmonary artery. The standard treatment of aortopulmonary window is surgical; however, few cases are amenable to closure via percutaneous intervention. We present a case of aortopulmonary window closure using Lifetech™ Konar-MF occluder device (Lifetech Scientific Co. Ltd., Shenzhen).

In this article, we study rational matrix representations of VZ p-groups (p is any prime). Using our findings on VZ p-groups, we explicitly obtain all inequivalent irreducible rational matrix representations of all p-groups of order $\leq p^4$. Furthermore, we establish combinatorial formulae to determine the Wedderburn decompositions of rational group algebras for VZ p-groups and all p-groups of order $\leq p^4$, ensuring simplicity in the process.

Natural resources such as soil and water are essential to agriculture, especially in arid and semi-arid rain-fed areas, yet the impacts of managing these crucial natural resources on farm technical efficiency are little known. Using data from 400 households with 1031 plots, we examined the impacts of soil and water conservation measures (SWCMs) on the technical efficiency of farmers in the semi-arid Bundelkhand (central India). We estimated stochastic production frontiers, considering potential self-selection bias stemming from both observable and unobservable factors in the adoption of SWCMs at the farm level. The farm technical efficiency for adopters of SWCMs ranged from 0.68 to 0.72, and that for non-adopters ranged from 0.52 to 0.65, depending on how biases were controlled for. As the average efficiency is consistently higher for adopter farmers than the control group, promoting SWCMs could help to increase input use efficiency, especially in resource-deprived rain-fed systems in the semi-arid tropics.

Semen sexing is among one of the most remarkable inventions of the past few decades in the field of reproductive biotechnology. The urge to produce offspring of a desired sex has remained since traditional times. Researchers have tried many methods for accurate semen sexing, but only the flow cytometry method has proved to be effective for commercial utilization. However, there were always concerns about the effects of sexed semen, especially on fertility and the rate of genetic gain. Some concerns were genuine because of factors such as low semen dosage in sexed semen straws and damage to sperm during the sorting process. Various researchers have conducted numerous studies to find out the effect of sexed semen on fertility and, in this article, we reflect on their findings. Initially, there were comparatively much lower conception rates (∼70% of conventional semen) but, with refinement in technology, this gap is bridging and the use of sexed semen will increase over time. Concerning genetic gain with use of sexed semen, a positive effect on rate of genetic progress with the use of sexed semen has been observed based on various simulation studies, although there has been a mild increase in inbreeding.

The North-Eastern region (NER) of India falls under the Eastern Himalayan region and it is a bio-diversity hub. Diverse maize landraces with wide adaptability to extreme climatic and soil scenario like heavy rainfall, drought and acidic soil conditions have been grown in NER since time immemorial. However, maize diversity in NER region has drastically reduced due to introduction of high yielding varieties and hybrids. Modern maize breeding programmes are focused on high yield but other unique traits like stay green trait, prolificacy (more than one fertile ear per plant), self-fertilizing ability are also important and the local germplasm of the NER region can contribute with these unique traits. Prior to the selection of any lines in several breeding programmes, assessment of genetic diversity and population structure are basic requirements. Hence, in the present study assessment of genetic diversity and population structure study in 30 maize inbreds developed from different germplasm of NER was undertaken using SSR markers, selected for their broad distribution throughout the genome, in order to assess the extent of allelic diversity among the lines and whether any population structure could be established. In addition to assessing molecular diversity, the study aims to evaluate the potential for yield and other beneficial and unique alleles that have high potential to contribute in the genetic enhancement programme of maize.

This Research Communication aims to compare the effect of A1A2 and A2A2 cow milk diets on the biochemical and histological parameters of rats. The rats were divided into four groups and fed with a normal diet, A2 milk powder, A1A2 or A2A2 cow milk diets for 90 d. Blood glucose, kidney function, liver function and lipid profile were examined during the experimental period. The study showed an increase in the body weight of the A1A2 group whereas a slight decrease in the A2A2 group, and blood glucose levels increased from d 0 to day 90 in all experimental groups. However, none of these changes were found to be statistically insignificant (P > 0.05). Moreover, no significant changes were recorded in other parameters (serum glutamic pyruvic transferase and serum glutamic-oxaloacetic transaminase for liver function, bilirubin direct, cholesterol, triglycerides, creatinine and uric acid). The histology of the liver, kidney and pancreas also showed no changes in all groups. Overall, this study revealed no significant difference in the nutritional values of A1A2 and A2A2 milk types and hence equally beneficial for health. Although the present study showed no significant difference in the effect of both milk types in 90 d, further studies might be conducted to evaluate their longer term effects.

