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During the existence of Proto-Tethys Ocean (550–430 Ma), microcontinents in northern East Gondwana merged with the northern margin of India-Australia, completing the assembly of Gondwana. Ongoing controversy surrounds the disappearance of the Proto-Tethys Ocean, the dynamic mechanisms of suturing and the palaeogeographic relationships among microcontinents in northern East Gondwana, contributing to the uncertainty about the tectonic evolution of the region. This paper concerns the lower Silurian Zusailing Formation in the Hainan Island and focuses on the affinity between Hainan Island and various microcontinents in northern East Gondwana during the early Silurian. We use detrital zircon geochronology to reconstruct the closure process of the Proto-Tethys Ocean and show that the detrital zircon U–Pb age groups of the lower Silurian Zusailing Formation are 2800–2200, 2100–1350, 1250–950, 600–480 and 480–430 Ma, with a significant age peak of ca. 449 Ma. Furthermore, the analysis of detrital zircon geochemistry and europium anomalies shows that the Hainan Island crust continued to thicken during 600–434 Ma. Comparing the age spectrum of early Palaeozoic detrital zircons from Hainan Island and various microcontinents in northern East Gondwana, as well as the affinity among them during the Silurian, we conclude that the closure of the eastern Proto-Tethys Ocean evolved from unidirectional subduction (600–480 Ma) to bidirectional subduction (480–430 Ma).
To meet the demands of laser-ion acceleration at a high repetition rate, we have developed a comprehensive diagnostic system for real-time and in situ monitoring of liquid sheet targets (LSTs). The spatially resolved rapid characterizations of an LST’s thickness, flatness, tilt angle and position are fulfilled by different subsystems with high accuracy. With the help of the diagnostic system, we reveal the dependence of thickness distribution on collision parameters and report the 238-nm liquid sheet generated by the collision of two liquid jets. Control methods for the flatness and tilt angle of LSTs have also been provided, which are essential for applications of laser-driven ion acceleration and others.
Here, we report the generation of MeV alpha-particles from H-11B fusion initiated by laser-accelerated boron ions. Boron ions with maximum energy of 6 MeV and fluence of 109/MeV/sr@5 MeV were generated from 60 nm-thick self-supporting boron nanofoils irradiated by 1 J femtosecond pulses at an intensity of 1019 W/cm2. By bombarding secondary hydrogenous targets with the boron ions, 3 × 105/sr alpha-particles from H-11B fusion were registered, which is consistent with the theoretical yield calculated from the measured boron energy spectra. Our results demonstrated an alternative way toward ultrashort MeV alpha-particle sources employing compact femtosecond lasers. The ion acceleration and product measurement scheme are referential for the studies on the ion stopping power and cross section of the H-11B reaction in solid or plasma.
Post-acceleration of protons in helical coil targets driven by intense, ultrashort laser pulses can enhance ion energy by utilizing the transient current from the targets’ self-discharge. The acceleration length of protons can exceed a few millimeters, and the acceleration gradient is of the order of GeV/m. How to ensure the synchronization between the accelerating electric field and the protons is a crucial problem for efficient post-acceleration. In this paper, we study how the electric field mismatch induced by current dispersion affects the synchronous acceleration of protons. We propose a scheme using a two-stage helical coil to control the current dispersion. With optimized parameters, the energy gain of protons is increased by four times. Proton energy is expected to reach 45 MeV using a hundreds-of-terawatts laser, or more than 100 MeV using a petawatt laser, by controlling the current dispersion.
Numerous technologies have contributed to the recent development of agriculture, especially the advancement in hyperspectral remote sensing (HRS) constituted a revolution in crop monitoring. The widespread use of HRS to obtain crop parameters suggests the need for a review of research advances in this area. HRS offers new theories and methods for studying crop parameters, but much work needs to be done both experimentally and theoretically before we can truly understand the physical and chemical processes that predict these crop parameters. The study focuses on the following elements: 1) The article provides a relatively comprehensive introduction to HRS and how it can be applied to crop monitoring; 2) Current state-of-the-art techniques are summarized and analyzed to inform further advances in crop monitoring; 3) Opportunities and challenges for crop monitoring applications using HRS are discussed, and future research is summarized. Finally, through a comprehensive discussion and analysis, the article proposes new directions for using HRS to study crop characteristics, such as new data mining techniques including deep learning provide opportunities for efficient processing of large amounts of HRS data; combining the temporal and dynamic characteristics of crop parameters and vegetation growth processes will greatly improve the accuracy of crop parameter detection and monitoring; multidata fusion and multiscale data assimilation will become HRS monitoring. Multidata fusion and multiscale data assimilation will become another research hotspot for HRS monitoring of crop parameters.
