Greenhouse gas (GHG) emissions significantly affect the environment, public health, and socioeconomic systems. Many countries and organizations have launched sustainable strategies to ease damaging consequences caused by the global climate change. Food services contribute greatly to greenhouse gas emissions. Service factors involved are food waste, the type of food service provided, and the use of single-use plastic products. For example, a single-use plastic food container related greenhouse gas emissions ranges from 0.16 to 0.48 kg CO2e. We have encouraged staffs to use reusable food containers since July 2024, and we shared the related information with all of staffs via emails and official website. This study aimed to evaluate the impact of sustainability initiatives—particularly the promotion of reusable food containers and a variable price buffet system. In our staff restaurant, 3 types of food services were in place: (i) variable price buffet service, (ii) fixed price canteen service, and (iii) fixed price box lunch. Data were first collected from July 2023 to December 2024, and then analysed according to the following 4 aspects: (i) the average number of lunches consumed each day, (ii) the amount of reusable food containers used, (iii) the reduction of greenhouse gas emissions, and (iv) an observation of food waste in food services. Statistical analysis was carried out using the SPSS software, version 22. We found that in 2024, the restaurant provided 1,200 to 1,800 meals/day during lunch time. Within these meals, 37.1% were from variable price buffets, 18.8% were from fixed price canteen, and 44.1% were from fixed price box lunches. First, in 2024, the use of reusable food containers in the variable price buffet averaged at 50% (47.9% to 56.3% on a monthly basis). In comparison to the period July to December 2023, our results show a significant increase in use of reusable food containers from July to December in 2024 (p < 0.05). Second, from July to December 2024, an estimated GHG emission reduction of 15,387–46,163 kg CO2e. Finally, based on the observation of food waste in different types of food services, there was almost no food waste in variable-price buffet service. In the literature, Matzembacher et al. have reported that the variable-price buffet service generates 116% less avoidable food wastes when compared with the fixed price canteen service(1). With the increasing public awareness of sustainable practices aimed at environmental protection, the adoption of reusable food containers and a variable-price buffet model effectively reduced plastic waste and GHG emissions. These initiatives included the implementation of a variable price buffet service to reduce food wastes and minimizing single-use plastic items and carbon footprints.

The gut–liver axis represents a bidirectional communication network for maintaining metabolic and immunological homoeostasis. Alterations in this axis allow bacterial products to reach the liver via the portal vein, promoting inflammation, oxidative stress and lipid accumulation. In this scenario, the consumption of bioactive compounds has become prominent due to its antioxidant and anti-inflammatory effects. This study aimed to investigate the effects of camu-camu (Myrciaria dubia) extract, an Amazonian fruit rich in phenolic compounds, on intestinal morphology, barrier-related gene expression and hepatic outcomes of chicken (Gallus gallus) embryos exposed to dextran sulfate sodium (DSS). Fertile eggs were divided into three groups (n 20/group): water (control), DSS (1·5 %), and camu-camu (10 %) + DSS (1·5 %). On the seventeenth day of embryonic development, treatments were injected into the amniotic fluid, and samples were collected at hatching (twenty-first day). Results showed that camu-camu was associated with changes in intestinal histomorphology, increasing villus height, surface area and the number of goblet cells, along with increased expression of selected barrier-related genes (MUC2, CLDN-1 and ZO-2). In the liver, camu-camu significantly reduced NF-κB expression compared with the DSS and water-treated groups, consistent with modulation of inflammatory-related gene expression. Furthermore, the decreased expression of iNOS, CAT and SOD-1 indicates modulation of oxidative stress-related gene expression markers. Histological analysis indicated alterations in hepatic morphology, including reduced lipid droplets and inflammatory infiltrates. These findings indicate that camu-camu is associated with changes in intestinal histomorphology, selected barrier-related gene expressions, hepatic histology and inflammatory- and oxidative stress-related gene expression markers.

Phenomenon-based research involves uncovering context-specific mechanisms underlying complex organizational realities and, when applied to Chinese contexts, offers valuable potential to extend and refine global management theories. Drawing on three illustrative studies on person–environment fit (Chuang, Hsu, Wang, & Judge, 2015), CEO humility (Ou, Waldman, & Peterson, 2014), and authoritarian leadership (Huang, Chiu, Lam, & Farh, 2015) respectively, this editorial highlights how each exemplifies different stages in the evolution of theories, from indigenous, middle-range insights to universal, general frameworks. In doing so, it addresses challenges and potential solutions for publishing phenomenon-based Chinese management research in premier journals. Across these cases, several recurring challenges emerge, including difficulties in positioning context-specific findings within existing theoretical frameworks, translating culturally embedded constructs for international audiences, and balancing cultural authenticity with global understanding. The authors also reflect on practical challenges such as building research partnerships and gaining organizational support within Chinese contexts. By comparing experiences across these studies, this editorial offers guidance on how phenomenon-based research can deepen theoretical innovation while maintaining methodological rigor and practical relevance. Lastly, it argues that Chinese management research plays a vital role in advancing universal management knowledge and offers opportunities for future research.