Wake interaction of two rotationally oscillating cylinders in side-by-side configuration is studied experimentally at a Reynolds number of 150. Five spacing ratios, $T/D$ (ratio of centre-to-centre spacing to cylinder diameter), are considered, namely, 1.4, 1.8, 2.5, 4.0 and 7.5. Both in-phase and antiphase forcing are investigated. Oscillation amplitude is varied from ${\rm \pi} /8$ to ${\rm \pi}$, and forcing frequency, $FR$ (ratio of the oscillation frequency to the vortex-shedding frequency of a stationary cylinder) is varied from 0 to 5. The experimental investigation is done using laser-induced fluorescence, hot film anemometry and particle-image velocimetry (PIV). The interaction between the two cylinders under forcing results in new wake modes and vortex structures and a comprehensive study from the wake visualisations is conducted. Quantitative results are presented in terms of streamwise and cross-stream mean velocity profiles, centreline velocity recovery, peak velocity deficit, wake width, fluctuation intensity, circulation, vorticity contours and drag coefficient. The magnitude of streamwise velocity deficit and cross-stream velocity variation is strongly affected by the presence of second cylinder. The recirculation region behind the cylinders is found to extend further downstream with increase in the forcing. Scaling analysis is carried out to express the peak velocity deficit variation with forcing. It is observed that the relative strength of the vortices shed from inner and outer shear layers depends on the phase of oscillation. An experimental set-up for direct force measurement is designed and the drag force acting on the oscillating cylinders assembly is directly measured and the effect of forcing on the variation of ${C}_{d}$ is studied. An estimate for drag coefficient is also made from the PIV data following a detailed control volume analysis. It is observed that the set of forcing parameters that correspond to maximum and minimum drag also yield extrema in the values of circulation and fluctuation intensity.

The quantification of fossil-fuel derived carbon dioxide (CO2ff) emissions is critical for regional carbon budgets. Radiocarbon (14C) is an effective tool to estimate the contribution of CO2ff to the total atmospheric CO2. In the present study, we have determined the spatial distribution of fossil fuel derived CO2 across Delhi using 14C measurements in Peepal tree leaves from April 2016 to March 2017 at city scale. Our analysis results show that the Δ14C values vary between –67.78‰ to 5.61‰ and corresponding CO2ff values are varying from 1.63 ppm to 33.34 ppm. CO2ff values from campus sites vary between 6.99 ppm to 16.38 ppm with an average value of 10.22 ± 3.20 ppm, while CO2ff values vary from 2.41 ppm to 33.34 ppm with an average value of 13.32 ± 9.40 ppm for sites located in the parks. Further, we observed the higher contributions of fossil fuels in the CO2 from northwest Delhi, central Delhi, and some parts of east and southwest Delhi. In the absence of real-time CO2 monitoring, the results of this study provide a potential method for analyzing the contribution of CO2ff values over the urban landscape to total CO2 over the study region.

Bispyribac-sodium, a herbicide that inhibits acetolactate synthase (ALS), is frequently used in rice fields in India to control weeds, including the most common noxious weed, barnyardgrass. However, rice growers have recently reported reduced control of barnyardgrass with bispyribac-sodium. Hence, a large-scale survey was carried out to assess bispyribac-sodium resistance in Chhattisgarh and Kerala, two rice-growing states. Open-field pot experiments were conducted for 2 yr to confirm resistance to bispyribac-sodium. Of the 37 biotypes tested, 30% (11) survived the recommended label rate of bispyribac-sodium (25 g ai ha−1). The effective rate of bispyribac-sodium required to achieve 50% control (ED50) of putative resistant biotypes ranged from 18 to 41 g ha−1, whereas it was about 10 g ha−1 for susceptible biotypes. This suggests that putative biotypes were two to four times more resistant to bispyribac-sodium. At 6 d after herbicide application, an in vitro enzyme assay demonstrated higher ALS enzyme activity in putative resistant biotypes (66% to 75%) compared with susceptible biotypes (48% to 52%). This indicates the presence of an insensitive ALS enzyme in those biotypes and a target site mutation as a possible mechanism for resistance. Whole-plant bioassays also suggested that the resistance problem is more widespread in Chhattisgarh than in Kerala. This study confirmed the first case of evolved resistance in barnyardgrass to bispyribac-sodium in rice fields of India.