Dietary l-carnitine (LC) is a nutritional factor that reduces liver lipid content. However, whether dietary LC can improve lipid metabolism via simultaneous activation of mitochondrial fatty acid (FA) β-oxidation and suppression of endoplasmic reticulum (ER) stress is still unknown. Large yellow croaker were fed with a high-fat diet (HFD) supplemented with dietary LC at 0, 1·2 or 2·4 ‰ for 10 weeks. The results indicated that a HFD supplemented with LC reduced the liver total lipid and TAG content and improved serum lipid profiles. LC supplementation administered to this fish increased the liver antioxidant capacity by decreasing serum and liver malondialdehyde levels and enhancing the liver antioxidant capacity, which then relieved the liver damage. Dietary LC increased the ATP dynamic process and mitochondrial number, decreased mitochondrial DNA damage and enhanced the protein expression of mitochondrial β-oxidation, biogenesis and mitophagy. Furthermore, dietary LC supplementation increased the expression of genes and proteins related to peroxisomal β-oxidation and biogenesis. Interestingly, feeding fish with LC-enriched diets decreased the protein levels indicative of ER stress, such as glucose-regulated protein 78, p-eukaryotic translational initiation factor 2a and activating transcription factor 6. Dietary LC supplementation downregulated mRNA expression relative to FA synthesis, reduced liver lipid and relieved liver damage through regulating β-oxidation and biogenesis of mitochondria and peroxisomes, as well as the ER stress pathway in fish fed with HFD. The present study provides the first evidence that dietary LC can improve lipid metabolism via simultaneously promoting FA β-oxidation capability and suppressing the ER stress pathway in fish.
We performed U–Pb dating of detrital zircons and conducted petrological and whole-rock geochemical analyses to assess the provenance of the Upper Triassic – Lower Jurassic clastic rocks in the southeastern margin of the South China Block. Detrital zircon U–Pb ages are mainly classified into age groups of 2000–1700, 900–700, 490–390 and 280–210 Ma, consistent with derivation from the Jiangnan orogenic belt, Nanling Belt, as well as Wuyi and Yunkai domains. Lower Jurassic samples yield a special main age population of 200–190 Ma, and these detrital zircon grains have low Th/U and Nb/Hf ratios and high Th/Nb and Hf/Th ratios, showing they are derived from a continental magmatic arc. However, the cross-correlation and likeness coefficients of kernel density estimates of Upper Triassic and Lower Jurassic sandstones are 0.8608 and 0.8403, indicating that their populations are highly similar. Since the tectonic setting is the key factor in controlling the relationship between source and sink, the stable supply of identical provenance suggests that the tectonic setting did not significantly change during Late Triassic – Early Jurassic time. Sandstone petrography, regional facies distribution and the detrital zircon age patterns all reflect a consistent tectonic setting for the South China Block during Late Triassic – Early Jurassic time. The Palaeo-Pacific subduction therefore did not control the tectonic evolution of the South China Block until after the Early Jurassic Epoch.
Carbon nanotube foams (CNFs) have been successfully used as near-critical-density targets in the laser-driven acceleration of high-energy ions and electrons. Here we report the recent advances in the fabrication technique of such targets. With the further developed floating catalyst chemical vapor deposition (FCCVD) method, large-area ($>25\kern0.5em {\mathrm{cm}}^2$) and highly uniform CNFs are successfully deposited on nanometer-thin metal or plastic foils as double-layer targets. The density and thickness of the CNF can be controlled in the range of $1{-}13\kern0.5em \mathrm{mg}/{\mathrm{cm}}^3$ and $10{-}200\kern0.5em \mu \mathrm{m}$, respectively, by varying the synthesis parameters. The dependence of the target properties on the synthesis parameters and the details of the target characterization methods are presented for the first time.
