Recent experiments and simulations have sparked growing interest in the study of Rayleigh–Bénard convection in very slender cells. One pivotal inquiry arising from this interest is the elucidation of the flow structure within these very slender cells. Here we employ tomographic particle image velocimetry, for the first time, to capture experimentally the full-field three-dimensional and three-component velocity field in a very slender cylindrical cell with aspect ratio $\Gamma =1/10$. The experiments cover a Rayleigh number range $5.0 \times 10^8 \leqslant Ra \leqslant 5.0 \times 10^9$ and Prandtl number 5.7. Our experiments reveal that the flow structure in the $\Gamma =1/10$ cell is neither in the multiple-roll form nor in the simple helical form; instead, the ascending and descending flows can intersect and cross each other, resulting in the crossing events. These crossing events separate the flow into segments; within each segment, the ascending and descending flows ascend or descend side by side vertically or in the twisting manner, and the twisting is not unidirectional, while the segments near the boundary can also be in the form of a donut like structure. By applying the mode decomposition analyses to the measured three-dimensional velocity fields, we identified the crossing events as well as the twisting events for each instantaneous flow field. Statistical analysis of the modes reveals that as $Ra$ increases, the average length of the segments becomes smaller, and the average number of segments increases from 2.5 to 3.9 in the $Ra$ range of our experiments.

Although it is well established that gestational diabetes mellitus (GDM) is associated with fetal overgrowth in singleton pregnancies, little is known about its role in twins. We aimed to explore the relationship between GDM and the longitudinal fetal growth in twin pregnancies. This was a retrospective matched cohort study of GDM and non-GDM twin pregnancies delivered ≥36 weeks without other complications. All the women performed ≥3 ultrasounds after 22 weeks. Linear mixed models (LMMs) were used to explore the relationships between longitudinal fetal growth trajectories and GDM. Group-based trajectory modeling (GBTM) and generalized estimating equation (GEE) were applied to identify the latent growth patterns and investigate their relationships with GDM. In total, 215 GDM and 645 non-GDM twins were included, the majority of the patients did not require medication therapy (n = 202, GDMA1). LMM revealed that, compared with non-GDM, GDM was associated with an average increase in fetal weight of 4.36 g (95% CI [1.25, 7.48]) per week. GBTM and GEE further revealed that GDM increased the odds of fetal weight trajectory to nearly 40% of the total fetal weight trajectory, classified into the high-speed group (aOR = 1.39, 95% CI [1.03, 1.88]), associating with a 49.44 g (95% CI [11.41, 87.48]) increase in birth weight. Subgroup analysis revealed that all these differences were only significant among the GDMA1 pregnancies (p < .05). GDM (GDMA1) is significantly associated with an increase in fetal weight during gestation in twin pregnancies. However, this acceleration is mild, and its significance requires further exploration.

We develop a latent variable selection method for multidimensional item response theory models. The proposed method identifies latent traits probed by items of a multidimensional test. Its basic strategy is to impose an $L_1$\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$L_{1}$$\end{document} penalty term to the log-likelihood. The computation is carried out by the expectation–maximization algorithm combined with the coordinate descent algorithm. Simulation studies show that the resulting estimator provides an effective way in correctly identifying the latent structures. The method is applied to a real dataset involving the Eysenck Personality Questionnaire.

Item replenishing is essential for item bank maintenance in cognitive diagnostic computerized adaptive testing (CD-CAT). In regular CAT, online calibration is commonly used to calibrate the new items continuously. However, until now no reference has publicly become available about online calibration for CD-CAT. Thus, this study investigates the possibility to extend some current strategies used in CAT to CD-CAT. Three representative online calibration methods were investigated: Method A (Stocking in Scale drift in on-line calibration. Research Rep. 88-28, 1988), marginal maximum likelihood estimate with one EM cycle (OEM) (Wainer & Mislevy In H. Wainer (ed.) Computerized adaptive testing: A primer, pp. 65–102, 1990) and marginal maximum likelihood estimate with multiple EM cycles (MEM) (Ban, Hanson, Wang, Yi, & Harris in J. Educ. Meas. 38:191–212, 2001). The objective of the current paper is to generalize these methods to the CD-CAT context under certain theoretical justifications, and the new methods are denoted as CD-Method A, CD-OEM and CD-MEM, respectively. Simulation studies are conducted to compare the performance of the three methods in terms of item-parameter recovery, and the results show that all three methods are able to recover item parameters accurately and CD-Method A performs best when the items have smaller slipping and guessing parameters. This research is a starting point of introducing online calibration in CD-CAT, and further studies are proposed for investigations such as different sample sizes, cognitive diagnostic models, and attribute-hierarchical structures.

