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Conventional thought holds that in formerly glaciated areas straying of anadromous fish from nearby unglaciated areas established contemporary salmon populations. An additional explanation for patterns of salmon life-history diversity and population structure derives from isolation of populations in proglacial lakes. We evaluate evidence for these potentially complementary hypotheses in chum salmon from two previously glaciated North American regions: the southern Alaska Peninsula/upper Cook Inlet and the Salish Sea of northwestern Washington and southern British Columbia. Some chum salmon populations in the southern Alaska Peninsula are genetic outliers compared with other nearby populations, while Salish Sea chum salmon populations have greater region-wide genetic divergence and lower gene diversity. Within-population genetic diversity and among-population divergence in both study areas support a hypothesis of salmon persistence relying on cryptic isolation and freshwater-resident (trout-like) life histories in proglacial lakes. We find that ice age adaptation of salmon to a trout life history helps explain aspects of contemporary population structure and life-history diversity.
Community structure in networks naturally arises in various applications. But while the topic has received significant attention for static networks, the literature on community structure in temporally evolving networks is more scarce. In particular, there are currently no statistical methods available to test for the presence of community structure in a sequence of networks evolving over time. In this work, we propose a simple yet powerful test using e-values, an alternative to p-values that is more flexible in certain ways. Specifically, an e-value framework retains valid testing properties even after combining dependent information, a relevant feature in the context of testing temporal networks. We apply the proposed test to synthetic and real-world networks, demonstrating various features inherited from the e-value formulation and exposing some of the inherent difficulties of testing on temporal networks.
Living in a country with a large gap between high and low earners has been linked to poor health, including depression. Less studied is gene-by-environment interplay with income inequality as the environmental exposure. Here, we examine the association between childhood exposure to inequality and individual differences in adult depressive symptoms, testing for moderation of genetic influences by inequality using polygenic indices for major depressive disorder, as well as twin models.
Methods
The research participants were 69,924 members of twin studies from four developed countries, born between 1893 and 1979, aged 22–103 years at depressive symptom assessment. Genotyping was available for 6,256 participants. Income inequality was operationalized as share of income accruing to the top 1% for each country when the participants were between age 5 and 15 years.
Results
Childhood income inequality was associated with depressive symptom scores in adulthood, adjusting for covariates. Each 1% rise in inequality was associated with 0.295 higher depressive symptoms (scaled on T-score units). In genetic analyses, interaction effects showed that men who faced more inequality as children and had higher genetic risk for depression reported modestly higher depressive symptoms compared to other men. For women, both genetic risk and inequality mattered, with each independently associated with depressive symptoms. Twin models showed that inequality moderated genetic variance underlying depressive symptoms; heritability of depressive symptoms was higher where exposure to income inequality was higher.
Conclusions
Findings illustrate the long reach of childhood exposure to income inequality and suggest that advantaged environments may help protect against the effects of deleterious genes.
Subjective cognitive complaints (SCC) can precede cognitive decline and are associated with demographic, exposure, lifestyle, and psychological factors. Prevalences of SCC and their correlates in individuals with repetitive head impacts (RHI) are poorly understood. This study characterized SCC in former elite American football players by frequency, mood and behavioral correlates, concordance with informant reports, and associations with neuropsychological test performance, cerebrospinal fluid (CSF), and magnetic resonance imaging (MRI) markers of neurodegeneration.
Method:
Former American football players (n = 180) completed measures of global and domain-specific SCC, neuropsychiatric symptom questionnaires, neuropsychological testing, lumbar puncture, and MRI. Elastic net regression evaluated the relative importance of potential SCC correlates. Intraclass correlation coefficients measured concordance between self and informant reports. Multiple linear regressions tested associations between SCC and verbal memory and executive functioning scores. CSF Aβ1-42, p-tau181, t-tau, neurofilament light (NfL), hippocampal volume, and regional cortical thickness were examined for their potential associations with SCC.