This study assessed the impact of improved green fodder production activities on technical efficiency (TE) of dairy farmers in climate vulnerable landscapes of central India. We estimated stochastic production frontiers, considering potential self-selection bias stemming from both observable and unobservable factors in adoption of fodder interventions at farm level. The empirical results show that TE for treated group ranges from 0.55 to 0.59 and that for control ranges from 0.41 to 0.48, depending on how biases are controlled. Additionally, the efficiency levels of both adopters and non-adopters would be underestimated if the selectivity bias is not appropriately accounted. As the average TE is consistently higher for adopter farmers than the control group, promoting improved fodder cultivation would increase input use efficiency, especially in resource-deprived small holder dairy farmers in the semi-arid tropics.

Soil and water are crucial resources for agriculture, especially in arid and semi-arid rain-fed areas, yet farm-level economic impacts and the factors influencing the adoption of measures for their conservation are little studied. The present study used data from 400 farm households to assess factors influencing the adoption of soil and water conservation measures (SWCMs) and their impacts on farm productivity and income in a semi-arid region of central India. We employed a probit model to determine the factors influencing the on-farm adoption of SWCMs and a propensity score matching technique for assessing their impacts. The findings indicate that farmer age and education, off-farm income, farm size and land ownership and access to training are key drivers of the adoption of SWCMs. SWCMs accentuated the input costs by INR 1689–2847 per ha during the rabi cropping season (October–February), but also increased crop productivity and net revenue from farming. The impact in the rabi season was less sensitive to the unobserved confounders than in the kharif season (June–September). Therefore, SWCMs could represent an important strategy for unlocking the cultivation potential of large rain-fed areas and for sustaining the livelihoods of farm households in the ecologically fragile arid and semi-arid tropics.

The current COVID-19 pandemic contributed by the SARS-CoV-2 has put in place an urgent need for new and promising antiviral therapeutics. The viral RNA-dependent RNA polymerase (RdRp) enzyme plays a vital role in viral replication for all RNA viruses, including SARS-CoV-2, thereby making it a prime and promising candidate for novel antiviral targeting. Interestingly, the human telomerase reverse transcriptase (hTERT), a common catalytic subunit of the telomerase enzyme in many cancers, has also been identified with structural and functional similarities to the viral RdRp. Therefore, it becomes essential to evaluate and consider anticancer drugs that target hTERT towards antiviral RdRp activity, and vice versa. For instance, Floxuridine, an hTERT inhibitor, and VX-222, a hepatitis C virus RdRp inhibitor, are now gaining recognition as a potential antiviral against SARS-CoV-2 and anti-hTERT for cancer, simultaneously. While limited studies on hTERT inhibitors for use as viral RdRp, and anti-RdRp inhibitors as hTERT inhibitors are available, in this review, we aim at bringing to light this close structural and functional relationship between both these enzymes. We punctuate this idea with specific examples on how potential anticancer inhibitors can effectively be brought to use as inhibitors against the SARS-CoV-2 virus, a relatively new pathogen, compared to the very well-studied field of cancer research.

This study is on the absolute age dating of a multicultural site of Erenda, East Medinipur district, in coastal West Bengal, India. Charcoal samples were collected and measured using the accelerator mass spectrometry (AMS) facility at the Inter-University Accelerator Centre, New Delhi, India. These samples were collected from secured stratigraphic context of two excavated trenches. A careful collection of samples from two trenches provided us with the first calendar dates, 950 BCE and 1979 BCE, of protohistoric sites in coastal West Bengal. These calibrated calendar dates not only have wider significance in terms of archaeology but also methodological implications to understand the relevance of application of AMS from the dynamic coastal landscape in the humid tropics during the late Holocene period.

Accelerator mass spectrometry (AMS) activities at the Inter-University Accelerator Centre (IUAC) in New Delhi, India, started with its 15UD Pelletron accelerator and cosmogenic radionuclide (CRN) measurements of 10Be and 26Al. Realizing the demand of a radiocarbon (14C) AMS facility in India, a 500kV Pelletron accelerator based AMS system was installed in 2015. This facility was designated with the lab code IUACD for 14C measurements. 14C dates measured in 2015 and 2016 were published in the first radiocarbon date list (see text for details). The present list is the second 14C date list and consists of dates measured from January to December 2017.