Despite being almost 4000m above sea level, cereal crops have been grown in the Ngari Prefecture on the Tibetan Plateau for thousands of years. Where and when domestic crop species adapted to high-altitude growing conditions is a matter of ongoing debate. Here, the authors present a new radiocarbon date from the Gepa serul cemetery, providing the earliest evidence of naked six-rowed barley in Tibet (c. 3500 BP). Evaluating the available evidence for barley cultivation and interregional connections in central Asia at this time, two hypotheses are considered—a generational advance with farmers migrating up river valleys or rapid, long-distance trade through mountain corridors.

In the contemporary maritime industry, characterised by intense competition, reduced visibility due to heavy fog is a primary cause of accidents, significantly impairing maritime operational efficiency. Consequently, investigating foggy weather navigation safety holds crucial practical significance. This paper, through an analysis and synthesis of various aspects of foggy navigation technology, including foggy navigation regulations at different ports, fog warnings, foggy vessel environmental perception and foggy auxiliary navigation systems, explores the key issues concerning vessel navigation during foggy conditions from a scientific perspective. This discussion encompasses the aspects of regulatory frameworks, standardisation, and the development of intelligent and responsive onboard equipment. Finally, the paper offers a glimpse into potential strategies for fog navigation.

Wall-climbing robots work on large steel components with magnets, which limits the use of wireless sensors and magnetometers. This study aims to propose a novel autonomous localisation method (RGBD-IMU-AL) with an inertial measurement unit and a fixed RGB-D camera to improve the localisation performance of wall-climbing robots. The method contains five modules: calibration, tracking, three-dimensional (3D) reconstruction, location and attitude estimation. The calibration module is used to obtain the initial attitude angle. The tracking and 3D reconstruction module are used jointly to obtain the rough position and normal vector of the robot chassis. For the location module, a normal vector projection method is established to screen out the top point on the robot shell. An extended Kalman filter (EKF) is used to estimate the heading angle in the attitude estimation module. Experimental results show that the positioning error is within 0⋅02 m, and the positioning performance is better than that of the MS3D method. The heading angle error remains within 3⋅1°. The obtained results prove its applicability for the autonomous localisation in low-texture and magnetically disturbed environments.

Substantial changes resulting from the interaction of environmental and dietary factors contribute to an increased risk of obesity, while their specific associations with obesity remain unclear. Identify inflammation-related dietary patterns (DPs) and explore their associations with obesity among urbanized Tibetan adults under significant environmental and dietary changes.Totally, 1826 subjects from the suburbs of Golmud City were enrolled in an open cohort study, of which 514 were followed up. Height, weight, and waist circumference were used to define overweight and obesity. DPs were derived using reduced rank regression with 41 food groups as predictors and hs-CRP and prognostic nutritional index as inflammatory response variables. Altitude was classified as high or ultra-high. Two DPs were extracted. DP-1 was characterized by having high consumptions of sugar-sweetened beverages, savory snacks, and poultry, and a low intake of tsamba. DP-2 had high intakes of poultry, pork, animal offal, and fruits, and a low intake of butter tea. Participants in the highest tertiles (T3) of DPs had increased risks of overweight and obesity (DP-1: OR=1.37, 95% CI: 1.07, 1.77; DP-2: OR=1.48, 95% CI: 1.18, 1.85) than those in the lowest tertiles (T1). Participants in T3 of DP-2 had an increased risk of central obesity (OR=2.25, 95% CI: 1.49, 3.39) than those in T1. The positive association of DP-1 with overweight and obesity was only significant at high altitudes, while no similar effect was observed for DP-2. Inflammation-related DPs were associated with increased risks of overweight and/or obesity.

Natural infection by Trichinella sp. has been reported in humans and more than 150 species of animals, especially carnivorous and omnivorous mammals. Although the presence of Trichinella sp. infection in wild boars (Sus scrofa) has been documented worldwide, limited information is known about Trichinella circulation in farmed wild boars in China. This study intends to investigate the prevalence of Trichinella sp. in farmed wild boars in China. Seven hundred and sixty-one (761) muscle samples from farmed wild boars were collected in Jilin Province of China from 2017 to 2020. The diaphragm muscles were examined by artificial digestion method. The overall prevalence of Trichinella in farmed wild boars was 0.53% [95% confidence interval (CI): 0.51–0.55]. The average parasite loading was 0.076 ± 0.025 larvae per gram (lpg), and the highest burden was 0.21 lpg in a wild boar from Fusong city. Trichinella spiralis was the only species identified by multiplex polymerase chain reaction. The 5S rDNA inter-genic spacer region of Trichinella was amplified and sequenced. The results showed that the obtained sequence (GenBank accession number: OQ725583) shared 100% identity with the T. spiralis HLJ isolate (GenBank accession number: MH289505). Since the consumption of farmed wild boars is expected to increase in the future, these findings highlight the significance of developing exclusive guidelines for the processing of slaughtered farmed wild boar meat in China.

