Rationality is a fundamental pillar of Economics. It is however unclear if this assumption holds when decisions are made under stress. To answer this question, we design two laboratory experiments where we exogenously induce physiological stress in participants and test the consistency of their choices with economic rationality. In both experiments we induce stress with the Cold Pressor test and measure economic rationality by the consistency of participants’ choices with the Generalized Axiom of Revealed Preference (GARP). In the first experiment, participants delay the decision-making task for 20 min until the cortisol level peaks. We find significant differences in cortisol levels between the stressed group and the placebo group which, however, do not affect the consistency of choices with GARP. In a second experiment, we study the immediate effect of the stressor on rationality. Overall, results from the second experiment confirm that rationality is not impaired by the stressor. If anything, we observe that compared to the placebo group, participants are more consistent with rationality immediately after the stressor. Our findings provide strong empirical support for the robustness of the economic rationality assumption under physiological stress.

Let $\mathcal H$ be a complex, separable Hilbert space, and set . When $\dim \, \mathcal H$ is finite, we characterise the set and its norm-closure . In the infinite-dimensional setting, we characterise the intersection of with the set of biquasitriangular operators, and we exhibit an index obstruction to belonging to .

Understanding protein fermentation in the hindgut of pigs is essential due to its implications for health, and ileal digesta is commonly used to study this process in vitro. This study aimed to assess the feasibility of utilising in vitro digested residues as a replacement for ileal digesta in evaluating the protein fermentation potential. In vitro residues from cottonseed meal, maize germ meal, peanut meal, rapeseed cake, rapeseed meal, soyabean meal and sunflower meal were analysed using a modified gas production (GP) technique and curve fitting model to determine their fermentation dynamics and compare with the use of ileal digesta. Significant variations were observed in GP parameters between in vitro digested residues, indicating differences in nitrogen utilisation by fecal microbiota. Soyabean meal and sunflower meal exhibited the highest maximum GP rates (Rmax), with values of 29·5 ± 0·6 and 28·0 ± 1·2 ml/h, respectively, while maize germ meal showed slowest protein utilisation (17·3 ± 0·2 ml/h). A positive relationship was found between the Rmax of in vitro residues and ileal digesta (R2 = 0·85, P < 0·01). However, GP potential (GPs) showed a tendency for a negative relationship (R2 = 0·39, P < 0·1), likely due to narrow observed GPs values and the presence of varied endogenous proteins in ileal digesta. Our results demonstrate the potential of using in vitro digested residues as a substitute for ileal digesta in assessing the fermentation potential of protein ingredients, particularly regarding the rate of protein fermentation.

Unmanned aerial vehicle (UAV) formations for bearing-only passive detection are increasingly important in modern military confrontations, and the array of the formation is one of the decisive factors affecting the detection accuracy of the system. How to plan the optimal geometric array in bearing-only detection is a complex nondeterministic polynomial problem, and this paper proposed the distributed stochastic subgradient projection algorithm (DSSPA) with layered constraints to solve this challenge. Firstly, based on the constraints of safe flight altitude and fixed baseline, the UAV formation is layered, and the system model for bearing-only cooperative localisation is constructed and analysed. Then, the calculation formula for geometric dilution of precision (GDOP) in the observation plane is provided, this nonlinear objective function is appropriately simplified to obtain its quadratic form, ensuring that it can be adapted and used efficiently in the system model. Finally, the proposed distributed stochastic subgradient projection algorithm (DSSPA) combines the idea of stochastic gradient descent with the projection method. By performing a projection operation on each feasible solution, it ensures that the updated parameters can satisfy the constraints while efficiently solving the convex optimisation problem of array planning. In addition to theoretical proof, this paper also conducts three simulation experiments of different scales, validating the effectiveness and superiority of the proposed method for bearing-only detection array planning in UAV formations. This research provides essential guidance and technical reference for the deployment of UAV formations and path planning of detection platforms.