Results:
Rates of SCC ranged from 43 to 77% depending on the domain. Symptoms of depression, impulsivity, and anxiety were strongly associated with SCC. Self- and informant-reported SCC showed moderate inter-rater agreement. Adjusting for age, race, education, APOE ϵ4 carrier status, and depressive symptoms, SCC were associated with lower objective verbal memory and executive functioning performance. SCC were associated with lower parahippocampal cortical thickness but not with hippocampal volume or any of the measured CSF tests.
Conclusions:
SCC are strongly associated with neuropsychiatric factors in former American football players. SCC may also be a marker of cognitive decline and neurodegeneration.
The Radio Neutrino Observatory-Greenland (RNO-G, at Summit Station) experiment comprises an extensive fat-dipole antenna array deployed into ice boreholes over an eventual area of approximately 35 km2. Since the RNO-G experimental sensitivity depends on the radio-frequency properties of the firn, which are known to vary laterally on sub-km distance scales and vertically on sub-meter distance scales, a technique for quickly extracting information on firn ice properties with depth ($n(z)$) during drilling and deployment is desirable. Given that a dipole’s resonant wavelength is fixed by geometry, the resonant frequency $f_{res}$ (measured as an S-parameter reflection coefficient [‘$S_{11}$’] minimum) scales inversely with the local refractive index, allowing a translation of a depth-dependent $S_{11}$(z) profile into $n(z)$. $S_{11}$(z) data were initially taken in August 2024 using a dipole lowered into a newly drilled 98 ± 1 mm diameter, 350 m deep borehole at Summit Station, Greenland, approximately 1 km from the site of the original GISP-2 core; improved measurements were subsequently made in May 2025. We conclude that $S_{11}$(z) data can be used to estimate $n(z)$, on 50 cm vertical scales, at the per cent level of accuracy required by experiments such as RN0-G.
We aimed to examine the association between team functioning in primary care and patients’ self-efficacy and quality of life. We also examined the moderation effect of multimorbidity and social vulnerability on this association.
Background:
Team-based care has been adopted as an appropriate model to deliver comprehensive primary care services to meet the complex needs of patients. Little is known about the association between team functioning and patients’ self-efficacy for managing chronic conditions (SEMCD) and quality of life.
Methods:
We used mixed-random effect modelling to analyse secondary cross-sectional data. Data were collected in primary care practices in three Canadian regions. Dependent variables included patients’ SEMCD and quality of life. The independent variable was team functioning measured using the Team Climate Inventory scale (TCI). We also included two interaction terms: social vulnerability and TCI, and multimorbidity and TCI. Control variables included patient characteristics, patients’ experience with care and practice characteristics.
Findings:
Eighty-seven practices and 1,929 patients participated in the study. Of these, 67% were female, 5% had two or more social vulnerabilities and 65% had multimorbidity. Regression analyses failed to find an association between team functioning and patients’ self-efficacy or quality of life. There was a strong positive association between team functioning and self-efficacy for people with multimorbidity (p = .005) compared to those without multimorbidity. There was also a strong positive association between team functioning and quality of life for those with two or more vulnerabilities (p < .001) but not for those with fewer vulnerabilities. The findings showed people with multimorbidity and increased vulnerabilities could benefit from well-functioning teams. Supporting better team functioning through effective communication (e.g., team meetings) and care coordination; encouraging full participation of all team members in service delivery; and establishing clear team objectives, roles and responsibilities can better meet the needs of complex patients.