Mystical experiences are often regarded as potential sources of epistemic justification for religious beliefs. However, the ‘disanalogy objection’ maintains that, in contrast to sense perceptions, mystical experiences lack social verifiability and are thus merely subjective states that cannot substantiate objective truths. This article explores a novel externalist response that involves the concept of angels. As spiritual beings, angels can directly perceive God and verify these perceptions in their celestial community. Thus, the ‘direct perception of God’ is not inherently incapable of social verification. While invoking angels might appear contentious, it coheres with the externalist approach of conceptualising cognitive states under hypothetical settings. Despite the differences between humans and angels and their lack of interaction for verification purposes, our approach remains valid because mystics not only exemplify the same general type of ‘direct perception of God’ as angels but can also be preliminary members of a wider celestial community.

This study investigated the impact of diallyl disulfide (DADS) on oxidative stress induced by hydrogen peroxide (H2O2) in ovine rumen epithelial cells (RECs). Initially, the effects of DADS were evaluated on cellular reactive oxygen species (ROS) levels, antioxidant capacity in RECs were estimated. Then, RNA-seq analysis was conducted in DADS-treated and untreated cells to analyze the differential gene expression, as well as Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Finally, the effects of DADS on Kelch-like ECH associated protein 1/the nuclear factor erythroid 2-related factor 2 (Keap1/Nrf2) signaling pathway in RECs were evaluated. Results showed that DADS remarkably enhanced superoxide dismutase (SOD) activity and total antioxidant capacity (T-AOC) (P < 0.05) while reducing ROS and malonaldehyde production (P < 0.05) in H2O2-treated RECs. Transcriptomic analysis revealed that DADS might influence glutathione synthesis through cysteine and methionine metabolism, thereby affecting the transcription of genes involved in immunity and oxidative stress. The DADS treatment resulted in increased nuclear translocation of Nrf2 and upregulation of mRNA and protein levels of quinone oxidoreductase 1, heme oxygenase 1, and Nrf2. The Nrf2-specific inhibitor nullified the protective effects of DADS on malonaldehyde formation induced by H2O2 and decreased T-AOC and SOD activities. In conclusion, DADS demonstrated the ability to alleviate oxidative stress in RECs by promoting antioxidative capacity through the Keap1/Nrf2 signaling pathway.

Studies on obesity and risk factors from a life-course perspective among residents in the Tibet Plateau with recent economic growth and increasing obesity are important and urgently needed. The birth cohort in this area provides a unique opportunity to examine the association between maternal dietary practice and neonatal obesity. The study aims to detect the prevalence of obesity among neonates, associated with maternal diet and other factors, supporting life-course strategies for obesity control. A cohort of pregnant women was enrolled in Tibet Plateau and followed till childbirth. Dietary practice during pregnancy was assessed using the Chinese FFQ – Tibet Plateau version, food items and other variables were associated with the risk for obesity of neonates followed by logistic regression, classification and regression trees (CART) and random forest. Of the total 1226 mother–neonate pairs, 40·5 % were Tibetan and 5·4 % of neonates with obesity. Consuming fruits as a protective factor for obesity of neonates with OR (95 % CI) = 0·61 (0·43, 0·87) from logistic regression; as well as OR = 0·20 (0·12, 0·35) for consuming fruits (≥ weekly) from CART. Removing fruit consumption to avoid overshadowing effects of other factors, the following were influential from CART: maternal education (more than middle school, OR = 0·22 (0·13, 0·37)) and consumption of Tibetan food (daily, OR = 3·44 (2·08, 5·69). Obesity among neonates is prevalent in the study population. Promoting healthy diets during pregnancy and strengthening maternal education should be part of the life-course strategies for obesity control.