Situated between the South China Block and the Simao Block, the Ailaoshan Belt is a significant component of the Jinshajiang–Ailaoshan tectonic-magmatic-metallogenic belt of southwestern China. The formation of the Ailaoshan Belt is closely related to the evolution of the Palaeo-Tethys Ocean. In this study, we constrain ages of sedimentation in the Jinchang Au–Ni deposit in the Ailaoshan Belt, using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) U–Pb ages of the youngest populations of detrital zircons separated from a chert layer and two uncomfortably overlying meta-sandstones. The combined data of the meta-sandstone samples from the Yiwanshui Formation yielded a concordant age of 250.8 ± 0.6 Ma (mean square weighted deviation (MSWD), 2.8; n = 26). The chert sample from the Jinchangyan Formation yielded a concordant age of 347.0 ± 1.5 Ma (MSWD, 2.8; n = 16). Detrital zircons from the meta-sandstone are characterized by low rare earth element contents (∑REE) and low Y, and high U and U/Yb ratio, suggesting a continental crustal origin. Zircons in the meta-sandstones were derived mainly from pre-collision subduction zone magmatic rocks related to the closure of the Palaeo-Tethys Ocean. In contrast, detrital zircons from the chert contain relatively high ∑REE and Y, and low U and U/Yb ratio, suggesting an oceanic crust origin. Zircons in the chert bed were derived mainly from ophiolites related to seafloor spreading in a branch of the Palaeo-Tethys Ocean.
The razor clam, Sinonovacula constricta, contains high levels of long-chain PUFA (LC-PUFA), which are critical for human health. In addition, S. constricta is the first marine mollusc demonstrated to possess Δ6 fatty acyl desaturase (Fad) and complete LC-PUFA biosynthetic ability, providing a good representative to investigate the molecular mechanism of sterol regulatory element binding proteins (SREBP) in regulating Δ6 Fad for LC-PUFA biosynthesis in marine molluscs. Herein, S. constricta SREBP and Δ6 Fad promoter were cloned and characterised. Subsequently, dual luciferase and electrophoretic mobility shift assays were conducted to explore the SREBP binding elements in the core regulatory region of S. constricta Δ6 Fad promoter. Results showed that S. constricta SREBP had a very conservative basic helix-loop-helix-leucine zipper motif, while S. constricta Δ6 Fad promoter exhibited very poor identity with teleost Fads2 promoters, indicating their differentiation during evolution. A 454 bp region harbouring a core sequence in S. constricta Δ6 Fad promoter was predicted to be essential for the transcriptional activation by SREBP. This was the first report on the regulatory mechanism of LC-PUFA biosynthesis in marine molluscs, which would facilitate optimising the LC-PUFA biosynthetic pathway of bivalves in further studies.
Antipsychotic drugs (APDs) are the first-line pharmacological treatments for schizophrenia. Recent human studies have found that myelin integrity could be improved by APD treatment in schizophrenia patients. Previous studies indicated that regulation of oligodendrocyte development and function may be a novel target for APDs.
Aims:
The aim of this current study was to examine the possible effects of the antipsychotic drugs (APDs) haloperidol (HAL), olanzapine (OLA), and quetiapine (QUE) on the development of oligodendroglial lineage cells.
Main methods:
CG4 cells, an oligodendrocyte progenitor cell line, were treated with various concentrations of HAL, OLA, or QUE for specific periods. The proliferation and differentiation of the CG4 cells were measured. The regulation of CG4 cell differentiation by oligodendrocyte lineage transcription factors 1 and 2 (Olig1 and Olig2) was examined.
Results:
The APDs used in this study had no effect on the proliferation of CG4 cells. The APDs elevated the expression of 2’,3’-cyclic nucleotide 3’-phosphodiesterase (CNP), a specific marker of oligodendrocytes, and promoted the CG4 cells to differentiate into CNP positive oligodendrocytes. QUE and OLA increased the expression of Olig1 and Olig2 whereas HAL only increased the expression of Olig2.
