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There is an increased recognition of the role of systemic inflammation, mediated through inflammatory markers like IL-6, CRP, in pathophysiology of psychiatric disorders like depression, schizophrenia and substance abuse. While bidirectional influence of chronic pain and psychiatric morbidity is also understood, large-scale, real-world estimates on this topic remain limited. We aim to bridge this gap through a cohort study using TriNetX.
Objectives
To compare 5-year risk of major depressive disorder (MDD), suicidality, and substance use disorder (SUD) in chronic pain patients with high vs. low inflammatory biomarkers.
Methods
We used the TriNetX US Collaborative Network (71 health systems). Adults (≥18y) with chronic pain (ICD-10: G89.21, G89.28, G89.29, G89.4, M79.7) were stratified by inflammatory status using most-recent lab thresholds, each with ≥2 instances: high inflammation (ESR ≥20 mm/h [LOINC 4537-7], CRP ≥3 mg/L [1988-5], hs-CRP ≥3 mg/L [30522-7], or haptoglobin ≥200 mg/dL [4542-7]) vs. low (≤ these thresholds). Index was first date meeting pain + lab criteria; outcomes were assessed from day 1 to 5 years. Propensity-score matching (1:1) balanced demographics (642,785 per group post-match). We ran risk analyses excluding prior outcomes and Kaplan–Meier with log-rank tests and hazard ratios (Table 1)
Results
After matching, MDD risk over 5 years was 19.2% in the high-inflammation cohort vs. 17.9% in low-inflammation (risk ratio [RR] = 1.074, 95% CI 1.064–1.083; HR = 1.162, 95% CI 1.151–1.174; log-rank p<0.001). Suicidality risk was 2.1% vs. 1.8% (RR = 1.170, 95% CI 1.141–1.199; HR = 1.247, 95% CI 1.216–1.279; p<0.001). SUD risk was 11.5% vs. 10.3% (RR = 1.112, 95% CI 1.100–1.125; HR = 1.188, 95% CI 1.174–1.203; p<0.001) (Table 2). Absolute risk differences were +1.3% (MDD), +0.3% (suicidality), and +1.2% (SUD).Image 1:
Image 2:
Conclusions
Among adults with chronic pain, elevated inflammatory biomarkers are associated with higher 5-year incidence of MDD, suicidality, and SUD. Findings support routine mental-health screening when inflammatory markers are elevated and motivate trials testing anti-inflammatory or immunomodulatory strategies alongside standard psychiatric care. Observational design and EHR limitations (measurement variability, residual confounding) apply.
GLP-1 receptor agonists (GLP-1RAs) reduce appetite, energy intake, and serum glucose levels by activating glucagon-like peptide-1 (GLP-1) receptors. They, potentially, act on the central and peripheral nervous system to reduce nerve damage, inflammation, and pain hypersensitivity. Fibromyalgia (FM) presents with neuropathic pain and small fiber neuropathy, resulting in significant opioid use, estimates range from 20-55%. We hypothesize that GLP-1RAs might prove to be opioid sparing, reduce acute care use, and increase the overall mental health quality in FM
Objectives
Compare the pain-related medication burden, acute-healthcare use, and psychiatric outcomes in adult patients with comorbid FM and obesity utilizing GLP-1RAs vs. other anti-obesity pharmacotherapies in a cohort design
Methods
We conducted a retrospective, multi-network cohort study on the TriNetX Research Network. Adults (≥18 years) with an FM diagnosis (ICD-10-CM M79.7) and ≥12 months of data before and after the index drug initiation (GLP-1RAs) were eligible. The exposure was incident GLP-1RA initiation (semaglutide, liraglutide, exanatide, lixisenatide, dulaglutide, or tirzepatide) identified in EMR; the comparator was patients with FM without GLP-1RA exposure on a random outpatient visit. Propensity scores using demographics, BMI, type 2 DM, baseline pain score, PHQ-9/GAD-7 score, antidepressant/anxiolytic use, ED visits, and comorbidities (depression, anxiety, OSA, osteoarthritis). Primary outcome: Comparing any opioid fills. Secondary outcomes: Comparing neuromodulator/adjunct fills (duloxetine/ pregabalin/gabapentin/tizanidine), pain-related ED/hospital utilization, and symptom-burden proxies (PHQ-9 ≥10, GAD-7 ≥10, or pain NRS ≥4 where available). Analyses used measures of association, Kaplan-Meier, and number-of-instances. Patients with pre-window outcomes were excluded, and propensity score matching was applied (Figure 1).
