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This study explores an interesting fluid–structure interaction scenario: the flow past a flexible filament fixed at two ends. The dynamic performance of the filament under various inclination angles ($\theta$) was numerically investigated using the immersed boundary method. The motion of the filament in the $\theta$–$Lr$ space was categorised into three flapping modes and two stationary modes, where $Lr$ is the ratio of filament length to the distance between its two ends. The flow fields for each mode and their transitions were introduced. A more in-depth analysis was carried out for flapping at a large angle (FLA mode), which is widely present in the $\theta$–$Lr$ space. The maximum width $W$ of the time-averaged shape of the filament has been shown to strongly correlate with the flapping frequency. After non-dimensionalising based on $W$, the flapping frequency shows little variation across different $Lr$ and $\theta$. Moreover, two types of lift variation process were also identified. Finally, the total lift, drag and lift-to-drag ratio of the system were studied. Short filaments, such as those with $Lr\leqslant 1.5$, were shown to significantly increase lift and the lift-to-drag ratio over a wide range of $\theta$ compared with a rigid plate. Flow field analysis concluded that the increases in pressure difference on both sides of the filament, along with the upper part of the flexible filament having a normal direction closer to the $y$ direction, were the primary reasons for the increase in lift and lift-to-drag ratio. This study can provide some guidance for the potential applications of flexible structures.
Depressive and anxiety disorders constitute a major component of the disease burden of mental disorders in China.
Aims
To comprehensively evaluate the disease burden of depressive and anxiety disorders in China.
Method
The raw data is sourced from the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2021. This study presented the disease burden by prevalence and disability-adjusted life years (DALYs) of depressive and anxiety disorders at both the national and provincial levels in China from 1990 to 2021, and by gender (referred to as 'sex' in the GBD 2021) and age.
Results
From 1990 to 2021, the number of depressive disorder cases (from 34.4 to 53.1 million) and anxiety disorders (from 40.5 to 53.1 million) increased by 54% (95% uncertainty intervals: 43.9, 65.3) and 31.2% (19.9, 43.8), respectively. The age-standardised prevalence rate of depressive disorders decreased by 6.4% (2.9, 10.4), from 3071.8 to 2875.7 per 100 000 persons, while the prevalence of anxiety disorders remained stable. COVID-19 had a significant adverse impact on both conditions. There was considerable variability in the disease burden across genders, age groups, provinces and temporal trends. DALYs showed similar patterns.
Conclusion
The burden of depressive and anxiety disorders in China has been rising over the past three decades, with a larger increase during COVID-19. There is notable variability in disease burden across genders, age groups and provinces, which are important factors for the government and policymakers when developing intervention strategies. Additionally, the government and health authorities should consider the potential impact of public health emergencies on the burden of depressive and anxiety disorders in future efforts.
In contemporary neuroimaging studies, it has been observed that patients with major depressive disorder (MDD) exhibit aberrant spontaneous neural activity, commonly quantified through the amplitude of low-frequency fluctuations (ALFF). However, the substantial individual heterogeneity among patients poses a challenge to reaching a unified conclusion.
Methods
To address this variability, our study adopts a novel framework to parse individualized ALFF abnormalities. We hypothesize that individualized ALFF abnormalities can be portrayed as a unique linear combination of shared differential factors. Our study involved two large multi-center datasets, comprising 2424 patients with MDD and 2183 healthy controls. In patients, individualized ALFF abnormalities were derived through normative modeling and further deconstructed into differential factors using non-negative matrix factorization.
Results
Two positive and two negative factors were identified. These factors were closely linked to clinical characteristics and explained group-level ALFF abnormalities in the two datasets. Moreover, these factors exhibited distinct associations with the distribution of neurotransmitter receptors/transporters, transcriptional profiles of inflammation-related genes, and connectome-informed epicenters, underscoring their neurobiological relevance. Additionally, factor compositions facilitated the identification of four distinct depressive subtypes, each characterized by unique abnormal ALFF patterns and clinical features. Importantly, these findings were successfully replicated in another dataset with different acquisition equipment, protocols, preprocessing strategies, and medication statuses, validating their robustness and generalizability.