Neurocysticercosis is a poorly understood infection of the central nervous system with Taenia solium larva, and the treatment often fails to kill all the parasitic larva. Most research on this infection has used patient-level data, looking at summaries of the encysted parasitic cysticercus burden. Cyst-level analysis is needed to identify factors that impact individual cyst trajectories and how that may vary based on characteristics of the patient, infection and cyst being followed. We disaggregated data on 221 cysts from 117 patients who participated in a trial evaluating the impact of albendazole treatment to identify factors that impact cyst evolution over time from the active to the degenerating and calcified phases, and eventual resolution. We found that having calcified cysts at baseline was associated with a faster rate of transition from the degenerative phase to calcified phase or resolution. Age and sex were not associated with cyst evolution in the main effect analysis, but after stratifying on treatment we found that the direction of some associations by patient age and sex was reversed for patients in the albendazole arm compared to those in the placebo arm. These findings suggest that differences in host immune response by sex and age as well as by past exposure, potentially indicated by having calcified cysts together with active cysts at baseline, are important to cyst evolution and may be modified by treatment. Future research is needed to assess if these differences suggest distinct treatment recommendations.

Exploratory process factor analysis (EPFA) is a data-driven latent variable model for multivariate time series. This article presents analytic standard errors for EPFA. Unlike standard errors for exploratory factor analysis with independent data, the analytic standard errors for EPFA take into account the time dependency in time series data. In addition, factor rotation is treated as the imposition of equality constraints on model parameters. Properties of the analytic standard errors are demonstrated using empirical and simulated data.

The composite direct product (CDP) model is a multiplicative model for multitrait-multimethod (MTMM) designs. It is extended to incomplete MTMM correlation matrices where some trait-method combinations are not available. Rules for omitting trait-method combinations without resulting in an indeterminate model are also suggested. Maximum likelihood estimation and the log absolute correlation procedure are used to fit the model, and are found to yield similar results. The balanced incomplete MTMM design tends to yield more accurate estimates than the randomly missing design.

This paper proposes a cooperative midcourse guidance law with target changing and topology switching for multiple interceptors intercepting targets in the case of target loss and communication topology switching. Firstly, a three-dimensional guidance model is established and a cooperative trajectory shaping guidance law is given. Secondly, the average position consistency protocol of virtual interception points is designed for communication topology switching, and the convergence of the average position of virtual interception points under communication topology switching is proved by Lyapunov stability theory. Then, in the case of the target changing, the target handover law and the handover phase guidance law are designed to ensure the acceleration smoothing, at last, the whole cooperative midcourse guidance law is given based on the combination of the above guidance laws. Finally, numerical simulation results show the effectiveness and the superiority of the proposed cooperative midcourse guidance law.

Soluble Intercellular Adhesion Molecule-1 (sICAM-1) has emerged as an inflammatory biomarker of many essential functions. We investigated the level of sICAM-1 influenced by Clonorchis sinensis (C. sinensis) co-infection in chronic hepatitis B (CHB) patients to explore the degree of liver tissue inflammation and liver function damage after co-infection. The study included data from patients with C. sinensis mono-infection (n=27), hepatitis B virus (HBV) mono-infection (n=32), C. sinensis and HBV co-infection (n=24), post-hepatitis B liver cirrhosis (n=18), post-hepatitis B liver cirrhosis co-infected with C. sinensis (n=16), and healthy controls (n=39). The level of sICAM-1 was measured with specific enzyme-linked immunosorbent assay method. Compared to the healthy control group, all the experimental groups had significantly higher serum sICAM-1 levels. The levels of sICAM-1 in co-infected groups were significantly higher compared to the mono-infection groups and were positively correlated with the levels of glutamate aminotransferase (ALT) and aspartate aminotransferase (AST). Our research findings confirmed that co-infection could exacerbate liver tissue inflammation and liver function damage in patients, could raise the sICAM-1 level, and may lead to the chronicity of HBV infection. These results provide clues for pathological mechanism study and formulating treatment plans.