Results
After exclusions, opioid risk was lower with GLP-1RA vs comparator (risk 0.334 [7,574/22,686] vs 0.460 [13,690/29,767]; risk ratio 0.726, 95% CI 0.710-0.742). Opioid hazard was lower (HR 0.893, 95% CI 0.868-0.919; log-rank p<0.001). Opioid instances per patient were also lower (mean 1.34 vs 2.55; t=−22.35, p<0.001) (Figure 2). Neuromodulator/adjunct fills showed lower risk with GLP-1RA (0.246 vs 0.329; RR 0.748, 95% CI 0.732-0.765). A composite of pain-related ED/hospital outcomes favored GLP-1RA (risk 0.424 vs 0.494; RR 0.858, 95% CI 0.837-0.880) (Figure 3). Symptom-burden proxies were infrequent overall but nominally lower with GLP-1RA (RR 0.756, 95% CI 0.634-0.903).Image 1:
Image 2:
Image 3:
Conclusions
In a large national EHR network, GLP-1RA initiation among adults with FM and obesity was associated with clinically meaningful reductions in opioid exposure and other pain-related utilization over 6-12 months. Our findings support prospective evaluation of GLP-1RAs as adjuncts for FM care and opioid-sparing strategies.
Suicidality is a significant concern in patients living with chronic pain, with suicidal ideation reported in 18-50% of this population, and 5-14% attempting suicide. GLP-1 receptor agonists (GLP-1RAs) reduce pain hypersensitivity by acting on peripheral and central nervous systems through glucagon-like peptide-1 (GLP-1) receptors. GLP-1R–based anti-obesity/diabetes therapies, can potentially be useful in high-risk groups such as those with chronic pain, a research gap we aim to fulfill through this cohort study.
Objectives
To compare 12-month risk of suicidality and related psychiatric/health-services outcomes among chronic-pain patients initiating GLP-1 therapies versus other anti-obesity medications (AOMs).
Methods
Retrospective cohort using TriNetX US Collaborative Network (72 HCOs). Adults (≥18) meeting a prespecified chronic-pain phenotype (ICD-10: G89.2x, G89.4, M79.7, chronic headache subtypes, vertebrogenic/other low-back pain, osteoarthritis subtypes) formed the base population. Exposure: GLP-1 agents (semaglutide, liraglutide, dulaglutide, exenatide, lixisenatide, tirzepatide); Comparator: non-GLP AOMs (orlistat, phentermine, bupropion, naltrexone, topiramate). Cohorts mutually excluded the other drug class. Index = first qualifying medication after pain documentation. Outcomes (12-month window, excluding prior outcome): suicidal ideation (R45.851), suicide attempt (T14.91*), any ED visit (CPT 99281–99285), and exploratory psychiatric outcomes (F32.9 depression, F41.9 anxiety, G47.00 insomnia, F11.20 opioid dependence). Propensity-score matching (1:1) balanced age, sex, ethnicity, type-2 diabetes, and BMI percentile.
Results
After matching (N=501,736 per arm) (Table 1), GLP-1 initiation was associated with lower risk of:
Suicidal ideation: RR 0.19 (95% CI 0.17–0.20); HR 0.21 (0.19–0.22).