Conclusions
This research identifies shared differential factors underlying individual spontaneous neural activity abnormalities in MDD and contributes novel insights into the heterogeneity of spontaneous neural activity abnormalities in MDD.
We present evidence revealing that an object with specific properties can exhibit multiple stable falling postures at low Reynolds numbers. By scrutinizing the force equilibrium relationship of a fixed object at various attack angles and Reynolds numbers, we introduce a methodology that can obtain the stable falling postures of the object. This method saves computational resources and more intuitively presents the results in the full parameter domain. Our findings are substantiated by free-fall tests conducted through both physical experiments and numerical simulations, which validate the existence of multiple stable solutions in accordance with the interpolation results obtained with fixed objects. Additionally, we quantify the abundance and distribution patterns of stable falling postures for a diverse range of representative shapes. This discovery highlights the existence of multiple stable solutions that are universally present across objects of different shapes. The implications of this research extend to the design, stability control and trajectory prediction of all free and controlled flights in both air and water.
Accurate online estimation of the payload parameters benefits robot control. In the existing approaches, however, on the one hand, only the linear friction model was used for online payload identification, which reduced the online estimation accuracy. On the other hand, the estimation models contain much noise because of using actual joint trajectory signals. In this article, a new estimation algorithm based on parameter difference for the payload dynamics is proposed. This method uses a nonlinear friction model for the online payload estimation instead of the traditionally linear one. In addition, it considers the commanded joint trajectory signals as the computation input to reduce the model noise. The main contribution of this article is to derive a symbolic relationship between the parameter difference and the payload parameters and then apply it to the online payload estimation. The robot base parameters without payload were identified offline and regarded as the prior information. The one with payload can be solved online by the recursive least squares method. The dynamics of the payload can be then solved online based on the numerical difference of the two parameter sets. Finally, experimental comparisons and a manual guidance application experiment are shown. The results confirm that our algorithm can improve the online payload estimation accuracy (especially the payload mass) and the manual guidance comfort.
This study investigates the impacts of the timing of an extreme cyclone that occurred in August 2012 on the sea-ice volume evolution based on the Arctic Ice Ocean Prediction System (ArcIOPS). By applying a novel cyclone removal algorithm to the atmospheric forcing during 4–12 August 2012, we superimpose the derived cyclone component onto the atmospheric forcing one month later or earlier. This study finds that although the extreme cyclone leads to strong sea-ice volume loss in all runs, large divergence occurs in sea-ice melting mechanism in response to various timing of the cyclone. The extreme cyclone occurred in August, when enhanced ice volume loss is attributed to ice bottom melt primarily and ice surface melt secondarily. If the cyclone occurs one month earlier, ice surface melt dominates ice volume loss, and earlier appearance of open water within the ice zone initiates positive ice-albedo feedback, leading to a long lasting of the cyclone-induced impacts for approximately one month, and eventually a lower September ice volume. In contrast, if the cyclone occurs one month later, ice bottom melt entirely dominates ice volume loss, and the air-open water heat flux in the ice zone tends to offset ice volume loss.
The comorbidity between schizophrenia (SCZ) and inflammatory bowel disease (IBD) observed in epidemiological studies is partially attributed to genetic overlap, but the magnitude of shared genetic components and the causality relationship between them remains unclear.
Methods
By leveraging large-scale genome-wide association study (GWAS) summary statistics for SCZ, IBD, ulcerative colitis (UC), and Crohn's disease (CD), we conducted a comprehensive genetic pleiotropic analysis to uncover shared loci, genes, or biological processes between SCZ and each of IBD, UC, and CD, independently. Univariable and multivariable Mendelian randomization (MR) analyses were applied to assess the causality across these two disorders.