We present direct numerical simulation (DNS) and modelling of incompressible, turbulent, generalized Couette–Poiseuille flow. A particular example is specified by spherical coordinates $(Re,\theta,\phi )$, where $Re = 6000$ is a global Reynolds number, $\phi$ denotes the angle between the moving plate, velocity-difference vector and the volume-flow vector and $\tan \theta$ specifies the ratio of the mean volume-flow speed to the plate speed. The limits $\phi \to 0^\circ$ and $\phi \to 90^\circ$ give alignment and orthogonality, respectively, while $\theta \to 0^\circ,\ \theta \to 90^\circ$ correspond respectively to pure Couette flow in the $x$ direction and pure Poiseuille flow at angle $\phi$ to the $x$ axis. Competition between the Couette-flow shear and the forced volume flow produces a mean-velocity profile with directional twist between the confining walls. Resultant mean-speed profiles relative to each wall generally show a log-like region. An empirical flow model is constructed based on component log and log-wake velocity profiles relative to the two walls. This gives predictions of four independent components of shear stress and also mean-velocity profiles as functions of $(Re,\theta,\phi )$. The model captures DNS results including the mean-flow twist. Premultiplied energy spectra are obtained for symmetric flows with $\phi =90^\circ$. With increasing $\theta$, the energy peak gradually moves in the direction of increasing $k_x$ and decreasing $k_z$. Rotation of the energy spectrum produced by the faster moving velocity near the wall is also observed. Rapid weakening of a spike maxima in the Couette-type flow regime indicates attenuation of large-scale roll structures, which is also shown in the $Q$-criterion visualization of a three-dimensional time-averaged flow.

In 2018, an Ionplus 200 kV MIni-CArbon DAting System (MICADAS) accelerator mass spectrometer (AMS) was installed at the Laboratory of AMS Dating and the Environment, Nanjing University (NJU-AMS Laboratory), China. The NJU-AMS Laboratory is largely devoted to research on radiocarbon dating and 14C analysis in fields of earth, environmental and archaeological sciences. The laboratory has successfully employed various pretreatment methods, including routine pretreatment of tree rings, buried wood and subfossil wood, seeds, charcoal, pollen concentrates, organic matter, and shells. In this study, operational status of the NJU-AMS is presented, and results of radiocarbon measurements made on different sample types are reported. Measurements on international standards, references of known age, and blank samples demonstrate that the NJU-AMS runs stably and has good reproducibility on measurement of single samples. The facility is capable of measuring 14C in samples with the precision and accuracy that meet the requirements for investigating annual 14C changes, history-prehistory age dating, and Late Quaternary stratigraphic chronology research.

Background: Duchenne muscular dystrophy (DMD) is caused by DMD gene mutations. Delandistrogene moxeparvovec is an investigational gene transfer therapy, developed to address the underlying cause of DMD. We report findings from Part 1 (52 weeks) of the two-part EMBARK trial (NCT05096221). Methods: Key inclusion criteria: Ambulatory patients aged ≥4-<8 years with a confirmed DMD mutation within exons 18–79 (inclusive); North Star Ambulatory Assessment (NSAA) score >16 and <29 at screening. Eligible patients were randomized 1:1 to intravenous delandistrogene moxeparvovec (1.33×1014 vg/kg) or placebo. The primary endpoint was change from baseline in NSAA total score to Week 52. Results: At Week 52 (n=125), the primary endpoint did not reach statistical significance, although there was a nominal difference in change from baseline in NSAA total score in the delandistrogene moxeparvovec (2.6, n=63) versus placebo groups (1.9, n=61). Key secondary endpoints (time to rise, micro-dystrophin expression, 10-meter walk/run) demonstrated treatment benefit in both age groups (4-5 and 6-7 years; p<0.05).There were no new safety signals, reinforcing the favorable and manageable safety profile observed to date. Conclusions: Based on the totality of functional assessments including the timed function tests, treatment with delandistrogene moxeparvovec indicates beneficial modification of disease trajectory.

