We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
Online ordering will be unavailable from 17:00 GMT on Friday, April 25 until 17:00 GMT on Sunday, April 27 due to maintenance. We apologise for the inconvenience.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
This study aims to investigate the relationship between serum folate levels and the risk of psoriasis by integrating observational study with Mendelian Randomization (MR) analysis.We firstly conducted an observational study using data from the National Health and Nutrition Examination Survey (NHANES). Subsequently, genetic instruments were selected for two-sample MR analyses to investigate the causal relationship between serum folate levels and the risk of psoriasis. The observational study showed no significant association between serum folate levels and psoriasis. In the fully adjusted model: serum folate as a continuous variable (OR = 0.99, 95% CI: 0.98 to 1.00, P = 0.071); serum folate quartiles Q4 vs Q1 (OR = 0.83, 95% CI: 0.58 to 1.19, P = 0.309). The MR analysis revealed that higher genetically predicted serum folate levels from Icelandic and Danish populations was significantly associated with a reduced risk of psoriasis (OR = 0.63, 95% CI, 0.45 to 0.88, P = 0.005). Similarly, higher genetically predicted serum folate levels from South Asian populations were also significantly associated with a lower risk of psoriasis (OR = 0.84, 95% CI, 0.72 to 0.98, P = 0.025). Integrating observational study with MR analysis suggests that serum folate levels are protective factors against psoriasis, indicating that higher serum folate levels may help prevent the onset of the disease.
This paper investigates the long-run nexus between wealth inequality and aggregate output using a DSGE model in which wealth inequality endogenously affects individual entrepreneurship incentives, thereby influencing aggregate output. Our model passes the indirect inference test against the UK data from 1870 to 2015. We find that shocks to aggregate TFP, entrepreneurial barriers, government grant support and general government spending played significant roles in shaping historical inequality dynamics in the UK. Directly removing entrepreneurial barriers or indirectly providing government grant support to the private sector such as through inclusive loan subsidies are effective means of reducing inequality and stimulating output growth.
This study investigated the impact of diallyl disulfide (DADS) on oxidative stress induced by hydrogen peroxide (H2O2) in ovine rumen epithelial cells (RECs). Initially, the effects of DADS were evaluated on cellular reactive oxygen species (ROS) levels, antioxidant capacity in RECs were estimated. Then, RNA-seq analysis was conducted in DADS-treated and untreated cells to analyze the differential gene expression, as well as Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Finally, the effects of DADS on Kelch-like ECH associated protein 1/the nuclear factor erythroid 2-related factor 2 (Keap1/Nrf2) signaling pathway in RECs were evaluated. Results showed that DADS remarkably enhanced superoxide dismutase (SOD) activity and total antioxidant capacity (T-AOC) (P < 0.05) while reducing ROS and malonaldehyde production (P < 0.05) in H2O2-treated RECs. Transcriptomic analysis revealed that DADS might influence glutathione synthesis through cysteine and methionine metabolism, thereby affecting the transcription of genes involved in immunity and oxidative stress. The DADS treatment resulted in increased nuclear translocation of Nrf2 and upregulation of mRNA and protein levels of quinone oxidoreductase 1, heme oxygenase 1, and Nrf2. The Nrf2-specific inhibitor nullified the protective effects of DADS on malonaldehyde formation induced by H2O2 and decreased T-AOC and SOD activities. In conclusion, DADS demonstrated the ability to alleviate oxidative stress in RECs by promoting antioxidative capacity through the Keap1/Nrf2 signaling pathway.
Over the past 20 years, gender relations and the expression of power and authority between men and women in Indonesia have been shaped by the forces of reformasi, decentralisation, a reassertion of central power, and economic transitions. These changes have given rise to policy reform, an increase in women's political representation, and new expressions of diverse gender identities. But to what extent has the 'gender order' of the New Order, where women's role as a mother was the basis of citizenship, been challenged or just found new articulations? What shape do contemporary contestations to gendered power take? The chapters in this volume bring gender to the centre stage and provide reflections on the political, economic, social, and cultural progress and barriers in achieving gender equality and diversity in Indonesia.