Results
SCZ genetically correlated with IBD (rg = 0.14, p = 3.65 × 10−9), UC (rg = 0.15, p = 4.88 × 10−8), and CD (rg = 0.12, p = 2.27 × 10−6), all surpassed the Bonferroni correction. Cross-trait meta-analysis identified 64, 52, and 66 significantly independent loci associated with SCZ and IBD, UC, and CD, respectively. Follow-up gene-based analysis found 11 novel pleiotropic genes (KAT5, RABEP1, ELP5, CSNK1G1, etc) in all joint phenotypes. Co-expression and pathway enrichment analysis illustrated those novel genes were mainly involved in core immune-related signal transduction and cerebral disorder-related pathways. In univariable MR, genetic predisposition to SCZ was associated with an increased risk of IBD (OR 1.11, 95% CI 1.07–1.15, p = 1.85 × 10−6). Multivariable MR indicated a causal effect of genetic liability to SCZ on IBD risk independent of Actinobacteria (OR 1.11, 95% CI 1.06–1.16, p = 1.34 × 10−6) or BMI (OR 1.11, 95% CI 1.04–1.18, p = 1.84 × 10−3).
Conclusions
We confirmed a shared genetic basis, pleiotropic loci/genes, and causal relationship between SCZ and IBD, providing novel insights into the biological mechanism and therapeutic targets underlying these two disorders.
Two-dimensional oblique detonation wave (ODW) propagations in partially prevaporized n-heptane sprays are numerically simulated with a skeletal chemical mechanism. The influences of the droplet diameter and total equivalence on oblique detonation are considered. The initiation length is found to increase first and then decrease with increasing initial droplet diameter, and the effect of droplet size is maximized when the initial droplet diameter is approximately $10\ \mathrm {\mu } {\rm m}$. As the initial droplet diameter varies, unsteady and steady ODWs are observed. In the cases of unsteady ODWs, temperature gradients and non-uniform distributions of the reactant mixture due to droplet evaporation lead to formation of unsteady detonation propagation, therefore leading to fluctuations in the initiation length. The fluctuations in initiation length decrease as the pre-evaporation gas equivalence ratio increases for the unsteady cases. The results further suggest that the relationship between the evaporation layer thickness along the streamline and the corresponding theoretical initiation length can be used to identify an unsteady or steady ODW in cases with large droplets that evaporate behind an oblique shock wave or ODW under the effects of different initial droplet diameters.
In order to establish a compact all-optical Thomson scattering source, experimental studies were conducted on the 45 TW Ti: sapphire laser facility. By including a steel wafer, mixed gas, and plasma mirror into a double-exit jet, several mechanisms, such as shock-assisted ionization injection, ionization injection, and driving laser reflection, were integrated into one source. So, the source of complexity was remarkably reduced. Electron bunches with central energy fluctuating from 90 to 160 MeV can be produced. Plasma mirrors were used to reflect the driving laser. The scattering of the reflected laser on the electron bunches led to the generation of X-ray photons. Through comparing the X-ray spots under different experimental conditions, it is confirmed that the X-ray photons are generated by Thomson scattering. For further application, the energy spectra and source size of the Thomson scattering source were measured. The unfolded spectrum contains a large amount of low-energy photons besides a peak near 67 keV. Through importing the electron energy spectrum into the Monte Carlo simulation code, the different contributions of the photons with small and large emitting angles can be used to explain the origin of the unfolded spectrum. The maximum photon energy extended to about 500 keV. The total photon production was 107/pulse. The FWHM source size was about 12 μm.