Conclusions:
Our findings suggest that oligodendrocyte development is a target of HAL, OLA, and QUE and provide further evidence of the important role of oligodendrocytes in the pathophysiology and treatment of schizophrenia. They also indicate that the expression level of oligodendrocyte/myelinrelated genes could be profoundly affected by APDs.
Recently, autonomous field robots have been investigated as a labor-reducing means to scout through commercial strawberry fields for disease detection or fruit harvesting. To achieve accurate over-bed and cross-bed motions, it is preferred to design the motion controller based on a precise dynamic model. Here, a dynamic model is developed for a custom-designed strawberry field robot considering terramechanic wheel–terrain interaction. Different from existing models, a torus geometry is considered for the wheels. In order to obtain a control affine model, the longitudinal force is curve-fitted using a polynomial function of the slip/skid ratio, while the lateral force is curve-fitted using an exponential function of both the slip/skid ratio and slip angle. An extended Kalman filter (EKF) is then developed to estimate the unknown parameters in the approximated model such that the state variables propagated by such a model can match experimental data. The approximated model and the EKF-based parameter estimation method are then validated in a commercial strawberry farm.
Dengue fever (DF) has been a growing public-health concern in China since its emergence in Guangdong Province in 1978. Of all the regions that have experienced dengue outbreaks in mainland China, the city of Guangzhou is the most affected. This study aims to investigate the potential risk factors for dengue virus (DENV) transmission in Guangzhou, China, from 2006 to 2014. The impact of risk factors on DENV transmission was qualified by the q-values calculated using a novel spatial-temporal method, the GeoDetector model. Both climatic and socioeconomic factors were considered. The impacts on DF incidence of each single factor and the interaction of two factors were analysed. The results show that the number of days with rainfall of the month before last has the highest determinant power, with a q-value of 0.898 (P < 0.01); the q-values of the other factors related to temperature and precipitation were around 0.38–0.50. Integrating a Pearson correlation analysis, nonlinear associations were found between the DF incidence in Guangzhou and the climatic factors considered. The coupled impact of the different variables considered was enhanced compared with their individual effects. In addition, an increased number of tourists in the city were associated with a high incidence of DF. This study demonstrates that the number of rain days in a month has great influence on the DF incidence of the month after next; the temperature and precipitation have nonlinear impacts on the DF incidence in Guangzhou; both the domestic and overseas tourists coming to the city increase the risk of DENV transmission. These findings are useful in the risk assessment of DENV transmission, to predict DF outbreaks and to implement preventive DF reduction strategies.
The overwhelming majority of galaxies in the Universe are dwarf galaxies. But although they are important components in understanding galaxy evolution, these systems are typically too faint to be observed at high redshifts. However, we are able to obtain an unobscured view of early star formation and chemical enrichment in these galaxies at low redshift and low-redshift analogs at high redshift. In this talk, I will review the mass-metallicity relation, the mass-star formation rate relation of galaxies, the classifications of dwarf galaxies, and the importance of dwarf galaxies for both astronomy and physics. Then I will introduce some work in our group on connections among between different types of dwarf galaxies,the mass-metallicity relations and the main sequence relations of dwarf galaxies, using the deep optical and near infrared images and spectra of large dwarf galaxy sample. At the end, I will talk about some projects of dwarf galaxies we are working on, including the spectroscopic survey for compact dwarf galaxies using the LAMOST.
A novel Gysel power divider with high power-handling capability based on half-mode substrate integrated waveguide (HMSIW) has been presented in this paper. A HMSIW ring is used and good input/output impedance matching is achieved based on HMSIW-microstrip taper transition. Two microstrip stubs are introduced in HMSIW ring to assemble two isolation resistors to improve the isolation between the output ports. The even- and odd-mode analysis method is used for the presented circuit. A prototype of the presented power divider is designed, fabricated, and measured. The measured results show a reasonable agreement with the simulated ones.