Pro-environmental behavior, including waste sorting and recycling, involves a combination of future-oriented (futureness) and other-oriented (otherness) attributes. Inspired by the perspective of intergenerational choice, this work explores whether eliciting concerns for future others could increase public support for recycling policy and recycling behavior. Study 1 consisted of an online random controlled trial and a laboratory experiment. In Study 1A (N = 400), future other-concern was primed using a static text manipulation, whereas in Study 1B (N = 192), a dynamic virtual manipulation was employed. The results showed that people in the conditions that elicited future other-concern reported greater household recycling intentions and more actual recycling behavior than those in the control conditions. Study 2A (N = 467) and Study 2B (N = 600) generalized this effect on the acceptance of the ‘Certain Time Certain Place’ waste sorting policy in China. Consistent with the intergenerational choice model, envisioning the future of subsequent generations is more impactful in gaining policy approval than merely envisioning a future time. These findings provide a new method for promoting public policy approval and recycling behavior, suggesting that people could become environmentally friendly when they are guided to consider future others.

A recent study published in Oryx proposed that the extinct Javan tiger Panthera tigris sondaica may still survive on the Island of Java, Indonesia, based on mitochondrial DNA analysis of a single hair sample collected from a location where a tiger was reportedly encountered. However, upon reanalysing the genetic data presented in that study, we conclude that there is little support for this claim. The sequences of the putative tiger hair and Javan tiger museum specimens generated are not from tiger cytoplasmic mitochondrial DNA but more likely the nuclear pseudogene copies of mitochondrial DNA. In addition, the number of mismatches between the two Javan tiger sequences is unusually high for homologous sequences that are both from tigers, suggesting potential issues with data reliability. The paper provides insufficient details on quality control measures, making it impossible to rule out the possibility that errors were introduced during the analysis. Consequently, it is inappropriate to use the sequences presented in that study to infer the existence of the Javan tiger.

We report an experimental study of Rayleigh–Bénard convection of liquid metal GaInSn in a cuboid cell with an aspect ratio of 0.5 under the effect of a horizontal magnetic field. The Rayleigh number spans a range of $3.8\times 10^5 \leqslant Ra \leqslant 1.1\times 10^7$, while the magnetic field strength reaches up to 0.5 T, corresponding to a maximum Hartmann number to 2041. By combining temperature and velocity measurements, we identify several flow morphologies, including a novel cellular pattern characterized by four stacked vortices that periodically squeeze and induce velocity reversals. Based on the identified flow morphologies, we partition the entire ($Ra, Ha$) parameter space into five distinct flow regimes and systematically investigate the flow characteristics within each regime. The temperature gradient and oscillation frequency exhibit scaling relationships with the combined parameters $Ra$ and $Ha$. Notably, we observe a coupling between flow regime and global transport efficiencies, particularly in a regime dominated by the double-roll structure, which experiences a maximum 36 % decrease in heat transfer efficiency compared with the single-roll structure. The dependencies of heat and momentum transport on $Ra$ and $Ha$ follow scaling laws as $Nu \sim (Ha^{-2/3}RaPr^{-1})^{3/5}$ and $Re \sim (Ha^{-1}RaPr^{-1})^{4/3}$, respectively.

The nonlinear waves in a sheared liquid film on a horizontal plate at small Reynolds numbers are examined by theoretical and numerical approaches. The analysis employs the long-wave approximation along with finite difference schemes. The results show that the surface tension can suppress disturbances and prevent the occurrence of singularities. While the film flow is driven by the shear stress on the interface, its instability highly depends on the magnitude and direction of gravity. Specifically, when the direction of gravity is opposite to the wall-normal direction, perturbations are stabilized by gravity. In contrast, when these two directions are the same, the gravitational force is destabilizing, and stationary travelling waves can exist if a balance is reached between the effects of gravity and surface tension. For the steady solitary waves, there are quasi-periodic oscillations occurring between two stationary points, indicating the presence of heteroclinic trajectories. For periodic waves, the evolutions are sensitive to several parameters and initial disturbances, while one steady-state wave exhibits a sine function-like behaviour.