In adults with chronic pain, GLP-1 therapy versus other AOMs was associated with substantially reduced 12-month suicidality and reduced acute care utilization, with consistent reductions across psychiatric endpoints. These findings are hypothesis-generating and require confirmation with additional confounding control (e.g., baseline psychiatric burden), sensitivity analyses (new-user washout, early-risk windows), and prospective designs.
Tinnitus, particularly in cases without an identifiable physical cause, often poses a significant treatment challenge, with limited effectiveness of pharmacological interventions.Transcranial Magnetic Stimulation (TMS), has shown promise in alleviating tinnitus symptoms
Objectives
To evaluate the effectiveness of TMS in reducing severity of Chronic subjective Tinnitus, as measured by changes in Tinnitus Handicap Inventory (THI) scores
Methods
This retrospective study involved 32 adult patients diagnosed with tinnitus, who received TMS. The number of treatments (10) and the follow-up duration (4 weeks) were chosen based on standardized treatment guidelines and tailored to patients’ needs.-The assessment included pre-and post-treatment evaluations using the THI (Tinnitus Handicap Inventory) to measure changes in patient-reported tinnitus severity. The Wilcoxon rank sum test was used to compare the THI scores among patients at baseline and 4 weeks of follow-up
Results
Our participants were predominantly men (72%) with a median age of 36 years (IQR: 28-51 years) and a median disease duration of 2.0 years (IQR:0.7-3.3 years). Significant improvement was observed in the THI scores, decreasing from a median of 53 (IQR: 34-67) at baseline to 35 (IQR: 24-57) post-treatment (p-value = 0.0151). Most treatments were conducted at 1 Hz frequency (79%). Around one-fifth of the patients were on benzodiazepines
Conclusions
This study provides evidence for the effectiveness of TMS for tinnitus. We are hopeful that future studies would replicate our findings and efforts would be directed at optimizing TMS protocols for its more widespread use in treating tinnitus.
Use of opioids peri-operatively, for both analgesia and anesthesia, is being highlighted negatively due to the opioid crisis in the United States. There is evidence that being exposed to opioids peri-operatively, alters neurobiology by disrupting the dopamine and serotonin pathways, through action on the hypothalamic-pituitary-axis, especially in the pliable adolescent brain. This can result in development of long term psychiatric comorbidity, opioid use disorder and consequent increased emergency healthcare visits.
Objectives
To test whether perioperative opioid exposure after common adolescent procedures is associated with long-term psychiatric diagnoses, emergency department (ED) utilization, overdose, and indicators of opioid use treatment, when compared with non-opioid analgesia.
Methods
We conducted a retrospective cohort study on the TriNetX US Collaborative Network (71 health systems). Adolescents aged 12–19 undergoing common procedures (appendectomy, tonsil/adenoid, select orthopedic and dental procedures) were identified. The opioid cohort had a perioperative opioid use (−3 to +7 days around surgery); the comparison cohort had no perioperative opioid use. Key exclusions at baseline: prior opioid-related disorders (F11), any substance-use disorders (F10–F19), and chronic pain (G89.2). Outcomes (depression, anxiety, PTSD, sleep disorders, suicidal ideation/attempt, ED utilization, opioid poisoning/overdose, long-term opioid therapy [Z79.891], and MOUD/overdose-related medications [buprenorphine, methadone, naltrexone, naloxone]) were assessed from day 1 to 3,650 (~10 years) post-index. Propensity score matching 1:1 was performed on age, sex, and ethnicity; measures of association and Kaplan–Meier analyses were run on matched cohorts (Table 1).