Leaders’ implicit followership theory describes leaders’ personal assumptions about the traits and behaviors that characterize followers. Unlike traditional organizational behavior research, studies on leaders’ implicit followership theory can deepen our understandings of ‘how leaders and followers perceive, decide and take action’ from follower-centric perspective. Adopting 267 follower–leader dyads from 16 Chinese enterprises as our final sample, we found that: (1) positive leaders’ implicit followership theory had significant positive effect on followers’ creativity; (2) followers’ leader–member exchange with leader, intrinsic motivation and creative self-efficacy mediated the positive relationship between positive leaders’ implicit followership theory and followers’ creativity; (3) no significance difference was found between the mediating effects of leader–member exchange, intrinsic motivation and creative self-efficacy. The current study not only extended the application of social cognitive theory in leadership research, but also made contributions to the enrichment of social exchange theory and componential theory of creativity.
We present a measurement of the spatial clustering of massive compact galaxies at 1 ≤ z ≤ 3 in CANDELS/3D-HST. We obtain the correlation length and characteristic DM halo masses for compact quiescent galaxies (cQGs) at z ~ 1.5 and compact starforming galaxies (cSFGs) at z ~ 2.5. By comparison with extended starforming galaxies (eSFGs), our result indicates that eSFGs are less possible to be the progenitors of cQGs at lower redshift. Our results indicates that cQGs at z ~ 1.5 could be the progenitors of local luminous ETGs and the descendants of cSFGs and SMGs at z > 2.
Star-formation regions in nearby galaxies provide an excellent laboratory to study star formation processes, evolution of massive stars and the properties of the surrounding interstellar medium. A wealth of information can be obtained from their spectral analysis of the emission lines and the stellar continuum. Considering these, we proposed a long-term project “Spectroscopic Observations of the Star Formation Regions in Nearby Galaxies”. The primary goal of this project is to observe spectroscopy of star formation regions in 20 nearby galaxies, with the NAOC 2.16 m telescope and the Hectospec/MMT multifiber spectrograph. With the spectra of a large sample of star formation regions, combining multi-wavelength data from UV to IR, we can investigate, understand and quantify the dust extinction, star formation rate, metal abundance, and the two-dimensional distributions of stellar population properties of nearby galaxies. It will be important for a better understanding of galaxy formation. Here we report on the observations, data reduction, and analysis of the spectra of ~ 400 star formation regions in M33, via multifiber spectroscopy with Hectospec at the MMT.
The aim of the study is to explore the association of serum bilirubin levels with admission severity and short term clinical outcomes among acute ischemic stroke patients.
Methods:
Data were collected from 2361 acute ischemic stroke patients in four hospitals of Shangdong Province during January 2006 and December 2008. National Institutes of Health Stroke Scale (NIHSS) was used to assess admission and discharge severity. NIHSS≥10 at discharge or in-hospital death was defined as short-term clinical outcomes. Logistic regression and trend test were used to examine the association of serum bilirubin levels with admission severity and short term clinical outcomes.
Results:
Serum bilirubin levels were significantly and positively associated with admission severity (P for trend <0.05). The age-sex adjusted odds ratios (95% confidential intervals) of NIHSS≥10 associated with the second, third and fourth quartile of total bilirubin/direct bilirubin were 1.245 (0.873, 1.777)/1.276 (0.895, 1.818), 1.484 (1.048, 2.102)/1.628 (1.158, 2.289) and 2.869 (2.076, 3.966)/2.765 (1.996, 3.828), respectively, compared with the lowest quartile; the multivariate adjusted odds ratios of NIHSS≥10 associated with the second, third and fourth quartile of total bilirubin/direct bilirubin were 1.088(0.711, 1.665)/1.436(0.94, 2.193), 1.328(0.877, 2.011)/1.647(1.092, 2.485) and 2.336(1.579, 3.458)/3.079 (2.049, 4.623), respectively, compared with the lowest quartile. However, no association between serum bilirubin levels and short-term clinical outcomes was observed in our study.
Conclusion:
Serum bilirubin levels were associated with initial stroke severity closely. Nevertheless, there is no significant relationship between serum bilirubin levels and short-term clinical outcomes among acute ischemic stroke patients.