Galaxy morphology in stellar light can be described by a series of ‘non-parametric’ or ‘morphometric’ parameters, such as concentration-asymmetry-smoothness, Gini, $M_{20}$, and Sérsic fit. These parameters can be applied to column density maps of atomic hydrogen (H 1). The H 1 distribution is susceptible to perturbations by environmental effects, for example, intergalactic medium pressure and tidal interactions. Therefore, H 1 morphology can potentially identify galaxies undergoing ram-pressure stripping or tidal interactions. We explore three fields in the WALLABY Pilot H 1 survey and identify perturbed galaxies based on a k-nearest neighbour (kNN) algorithm using an H 1 morphometric feature space. For training, we used labelled galaxies in the combined NGC 4808 and NGC 4636 fields with six H 1 morphometrics to train and test a kNN classifier. The kNN classification is proficient in classifying perturbed galaxies with all metrics – accuracy, precision, and recall – at 70–80%. By using the kNN method to identify perturbed galaxies in the deployment field, the NGC 5044 mosaic, we find that in most regards, the scaling relations of perturbed and unperturbed galaxies have similar distribution in the scaling relations of stellar mass versus star formation rate and the Baryonic Tully–Fisher relation, but the H 1 and stellar mass relation flatter than of the unperturbed galaxies. Our results for NGC 5044 provide a prediction for future studies on the fraction of galaxies undergoing interaction in this catalogue and to build a training sample to classify such galaxies in the full WALLABY survey.

The National Financial Capability Study (NFCS) is a large-scale, ongoing research project of the FINRA Foundation that provides a broad range of stakeholders the ability to examine and better understand the financial capability of U.S. adults. First introduced in 2009, the NFCS has dozens of publicly available reports and data sets that are free to download. Data from the NFCS contain information on people’s ability to make ends meet, their management of financial products and services, the extent to which they plan ahead, their financial knowledge and decision-making, and numerous other topics. This paper provides an overview of the history, methodology, and some insights gained from the NFCS over the years. In addition, given the NFCS’ unique role as the birthplace of the Big 5 financial literacy questions that are present in all waves of the NFCS, we discuss the role of the NFCS in aiding our understanding of financial knowledge in the United States. The paper concludes with a look toward the future of the NFCS.

To meet the development needs of aeroengines for high thrust-to-weight ratios and fuel-air ratios, a high temperature rise triple-swirler main combustor was designed with a total fuel-air ratio of 0.037, utilising advanced technologies including staged combustion, multi-point injection and multi-inclined hole cooling. Fluent software was used to conduct numerical simulations under both takeoff and idle conditions, thereby obtaining the distribution characteristics of the velocity and temperature fields within the combustor, as well as the generation of pollutants. The simulation results indicate that under takeoff conditions, the high temperature rise triple-swirler combustor achieves a total pressure loss coefficient of less than 6% and a combustion efficiency exceeding 99%. Under takeoff conditions, the OTDF and RTDF values are 0.144 and 0.0738, respectively. The mole fraction of NOx emissions is 3,700ppm, while the mole fraction of soot emissions is 2.55×10−5ppm. Under idle conditions, the triple-swirler combustor maintains a total pressure loss coefficient of less than 6% and a combustion efficiency greater than 99.9%. The OTDF and RTDF values are 0.131 and 0.0624, respectively. The mole fractions of CO and UHC emissions are both 0×10−32ppm at the calculation limit of Fluent software.

Background: Efgartigimod, a human immunoglobulin G (IgG)1 antibody Fc fragment, blocks the neonatal Fc receptor, decreasing IgG recycling and reducing pathogenic IgG autoantibody levels. ADHERE assessed the efficacy and safety of efgartigimod PH20 subcutaneous (SC; co-formulated with recombinant human hyaluronidase PH20) in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: ADHERE enrolled participants with CIDP (treatment naive or on standard treatments withdrawn during run-in period) and consisted of open-label Stage A (efgartigimod PH20 SC once weekly [QW]), and randomized (1:1) Stage B (efgartigimod or placebo QW). Primary outcomes were clinical improvement (assessed with aINCAT, I-RODS, or mean grip strength; Stage A) and time to first aINCAT score deterioration (relapse; Stage B). Secondary outcomes included treatment-emergent adverse events (TEAEs) incidence. Results: 322 participants entered Stage A. 214 (66.5%) were considered responders, randomized, and treated in Stage B. Efgartigimod significantly reduced the risk of relapse (HR: 0.394; 95% CI: 0.25–0.61) versus placebo (p=0.000039). Reduced risk of relapse occurred in participants receiving corticosteroids, intravenous or SC immunoglobulin, or no treatment before study entry. Most TEAEs were mild to moderate; 3 deaths occurred, none related to efgartigimod. Conclusions: Participants treated with efgartigimod PH20 SC maintained a clinical response and remained relapse-free longer than those treated with placebo.