Aerospace represents the development of national science and technology. It is an important foundation for exploring space and an important guarantee for the construction of aerospace power. There are many large workpieces in the aerospace field. The box insulation layer of large workpieces is an important processing problem. A new thick processing equipment is proposed to process the box insulation layer of large workpieces. The thick processing equipment consists of the XYZ shaft long guide rail and five degrees of freedom (5-DOF) RAPA. The mechanical structure of the 5-DOF RAPA is a redundantly actuated parallel mechanism (RAPM). Meanwhile, this paper proposes a new method to design 5-DOF redundantly actuated parallel mechanisms (RAPMs) with large output rotational angles. Based on configuration evolution and Li group, two articulated moving platforms (AMPs) and four kinds of limbs are designed, and a series of 3T2R (T represents translation, R represents rotation) RAPMs and 2T3R RAPMs are synthesized. To verify the designed RAPMs with large angle, an example of RAPMs, 4UPS-{2UPR}-R is analyzed. To ensure that the RAPM has no mechanism vibration impact in movement, this paper represents the RAPM adopts a newly proposed trajectory planning method. The results show that the 4SPU-(2UPR)R mechanism possesses large angles and verifies the efficiency of the new proposed trajectory planning method in simplified trajectories. This work lays the foundation for processing the box insulation layer of large workpieces with straight lines and arcs paths.
Carotenoids are important bioactive substances in breast milk, the profile of which is seldom studied. This study aimed to explore the profile of carotenoids in breast milk and maternal/cord plasma of healthy mother–neonate pairs in Shanghai, China, and their correlation with dietary intake. Maternal blood, umbilical cord blood and breast milk samples from five lactation stages (colostrum, transitional milk and early-, mid- and late-term mature milk) were collected. Carotenoid levels were analysed by HPLC. Carotenoid levels in breast milk changed as lactation progressed (P < 0·001). β-Carotene was the primary carotenoid in colostrum. Lutein accounted for approximately 50 % of total carotenoids in transitional milk, mature milk and cord blood. Positive correlations were observed between five carotenoids in umbilical cord blood and maternal blood (P all < 0·001). β-Carotene levels were also correlated between maternal plasma and three stages of breast milk (r = 0·605, P < 0·001; r = 0·456, P = 0·011, r = 0·446; P = 0·013, respectively). Dietary carotenoid intakes of lactating mothers also differed across lactation stages, although no correlation with breast milk concentrations was found. These findings suggest the importance of exploring the transport mechanism of carotenoids between mothers and infants and help guide the development of formulas for Chinese infants as well as the nutritional diets of lactating mothers.
To solve the constant contact force control problem between the end tool of a 5 degrees of freedom hybrid optical mirror processing robot and a workpiece, an adaptive impedance control method for the pneumatic servo-polishing system of the robot is designed. Firstly, the pneumatic servo-polishing control system at the end of the robot is set up. Secondly, the impedance control method for contact force is investigated based on the mathematical model of the pneumatic servo-polishing control system. Additionally, the causes of steady-state error of impedance control are analyzed theoretically, and the calculation method for steady-state error of impedance control is deduced. Finally, an indirect adaptive impedance controller based on Lyapunov Stability Principle is developed to estimate the environmental stiffness and position online, so as to reduce steady-state error and realize the tracking of polishing contact force. The simulation and experimental results suggest that the adaptive impedance control method not only recognizes that the contact force of the robot is relatively constant during the polishing process but also has high control accuracy for the force, fast-tracking response for the abrupt force, and considerable adaptability to the variable environmental stiffness.
The penultimate deglaciation was characterized by a sub-millennial-scale warm event in the Heinrich Stadial 11(HS11), termed the 134-ka event. However, its precise timing and structure remain poorly constrained due to the lack of high-resolution and precisely dated records. We present an oxygen isotope record of a speleothem with well-developed annual lamina from Zhangjia Cave, located on the north margin of the Sichuan Basin, characterizing Asian summer monsoon (ASM) changes in the 134-ka event, which included an increase excursion of ca. 149 years and decrease excursion of ca. 200 years, inferred from 3.3‰ δ18O variations. This event also divided the weak ASM interval-II (WMI-II), corresponding to HS11, into two stages, the WMI-IIa 132.8–134.1 ka and WMI-IIb 134.4–136.4 ka. With a comparable climatic pattern globally, the 134-ka event is essentially similar to the millennial-scale events in last glacial–deglacial period. Particularly, the observed weak-strong-weak ASM sequence (138.8–132.8 ka) is largely controlled by changes in the Atlantic Meridional Overturning Circulation (AMOC) forced by the meltwater of northern high-latitude ice sheets. Moreover, our results underpin that AMOC, rather than the global ice volume, is more critical to ASM variations during the last two deglaciations.
