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Head-up tilt test (HUTT) is an important tool in the diagnosis of pediatric vasovagal syncope. This research will explore the relationship between syncopal symptoms and HUTT modes in pediatric vasovagal syncope.
Methods:
A retrospective analysis was performed on the clinical data of 2513 children aged 3–18 years, who were diagnosed with vasovagal syncope, from Jan. 2001 to Dec. 2021 due to unexplained syncope or pre-syncope. The average age was 11.76 ± 2.83 years, including 1124 males and 1389 females. The patients were divided into the basic head-up tilt test (BHUT) group (596 patients) and the sublingual nitroglycerine head-up tilt test (SNHUT) group (1917 patients) according to the mode of positive HUTT at the time of confirmed pediatric vasovagal syncope.
Results:
(1) Baseline characteristics: Age, height, weight, heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and composition ratio of syncope at baseline status were higher in the BHUT group than in the SNHUT group (all P < 0.05). (2) Univariate analysis: Age, height, weight, HR, SBP, DBP, and syncope were potential risk factors for BHUT positive (all P < 0.05). (3) Multivariate analysis: syncope was an independent risk factor for BHUT positive, with a probability increase of 121% compared to pre-syncope (P<0.001).
Conclusion:
The probability of BHUT positivity was significantly higher than SNHUT in pediatric vasovagal syncope with previous syncopal episodes.
Strategic management scholars have shown increasing interest in explaining strategic change from the perspective of cognitive bias. However, most studies focus on individual cognitive bias but pay little attention to group cognitive bias. This study introduces a typical group cognitive bias (group polarization) to explain strategic change decisions made by the board of directors. Following the theory of group polarization, we argue that, when the average prior strategic change experienced in performance decline by board directors is relatively high (or low), the focal strategic change in performance decline will become even higher (or lower). We further contend that the proportion of female directors and board versus CEO power as the contingencies can mitigate this group polarization effect. Our hypotheses were strongly supported by a longitudinal sample of Chinese publicly listed companies during 2008–2018. The study's framework and findings contribute to the contextualization of social psychology research on group polarization in the study of board's strategic decision-making.
Copy number variation (CNV) is a very common type of gene variation with high frequency. In recent years, CNV has been paid more attention in various fields, especially in livestock and poultry breeding, which has promoted the progress of breeding. WW domain binding protein 1-like (WBP1L) is a protein coding gene, which plays an important role in cattle populations, and its function has been extensively studied, but it is not clear whether the copy number of the gene can affect the growth and development of cattle populations. In this study, CNV of WBP1L gene was detected in 732 cattle of seven breeds (Qinchuan cattle, QC; Pinan cattle, PN; Yuengling cattle, YL; Xianan cattle, XN; Jiaxian cattle, JX; natural Guyuan cattle, NGY; Jian cattle, JA). In addition, the relationship between CNV and growth phenotype of cattle was studied. The experimental data indicate that the copy number of WBP1L was obviously correlated with heart girth of PN cattle (**P < 0.01), rump length (RL) and body weight (BW) of PN cattle (*P < 0.05), withers height (WH), RL, body length, chest depth and BW of JX cattle (*P < 0.05), WH of NGY cattle (*P < 0.05) and WH of JA cattle (*P < 0.05). It was proved that CNV of WBP1L gene could be used as molecular marker locus for genetic breeding of the above four cattle breeds.
Major depressive disorder (MDD) is a clinically and biologically heterogeneous syndrome. Identifying discrete subtypes of illness with distinguishing neurobiological substrates and clinical features is a promising strategy for guiding personalised therapeutics.
Aims
This study aimed to identify depression subtypes with correlated patterns of functional network connectivity and clinical symptoms by clustering patients according to a weighted linear combination of both features in a relatively large, medication-naïve depression sample.
Method
We recruited 115 medication-naïve adults with MDD and 129 matched healthy controls, and evaluated all participants with magnetic resonance imaging. We used regularised canonical correlation analysis to identify component mapping relationships between functional network connectivity and symptom profiles, and K-means clustering was used to define distinct subtypes of patients.
Results
Two subtypes of MDD were identified: insomnia-dominated subtype 1 and anhedonia-dominated subtype 2. Subtype 1 was characterised by abnormal hyperconnectivity within the ventral attention network and sleep maintenance insomnia. Subtype 2 was characterised by abnormal hypoconnectivity in the subcortical and dorsal attention networks, and prominent anhedonia symptoms.
