In this study, the mitochondrial genome of Eulaelaps silvestris, which parasitizes Apodemus chevrieri, was sequenced and assembled to fill the gap in understanding the molecular evolution of the genus Eulaelaps. The E. silvestris mitochondrial genome is a double-stranded DNA molecule with a length of 14 882 bp, with a distinct AT preference for base composition and a notably higher AT content than GC content. The arrangement between genes is relatively compact, with a total of 10 gene intergenic regions and 12 gene overlap regions. All protein-coding genes had a typical ATN initiation codon, and only 2 protein-coding genes had an incomplete termination codon T. Out of the 13 protein-coding genes, the 5 most frequently used codons ended in A/U, with only 1 codon ending in G/C had an relative synonymous codon usage value >1. Except for trnS1 and trnS2, which lacked the D arm, all other tRNAs were able to form a typical cloverleaf structure; and there were a total of 38 mismatches in the folding process of tRNA genes. Unlike the gene arrangement order of the arthropod hypothetical ancestor, the E. silvestris mitochondrial genome underwent fewer rearrangements, mainly near tRNA genes and control regions. Both the maximum likelihood tree and the Bayesian tree showed that the family Haemogamasidae is most closely related to the family Dermanyssidae. The results not only provide a theoretical basis for studying the phylogenetic relationships of the genus Eulaelaps, but also provide molecular evidence that the family Haemogamasidae does not belong to the subfamily Laelapidae.

Richtmyer–Meshkov (RM) instability in convergent geometries (such as cylinders and spheres) plays a fundamental role in natural phenomena and engineering applications, e.g. supernova explosion and inertial confinement fusion. Convergent geometry refers to a system in which the interface converges and the fluids are compressed correspondingly. By applying a decomposition formula, the stretching or compression (S(C)) effect is separated from the perturbation growth as one of the main contributions, which is defined as the averaged velocity difference between two ends of the mixing zone. Starting from linear theories, the S(C) effect in planar, cylindrical and spherical geometries is derived as a function of geometrical convergence ratio, compression ratio and mixing width. Specifically, geometrical convergence stretches the mixing zone, while fluid compression compresses the mixing zone. Moreover, the contribution of geometrical convergence in the spherical geometry is more important than that in the cylindrical geometry. A series of cylindrical cases with high convergence ratio is simulated, and the growth of perturbations is compared with that of the corresponding planar cases. As a result, the theoretical results of the S(C) effect agree well with the numerical results. Furthermore, results show that the S(C) effect is a significant feature in convergent geometries. Therefore, the S(C) effect is an important part of the Bell–Plesset effect. The present work on the S(C) effect is important for further modelling of the mixing width of convergent RM instabilities.

No relevant studies have yet been conducted to explore which measurement can best predict the survival time of patients with cancer cachexia. This study aimed to identify an anthropometric measurement that could predict the 1-year survival of patients with cancer cachexia. We conducted a nested case–control study using data from a multicentre clinical investigation of cancer from 2013 to 2020. Cachexia was defined using the Fearon criteria. A total of 262 patients who survived less than 1 year and 262 patients who survived more than 1 year were included in this study. Six candidate variables were selected based on clinical experience and previous studies. Five variables, BMI, mid-arm circumference, mid-arm muscle circumference, calf circumference and triceps skin fold (TSF), were selected for inclusion in the multivariable model. In the conditional logistic regression analysis, TSF (P = 0·014) was identified as a significant independent protective factor. A similar result was observed in all patients with cancer cachexia (n 3084). In addition, a significantly stronger positive association between TSF and the 1-year survival of patients with cancer cachexia was observed in participants aged > 65 years (OR: 0·94; 95 % CI 0·89, 0·99) than in those aged ≤ 65 years (OR: 0·96; 95 % CI 0·93, 0·99; Pinteraction = 0·013) and in participants with no chronic disease (OR: 0·92; 95 % CI 0·87, 0·97) than in those with chronic disease (OR: 0·97; 95 % CI 0·94, 1·00; Pinteraction = 0·049). According to this study, TSF might be a good anthropometric measurement for predicting 1-year survival in patients with cancer cachexia.

The recent observation of spectacular photocatalytic activity enhancements generated tremendous interest in the synthesis, properties, and potential applications of black titania. Most black titania are core–shell structures consisting of a perfect crystalline core surrounded by a defective surface shell. Because the properties are attributed to the defective shell, it is particularly important, but very challenging, to obtain atomic structure information of the core, the shell, and the core–shell relationship on a single particle level. While the role of various synthesis approaches for producing black titania with different properties has been extensively reviewed, this review focuses on understanding the structure–functionality relationship in black titania on a single particle level. We start by introducing the crystal and electronic band structure of different TiO2 phases, followed by the discussion of particle size effects, the origin of lattice distortions, and phase control by synthesis, and concluding with the discussion of crystalline order formation and evolution creating the defective shell.

In this paper, we study a two-component Lotka–Volterra competition systemon a one-dimensional spatial lattice. By the comparison principle, together with the weighted energy, we prove that the traveling wavefronts with large speed are exponentially asymptotically stable, when the initial perturbation around the traveling wavefronts decays exponentially as $j\,+\,ct\,\to \,-\,\infty $, where $j\,\in \,\mathbb{Z}$, $t\,>\,0$, but the initial perturbation can be arbitrarily large on other locations. This partially answers an open problem by J.-S. Guo and C.-H.Wu.