We present evidence revealing that an object with specific properties can exhibit multiple stable falling postures at low Reynolds numbers. By scrutinizing the force equilibrium relationship of a fixed object at various attack angles and Reynolds numbers, we introduce a methodology that can obtain the stable falling postures of the object. This method saves computational resources and more intuitively presents the results in the full parameter domain. Our findings are substantiated by free-fall tests conducted through both physical experiments and numerical simulations, which validate the existence of multiple stable solutions in accordance with the interpolation results obtained with fixed objects. Additionally, we quantify the abundance and distribution patterns of stable falling postures for a diverse range of representative shapes. This discovery highlights the existence of multiple stable solutions that are universally present across objects of different shapes. The implications of this research extend to the design, stability control and trajectory prediction of all free and controlled flights in both air and water.

The mean flow in a turbulent boundary layer (TBL) deviates from the canonical law of the wall (LoW) when influenced by a pressure gradient. Consequently, LoW-based near-wall treatments are inadequate for such flows. Chen et al. (J. Fluid Mech., vol. 970, 2023, A3) derived a Navier–Stokes-based velocity transformation that accurately describes the mean flow in TBLs with arbitrary pressure gradients. However, this transformation requires information on total shear stress, which is not always readily available, limiting its predictive power. In this work, we invert the transformation and develop a predictive near-wall model. Our model includes an additional transport equation that tracks the Lagrangian integration of the total shear stress. Particularly noteworthy is that the model introduces no new parameters and requires no calibration. We validate the developed model against experimental and computational data in the literature, and the results are favourable. Furthermore, we compare our model with equilibrium models. These equilibrium models inevitably fail when there are strong pressure gradients, but they prove to be sufficient for boundary layers subjected to weak, moderate and even moderately high pressure gradients. These results compel us to conclude that history effects in mean flow, which negatively impact the validity of equilibrium models, can largely be accounted for by the material time derivative term and the pressure gradient term, both of which require no additional modelling.

Pebrine disease, caused by Nosema bombycis (Nb) infection in silkworms, is a severe and long-standing disease that threatens sericulture. As parasitic pathogens, a complex relationship exists between microsporidia and their hosts at the mitochondrial level. Previous studies have found that the translocator protein (TSPO) is involved in various biological functions, such as membrane potential regulation, mitochondrial autophagy, immune responses, calcium ion channel regulation, and cell apoptosis. In the present study, we found that TSPO expression in silkworms (BmTSPO) was upregulated following Nb infection, leading to an increase in cytoplasmic calcium, adenosine triphosphate, and reactive oxygen species levels. Knockdown and overexpression of BmTSPO resulted in the promotion and inhibition of Nb proliferation, respectively. We also demonstrated that the overexpression of BmTSPO promotes host cell apoptosis and significantly increases the expression of genes involved in the immune deficiency and Janus kinase-signal transducer and the activator of the transcription pathways. These findings suggest that BmTSPO activates the innate immune signalling pathway in silkworms to regulate Nb proliferation. Targeting TSPO represents a promising approach for the development of new treatments for microsporidian infections.

This study proposes a novel super-resolution (or SR) framework for generating high-resolution turbulent boundary layer (TBL) flow from low-resolution inputs. The framework combines a super-resolution generative adversarial neural network (SRGAN) with down-sampling modules (DMs), integrating the residual of the continuity equation into the loss function. The DMs selectively filter out components with excessive energy dissipation in low-resolution fields prior to the super-resolution process. The framework iteratively applies the SRGAN and DM procedure to fully capture the energy cascade of multi-scale flow structures, collectively termed the SRGAN-based energy cascade reconstruction framework (EC-SRGAN). Despite being trained solely on turbulent channel flow data (via ‘zero-shot transfer’), EC-SRGAN exhibits remarkable generalization in predicting TBL small-scale velocity fields, accurately reproducing wavenumber spectra compared to direct numerical simulation (DNS) results. Furthermore, a super-resolution core is trained at a specific super-resolution ratio. By leveraging this pretrained super-resolution core, EC-SRGAN efficiently reconstructs TBL fields at multiple super-resolution ratios from various levels of low-resolution inputs, showcasing strong flexibility. By learning turbulent scale invariance, EC-SRGAN demonstrates robustness across different TBL datasets. These results underscore the potential of EC-SRGAN for generating and predicting wall turbulence with high flexibility, offering promising applications in addressing diverse TBL-related challenges.