In Antimicrobial Stewardship and Infection Prevention and Control, programmatic goals often strive to achieve clinical benefit by practice change in the direction of doing less. Practically, this may include reducing the number of tests ordered, encouraging shorter and more narrow courses of antimicrobials, or discontinuing practices that are no longer contextually appropriate. Because promoting practice change in the direction of doing less is a critical aspect of day-to-day operations in Antimicrobial Stewardship and Infection Prevention and Control, the goals of this Society for Healthcare Epidemiology Research Committee White Paper are to provide a roadmap and framework for leveraging principles of implementation and de-implementation science in day-to-day practice. Part II of this series focuses on some practical case studies, including real-world examples of applied de-implementation science to promote discontinuation of practices that are ineffective, overused, or no longer effective.

De-implementation of established practices is a common challenge in infection prevention and antimicrobial stewardship and a necessary part of the life cycle of healthcare quality improvement programs. Promoting de-implementation of ineffective antimicrobial use and increasingly of low-value diagnostic testing are cornerstones of stewardship practice. Principles of de-implementation science and the interplay of implementation and de-implementation are discussed in part I of this Society for Healthcare Epidemiology of America White Paper Series.In this second part of the series, we discuss a process for applying principles of de-implementation science in infection prevention and stewardship and then review some real-world examples and case studies, including a national blood culture shortage, contact precautions, and surgical and dental prophylaxis. We use these examples to demonstrate how barriers and facilitators can be mapped to evidence-informed implementation/de-implementation strategies to promote efforts to reduce low-value, ineffective, or out-of-date practices. These real-world examples highlight the need for infection prevention and stewardship programs to adapt to changing evidence, contexts, and conditions. Although barriers to practice change are often a bit different, de-implementation can sometimes be thought of as the implementation of a new program—but the new program aims to stop rather than start doing something.

As the saying goes, sometimes less really is more. Medicine and public health have a strong action bias and a strong aversion to risk and uncertainty. Although our best intentions may point us to implementing more interventions, often, the best medicine instead dictates that we do less, or nothing at all. Leveraging principles of de-implementation science can help move healthcare in the right direction when interventions are low-value, ineffective, or no longer needed.

The genus Bursaphelenchus has attracted significant attention due to its economically devastating and quarantined species – notably the pine wood nematode B. xylophilus and B. cocophilus. Despite their ecological and agricultural importance, genomic data for this genus remain scarce. In this study, we sequenced and assembled the complete mitochondrial genomes of three Bursaphelenchus species (B. chengi, B. parantoniae, and B. sinensis) using high-throughput sequencing. The circular mitogenomes exhibited size variation, with B. chengi (17,670 bp), B. parantoniae (15,021 bp), and B. sinensis (18,386 bp) each containing the typical nematode mitochondrial gene complement: 12 protein-coding genes (PCGs), 2 ribosomal RNA (rRNA) genes, and 22 transfer RNA (tRNA) genes. Phylogenetic analysis based on the concatenated amino acid sequences of the 12 PCGs revealed that these species form a sister clade to B. xylophilus and B. mucronatus. Comparative mitogenomic analysis demonstrated a conserved gene arrangement shared among Bursaphelenchus, Aphelenchoides, Caenorhabditis, Cruznema tripartitum, and Pristionchus pacificus, suggesting strong evolutionary conservatism across the families Aphelenchoididae, Neodiplogasteridae, and Rhabditidae. Our study enriched the mitochondrial genomic resources for Bursaphelenchus and advanced resolution of their intrageneric phylogenetic relationships.

The impact of the self-sealing band on interior ballistics is investigated during the gun launching, and a high-precision interior ballistics coupling algorithm that takes leakage into account is proposed. This study focuses on a 65 mm short-barrel, equal-caliber balanced cannon, integrating Abaqus finite element software with an interior ballistics calculation programme. It uses a User-defined AMPlication Load (VUAMP) subroutine to achieve real-time coupling calculations of the chamber pressure and self-sealing band deformation, correcting variations in the chamber pressure. Experimental results show that the coupling algorithm offers the higher precision compared to traditional interior ballistics models and can effectively capture the impact of leakage on the interior ballistics performance. Further research reveals that changes in the charge amount and assembly gap significantly affect the sealing performance of the self-sealing band and the leakage of propellant gases, which in turn influence the chamber pressure and projectile velocity. The high-precision coupling algorithm proposed in this paper provides the effective theoretical support for the design of the self-sealing band and the analysis of cannon performance.