The AIMTB rapid test assay is an emerging test, which adopted a fluorescence immunochromatographic assay to measure interferon-γ (IFN-γ) production following stimulation of effector memory T cells in whole blood by mycobacterial proteins. The aim of this article was to explore the ability of AIMTB rapid test assay in detecting Mycobacterium tuberculosis (MTB) infection compared with the widely applied QuantiFERON-TB Gold Plus (QFT-Plus) test among rural doctors in China. In total, 511 participants were included in the survey. The concordance between the QFT-Plus test and the AIMTB rapid test assay was 94.47% with a Cohen’s kappa coefficient (κ) of 0.84 (95% CI, 0.79–0.90). Improved concordance between the two tests was observed in males and in participants with 26 or more years of service as rural doctors. The quantitative values of the QFT-Plus test was higher in individuals with a result of QFT-Plus-/AIMTB+ as compared to those with a result of QFT-Plus-/AIMTB- (p < 0.001). Overall, our study found that there was an excellent consistency between the AIMTB rapid test assay and the QFT-Plus test in a Chinese population. As the AIMTB rapid test assay is fast and easy to operate, it has the potential to improve latent tuberculosis infection testing and treatment at the community level in resource-limited settings.

Tea is one of the most widely consumed beverages in the world. However, the association between tea and risk of pancreatic adenocarcinoma remains controversial. This study aimed to investigate the causal relationship between tea consumption and risk of pancreatic adenocarcinoma and to explore their mediating effects. The two-sample Mendelian randomisation (MR) analysis showed an inverse causal relationship between tea intake and pancreatic adenocarcinoma (OR: 0·111 (0·02, 0·85), P < 0·04). To examine the mediating effects, we explored the potential mechanisms by which tea intake reduces the risk of pancreatic adenocarcinoma. Based on the oral bioavailability and drug-like properties in Traditional Chinese Medicine Systems Pharmacology database, we selected the main active ingredients of tea. We screened out the fifteen representative targeted genes by Pharmmapper database, and the gene ontology enrichment analysis showed that these targeted genes were related to vascular endothelial growth factor (VEGF) pathway. The two-step MR analysis of results showed that only VEGF-D played a mediating role, with a mediation ratio of 0·230 (0·066, 0·394). In conclusion, the findings suggest that VEGF-D mediates the effect of tea intake on the risk of pancreatic adenocarcinoma.

Artificial sweeteners are generally used and recommended to alternate added sugar for health promotion. However, the health effects of artificial sweeteners remain unclear. In this study, we included 6371 participants from the National Health and Nutrition Examination Survey with artificial sweetener intake records. Logistic regression and Cox regression were applied to explore the associations between artificial sweeteners and risks of cardiometabolic disorders and mortality. Mendelian randomisation was performed to verify the causal associations. We observed that participants with higher consumption of artificial sweeteners were more likely to be female and older and have above medium socio-economic status. After multivariable adjustment, frequent consumers presented the OR (95 % CI) for hypertension (1·52 (1·29, 1·80)), hypercholesterolaemia (1·28 (1·10, 1·50)), diabetes (3·74 (3·06, 4·57)), obesity (1·52 (1·29, 1·80)), congestive heart failure (1·89 (1·35, 2·62)) and heart attack (1·51 (1·10, 2·04)). Mendelian randomisation confirmed the increased risks of hypertension and type 2 diabetes. Moreover, an increased risk of diabetic mortality was identified in participants who had artificial sweeteners ≥ 1 daily (HR = 2·62 (1·46, 4·69), P = 0·001). Higher consumption of artificial sweeteners is associated with increased risks of cardiometabolic disorders and diabetic mortality. These results suggest that using artificial sweeteners as sugar substitutes may not be beneficial.

