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2 results

  • Effects of lowered serotonin transmission on cocaine-induced striatal dopamine response: PET [11C]raclopride study in humans

  • Sylvia M. L. Cox, Chawki Benkelfat, Alain Dagher, J. Scott Delaney, France Durand, Theodore Kolivakis, Kevin F. Casey, Marco Leyton
  • Journal:
    The British Journal of Psychiatry / Volume 199 / Issue 5 / November 2011
    Published online by Cambridge University Press:
    02 January 2018, pp. 391-397
    Print publication:
    November 2011
    • Article
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  • Background

    Low serotonin transmission is thought to increase susceptibility to a wide range of substance use disorders and impulsive traits.

    Aims

    To investigate the effects of lowered serotonin on cocaine-induced (1.0 mg/kg cocaine, self-administered intranasally) dopamine responses and drug craving.

    Method

    In non-dependent cocaine users, serotonin transmission was reduced using the acute tryptophan depletion method. Striatal dopamine responses were measured using positron emission tomography with [11C]raclopride.

    Results

    Acute tryptophan depletion increased drug craving and striatal dopamine responses to cocaine. These acute tryptophan depletion-induced increases did not occur in the absence of cocaine.

    Conclusions

    The results suggest that low serotonin transmission can increase dopaminergic and appetitive responses to cocaine. These findings might identify a mechanism by which individuals with low serotonin are at elevated risk for both substance use disorders and comorbid conditions.