Conclusions
Our study identified two distinct subtypes of patients with specific neurobiological and clinical symptom profiles. These findings advance understanding of the biological and clinical heterogeneity of MDD, offering a pathway for defining categorical subtypes of illness via consideration of both biological and clinical features.
This study aimed to investigate the environmental contamination of nucleic acid at 2019 novel coronavirus (2019-nCOV) vaccination site and to evaluate the effect of improvement to the vaccination process. Nucleic acid samples were collected from the surface of the objects in 2019-nCOV vaccination point A (used between 15 November 2020 and 25 December 2020) and point B (used after 27 December 2020) in a comprehensive tertiary hospital. Samples were collected from point A before improvement to the vaccination process, and from point B (B1 and B2) after improvement to the vaccination process. The real-time fluorescence polymerase chain reaction method was used for detection. The positive rate of vaccination room was 47.06% (24/51) at point A. No positive result was found in point B1 both at working hours (0/27) and after terminal disinfection (0/27). In point B2, the positive results were found in vaccine's outer packaging and staff gloves at working hours, with a positive rate of 7.41% (2/27). The positive rate was 0 (0/27) after terminal disinfection in point B2. The nucleic acid contamination in the vaccination room of 2019-nCOV vaccine nucleic acid sampling point is serious, which can be avoided through the improvement and intervention (such as personal protection, vaccination operation and disinfection methods).
To determine the effects of sperm DNA fragmentation (SDF) on embryo morphokinetic parameters, cleavage patterns and embryo quality, this retrospective study analyzed 151 intracytoplasmic sperm injection (ICSI) cycles (1152 embryos collected) between November 2016 and June 2019. SDF was assessed using sperm chromatin dispersion. The cycles were divided into two groups based on the SDF rate: SDF < 15% (n = 114) and SDF ≥ 15% (n = 37). The embryo morphokinetic parameters, cleavage patterns, and embryo quality were compared between the two groups. The morphokinetic parameters tPNf, t2, t3, t4, t5, t6, and t8 were achieved significantly earlier in the SDF < 15% group compared with in the SDF ≥ 15% group. The fertilization and 2PN rates seemed to be significantly higher in the SDF < 15% group compared with in the SDF ≥ 15% group, while the abnormal cleavage rates were similar. However, a significantly higher rate of chaotic cleavage (CC) was observed in the SDF ≥ 15% group. The D3 high-quality embryo and available embryo rates were similar between the two groups. The blastocyst formation, high-quality blastocyst, and available blastocyst rates in the SDF < 15% group were significantly higher than those in the SDF ≥ 15% group. With an increase in SDF level, the chemical pregnancy, clinical pregnancy and implantation rates tended to decrease, while the miscarriage rate increased. This study demonstrated that SDF ≥ 15% reduces the fertilization rate of ICSI cycles and affects certain morphokinetic parameters. A higher SDF level can also induce a higher rate of CC, with subsequent decreases in the blastocyst formation rate and blastocyst quality.
The disease burden of infectious diarrhea cannot be underestimated. Its seasonal patterns indicate that weather patterns may play an important role and have an important effect on it. The objective of this study was to clarify the relationship between temperature and infectious diarrhea, and diarrhea-like illness.
Methods:
Distributed lag non-linear model, which was based on the definition of a cross-basis, was used to examine the effect.
Results:
Viral diarrhea usually had high incidence in autumn-winter and spring with a peak at -6°C; Norovirus circulated throughout the year with an insignificant peak at 8°C, while related bacteria usually tested positive in summer and peaked at 22°C. The lag-response curve of the proportion of diarrhea-like cases in outpatient and emergency cases revealed that at -6°C, with the lag days increasing, the proportion increased. Similar phenomena were observed at the beginning of the curves of virus and bacterial positive rate, showing that the risk increased as the lag days increased, peaking on days 16 and 9, respectively. The shape of lag-response curve of norovirus positive rate was different from others, presenting m-type, with 2 peaks on day 3 and day 18.
Conclusion:
Weather patterns should be taken into account when developing surveillance programs and formulating relevant public health intervention strategies.