We present evidence revealing that an object with specific properties can exhibit multiple stable falling postures at low Reynolds numbers. By scrutinizing the force equilibrium relationship of a fixed object at various attack angles and Reynolds numbers, we introduce a methodology that can obtain the stable falling postures of the object. This method saves computational resources and more intuitively presents the results in the full parameter domain. Our findings are substantiated by free-fall tests conducted through both physical experiments and numerical simulations, which validate the existence of multiple stable solutions in accordance with the interpolation results obtained with fixed objects. Additionally, we quantify the abundance and distribution patterns of stable falling postures for a diverse range of representative shapes. This discovery highlights the existence of multiple stable solutions that are universally present across objects of different shapes. The implications of this research extend to the design, stability control and trajectory prediction of all free and controlled flights in both air and water.

To date, a comprehensive understanding of the influence of the Prandtl number ($Pr$) on flow topology in turbulent Rayleigh–Bénard convection (RBC) remains elusive. In this study, we present an experimental investigation into the evolution of flow topology in quasi-two-dimensional turbulent RBC with $7.0 \leq Pr \leq 244.2$ and $2.03\times 10^{8} \leq Ra \leq 2.81\times 10^{9}$. Particle image velocimetry (PIV) measurements reveal the flow transitions from multiple-roll state to single-roll state with increasing $Ra$, and the transition is hindered with increasing $Pr$, i.e. the transitional Rayleigh number $Ra_t$ increases with $Pr$. We mapped out a phase diagram on the flow topology change on $Ra$ and $Pr$, and identified the scaling of $Ra_t$ on $Pr$: $Ra_t \sim Pr^{0.93}$ in the low $Pr$ range, and $Ra_t \sim Pr^{3.3}$ in the high $Pr$ range. The scaling in the low $Pr$ range is consistent with the model of balance of energy dissipation time and plume travel time that we proposed in our previous study, while the scaling in the high $Pr$ range implies a new governing mechanism. For the first time, the scaling of $Re$ on $Ra$ and $Pr$ is acquired through full-field PIV velocity measurement, $Re \sim Ra^{0.63}\,Pr^{-0.87}$. We also propose that increasing horizontal velocity promotes the formation of the large-scale circulation (LSC), especially for the high $Pr$ case. Our proposal was verified by achieving LSC through introducing horizontal driving force $Ra_H$ by tilting the convection cell with a small angle.

Path planning for the unmanned aerial vehicle (UAV) is to assist in finding the proper path, serving as a critical role in the intelligence of a UAV. In this paper, a path planning for UAV in three-dimensional environment (3D) based on enhanced gravitational search algorithm (EGSA) is put forward, taking the path length, yaw angle, pitch angle, and flight altitude as considerations of the path. Considering EGSA is easy to fall into local optimum and convergence insufficiency, two factors that are the memory of current optimal and random disturbance with chaotic levy flight are adopted during the update of particle velocity, improving the balance between exploration and exploitation for EGSA through different time-varying characteristics. With the identical cost function, EGSA is compared with seven peer algorithms, such as moth flame optimization algorithm, gravitational search algorithm, and five variants of gravitational search algorithm. The experimental results demonstrate that EGSA is superior to the seven comparison algorithms on CEC 2020 benchmark functions and the path planning method based on EGSA is more valuable than the other seven methods in diverse environments.

In this paper, we have experimentally demonstrated a high-power and high-brightness narrow-linewidth fiber amplifier seeded by an optimized fiber oscillator. In order to improve the temporal stability, the fiber oscillator consists of a composite fiber Bragg grating-based cavity with an external feedback structure. By optimizing the forward and backward pumping ratio, the nonlinear effects and stimulated Raman scattering-induced mode distortion of the fiber amplifier are suppressed comprehensively, accompanied with the simultaneous improvement of beam quality and output power. The laser brightness is enhanced further by raising the threshold of transverse mode instability by approximately 1.0 kW by coiling the gain fiber with a novel curvature shape. Finally, a 6 kW narrow-linewidth laser is achieved with beam quality (M2) of approximately 1.4. The laser brightness doubled compared to the results before optimization. To the best of our knowledge, it is the highest brightness narrow-linewidth fiber laser based on a one-stage master oscillator power amplification structure.