Gender ideologies, representation and contestation
The reformasi era of the past twenty years has ushered in many changes that have simultaneously progressed and challenged gender equality. At the end of the Suharto era, gender equality was a major political demand that underpinned democratic reform. Many legislative changes were made, and with these changes the dismantling of the ‘gender order’ that the New Order established began to be disrupted. However, with every legislative change came also contrary moves that sought to challenge progress towards gender equality. The political ideology of the New Order seems difficult to dismantle completely and has found new expressions and contestations.
The ‘gender order’ that underpinned the political ideology of Suharto’s New Order had heteronormative, binary and static understandings at its core. This period saw ‘male’ and ‘female’ defined more clearly according to a specific set of appearances, social roles and spatial distinctions that privileged the family or kekeluargaan as the foundation on which development—pembangunan—took place. Motherhood for example, was the basis of citizenship for women and assumed subordinate to men in what Julia Suryakusuma (2011) termed ‘state ibuism’. Repressive and restrictive representations of women and circumscribed female roles in public life underpinned the political system. Its binary counterpart, bapakism, heralded the construction of fathers of the nation, as well as the household. These binary constructs were underpinned by kodrat (biologically specific nature), assumed to be God-given and sanctioned by Islam.
Kathryn Robinson (2008, and this volume) developed an approach that identified ways in which this gender order mapped on to specific areas of power during the New Order. Drawing on social theory of gender from R.W. Connell, Robinson’s analysis reflected that ‘gender relations are present in all types of institutions. They may not be the most important structure in a particular case, but they are certainly a major structure of most’ (Connell 1987: 120). Gender relations can be understood as foci for the exercise of social, political and economic power in society; as a multidimensional structure operating in a complex network of institutions. As Kathy Robinson updates in her contribution to this volume, these institutions include, for example, marriage, political representation, laws on domestic violence and sexual violence, and employment settings. Changes to these institutions and processes over the past twenty years have provided room for gender equality gains to be made.
The advancement of gender equality is a long-term social change and can be reflected in measurable economic indicators. In the Western world, the improvement of women’s status and freedom in society is accompanied by dramatic changes in economic indicators, including an increase in female labour market participation, an increase in female educational attainment, narrowing of the gender wage gap, an increase in age at first marriage, and a decline in fertility rate (Goldin 2006). Similar changes have occurred in the developing world in the past few decades where there was relatively fast economic growth. Education of girls caught up with that of boys by the mid-2010s; labour force participation of women has increased significantly, especially in Latin America and the Caribbean; and the fertility rate has dramatically declined (World Bank 2012). However, there are still persistent large gender gaps in earnings, health and asset ownership (ibid.).
The trajectory of economic gender equality in Indonesia has been consistent with that of the developing world in many aspects. Since independence, Indonesia has made great progress in increasing schooling, reducing the fertility rate and increasing life expectancy of women. Economic liberalisation in the New Order era created fast economic growth and job opportunities for women, especially in export-oriented manufacturing. The end of the New Order, however, has seen a dramatic decline in the importance of export-oriented manufacturing as a growth engine. The new driver of economic growth has mainly been the resources boom. At the same time, the change from an authoritarian and highly centralised regime to a much more democratic and decentralised regime has allowed different social and religious groups and ideologies, including gender ideologies, to surface.
Against this backdrop, how has gender equality evolved from an economic perspective during the post-Suharto era? In this chapter we will use large-scale economic data to construct trends of many of the economic indicators of gender equality. We mainly use a cohort analysis approach to show long-term generational change. We find that employment opportunities for women have significantly improved during the post- Suharto era. Each new cohort of women is more likely to join the labour force, more likely to be employed in the formal sector, and more likely to be managers and professionals in the years following completion of their education. Educational attainment of women has also caught up and surpassed that of men in recent years.