Bentazon, a photosystem II–inhibiting postemergence herbicide, has been used in corn (Zea mays L.), soybean, wheat (Triticum aestivum L.), and vegetables to manage common lambsquarters (Chenopodium album L.), although growers have reported reduced efficacy across the country. The aim of this study was to describe the sensitivity response of C. album to bentazon and identify whether reported escapes could be considered to be cases of herbicide resistance evolution. We evaluated C. album populations collected from lima and snap bean (Phaseolus vulgaris L.) fields across Delaware, Illinois, Minnesota, New York, and Oregon. Dose–response experiments with 25 populations were conducted to create a reference response to bentazon, using rates that ranged from 0 to 8,406 g ai ha−1. Injury ratings and biomass were assessed at 28 d after herbicide application, and the herbicide rates required to reduce growth by 50% (I50 or GR50) and 80% (I80 or GR80) were calculated. Results indicated C. album responses to bentazon varied within and across states. Across all populations studied, the GR50 for biomass reduction ranged from 159 to 816 g ha−1, and GR80 from 230 to 1,944 g ha−1 with populations from Oregon exhibiting the highest average GR50, followed by those from New York, the Northcentral states, and Delaware. Based on our criteria that the injury rating- or biomass-based resistance index (ratio between I50 or GR50 of the suspected resistant and a local selected susceptible population) had to be at least 2, and the I80 or GR80 should be greater than the labeled field rate, one population from New York (NY6) and one from Oregon (OR29) were considered to be resistant. This research underscores the wide variation in C. album response to bentazon across the United States and the importance of herbicide resistance diagnostic strategies that account for local population variation, and highlights the increasing challenge of C. album management in specialty crops.
This review highlights 10 recent advances in climate change research with high policy relevance, spanning diverse topics: (1) the global temperature jump of 2023–2024; (2) sea surface warming and marine heatwaves; (3) land carbon sinks; (4) interactions between climate change and biodiversity loss; (5) accelerated groundwater decline; (6) global dengue incidence; (7) income and labour productivity loss; (8) strategic considerations for scaling carbon dioxide removal (CDR); (9) integrity of carbon credit markets; and (10) policy mixes for climate change mitigation.
Technical Summary
Interdisciplinary understanding is vital for delivering sound climate policy advice. However, navigating the ever-growing and increasingly diverse scholarly literature on climate change is challenging for any individual researcher. This annual synthesis highlights and explains recent advances across a variety of fields of climate change research. This year, the 10 insights focus on: (1) the record-warmth of 2023/2024 and the elevated Earth energy imbalance; (2) acceleration of ocean warming and intensifying marine heatwaves; (3) northern land carbon sinks under strain; (4) reinforcing feedback between biodiversity loss and climate change; (5) accelerated depletion of groundwater; (6) global dengue incidence; (7) global income losses and labour productivity declines; (8) strategic scaling of CDR; (9) integrity challenges in carbon credit markets and emerging responses; and (10) effective policy mixes for emissions reductions. The insights have been written to be accessible to researchers from different fields, serving as entry-points to specific topics, as well as providing an overview of the evolving landscape of climate change research. In the final section, the insights are used to develop overarching policy-relevant messages. This paper provides the basis for a science-policy report that was shared with all Party delegations ahead of COP30 in Belém, Brazil.
Social Media Summary
Highlights of climate change research in 2024–2025: 10insightsclimate.science
Pulsed gravity currents are generated by the sequential release of dense material into a lighter ambient. We investigate the dynamics of pulsed gravity currents using physical scale experiments, two-dimensional depth-averaged shallow water equation (SWE) based models and three-dimensional lattice Boltzmann method (LBM) simulations. Integrating these results we show for the first time that short duration pulsed releases generate intrusive layers, which accelerate front propagation relative to an instantaneously released current of the same total volume. Conversely, a long delay time between pulses produces a current that propagates slower than an equivalent instantaneous release. This finding is supported by physical experiments and depth-resolving LBM simulations. The depth-resolving simulations show that intrusions in pulsed flows experience less drag resistance than those generated by instantaneous releases. The depth-averaged model considered in the present study does not accurately capture the intrusive flow dynamics of pulsed currents. However, the limitations of the finite-depth SWE model may be mitigated by extensions to incorporate entrainment and density stratification. The results also motivate further research into the impact of buoyancy Reynolds number and channel slope on the propagation of pulsed currents.