To compare and validate neurocognitive tests in the Harmonized Cognitive Assessment Protocol (HCAP) for the China Health and Retirement Longitudinal Study (CHARLS), and to identify appropriate tests to be administered in future waves of CHARLS.
Methods:
We recruited 825 individuals from the CHARLS sample and 766 subjects from hospitals in six provinces and cities in China. All participants were administered the HCAP-neurocognitive tests, and their informants were interviewed regarding the respondents’ functional status. Trained clinicians administered the Clinical Dementia Rating scale (CDR) to assess the respondents’ cognitive status independently.
Results:
The testing protocol took an average of 58 minutes to complete. Refusal rates for tests of general cognition, episodic memory, and language were less than 10%. All neurocognitive test scores significantly correlated with the CDR global score (correlation coefficients ranged from 0.139 to 0.641). The Mini-Mental State Examination (MMSE), the Health and Retirement Study (HRS) - telephone interview for cognitive status (TICS), community screening instrument for dementia (CSI-D) for respondent, episodic memory and language tests each accounted for more than 20% of the variance in global CDR score (p < 0.001) in bivariate tests. In the CHARLS subsample, age and education were associated with neuropsychological performance across most cognitive domains, and with functional status.
Conclusion:
A brief set of the CHARLS-HCAP neurocognitive tests are feasible and valid to be used in the CHARLS sample and hospital samples. It could be applied in the future waves of the CHARLS study, and it allows estimating the prevalence of dementia in China through the population-based CHARLS.
This work designed a facile preparation for an SiO2/C composite as the anode material for lithium ion battery. Both SiO2 and carbon are amorphous. SiO2 and carbon are mixed uniformly. The SiO2/C composite shows high specific capacity, cycle stability, and rate capability in lithium ion battery charge–discharge test. A stable reversible capacity of 1024 mA h/g at the current density of 100 mA/g is reached. The capacity retains 83% after 100 cycles. The uniform mixture of SiO2 and carbon leads to reduced volume change during the lithiation and delithiation of SiO2, together with the amorphous nature of SiO2 explains the high cycling stability. The carbon coating is a key factor for the high capacity and stability due to the increased electrical conductivity and reduced volume change. The resistance of the solid electrolyte interface film and charge transfer resistance of the SiO2/C composite are much smaller than those of pure carbon, which is a direct proof of the improved conductivity of the material by the carbon coating.
The ‘Mystery Interval’ (MI, 17.5−14.5 ka) was the first stage of the last deglaciation, a key interval for understanding mechanisms of glacial–interglacial cycles. To elucidate possible causes of the MI, here we present three high-resolution, precisely dated oxygen-isotope records of stalagmites from Qingtian and Hulu Caves in China, reflecting changes in the East Asian summer monsoon (EASM) then. Based on well-established chronologies using precise 230Th dates and annual-band counting results, the two-cave δ18O profiles of ~7-yr resolution match well at decadal timescales. Both of the two-cave records document an abrupt weakening (2‰ of δ18O rise within 20 yr) in the EASM at ~16.1 ka, coinciding with the transition of the two-phased MI reconstructed from New Mexico's Lake Estancia. Our results indicate that the maximum southward displacement of the Intertropical Convergence Zone and associated southward shift of polar jet stream may generate this two-phase feature of the MI during that time. We also discover a linear relationship among decreasing EASM intensity, rising atmospheric CO2 and weakening Atlantic Meridional Overturning Circulation between the MI and Younger Dryas episodes, suggesting a strong coupling of atmospheric/oceanic circulations in response to the millennial-scale forcing, which in turn regulates global climate changes and carbon cycles.
A high-resolution, annual layer-counted and 230Th-dated multi-proxy record is constructed from a stalagmite in Hulu Cave, China. These proxies, including δ18O, annual layer thickness (ALT), gray level (GL) and Sr/Ca, cover a time span of ~ 3000 yr from 21 to 24 ka. The physical proxies (ALT and GL) and the geochemical index (Sr/Ca), all primarily reflecting karst hydrological processes, vary in concert and their coherence is supported by wavelet analyses. Variations in the δ18O data agree with fluctuations in the ALT and Sr/Ca records on multi-decadal to centennial scales, suggesting that the Hulu δ18O signal is strongly associated with varying local rainfall amounts on short timescales. A monsoon failure event at ~ 22.2 ka correlates with a decrease in tropical rainfall, a reduction in global CH 4 and an ice-rafted event in the North Atlantic. This correlation highlights roles of the Asian monsoon and tropical hydrological cycle in modulating global CH 4, because the high-latitude emission was inhibited during the Last Glacial Maximum (LGM). Spectral analysis of the δ18O record displays peaks at periodicities of 139, 59, 53, 43, 30, 23 and 19"15 yr. The absence of typical centennial solar cycles may be related to muted changes in ocean circulation during the LGM.