Results
After matching (n=77,810 per cohort), perioperative opioids were associated with higher risk of depression (RR 1.195, 95%CI 1.126–1.268), anxiety (RR 1.215, 1.168–1.264), sleep disorders (RR 1.296, 1.238–1.356), suicidal ideation/attempt (RR 1.121, 1.027–1.223), ED utilization (RR 1.187, 1.158–1.215), and opioid poisoning/overdose (RR 1.522, 1.049–2.208). Long-term opioid therapy (Z79.891) was not increased (RR 0.952, 0.820–1.104). Initiation of MOUD/overdose-related medications was markedly higher (RR 2.912, 2.572–3.298). Notably, PTSD diagnoses were lower in the opioid group (RR 0.581, 0.554–0.608). Kaplan–Meier results were directionally consistent for most outcomes (Table 2)Image 1:
Image 2:
Conclusions
In adolescents undergoing common procedures, perioperative opioid exposure was associated with small-to-moderate increases in long-term depression, anxiety, sleep disorders, suicidal ideation/attempt, ED utilization, and overdose, and a large increase in MOUD/overdose-related medication exposure. Findings support minimizing perioperative opioid exposure and proactive mental-health surveillance after surgery.
India’s Supplementary Nutrition Programme (SNP), under the Integrated Child Development Services, provides a Morning Snack and a Hot Cooked Meal to children aged 36–72 months through Anganwadis (day-care centres). This study assessed these meals against SNP standards (2012) and age-specific ICMR recommendations, when standards were unavailable, and explored the use of linear programming (LP) to improve nutrient quality of SNP meals. A cross-sectional survey documented the SNP-meals, ingredients, serving portions and other details, using questionnaires administered to Anganwadi workers and programme officials from purposively selected Anganwadis across 27 States and Union Territories. Nutrient composition was estimated using standard food composition tables, and State-specific food lists and retail prices were incorporated into the LP framework to identify foods that could improve nutrient content of SNP meals. Energy standards were met in 56% of States, while 22% fell more than 20% below recommendations. Protein standards were achieved in 74% of States; however, declined to 52% after adjusting for digestibility. Only 22% of States met the ICMR-based fat requirement. Zinc, iron and folate were largely met, whereas calcium and vitamins A, B6 and B12 were below recommendations in more than half the States. Meals were predominantly cereal-based with limited inclusion of nutrient-dense foods. LP identified foods that reduced nutrient gaps, although many improvements exceeded the per-child cost allocation. Overall, meals showed wide variability, with persistent gaps in fat and key micronutrients. LP provides a structured approach to enhance nutrient provision within the programme setting, although meeting all nutrient targets may require adjustments to cost and procurement strategies.
Extended radio sources present unique challenges for automated detection and classification in wide-field radio surveys. With current surveys such as the Evolutionary Map of the Universe (EMU), robust and scalable methods are essential to identify and catalogue these complex sources. We apply three automatic approaches to detect complex radio emission in EMU observations of the Galaxy And Mass Assembly (GAMA) 09 field (EMU-G09) in order to evaluate their relative strengths and limitations in preparation for large-scale application across future EMU data releases. These include DRAGNhunter, designed to detect likely DRAGNs (Double Radio sources associated with Active Galactic Nuclei) from a component catalogue; coarse-grained complexity, a metric designed to highlight regions of complex emission; and RG-CAT, a machine learning pipeline trained on radio sources identified in the EMU pilot survey. We find that together, the three methods recover nearly all extended sources in EMU-G09 but identify largely distinct, partially overlapping subsets, with only 375 sources identified by all finders. This demonstrates that a combination of complementary techniques will be required to achieve a complete census of extended radio sources in future large-scale surveys.
The American Society of Clinical Psychopharmacology convened a 45-member international expert task force to identify circumstances supporting the deprescribing of core psychotropic medications for major depressive disorder (MDD) and bipolar disorders. Three Delphi survey rounds plus a selective literature review identified points of consensus (predefined as ≥75% agreement) about when antidepressant, antipsychotic, mood stabiliser and sedative-hypnotic deprescribing is warranted. Twenty out of 32 statements (63%) achieved consensus across seven thematic areas. In MDD, panellists favoured discontinuing antidepressants when mechanisms of action are duplicative, adequate trials produce ≤25% improvement or loss of prior efficacy cannot be regained through dose increases or augmentations. Indefinite antidepressant maintenance in MDD was favoured after three or more lifetime episodes. In bipolar disorder, antidepressant deprescribing was favoured in the setting of rapid cycling, mixed features or emerging mania/hypomania symptoms; and discouraged if prior antidepressant cessation led to relapse. In nonpsychotic mood disorders, panellists favoured deprescribing antipsychotics that caused significant weight gain or tardive dyskinesia over adding pharmacological antidotes. Deprescribing to achieve an eventual medication-free status was considered inappropriate, in bipolar type 1, but not necessarily bipolar type 2 disorder. Although individualised circumstances necessarily inform psychopharmacology management, clinical presentations that misalign with existing pharmacotherapies may signal the desirability of cautious deprescribing.