Existing datasets provided by statistical agencies (e.g. Eurostat) show that the economic and financial crisis that unfolded in 2008 significantly impacted the lives and livelihoods of young people across Europe. Taking these official statistics as a starting point, the collaborative research project “Cultural Pathways to Economic Self-Sufficiency and Entrepreneurship in Europe” (CUPESSE) generated new survey data on the economic and social situation of young Europeans (18–35 years). The CUPESSE dataset allows for country-comparative assessments of young people’s perceptions about their socio-economic situation. Furthermore, the dataset includes a variety of indicators examining the socio-economic situation of both young adults and their parents. In this data article, we introduce the CUPESSE dataset to political and social scientists in an attempt to spark a debate on the measurements, patterns and mechanisms of intergenerational transmission of economic self-sufficiency as well as its political implications.
The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 21 twin studies from 5 countries (Australia, Denmark, Finland, Sweden, and United States) established to explore the nature of gene–environment interplay in cognitive, physical, and emotional health across the adult lifespan. The combined data from over 145,000 participants (aged 18 to 108 years at intake) has supported multiple research projects over the three phases of development since its inception in 2010. Phases 1 and 2 focused on launching and growing the consortium and supported important developments in data harmonization, analyses of data pooled across multiple studies, incorporation of linkages to national registries and conscription data, and integration of molecular genetic and classical twin designs. IGEMS Phase 3 focuses on developing appropriate infrastructure to maximize utilization of this large twin consortium for aging research.
The results of research on the human remains and artefacts recently discovered at Heaning Wood Bone Cave, Cumbria, UK are reported. A programme of radiocarbon dating has established that the human remains include the earliest so far discovered in northern Britain, the ‘Ossick Lass’, which date between 9290 and 8925 cal BC. The cave was used for burial during three phases in prehistory: one individual dating to the Early Mesolithic, four to the Early Neolithic and two to the Early Bronze Age and is thus an important addition to our developing knowledge about the deposition of human remains in caves in north-west Europe at these dates. Genomic analysis has established that all but one of the sampled individuals were biologically female. Osteological and taphonomic analysis shows that, in each phase, the burial practice seems to have been successive inhumation of the recently deceased body into the vertical entrance of the cave. Artefacts associated with the burials include perforated periwinkle shell beads radiocarbon dated to the Early Mesolithic, a small assemblage of worked stone, including diagnostically Early Neolithic pieces, and sherds of Early Bronze Age Collared Urn pottery.
An outbreak of emm92/ST82 Streptococcus pyogenes was detected through prospective genomic surveillance at a military treatment facility. Twenty-one of twenty-six patients had confirmed epidemiological links to grappling sports. One case resulted from household transmission. The benefits of routine surveillance extend beyond the hospital environment enabling the detection of community-driven transmission.
Delsarte theory, more specifically the study of codes and designs in association schemes, has proved invaluable in studying an increasing assortment of association schemes in recent years. Tools motivated by the study of error-correcting codes in the Hamming scheme and combinatorial t-designs in the Johnson scheme apply equally well in association schemes with irrational eigenvalues. We assume here that we have a commutative association scheme with irrational eigenvalues and wish to study its Delsarte T-designs. We explore when a T-design is also a $T'$-design, where $T'\supseteq T$ is controlled by the orbits of a Galois group related to the splitting field of the association scheme. We then study Delsarte designs in the association schemes of finite groups, with a detailed exploration of the dicyclic groups.