The double-orifice tricuspid valve (DOTV) is a rare lesion. We present a series of three patients encountered at the Stollery Children’s Hospital with a diagnosis of DOTV on 2D and/or 3D echocardiography. The patient’s medical records are reviewed for presentation history, investigative findings, and clinical course. We discuss the cases in the context of a complete review of all literature documenting cases of DOTV. In the majority of cases, the lesion is relatively benign, with little change in valve function over the short to medium term, and outcomes are determined largely by significant concomitant heart defects.

The estimated global preterm birth rate in 20201 was more than 10% of livebirths or 13.4 million infants. Nutrition in the neonatal period is a key factor to optimise growth, neurodevelopment, and later metabolic disease risk2. There is no consensus on optimal nutrition for preterm infants, leading to substantial practice variation3. We aimed to assess the quality of nutritional guidelines for preterm infants, the consistency of recommendations, and the gaps in these recommendations. This review is reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 checklist. The study protocol was registered with PROSPERO (CRD42022327248). We searched six databases and 44 websites for nutritional guidelines for preterm infants before first hospital discharge, which were endorsed, prepared, or authorised by a regional, national, or international body, written in English, and published between 2012-2023. Two reviewers independently screened articles and extracted relevant data including nutritional recommendations (ranges or descriptions), the quality of recommendations (certainty of evidence and strength of recommendation), and gaps in recommendations, defined as those identified by the guidelines or when recommendations were based on very low certainty evidence. Disagreements were resolved by discussion or a third reviewer. Four reviewers appraised the included guidelines using AGREE II. We identified 7051 records, 27 guidelines were included in the review, 26% of which were of high quality. Most guidelines lacked stakeholder involvement and rigour of development. Twelve guidelines had recommendations for macronutrient intake, 18 for micronutrient intake, 12 for feeding, eight for fortification, and 14 for monitoring of nutritional adequacy. Only two guidelines provided recommendations for all five of these aspects. We found considerable variation in recommendations, many of which lacked details of certainty of evidence and strength of recommendation. Recommendations for feeding types and breastmilk fortification were consistent among high quality guidelines, but recommendations varied for intakes of almost all nutrients and monitoring of nutritional adequacy. Different guidelines gave different certainty of evidence for the same recommendations. Most gaps in recommendations were due to a very low certainty of evidence. Future development of nutritional guidelines for preterm infants should follow the standard guideline development method and ensure rigorous process including stakeholders’ involvement to improve the reporting of strength of recommendation, certainty of evidence, and gaps in recommendation. Evidence is needed to support recommendations about macro and micronutrient intakes, breastmilk fortification, and markers on adequacy of intake of different nutrients.

We first sequenced and characterised the complete mitochondrial genome of Toxocara apodeme, then studied the evolutionary relationship of the species within Toxocaridae. The complete mitochondrial genome was amplified using PCR with 14 specific primers. The mitogenome length was 14303 bp in size, including 12 PCGs (encoding 3,423 amino acids), 22 tRNAs, 2 rRNAs, and 2 NCRs, with 68.38% A+T contents. The mt genomes of T. apodemi had relatively compact structures with 11 intergenic spacers and 5 overlaps. Comparative analyses of the nucleotide sequences of complete mt genomes showed that T. apodemi had higher identities with T. canis than other congeners. A sliding window analysis of 12 PCGs among 5 Toxocara species indicated that nad4 had the highest sequence divergence, and cox1 was the least variable gene. Relative synonymous codon usage showed that UUG, ACU, CCU, CGU, and UCU most frequently occurred in the complete genomes of T. apodemi. The Ka/Ks ratio showed that all Toxocara mt genes were subject to purification selection. The largest genetic distance between T. apodemi and the other 4 congeneric species was found in nad2, and the smallest was found in cox2. Phylogenetic analyses based on the concatenated amino acid sequences of 12 PCGs demonstrated that T. apodemi formed a distinct branch and was always a sister taxon to other congeneric species. The present study determined the complete mt genome sequences of T. apodemi, which provide novel genetic markers for further studies of the taxonomy, population genetics, and systematics of the Toxocaridae nematodes.