Edited by
Latika Chaudhary, Naval Postgraduate School, Monterey, California,Tirthankar Roy, London School of Economics and Political Science,Anand V. Swamy, Williams College, Massachusetts
In principle, economic development can be environmentally sustainable and compatible with the rights of the poor to the commons – forests, water and land. In practice, however, the economic transformation of India since independence – rapid increase in agricultural productivity, industrialization, urbanization and the building of much-needed infrastructure, has come at the expense of environmental degradation and the rights of the poor to common property resources. Indian economic policy has for the most part favoured ‘development’ over environmental concerns. But India is a democracy in which civil society and the people can protest and exert pressure to prevent environmental degradation and defend their rights to the commons. The Indian judiciary, the Supreme Court in particular, has also been proactive in intervening to protect the environment. As of now, the impetus toward natural-resource-intensive and polluting growth is winning the day, but the struggle to find a better balance continues. Climate change is making the task much harder.
The dhole Cuon alpinus is a large canid that is categorized as Endangered on the IUCN Red List and at risk of global extinction. Information on the spatial distribution of suitable habitat is important for conservation planning but is largely unavailable. We quantified the spatial distribution of potential range as well as the relative probability of dhole occurrence across large parts of the species’ global range. We used the MaxEnt algorithm to produce a multi-scale environmental niche model based on 24 environmental variables and dhole occurrence data from 12 countries. We identified three regions where dhole conservation should be focused: western India, central India, and across the Himalayan foothills through Southeast Asia. Connectivity between suitable areas was poor, so coordinated action among these regions should be a priority. For instance, transboundary dhole conservation initiatives across the Himalayas from southern China, Myanmar, north-east India, Nepal and Bhutan need to be initiated. We also highlight the value of improving dhole population viability on unprotected land and increasing monitoring in the northern parts of its historic distribution, in particular in areas within mainland China.
We present the first results from a new backend on the Australian Square Kilometre Array Pathfinder, the Commensal Realtime ASKAP Fast Transient COherent (CRACO) upgrade. CRACO records millisecond time resolution visibility data, and searches for dispersed fast transient signals including fast radio bursts (FRB), pulsars, and ultra-long period objects (ULPO). With the visibility data, CRACO can localise the transient events to arcsecond-level precision after the detection. Here, we describe the CRACO system and report the result from a sky survey carried out by CRACO at 110-ms resolution during its commissioning phase. During the survey, CRACO detected two FRBs (including one discovered solely with CRACO, FRB 20231027A), reported more precise localisations for four pulsars, discovered two new RRATs, and detected one known ULPO, GPM J1839 $-$10, through its sub-pulse structure. We present a sensitivity calibration of CRACO, finding that it achieves the expected sensitivity of 11.6 Jy ms to bursts of 110 ms duration or less. CRACO is currently running at a 13.8 ms time resolution and aims at a 1.7 ms time resolution before the end of 2024. The planned CRACO has an expected sensitivity of 1.5 Jy ms to bursts of 1.7 ms duration or less and can detect $10\times$ more FRBs than the current CRAFT incoherent sum system (i.e. 0.5 $-$2 localised FRBs per day), enabling us to better constrain the models for FRBs and use them as cosmological probes.