Paleontology provides insights into the history of the planet, from the origins of life billions of years ago to the biotic changes of the Recent. The scope of paleontological research is as vast as it is varied, and the field is constantly evolving. In an effort to identify “Big Questions” in paleontology, experts from around the world came together to build a list of priority questions the field can address in the years ahead. The 89 questions presented herein (grouped within 11 themes) represent contributions from nearly 200 international scientists. These questions touch on common themes including biodiversity drivers and patterns, integrating data types across spatiotemporal scales, applying paleontological data to contemporary biodiversity and climate issues, and effectively utilizing innovative methods and technology for new paleontological insights. In addition to these theoretical questions, discussions touch upon structural concerns within the field, advocating for an increased valuation of specimen-based research, protection of natural heritage sites, and the importance of collections infrastructure, along with a stronger emphasis on human diversity, equity, and inclusion. These questions offer a starting point—an initial nucleus of consensus that paleontologists can expand on—for engaging in discussions, securing funding, advocating for museums, and fostering continued growth in shared research directions.
Attention-deficit/hyperactivity disorder (ADHD) is more commonly missed or diagnosed later in females than in males. One explanation is that diagnostic criteria have been informed by research primarily based on male samples and may not adequately capture the female presentation of ADHD.
Aims
This study used a qualitative approach to better understand female ADHD in childhood, from the perspective of young women and non-binary adults with ADHD.
Method
Twelve young adults (10 women and 2 non-binary individuals assigned female at birth, aged 18–25 years) with ADHD were interviewed to describe their lived experiences of ADHD throughout childhood. Interviews were transcribed verbatim and qualitatively analysed using the framework method, a codebook approach to thematic analysis.
Results
Participants reported experiencing a range of ADHD symptoms, some of which are not included in current diagnostic criteria. Four core themes were identified: (a) socially oriented and internalised symptoms, (b) social impacts, (c) masking and compensation and (d) the importance of context. Theme one describes how girls with ADHD may experience symptoms as more socially oriented (e.g. losing track of thoughts in a conversation), non-disruptive (e.g. doodling) and internalised (e.g. feeling frustrated) than those described by current diagnostic criteria. Theme two highlights the importance of social impacts of ADHD on friends, home and school. Theme three describes the desire to ‘fit in’ socially, behaviours and strategies used to mask symptoms and associated unfavourable consequences. Theme four highlights variability in symptoms across different environmental contexts.
Conclusions
This study suggests that the presentation of ADHD symptoms in girls may be socially oriented, internalised and especially influenced by the social context. Also, female ADHD symptoms may be less visible due to scaffolding, masking and context. Future research should consider whether current ADHD diagnostic criteria require adjustment, to aid earlier recognition and diagnosis of ADHD in children and young people, especially in females.
Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement.
Methods
We conducted a genome-wide association study (GWAS) of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorders (DSM-NicDep) in 61,861 individuals (47,884 of European ancestry [EUR], 10,231 of African ancestry, and 3,746 of East Asian ancestry) and compared the results to other nicotine-related phenotypes.
Results
We replicated the well-known association at the CHRNA5 locus (lead single-nucleotide polymorphism [SNP]: rs147144681, p = 1.27E−11 in EUR; lead SNP = rs2036527, p = 6.49e−13 in cross-ancestry analysis). DSM-NicDep showed strong positive genetic correlations with cannabis use disorder, opioid use disorder, problematic alcohol use, lung cancer, material deprivation, and several psychiatric disorders, and negative correlations with respiratory function and educational attainment. A polygenic score of DSM-NicDep predicted DSM-5 tobacco use disorder criterion count and all 11 individual diagnostic criteria in the independent National Epidemiologic Survey on Alcohol and Related Conditions-III sample. In genomic structural equation models, DSM-NicDep loaded more strongly on a previously identified factor of general addiction liability than a “problematic tobacco use” factor (a combination of cigarettes per day and nicotine dependence defined by the Fagerström Test for Nicotine Dependence). Finally, DSM-NicDep showed a strong genetic correlation with a GWAS of tobacco use disorder as defined in electronic health records (EHRs).
Conclusions
Our results suggest that combining the wide availability of diagnostic EHR data with nuanced criterion-level analyses of DSM tobacco use disorder may produce new insights into the genetics of this disorder.