Caridroit, De Wever, and Dumitrica (1999) promoted stauraxon (Radiolaria) to an order, order Latentifistularia, and De Wever et al. (2001) proposed a classification using family and genus levels. However, the taxonomy of this order in genus level is still problematic because some genera were named according to broken specimens. A radiolarian fauna with a high diversity was collected from the late Changxingian in southern Guanxi, China. These specimens are very well preserved so that they are rare material for roundly describing the characters of some genera. They are identified as 42 species belonging to 16 genera and 5 families. Fifteen new species and one new genus are described, some genera are discussed, and some species are revised.
This paper describes a new genus Liaous, with L. shaiwensis He and Chen n. gen. n. sp. as the type species, from the Xinyuan Formation of Anisian age in Ziyun, southern Guizhou, China. The phylogenetic tree revealed by the parsimony analysis shows that Liaous is closely allied to both Mentzelia Quenstedt, 1871 and Paramentzelia Xu, 1978 of the subfamily Mentzeliinae. A new classification scheme for the Spiriferinoidea is also proposed based on a phylogenetic tree of the superfamily indicated by parsimony analysis. The Spiriferinoidea includes three families and nine subfamilies. Three new subfamilies—Madoinae He and Chen, new subfam., Qinghaispiriferininae He and Chen, new subfam., and Triadispirinae He and Chen, new subfam. are proposed. Liaous shaiwensis He and Chen n. gen. n. sp. is found in the Posidonia wengensis-Liaous shaiwensis (P-L) paleocommunity, which is dominated by r-strategists (i.e., organisms defined by a fauna with a high dominance and small body sizes) and has a low diversity and high dominance. The P-L paleocommunity therefore has little similarity to its coeval communities from the Anisian Stage of South China and instead it appears more similar to the Lower Triassic shelly faunas in community structures. This paleocommunity is interpreted to have inhabited a relatively deep, low-energy, dysaerobic offshore basin/slope setting with the influence of episodic storms.
A bivalve fauna from the Permian—Triassic interval of the Dongpan section, Guangxi, South China is described herein. This bivalve fauna includes 16 species belonging to 10 genera. New taxa are Euchondria fusuiensis, Palaeoneilo qinzhouensis, and Claraia liuqiaoensis. Bed 12 of the interval (Talung Formation) contains the typical late Late Permian ammonoids: Huananoceras sp., Laibinoceras cf. L. compressum Yang, and Qiangjiangoceras sp. Bed 13 (Luolou Formation) contains typical Early Triassic bivalves Claraia dieneri Nakazawa, C. cf. C. wangi (Patte), and C. griesbachi (Bittner), which coexist with the earliest Triassic ammonoid Ophiceras sp. The bivalve and ammonoid distributions at the Dongpan section indicate that bed 12 should be assigned to the Late Permian, and bed 13 should be assigned to the Early Triassic. From the early Changhsingian to the Induan, the byssal notches of Claraia species tend to become progressively narrower, and change from being ventrally extended to being horizontally extended. The species level diversity of Claraia also increases through this interval.
The prevalence and factors associated with delays in help seeking for people with dementia in China are unknown.
Methods:
Within 1,010 consecutively registered participants in the Clinical Pathway for Alzheimer's Disease in China (CPAD) study (NCT01779310), 576 persons with dementia (PWDs) and their informants reported the estimated time from symptom onset to first medical visit seeking diagnosis. Univariate analysis of general linear model was used to examine the potential factors associated with the delayed diagnosis seeking.
Results:
The median duration from the first noticeable symptom to the first visit seeking diagnosis or treatment was 1.77 years. Individuals with a positive family history of dementia had longer duration (p = 0.05). Compared with other types of dementia, people with vascular dementia (VaD) were referred for diagnosis earliest, and the sequence for such delays was: VaD < Alzheimer's disease (AD) < frontotemporal dementia (FTD) (p < 0.001). Subtypes of dementia (p < 0.001), family history (p = 0.01), and education level (p = 0.03) were associated with the increased delay in help seeking.