The reactivity of basal surfaces, steps and edges of muscovite was studied by imaging surface precipitates of PbCl2 using atomic force microscopy (AFM). We reacted PbCl2 solution with freshly cleaved muscovite surfaces and found that PbCl2 precipitates were formed on the basal surfaces, steps and edges. It was observed that PbCl2 precipitated preferentially along the steps compared to the basal surfaces and that PbCl2 precipitates at multiple-layer edges were needle-shaped and oriented in different directions. One of the muscovite samples we cleaved had muscovite fragments sitting on the freshly cleaved surfaces. These fragments resulted from previously formed cracks. Thus, we were able to compare the reactivity of the weathered surfaces with that of freshly cleaved surfaces. It was found that PbCl2 was not precipitated along the edges of previously cracked muscovite fragments. These results clearly demonstrated that the edges of freshly cleaved muscovite are the most reactive surface sites, whereas the edges of weathered muscovite are not as reactive. We believe that the surface reactivity of the edges of freshly cleaved muscovite is likely due to terminal or Al-OH1/2− groups on these crystalline surfaces, which favor adsorption of Pb2+ ions and the subsequent nucleation and precipitation reactions. We also investigated the effect of drying rate on the morphology of the surface precipitates. Fast drying resulted in a nearly complete covered surface with a leaflike morphology, whereas slow drying resulted in more isolated surface clusters.

Transient numerical simulations were conducted to investigate the influence of large amplitude and fast impact backpressure on a shock train. The fundamental problem consists of a shock train within a constant-area channel with a Ma=1.61 inflow and a pulse backpressure applied to the outlet. The pressure disturbance in the isolator has an intense forcing-response lag. From the moment of the backpressure peak appearance, it takes 36 times the backpressure duration for the pressure disturbance to reach the upstream end. It moves upstream with time in the form of a normal shock wave. As time progresses, the normal shock degenerates into a $\lambda $ shock and a compression wave behind due to the action of viscous dissipation in the boundary layer. Eventually, a multi-stage shock train is formed. The maximum backpropagation distance is a quadratic function of both the pulse backpressure peak and duration, and the relationship between these variables was determined by fitting. When the integral value of backpressure to time is fixed, reducing the backpressure peak while increasing the duration will reduce the backpressure pulsation at the isolator outlet, which will be more conducive to shortening the maximum backpropagation distance than reducing the duration and increasing the backpressure peak. The values of backpressure peak and duration are obtained from the detonation combustion case, which ensures the authenticity of backpressure characteristics. The relevant research conclusions can provide a reference for the design of the isolator of pulse detonation ramjet.

The attitude-tracking problem of hypersonic morphing vehicles (HMVs) is investigated in this research. After introducing variable-span wings, the optimal aerodynamic shape is available throughout the entire flight mission. However, the morphing wings cause significant changes in aerodynamic coefficients and mass distribution, challenging the attitude control. Therefore, a complete design procedure for the flight control system is proposed to address the issue. Firstly, the original model and the control-oriented model of HMVs are built. Secondly, in order to eliminate the influence caused by the multisource uncertainties, an adaptive fixed-time disturbance observer combined with fuzzy control theory is established. Thirdly, the fixed-time control method is developed to stabilise hypersonic morphing vehicles based on a multivariable sliding mode manifold. The control input can be obtained directly. Finally, the effectiveness of the proposed method is proved with the help of the Lyapunov theory and simulation results.

The poor environmental stability of natural anthocyanin hinders its usefulness in various functional applications. The objectives of the present study were to enhance the environmental stability of anthocyanin extracted from Lycium ruthenicum by mixing it with montmorillonite to form an organic/inorganic hybrid pigment, and then to synthesize allochroic biodegradable composite films by incorporating the hybrid pigment into sodium alginate and test them for potential applications in food testing and packaging. The results of X-ray diffraction, Fourier-transform infrared spectroscopy, and use of the Brunauer–Emmett–Teller method and zeta potential demonstrated that anthocyanin was both adsorbed on the surface and intercalated into the interlayer of montmorillonite via host–guest interaction, and the hybrid pigments obtained allowed good, reversible, acid/base behavior after exposure to HCl and NH3 atmospheres. The composite films containing hybrid pigments had good mechanical properties due to the uniform dispersion of the pigments in a sodium alginate substrate and the formation of hydrogen bonds between them. Interestingly, the composite films also exhibited reversible acidichromism. The as-prepared hybrid pigments in composite films could, therefore, serve simultaneously as a reinforced material and as a smart coloring agent for a polymer substrate.