Background: Nipocalimab (a fully human, effectorless anti-neonatal Fc receptor (FcRn) monoclonal antibody) may ameliorate gMG disease manifestations by selectively targeting FcRn IgG recycling and lowering IgG, including pathogenic autoantibodies in generalized myasthenia gravis (gMG). The objective was to evaluate the effectiveness and safety of intravenous nipocalimab added to background standard-of-care therapy in adolescents with gMG. Methods: Seropositive patients (12-<18 years) with gMG (MGFA Class II-IV) on stable therapy but inadequately controlled, were enrolled in a 24-week open label study. Nipocalimab was administered as a 30 mg/kg IV loading dose followed by 15 mg/kg IV every 2 Weeks. Results: Seven adolescents were enrolled; 5 completed 24-weeks of dosing. The mean(SD) age was 14.1(1.86) years; seven were anti-AChR+, six were female. Mean(SD) baseline MG-ADL/QMG scores were 4.29(2.430)/12.50(3.708). Nipocalimab showed a significant reduction in total serum IgG at week-24; the mean(SD) change from baseline to week-24 for total serum IgG was -68.98%(7.561). The mean(SD) change in MG-ADL/QMG scores at week-24 was -2.40(0.418)/-3.80(2.683); 4 of 5 patients achieved minimum symptom expression (MG-ADL score 0-1) by week-24. Nipocalimab was well-tolerated; there were no serious adverse events. There were no clinically meaningful laboratory changes. Conclusions: Nipocalimab demonstrated efficacy and safety in this 6-month trial in seropositive adolescents with gMG.

Background: Artificial intelligence (AI) holds promise to predict outcomes for patients sustaining moderate to severe traumatic brain injury (msTBI). This systematic review sought to identify studies utilizing AI-based methods to predict mortality and functional outcomes after msTBI, where prognostic uncertainty is highest. Methods: The APPRAISE-AI quantitative evidence appraisal tool was used to evaluate methodological quality of included studies by determining overall scores and domain-specific scores. We constructed a multivariable linear regression model using study sample size, country of data collection, publication year and journal impact factor to quantify associations with overall APPRAISE-AI scores. Results: We identified 38 studies comprising 591,234 patients with msTBI. Median APPRAISE-AI score was 45.5 (/100 points), corresponding to moderate study quality. There were 13 low-quality studies (34%) and only 5 high-quality studies (13%). Weakest domains were methodological conduct, robustness of results and reproducibility. Multivariable linear regression highlighted that higher journal impact factor, larger sample size, more recent publication year and use of data that were collected in a high-income country were associated with higher APPRAISE-AI overall scores. Conclusions: We identified several study weaknesses of existing AI-based prediction models for msTBI; this work highlights methodological domains that require quality improvement to ultimately ensure safety and effiicacy of clinical AI models.

With numerous applications of coilable masts in high-precision space application scenarios, there are also greater demands on the accuracy of their dynamic modelling and analysis. The modelling of hinges is a critical issue in the dynamic modelling of coilable masts, which significantly affects the accuracy of the dynamic response analysis. For coilable masts, the rotational effect is the most important problem in hinge modelling. However, few studies have focused on this topic. To address this problem, the concept of hinge equivalent rotational stiffness is proposed in this paper to describe the rotational effect of the coilable mast hinges. After that, a new coilable mast dynamic model containing the undetermined hinge equivalent rotational stiffness is introduced, and an identification method for the hinge equivalent rotational stiffness based on the hammer test is proposed. Finally, the dynamic modelling method is validated through an actual coilable mast example, and the analysis and test results show that the accuracy of the dynamic model established by the proposed method in this paper is greater than that of the traditional model.

Metabolic enzymes are the catalysts that drive the biochemical reactions essential for sustaining life. Many of these enzymes are tightly regulated by feedback mechanisms. To fully understand their roles and modulation, it is crucial to investigate the relationship between their structure, catalytic mechanism, and function. In this perspective, by using three examples from our studies on Mycobacterium tuberculosis (Mtb) isocitrate lyase and related proteins, we highlight how an integrated approach combining structural, activity, and biophysical data provides insights into their biological functions. These examples underscore the importance of employing fast-fail experiments at the early stages of a research project, emphasise the value of complementary techniques in validating findings, and demonstrate how in vitro data combined with chemical, biochemical, and physiological knowledge can lead to a broader understanding of metabolic adaptations in pathogenic bacteria. Finally, we address the unexplored questions in Mtb metabolism and discuss how we expand our approach to include microbiological and bioanalytical techniques to further our understanding. Such an integrated and interdisciplinary strategy has the potential to uncover novel regulatory mechanisms and identify new therapeutic opportunities for the eradication of tuberculosis. The approach can also be broadly applied to investigate other biochemical networks and complex biological systems.

Ultrafast optical probing is a widely used method of underdense plasma diagnostic. In relativistic plasma, the motion blur limits spatial resolution in the direction of motion. For many high-power lasers the initial pulse duration of 30–50 fs results in a 10–15 μm motion blur, which can be reduced by probe pulse post-compression. Here we used the compression after compressor approach [Phys.-Usp. 62, 1096 (2019); JINST 17 P07035 (2022)], where spectral broadening is performed in thin optical plates and is followed by reflections from negative-dispersion mirrors. Our initially low-intensity probe beam was down-collimated for a more efficient spectral broadening and higher probe-to-self-emission intensity ratio. The setup is compact, fits in a vacuum chamber and can be implemented within a short experimental time slot. We proved that the compressed pulse retained the high quality necessary for plasma probing.