Residual blood specimens collected at health facilities may be a source of samples for serosurveys of adults, a population often neglected in community-based serosurveys. Anonymized residual blood specimens were collected from individuals 15 – 49 years of age attending two sub-district hospitals in Palghar District, Maharashtra, from November 2018 to March 2019. Specimens also were collected from women 15 – 49 years of age enrolled in a cross-sectional, community-based serosurvey representative at the district level that was conducted 2 – 7 months after the residual specimen collection. Specimens were tested for IgG antibodies to measles and rubella viruses. Measles and rubella seroprevalence estimates using facility-based specimens were 99% and 92%, respectively, with men having significantly lower rubella seropositivity than women. Age-specific measles and rubella seroprevalence estimates were similar between the two specimen sources. Although measles seropositivity was slightly higher among adults attending the facilities, both facility and community measles seroprevalence estimates were 95% or higher. The similarity in measles and rubella seroprevalence estimates between the community-based and facility serosurveys highlights the potential value of residual specimens to approximate community seroprevalence.
Residual blood specimens provide a sample repository that could be analyzed to estimate and track changes in seroprevalence with fewer resources than household-based surveys. We conducted parallel facility and community-based cross-sectional serological surveys in two districts in India, Kanpur Nagar District, Uttar Pradesh, and Palghar District, Maharashtra, before and after a measles-rubella supplemental immunization activity (MR-SIA) from 2018 to 2019. Anonymized residual specimens from children 9 months to younger than 15 years of age were collected from public and private diagnostic laboratories and public hospitals and tested for IgG antibodies to measles and rubella viruses. Significant increases in seroprevalence were observed following the MR SIA using the facility-based specimens. Younger children whose specimens were tested at a public facility in Kanpur Nagar District had significantly lower rubella seroprevalence prior to the SIA compared to those attending a private hospital, but this difference was not observed following the SIA. Similar increases in rubella seroprevalence were observed in facility-based and community-based serosurveys following the MR SIA, but trends in measles seroprevalence were inconsistent between the two specimen sources. Despite challenges with representativeness and limited metadata, residual specimens can be useful in estimating seroprevalence and assessing trends through facility-based sentinel surveillance.
Depression is an independent risk factor for cardiovascular disease (CVD), but it is unknown if successful depression treatment reduces CVD risk.
Methods
Using eIMPACT trial data, we examined the effect of modernized collaborative care for depression on indicators of CVD risk. A total of 216 primary care patients with depression and elevated CVD risk were randomized to 12 months of the eIMPACT intervention (internet cognitive-behavioral therapy [CBT], telephonic CBT, and select antidepressant medications) or usual primary care. CVD-relevant health behaviors (self-reported CVD prevention medication adherence, sedentary behavior, and sleep quality) and traditional CVD risk factors (blood pressure and lipid fractions) were assessed over 12 months. Incident CVD events were tracked over four years using a statewide health information exchange.
Results
The intervention group exhibited greater improvement in depressive symptoms (p < 0.01) and sleep quality (p < 0.01) than the usual care group, but there was no intervention effect on systolic blood pressure (p = 0.36), low-density lipoprotein cholesterol (p = 0.38), high-density lipoprotein cholesterol (p = 0.79), triglycerides (p = 0.76), CVD prevention medication adherence (p = 0.64), or sedentary behavior (p = 0.57). There was an intervention effect on diastolic blood pressure that favored the usual care group (p = 0.02). The likelihood of an incident CVD event did not differ between the intervention (13/107, 12.1%) and usual care (9/109, 8.3%) groups (p = 0.39).
Conclusions
Successful depression treatment alone is not sufficient to lower the heightened CVD risk of people with depression. Alternative approaches are needed.