Direct numerical simulations are performed to investigate the wake transitions of the flow normal to a circular rotating disk. The diameter-thickness aspect ratio of the disk is $\chi =50$. The Reynolds number of the free stream is defined as $Re_s=U_\infty D/\nu$, with incoming flow velocity $U_\infty$, disk diameter $D$, and kinematic viscosity of the fluid $\nu$. The rotational motion of the disk is described by the Reynolds number of rotation $Re_r=\varOmega Re_s$, with non-dimensional rotation rate $\varOmega =\frac {1}{2}\omega D/U_\infty$, where $\omega$ is the angular rotation speed of the disk. Extensive numerical simulations are performed in the parameter space $50 \leqslant Re_s \leqslant 250$ and $0 \leqslant Re_r \leqslant 250$, in which six flow regimes are identified as follows: the axisymmetric state, the low-speed steady rotation (LSR) state, the high-speed steady rotation (HSR) state, the low-speed unsteady rotation (LUR) state, the rotational vortex shedding state, and the chaotic state. Although plane symmetry exists in the wake when the disk is stationary, a small rotation will immediately destroy its symmetry. However, the vortex shedding frequencies and wake patterns of the stationary disk are inherited by the unsteady rotating cases at low $Re_r$. A flow rotation rate jump is observed at $Re_s\approx 125$. The LUR state is intermediate between the LSR and HSR states. Due to the rotational motion, the wake of the disk enters the steady rotation state earlier at large $Re_r$, and is delayed into the vortex shedding state in the whole range of $Re_r$. In the steady rotation states (LSR and HSR), the steady flow rotation rate is linearly correlated with the disk rotation rate. It is found that the rotation of the disk can restrain the vortex shedding. The chaotic state can be regularized by the medium rotation speed of the disk.
Inflammation plays a crucial role in the pathogenesis of major depressive disorder (MDD) and bipolar disorder (BD). This study aimed to examine whether the dysregulation of complement components contributes to brain structural defects in patients with mood disorders.
Methods
A total of 52 BD patients, 35 MDD patients, and 53 controls were recruited. The human complement immunology assay was used to measure the levels of complement factors. Whole brain-based analysis was performed to investigate differences in gray matter volume (GMV) and cortical thickness (CT) among the BD, MDD, and control groups, and relationships were explored between neuroanatomical differences and levels of complement components.
Results
GMV in the medial orbital frontal cortex (mOFC) and middle cingulum was lower in both patient groups than in controls, while the CT of the left precentral gyrus and left superior frontal gyrus were affected differently in the two disorders. Concentrations of C1q, C4, factor B, factor H, and properdin were higher in both patient groups than in controls, while concentrations of C3, C4 and factor H were significantly higher in BD than in MDD. Concentrations of C1q, factor H, and properdin showed a significant negative correlation with GMV in the mOFC at the voxel-wise level.
Conclusions
BD and MDD are associated with shared and different alterations in levels of complement factors and structural impairment in the brain. Structural defects in mOFC may be associated with elevated levels of certain complement factors, providing insight into the shared neuro-inflammatory pathogenesis of mood disorders.