The aim of this study is to analyse the efficacy rate of folate for the treatment of hyperhomocysteinaemia (HHcy) and to explore how folate metabolism-related gene polymorphisms change its efficacy. This study also explored the effects of gene–gene and gene–environment interactions on the efficacy of folate. A prospective cohort study enrolling HHcy patients was performed. The subjects were treated with oral folate (5 mg/d) for 90 d. We analysed the efficacy rate of folate for the treatment of HHcy by measuring homocysteine (Hcy) levels after treatment. Unconditioned logistic regression was conducted to analyse the association between SNP and the efficacy of folic acid therapy for HHcy. The efficacy rate of folate therapy for HHcy was 56·41 %. The MTHFR rs1801133 CT genotype, TT genotype and T allele; the MTHFR rs1801131 AC genotype, CC genotype and C allele; the MTRR rs1801394 GA genotype, GG genotype and G allele; and the MTRR rs162036 AG genotype and AG+GG genotypes were associated with the efficacy of folic acid therapy for HHcy (P<0·05). No association was seen between other SNP and the efficacy of folic acid. The optimal model of gene–gene interactions was a two-factor interaction model including rs1801133 and rs1801394. The optimal model of gene–environment interaction was a three-factor interaction model including history of hypertension, history of CHD and rs1801133. Folate supplementation can effectively decrease Hcy level. However, almost half of HHcy patients failed to reach the normal range. The efficacy of folate therapy may be genetically regulated.

This work was to evaluate the differences of soil and plant analysis development (SPAD) and normalized difference vegetation index (NDVI) readings and their relationship with leaf nitrogen accumulation (LNA). The study explored new indices to diagnose nitrogen (N) status. These indices were obtained by multiplying SPAD readings and leaf area index (LAI). Linear regression relationships between Chlorophyll values and N indicators showed the SPAD readings (Chl: LNA=0.0546×Chl-0.479, R2=0.94***, P<0.001). The projected results suggested that Chl values could play an important role for improving N status diagnosis from stem elongation to heading stages in paddy rice.

The Mingshui–Jilasitai–Suolun area, located in the central part of the Great Xing’an Range, is characterized by large volumes of alkali feldspar granites. However, the formation time and tectonic setting of these rocks remains controversial owing to a lack of precise geochronological and detailed geochemical data. In this paper, we report new SIMS U–Pb zircon ages and mineralogical, petrographical and geochemical data for Lower Cretaceous alkali feldspar granites from the Mingshui–Jilasitai–Suolun area. The SIMS zircon dating results indicate that these granites formed at 133.6–135.9 Ma. The mineralogical, petrographical and geochemical data show that these granitic rocks belong to highly fractionated I-type granites. Combined with the regional geology data, we propose that the formation of the Lower Cretaceous alkali feldspar granitic rocks was related to an extension induced by delamination of the lithosphere that arose from subduction of the Palaeo-Pacific plate.

Introduction.Peach brown rot caused by the fungus Monilinia fructicola is a major disease leadingto considerable economic loss during storage. Our previous studyuncovered the striking inhibition of the natural alkaloid berberineagainst M. fructicola. Materials and methods.A berberine-chitosan composite membrane (BCCM) able to slowly releaseberberine was prepared and used for peach preservation. The examinedfruits were stored at 4 °C and treated as follows: (I) control fruits withoutpackaging; (ii) fruits that were transiently immersed in pre-solidifiedBCCM liquid and taken out; (iii) fruit coating either with a BCCM,or with a membrane containing chitosan only (without berberine),and (iv) fruit coating with a PVC membrane. Results and discussion.The group immersed in BCCM showed a high infection rate due to thecytotoxicity of acetic acid, but the coating group showed only a10% infection rate after 40 days of storage. Moreover, the BCCM-coatinggroup showed a significantly lower infection rate than that coatedwith chitosan membrane (without berberine), clearly indicating theantimicrobial activity of berberine therein. Consequently, packedin BCCM and stored at 4 °C, peach fruits could be well preservedover 40 days with very low infection. Conclusion. Consideringits safety and low cost, the berberine-containing chitosan composite membranecould be applicable in controlling diseases during peach storage.

Energetic divergent proton beams can be generated in the interaction of ultra-intense laser pulses with solid-density foil targets via target normal sheath acceleration (TNSA). In this paper, a scheme using a capillary to reduce the proton beam divergence is proposed. By two-dimensional particle-in-cell (PIC) simulations, it is shown that strong transverse electric and magnetic fields rapidly grow at the inner surface of the capillary when the laser-driven hot electrons propagate through the target and into the capillary. The spontaneous magnetic field collimates the electron flow, and the ions dragged from the capillary wall by hot electrons neutralize the negative charge and thus restrain the transverse extension of the sheath field set up by electrons. The proton beam divergence, which is mainly determined by the accelerating sheath field, is therefore reduced by the transverse limitation of the sheath field in the capillary.

Denote the Palm measure of a homogeneous Poisson process Hλ with two points 0 and x by P0,x. We prove that there exists a constant μ ≥ 1 such that P0,x(D(0, x) / μ||x||2 ∉ (1 − ε, 1 + ε) | 0, x ∈ C∞) exponentially decreases when ||x||2 tends to ∞, where D(0, x) is the graph distance between 0 and x in the infinite component C∞ of the random geometric graph G(Hλ; 1). We derive a large deviation inequality for an asymptotic shape result. Our results have applications in many fields and especially in wireless sensor networks.

In this paper, we investigate the existence of positive solutions to a second-order Sturm–Liouville boundary-value problem with impulsive effects. The ideas involve differential inequalities and variational methods.