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The Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing is a prospective study of 1,112 individuals (211 with Alzheimer's disease (AD), 133 with mild cognitive impairment (MCI), and 768 healthy controls (HCs)). Here we report diagnostic and cognitive findings at the first (18-month) follow-up of the cohort. The first aim was to compute rates of transition from HC to MCI, and MCI to AD. The second aim was to characterize the cognitive profiles of individuals who transitioned to a more severe disease stage compared with those who did not.
Methods:
Eighteen months after baseline, participants underwent comprehensive cognitive testing and diagnostic review, provided an 80 ml blood sample, and completed health and lifestyle questionnaires. A subgroup also underwent amyloid PET and MRI neuroimaging.
Results:
The diagnostic status of 89.9% of the cohorts was determined (972 were reassessed, 28 had died, and 112 did not return for reassessment). The 18-month cohort comprised 692 HCs, 82 MCI cases, 197 AD patients, and one Parkinson's disease dementia case. The transition rate from HC to MCI was 2.5%, and cognitive decline in HCs who transitioned to MCI was greatest in memory and naming domains compared to HCs who remained stable. The transition rate from MCI to AD was 30.5%.
Conclusion:
There was a high retention rate after 18 months. Rates of transition from healthy aging to MCI, and MCI to AD, were consistent with established estimates. Follow-up of this cohort over longer periods will elucidate robust predictors of future cognitive decline.
Of 120 specimens of garden fertilizers of animal origin purchased in retail shops, 40 (33·3%) were found to be contaminated with salmonella organisms. Untreated bone meal (53·1%) was the most heavily contaminated but 25% of specimens of this product classed as heat-treated or sterilized were positive. In all, 32 serotypes were identified.
Paul Tillich (1886–1965) was born and raised in Germany. He received his PhD in 1910 and in 1912 was ordained in the ministry. From 1914 to 1918 he served as a chaplain in the First World War. Returning from the war, he taught both philosophy and theology at several universities. In 1933 the Nazi government suspended Tillich's position at the University of Frankfurt. He then went to the United States where, until 1937, he was Visiting Professor of Philosophy of Religion and Systematic Theology at Union Theological Seminary. He served at Union as Associate Professor of Philosophical Theology (1937–40) and Professor (1941–55). From 1955 to 1962, he was a University Professor at Harvard, and during his last three years he was the Nuveen Professor of Theology in the Divinity School of the University of Chicago. He was buried in New Harmony, Indiana. Tillich wrote a number of books among which are the following: Systematic Theology (3 vols, 1951–63), The Courage to Be (1952), Biblical Religion and the Search for Ultimate Reality (1955) and Dynamics of Faith (1957).
In his writings Tillich describes certain basic questions (he calls them ‘existential questions’) that arise out of the human situation. These questions cannot be answered within that situation. Their answers, he claims, are found in the great symbols of the Christian message. In his writings he endeavours to analyse the human situation and to interpret the traditional Christian symbols as answers to this situation.
The issue between my view and Hasker's concerns a certain principle that he takes to be true, but I hold to be false. The principle in question asserts that failing to do better than one did is a defect only if doing the best one can is possible for one to do. I claim that this principle is false because if an all-knowing, all-powerful being were confronted with an unending series of increasingly better creatable worlds and deliberately chose to create the least good world, that being would thereby show itself to be something less than a supremely perfect world-creator. In fact, I argue that if a supremely perfect world-creator were to exist and create a world, it would have to be a world than which there is no better creatable world.
It is fitting that one of the last pieces of philosophical writing to come from Reid's hand should bear the title “Of Power.” For the concept “power” lies at the foundation of Reid's account of agent-causation, which in turn is the central idea in his account of human freedom and responsibility. In this final piece of philosophizing on this subject, Reid begins by pointing out that: “Every voluntary exertion to produce an event implies a conception of the event, and some belief or hope that the exertion will be followed by it” (OP: 3). Accordingly, our willing (deciding) to take a walk in the woods implies our having a conception of our taking a walk in the woods and some belief or hope that an exertion of ours intended to bring that about will be followed by our taking a walk in the woods. Reid takes this claim of his to imply that a conception of power is antecedent to every deliberate act.
Does he think that the earliest exertions by an infant involve a conception of power? No. Reid thinks that our earliest exertions are instinctive, unaccompanied by a conception of some goal to be accomplished. It is only when experience teaches us that certain exertions are followed by certain events that we learn to make these exertions voluntarily and deliberately in order to produce such an event. And once we believe that the event depends upon our exertion, we then have “the conception of power in ourselves to produce the event” (ibid.). Reid therefore concludes that our conception of power “is the fruit of experience and not innate” (ibid.).
According to religious pluralism, the profound differences among the chief objects of adoration in the great religious traditions are largely due to the different ways in which a single transcendent reality is experienced and conceived in human life. The most prominent developer and defender of religious pluralism in the twentieth century is John Hick. Hick uses the expression ‘the Real’ to designate the transcendent reality ‘authentically experienced’ as the different gods and impersonal absolutes worshipped in the major religious traditions. A central claim Hick makes is that, apart from some purely formal characteristics, the Real is ineffable in that the intrinsic properties making up its nature are beyond the scope of any human concepts. I explore this central claim and argue that it implies the dubious, if not incoherent, view that the Real in itself has neither one of many pairs of contradictory properties.