Conclusions:
In China, seeking diagnosis for PWDs is delayed for approximately 2 years, even in well-established memory clinics. Clinical features, family history, and less education may impede help seeking in dementia care.
Sufficient iodine intake by pregnant and lactating women is crucial to their offspring's cognitive development. The aim of the present study was to explore the impact of iodised salt intake on the iodine status of pregnant and lactating women. Thirty towns were selected from 211 towns in the rural areas of Shijiazhuang city using probability proportionate to size sampling in this cross-sectional survey. In each selected town, forty pregnant women and forty lactating women were randomly selected to contribute urine samples to determine iodine content. The median urinary iodine content (UIC) of 1200 pregnant women in all was 146 (interquartile range (IQR) 88–239) μg/l. The median UIC in the first, second and third trimesters were 166 (IQR 92–276) μg/l, 145 (IQR 83–248) μg/l and 134 (IQR 79–221) μg/l, respectively. The median UIC in the first trimester was significantly higher than that in the third trimester (P= 0·04). The median UIC of 1200 lactating women in all was 120 (IQR 66–195) μg/l. Their median UIC in every 4-week block was higher than the WHO criteria except in weeks 25–28 and weeks 33–36 of lactation. Pregnant women's median UIC did not correlate with median salt iodine (MSI) (P= 0·402); however, there was a linear correlation between MSI and the lactating women's median UIC (P= 0·007). Iodised salt failed to provide adequate iodine to pregnant women possibly due to limited intake of iodised salt during pregnancy, though it was found to provide adequate iodine to lactating women in the rural areas of Shijiazhuang city.
Early identification of patients with bipolar disorder during their first depressive episode is beneficial to the outcome of the disorder and treatment, but traditionally this has been a great challenge to clinicians. Recently, brain-derived neurotrophic factor (BDNF) has been suggested to be involved in the pathophysiology of bipolar disorder and major depressive disorder (MDD), but it is not clear whether BDNF levels can be used to predict bipolar disorder among patients in their first major depressive episode.
Aims
To explore whether BDNF levels can differentiate between MDD and bipolar disorder in the first depressive episode.
Method
A total of 203 patients with a first major depressive episode as well as 167 healthy controls were recruited. After 3 years of bi-annual follow-up, 164 patients with a major depressive episode completed the study, and of these, 21 were identified as having bipolar disorder and 143 patients were diagnosed as having MDD. BDNF gene expression and plasma levels at baseline were compared among the bipolar disorder, MDD and healthy control groups. Logistic regression and decision tree methods were applied to determine the best model for predicting bipolar disorder at the first depressive episode.
Results
At baseline, patients in the bipolar disorder and MDD groups showed lower BDNF mRNA levels (P<0.001 and P = 0.02 respectively) and plasma levels (P = 0.002 and P = 0.01 respectively) compared with healthy controls. Similarly, BDNF levels in the bipolar disorder group were lower than those in the MDD group. These results showed that the best model for predicting bipolar disorder during a first depressive episode was a combination of BDNF mRNA levels with plasma BDNF levels (receiver operating characteristics (ROC) = 0.80, logistic regression; ROC = 0.84, decision tree).
Conclusions
Our findings suggest that BDNF levels may serve as a potential differential diagnostic biomarker for bipolar disorder in a patient's first depressive episode.
The gene expression profile of a normal-suffering monozygotic twin pair is investigated to explore biological mechanisms of spastic type cerebral palsy. Main works include following three aspects: First, a cDNA microarray test is carried out to get the differentially expressed genes of the patient with cerebral palsy compared to her monozygotic twin sister. Second, these differentially expressed genes are searched for their bioinformation within 4 biological databases: FatiGO, FatiGOPlus, KEGG, and SOURCE. Third, a set of special genes and gene families are screened out from the spastic type cerebral palsy patient. These biological analyses reveal that those genes for cell junction are mostly down-regulated, while those genes for metabolism are mostly up-regulated. The individual genes, gene family, and their associated biological functions can reflect the pathological and physiological characteristics of the cerebral palsy.
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