Faecal examinations for helminth eggs were performed on 1869 people from two riverside localities, Vientiane Municipality and Saravane Province, along the Mekong River, Laos. To obtain adult flukes, 42 people positive for small trematode eggs (Opisthorchis viverrini, heterophyid, or lecithodendriid eggs) were treated with a 20–30 mg kg−1 single dose of praziquantel and purged. Diarrhoeic stools were then collected from 36 people (18 in each area) and searched for helminth parasites using stereomicroscopes. Faecal examinations revealed positive rates for small trematode eggs of 53.3% and 70.8% (average 65.2%) in Vientiane and Saravane Province, respectively. Infections with O. viverrini and six species of intestinal flukes were found, namely, Haplorchis taichui, H. pumilio, H. yokogawai, Centrocestus caninus, Prosthodendrium molenkampi, and Phaneropsolus bonnei. The total number of flukes collected and the proportion of fluke species recovered were markedly different in the two localities; in Vientiane, 1041 O. viverrini (57.8 per person) and 615 others (34.2 per person), whereas in Saravane, 395 O. viverrini (21.9 per person) and 155207 others (8622.6 per person). Five people from Saravane harboured no O. viverrini but numerous heterophyid and/or lecithodendriid flukes. The results indicate that O. viverrini and several species of heterophyid and lecithodendriid flukes are endemic in these two riverside localities, and suggest that the intensity of infection and the relative proportion of fluke species vary by locality along the Mekong River basin.

The status of the genera Euparagonimus Chen, 1963 and Pagumogonimus Chen, 1963 relative to Paragonimus Braun, 1899 was investigated using DNA sequences from the mitochondrial cytochrome c oxidase subunit I (CO1) gene (partial) and the nuclear ribosomal DNA second internal transcribed spacer (ITS2). In the phylogenetic trees constructed, the genus Pagumogonimus is clearly not monophyletic and therefore not a natural taxon. Indeed, the type species of Pagumogonimus,P. skrjabini from China, is very closely related to Paragonimus miyazakii from Japan. The status of Euparagonimus is less obvious. Euparagonimus cenocopiosus lies distant from other lungflukes included in the analysis. It can be placed as sister to Paragonimus in some analyses and falls within the genus in others. A recently published morphological study placed E. cenocopiosus within the genus Paragonimus and probably this is where it should remain.

The transition to dripping in the gravity-driven flow of a liquid film under an inclined plate is investigated at zero Reynolds number. Computations are carried out on a periodic domain assuming either a fixed fluid volume or a fixed flow rate for a hierarchy of models: two lubrication models with either linearised curvature or full curvature (the LCM and FCM, respectively), and the full equations of Stokes flow. Of particular interest is the breakdown of travelling-wave solutions as the plate inclination angle is increased. For any fixed volume, the LCM reaches the horizontal state where it attains a cosine-shaped profile. For sufficiently small volume, the FCM and Stokes solutions attain a weak Young–Laplace equilibrium profile, the approach to which is described by an asymptotic analysis generalising that of Kalliadasis & Chang (J. Fluid Mech., vol. 261, 1994, pp. 135–168) for the LCM. For large volumes, the bifurcation curves for the FCM and Stokes model have a turning point so that the fully inverted state is never reached. For fixed flow rate, the LCM blows up at a critical angle that is well predicted by asymptotic analysis. The bifurcation curve for the FCM either has a turning point or else reaches a point at which the surface profile has an infinite slope singularity, indicating the onset of multi-valuedness. The latter is confirmed by the Stokes model, which can be continued to obtain overturning surface profiles. Overall, the thin-film models either provide an accurate prediction for dripping onset or else supply an upper bound on the critical inclination angle.

Suitable systems for the assessment of animal welfare are in increasing demand. In Austria, the TGI 35 L Animal Needs Index is widely used and has been shown to be a feasible and reliable tool for animal welfare assessment on farms. Here we focus on the validity of TGI 35 L assessments, and explore the correlation between animal welfare as assessed by the TGI 35 L and animal health and behavioural parameters. From the results, it can be determined whether the criteria assessed by the TGI 35 L are preconditions for a high level of health and normal behaviour. Behaviour and health were examined in 11 cattle houses, totalling 169 animals. Behaviour was observed for two days on each farm. Data on resting behaviour, comfort behaviour, social behaviour, feed intake behaviour and eliminative behaviour were collected. Health was assessed using veterinary examinations carried out according to the General Clinical and the Orthopaedic Examination Proceedings. Significant correlations were found between the TGI scores and behaviour and health, including results for skin lesions and injuries. This indicates good validity of the TGI 35 L assessment system for cattle. A comprehensive system for the assessment of animal welfare on farms must comprise parameters of housing, climate, management and stockmanship, and animal-related parameters.

The Cambrian saw a dramatic increase in metazoan diversity and abundance. Between-assemblage diversity (beta diversity) soared in the first three Cambrian stages, suggesting a rapid increase in the geodisparity of marine animals during the Cambrian radiation. However, it remains unclear how these changes scale up to first-order biogeographic patterns. Here we outline time-traceable provinces for marine invertebrates across the Cambrian period using a compositional network based on species-level fossil occurrence data. Results confirm an increase in regional differences of faunal composition and a decrease in by-species geographic distribution during the first three stages. We also show that general biogeography tends to be reshaped after global extinction pulses. We suggest that the abrupt biogeographic differentiation during the Cambrian radiation was controlled by a combination of tectonics, paleoclimate, and dispersal capacity changes.