The United Nations’ Population Division (2019) projects global life expectancy to reach 74.5 years for males and 79.1 years for females by 2050. With approximately 1.40 billion inhabitants in 2021, India is projected to become the world's most populous country in 2023, surpassing China. In the 2011 census, the elderly population, aged 60 years and above, totalling to 103 million in number, accounted for 8.6 per cent of India's population. The share of the elderly population is projected to further rise to 19.5 per cent (around 319 million) by 2050 (Registrar General of India [RGI], 2011).
The dramatic and widespread nature of these ongoing demographic shifts indicates that the population-ageing challenges that India will face are both inevitable and exist on an enormous scale. These demographic changes present complex health, social, and economic challenges to which this heterogeneous country must rapidly adapt, both in the present and going forward into the future.
Social welfare schemes play an important role in addressing the problems of the weaker and vulnerable sections of society, particularly the elderly. The government has launched many policies and programmes for the welfare of the elderly, and such programmes are designed to enhance their quality of life. Apart from national schemes, there are many state-specific schemes for the welfare of the elderly that provide healthcare and economic support for older people. To access and avail themselves of the benefits, the elderly need to be aware of the relevant schemes and programmes implemented by the central and state governments. Many eligible elders are not aware of these schemes, or even if they are aware, they do not receive the benefits of such schemes for various reasons.
In this chapter, we discuss the three major social security schemes for the elderly in India. The Indira Gandhi National Old Age Pension Scheme (IGNOAPS) was introduced in 1995 as part of the National Social Assistance Programme (NSAP) to provide financial assistance to the elderly poor. The scheme was later transferred to the states in 2002–03 for implementation with additional central financial assistance. The main objective of this scheme is to provide social security to make older people economically independent.
Sustainability of maize production systems is threatened by poor economic returns and resource intensiveness. Therefore, an experiment was conducted at the ICAR-Indian Agricultural Research Institute, New Delhi during 2016–17 to 2017–18 to assess the effect of tillage and microbial inoculantsintegrated phosphorus (P) management on productivity, quality, economic outcome and energy dynamics of maize. Three tillage practices viz., CT–R (conventional tillage with no residue), ZT–R (zero tillage with no residue) and ZT + R (zero tillage with wheat crop residue at 2.5 Mg/ha) were assigned in main plots and five P management practices viz., P1 (control–NK as per recommendation, but no P), P2 (17.2 kg P/ha), P3 (17.2 kg P/ha + PSB), P4 (17.2 kg P/ha + compost inoculants) and P5 (34.4 kg P/ha) were allocated in subplots in three times replicated split-plot design. The maximum grain yield (5.96 Mg/ha), protein content (9.13%), protein yield (546 kg/ha) and gross energy returns (209 × 103 MJ/ha) were recorded under ZT + R while higher benefit: cost ratio (B: C ratio – the amount of economic gain per unit investment) (1.53) and energy efficiency (12.5) was noticed under ZT–R. Among the P management practices, the application of 34.4 kg P/ha recorded the highest grain yield (6.45 Mg/ha), protein content (9.34%), protein yield (603 kg/ha), B: C ratio (1.65) and energy efficiency (10.1). The results suggested that the application of P at the rate of 34.4 kg/ha under ZT + R is an economically robust approach for the quality maize production in semi-arid region.
To evaluate the effect of surgical intervention on serum insulin-like growth factor 1 levels in patients with obstructive sleep apnoea.
Methods
A prospective study was conducted in a tertiary care hospital of adult patients with obstructive sleep apnoea for whom continuous positive airway pressure therapy failed or was refused. All patients underwent polysomnography and serum insulin-like growth factor 1 evaluation pre-operatively and at three months post-operatively. The site of surgery was determined using Müller's manoeuvre and ApneaGraph AG 200.
Results
Fifteen patients were included with a mean age of 38 years: 11 males and 4 females. The mean pre-operative Apnoea–Hypopnoea Index using polysomnography was 53.7 events per hour, and the mean post-operative Apnoea–Hypopnoea Index at three months was 15.3 events per hour (p = 0.0001). The mean pre-operative serum insulin-like growth factor 1 was 160.2 μg/l, while the mean post-operative value was 236.98 μg/l (p = 0.005).