The evolution of the water-entry cavity affects the impact load and the motion of the body. This paper adopts the Eulerian finite element method for multiphase flow for simulations of the high-speed water-entry process. The accuracy and convergence of the numerical method are verified by comparing it with the experimental data and the results of the transient cavity dynamics theory. Based on the results, the representative characteristics of the cavity are discussed from the perspective of the cavity cross-section. It is found that the asymmetry of the cavity expansion and contraction durations is related to the motion of the free surface and the closure of the cavity. The uplift of the free surface suppresses cavity expansion, while the jet generated from free surface closure accelerates cavity contraction. The duration of the contraction of the cavity near the free surface is shorter than the expansion duration due to the change in the velocity distribution caused by the free surface motion. The necking phenomenon during deep closure leads to an increase in the internal pressure of the cavity, prolonging cavity contraction near the deep closure area. This work provides new insights into the cavity dynamics in high-speed water entry.

Vessel trajectories from the Automatic Identification System (AIS) play an important role in maritime traffic management, but a drawback is the huge amount of memory occupation which thus results in a low speed of data acquisition in maritime applications due to a large number of scattered data. This paper proposes a novel online vessel trajectory compression method based on the Improved Open Window (IOPW) algorithm. The proposed method compresses vessel trajectory instantly according to vessel coordinates along with a timestamp driven by the AIS data. In particular, we adopt the weighted Euclidean distance (WED), fusing the perpendicular Euclidean distance (PED) and synchronous Euclidean distance (SED) in IOPW to improve the robustness. The realistic AIS-based vessel trajectories are used to illustrate the proposed model by comparing it with five traditional trajectory compression methods. The experimental results reveal that the proposed method could effectively maintain the important trajectory features and significantly reduce the rate of distance loss during the online compression of vessel trajectories.

This research communication reports the effects of a compound enzyme preparation consisting of fibrolytic (cellulase 3500 CU/g, xylanase 2000 XU/g, β-glucanase 17 500 GU/g) and amylolytic (amylase 37 000 AU/g) enzymes on nutrient intake, rumen fermentation, serum parameters and production performance in primiparous early-lactation (47 ± 2 d) dairy cows. Twenty Holstein–Friesian cows in similar body condition scores were randomly divided into control (CON, n = 10) and experimental (EXP, n = 10) groups in a completely randomized single-factor design. CON was fed a basal total mixed ration diet and EXP was dietary supplemented with compound enzyme preparation at 70 g/cow/d. The experiment lasted 4 weeks, with 3 weeks for adaptation and then 1 week for measurement. Enzyme supplementation significantly increased diet non-fibrous carbohydrates (NFC) content as well as dry matter intake (DMI) and NFC intake (P < 0.05). EXP had increased ruminal butyrate and isobutyrate percentages (P < 0.01) but decreased propionate and valerate percentages (P < 0.05), as well as increased serum alkaline phosphatase activity and albumin concentration (P ≤ 0.01). Additionally, EXP had increased milk yield (0.97 kg/d), 4% fat corrected milk yield and energy corrected milk yield, as well as milk fat and protein yield (P < 0.01). In conclusion, dietary supplementation with a fibrolytic and amylolytic compound enzyme preparation increased diet NFC content, DMI and NFC intake, affected rumen fermentation by increasing butyrate proportion at the expense of propionate, and enhanced milk performance in primiparous early-lactation dairy cows.

A primary objective of integral methods, such as the momentum integral method, is to discern the physical processes contributing to skin friction. These methods encompass the momentum, kinetic energy and angular momentum integrals. This paper reformulates existing integrals based on the double-averaged Navier–Stokes equations, and extends their application to flows over rough walls. Our derivation yields distinct decompositions for the bottom-wall viscous friction coefficient, denoted as $C_S$, and the roughness element drag coefficient $C_R$. The decompositions comprise three terms: a viscous term, a turbulent term and a roughness (dispersive) term – regardless of the flow configuration, be it channel or boundary layer. Notably, when these integrals are evaluated for laminar flow scenarios, only the viscous term remains significant. In addition, we elucidate the spatial distributions of the terms within these decompositions. To demonstrate the practicality of our formulations, we apply them to analyse data from direct numerical simulations of turbulent half-channel flows. These flows feature aligned and staggered cubical roughness at various packing densities. Our analyses, based on kinetic-energy-oriented decompositions, reveal that when the surface coverage density $\lambda _p$ is small, the dominant terms within the decompositions are the viscous and turbulent terms. With increasing $\lambda _p$, the viscous dissipation term decreases, while the turbulent production term increases and then decreases. These variations arise from a subdued near-wall cycle and the development of a shear layer at the height of the cubes.