Numerical simulations have been conducted to identify the dominant mechanism responsible for driving secondary flow motions in horizontal particle-laden pipe flows, based on an analysis of the forces acting on each phase. A four-way coupling Euler–Lagrangian approach was employed, using direct numerical simulations for the gas phase and Lagrangian particle tracking to account for the drag, gravitational and lift forces, together with the interactions that occur for both particle–wall and inter-particle collisions. The four different flow regimes, which had been identified previously as depending on various combinations of flow parameters and are characterised by the secondary flow structures of both the fluid and particle phases, were identified via varying the mass loading alone from $\varPhi _m=0.4$ to $\varPhi _m=1.8$. The distribution of the divergence of Reynolds stresses was used to help characterise the classes of the secondary fluid flow. This shows that secondary fluid flows of both the first and second kinds can either exist separately or co-exist in such flows. The forces exerted on the fluid phase by the pressure gradient and fluid–particle interactions were examined qualitatively and quantitatively to identify their contribution to the secondary fluid flow motions. A similar study was also applied to the drag, lift and gravitational forces exerted on the particle phase for the secondary particle flow motions. These were found to explain the secondary flows of both the fluid and particle phases with regard to both the flow direction and magnitude, together with the interaction between the two phases.
Steinernema populi n. sp. was recovered by baiting from beneath poplar trees in China. Morphological and molecular features provided evidence for placing the new species into the Kushidai clade. The new species is characterized by the following morphological features: third-stage infective juveniles (IJ) with a body length of 1095 (973–1172) μm, a distance from the anterior end to excretory pore of 77 (70–86) μm and a tail length of 64 (55–72) μm. The Body length/Tail length (c) ratio and Anterior end to Excretory pore/ Tail length × 100 (E%) of S. populi n. sp. are substantially greater than those of all other ‘Feltiae–Kushidai–Monticolum’ group members. The first-generation males can be recognized by a spicule length of 66 (57–77) μm and a gubernaculum length of 46 (38–60) μm. The new species is further characterized by sequences of the internal transcribed spacer and partial 28S regions of the ribosomal DNA. Phylogenetic analyses show that Steinernema akhursti and Steinernema kushidai are the closest relatives to S. populi n. sp.
The inertial parameters of payloads attached to the end effector of robots benefit to several robotics applications, such as the model-based control, the task optimization, and so on. These applications require the accurate estimation of the inertial parameters. In the existing payload estimation approaches, however, the data weighting technique, which can reduce the adverse effects of outliers and significantly improve the final results, has not been applied yet. In this article, an accurate identification method based on double weighting for inertial parameters of robot payloads is proposed. In order to obtain the weighting matrices, a modified dynamic parameter identification method with two loops is firstly proposed. Then, based on the identified results of dynamic parameters, a payload identification model based on double weighting is constructed. In addition, the variations of both nonlinear friction parameters and linear friction parameters caused by the payload are considered in this model. Finally, experimental comparisons between our method and another four methods are conducted. The results confirm that our method shows the best performance, especially on improving the identification accuracy of mass and center of mass of the payload.
The incidence of scarlet fever has increased dramatically in recent years in Chongqing, China, but there has no effective method to forecast it. This study aimed to develop a forecasting model of the incidence of scarlet fever using a seasonal autoregressive integrated moving average (SARIMA) model. Monthly scarlet fever data between 2011 and 2019 in Chongqing, China were retrieved from the Notifiable Infectious Disease Surveillance System. From 2011 to 2019, a total of 5073 scarlet fever cases were reported in Chongqing, the male-to-female ratio was 1.44:1, children aged 3–9 years old accounted for 81.86% of the cases, while 42.70 and 42.58% of the reported cases were students and kindergarten children, respectively. The data from 2011 to 2018 were used to fit a SARIMA model and data in 2019 were used to validate the model. The normalised Bayesian information criterion (BIC), the coefficient of determination (R2) and the root mean squared error (RMSE) were used to evaluate the goodness-of-fit of the fitted model. The optimal SARIMA model was identified as (3, 1, 3) (3, 1, 0)12. The RMSE and mean absolute per cent error (MAPE) were used to assess the accuracy of the model. The RMSE and MAPE of the predicted values were 19.40 and 0.25 respectively, indicating that the predicted values matched the observed values reasonably well. Taken together, the SARIMA model could be employed to forecast scarlet fever incidence trend, providing support for scarlet fever control and prevention.