Conclusion
In adult patients with obstructive sleep apnoea for whom continuous positive airway pressure therapy fails, site-specific surgical intervention to treat the obstruction leads to an increase in serum insulin-like growth factor 1 levels.
We present WALLABY pilot data release 1, the first public release of H i pilot survey data from the Wide-field ASKAP L-band Legacy All-sky Blind Survey (WALLABY) on the Australian Square Kilometre Array Pathfinder. Phase 1 of the WALLABY pilot survey targeted three $60\,\mathrm{deg}^{2}$ regions on the sky in the direction of the Hydra and Norma galaxy clusters and the NGC 4636 galaxy group, covering the redshift range of $z \lesssim 0.08$. The source catalogue, images and spectra of nearly 600 extragalactic H i detections and kinematic models for 109 spatially resolved galaxies are available. As the pilot survey targeted regions containing nearby group and cluster environments, the median redshift of the sample of $z \approx 0.014$ is relatively low compared to the full WALLABY survey. The median galaxy H i mass is $2.3 \times 10^{9}\,{\rm M}_{{\odot}}$. The target noise level of $1.6\,\mathrm{mJy}$ per 30′′ beam and $18.5\,\mathrm{kHz}$ channel translates into a $5 \sigma$ H i mass sensitivity for point sources of about $5.2 \times 10^{8} \, (D_{\rm L} / \mathrm{100\,Mpc})^{2} \, {\rm M}_{{\odot}}$ across 50 spectral channels (${\approx} 200\,\mathrm{km \, s}^{-1}$) and a $5 \sigma$ H i column density sensitivity of about $8.6 \times 10^{19} \, (1 + z)^{4}\,\mathrm{cm}^{-2}$ across 5 channels (${\approx} 20\,\mathrm{km \, s}^{-1}$) for emission filling the 30′′ beam. As expected for a pilot survey, several technical issues and artefacts are still affecting the data quality. Most notably, there are systematic flux errors of up to several 10% caused by uncertainties about the exact size and shape of each of the primary beams as well as the presence of sidelobes due to the finite deconvolution threshold. In addition, artefacts such as residual continuum emission and bandpass ripples have affected some of the data. The pilot survey has been highly successful in uncovering such technical problems, most of which are expected to be addressed and rectified before the start of the full WALLABY survey.
Mung bean is highly susceptible to insect attack during storage. Hermetic storage is an effective technique to control insect damage. This study investigated the potential of the hermetic SuperGrain bag (SGB) for controlling bruchids during storage. The dry samples were packed in SGB infested with adult bruchids (SGB-I), SGB natural field infested (SGB-N), woven polypropylene bags (WPP-I and WPP-N) and kept at room temperature for 180 days. Oxygen (O2) and carbon dioxide (CO2) concentrations were measured at 15 days intervals. Moisture content, infestation level, seed damage and weight loss were determined at 60 days intervals. Seed colour, hardness, crude protein and fat contents were analysed before and after storage. The O2 level decreased to 10.09%, whereas the CO2 level increased to 8.87% in both SGB-I and SGB-N treatments. The moisture content of mung bean was maintained as onset storage in both SGB-N and SGB-I treatments, whereas reduced in WPP-N (9.26% db) and WPP-I (9.21% db). In SGB treatments, no significant bruchids were detected, but they increased drastically in WPP-N (52 ± 9) and WPP-I (377 ± 14). Seed damage (2–3%) and weight loss (0.8–1.0%) were recorded in both SGB-N and SGB-I. Conversely, seed damage reached 26.67 and 54.17%, corresponding to weight losses of 12.33 and 20.82% in WPP-N and WPP-I, respectively. Seed colour, hardness, crude protein and fat contents in SGBs showed no significant changes than in the WPP bags. The study illustrated that the SGB is an efficient hermetic device in protecting mung beans against bruchids attacks compared to the WPP bags.