Supporting the application of positive psychology in the workplace, the Shirom Melamed Vigor Scale (SMVS), which assesses vigorous feelings at work, was adapted to the Thai context. The Thai SMVS contains 14 items as in the original scale and was validated using a sample of 585 employed participants in Thailand. Results of a confirmatory factor analysis are consistent with the conceptual model of vigour as consisting of physical strength, cognitive liveliness, and emotional energy, with a suggestion that a 13-item scale can also be used. As expected, vigour has been found to be conceptually distinct from some similar constructs, and independent from job burnout. Vigour also showed unique predictive effects on employees’ health. These results support the previously-proposed conceptual framework of vigour and indicate crucial roles of positive emotion in the work setting. In concordance with a positive organisational psychology approach, applications of the Thai vigor scale are discussed with respect to its potential for enhancing employees’ wellbeing and productivity.